Resection Margin Width Does Not Influence the Prognosis of Solitary Hepatocellular Carcinoma After Anatomic Resection: A Real-World Study from China

References

• Benson AB, D’Angelica MI, Abbott DE, et al. Hepatobiliary cancers, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2021;19(5):541–565. doi:10.6004/jnccn.2021.0022
   PubMed Web of Science ®Google Scholar
• Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition). Liver Cancer. 2020;9(6):682–720. doi:10.1159/000509424
   PubMed Web of Science ®Google Scholar
• Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol. 2022;76(3):681–693. doi:10.1016/j.jhep.2021.11.018
   PubMed Web of Science ®Google Scholar
• Liao K, Yang K, Cao L, et al. Laparoscopic anatomical versus non-anatomical hepatectomy in the treatment of hepatocellular carcinoma: a randomised controlled trial. Int J Surg. 2022;102:106652. doi:10.1016/j.ijsu.2022.106652
   PubMed Web of Science ®Google Scholar
• Moris D, Tsilimigras DI, Kostakis ID, et al. Anatomic versus non-anatomic resection for hepatocellular carcinoma: a systematic review and meta-analysis. Eur J Surg Oncol. 2018;44(7):927–938. doi:10.1016/j.ejso.2018.04.018
   PubMed Web of Science ®Google Scholar
• Jiao S, Li G, Zhang D, Xu Y, Liu J, Li G. Anatomic versus non-anatomic resection for hepatocellular carcinoma, do we have an answer? A meta-analysis. Int J Surg. 2020;80:243–255. doi:10.1016/j.ijsu.2020.05.008
   PubMed Web of Science ®Google Scholar
• Shindoh J, Kobayashi Y, Umino R, Kojima K, Okubo S, Hashimoto M. Successful anatomic resection of tumor-bearing portal territory delays long-term stage progression of hepatocellular carcinoma. Ann Surg Oncol. 2021;28(2):844–853. doi:10.1245/s10434-020-08927-3
   PubMed Web of Science ®Google Scholar
• Villanueva A. Hepatocellular carcinoma. N Engl J Med. 2019;380(15):1450–1462. doi:10.1056/NEJMra1713263
   PubMed Web of Science ®Google Scholar
• Zhou Z, Qi L, Mo Q, et al. Effect of surgical margin on postoperative prognosis in patients with solitary hepatocellular carcinoma: a propensity score matching analysis. J Cancer. 2021;12(15):4455–4462. doi:10.7150/jca.57896
   PubMed Web of Science ®Google Scholar
• Yang P, Si A, Yang J, et al. A wide-margin liver resection improves long-term outcomes for patients with HBV-related hepatocellular carcinoma with microvascular invasion. Surgery. 2019;165(4):721–730. doi:10.1016/j.surg.2018.09.016
   PubMed Web of Science ®Google Scholar
• Shi M, Guo RP, Lin XJ, et al. Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trial. Ann Surg. 2007;245(1):36–43. doi:10.1097/01.sla.0000231758.07868.71
   PubMed Web of Science ®Google Scholar
• Wang H, Yu H, Qian YW, Cao ZY, Wu MC, Cong WM. Impact of surgical margin on the prognosis of early hepatocellular carcinoma (≤5 cm): a propensity score matching analysis. Front Med. 2020;7:139. doi:10.3389/fmed.2020.00139
   Web of Science ®Google Scholar
• Su CM, Chou CC, Yang TH, Lin YJ. Comparison of anatomic and non-anatomic resections for very early-stage hepatocellular carcinoma: the importance of surgical resection margin width in non-anatomic resection. Surg Oncol. 2021;36:15–22. doi:10.1016/j.suronc.2020.11.009
   PubMed Web of Science ®Google Scholar
• Shi C, Zhao Q, Liao B, et al. Anatomic resection and wide resection margin play an important role in hepatectomy for hepatocellular carcinoma with peritumoural micrometastasis. Anz J Surg. 2019;89(11):E482–E486. doi:10.1111/ans.15396
   PubMed Web of Science ®Google Scholar
• Zhang XP, Xu S, Lin ZY, et al. Significance of anatomical resection and resection margin status in patients with HBV-related hepatocellular carcinoma and microvascular invasion: a multicenter propensity score-matched study. Int J Surg. 2023;109(4):679–688. doi:10.1097/JS9.0000000000000204
   PubMed Web of Science ®Google Scholar
• Johnson PJ, Berhane S, Kagebayashi C, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-The ALBI grade. J Clin Oncol. 2015;33(6):550–558. doi:10.1200/JCO.2014.57.9151
   PubMed Web of Science ®Google Scholar
• Lai EC, You KT, Ng IO, Shek TW. The pathological basis of resection margin for hepatocellular carcinoma. World J Surg. 1993;17(6):786–791. doi:10.1007/BF01659097
   PubMed Web of Science ®Google Scholar
• Hyun J, Ha MS, Oh SY, et al. Urinary tract infection after radiation therapy or radical prostatectomy on the prognosis of patients with prostate cancer: a population-based study. BMC Cancer. 2023;23(1):395. doi:10.1186/s12885-023-10869-4
   PubMed Web of Science ®Google Scholar
• Wang L, Ke Q, Lin K, et al. Not all hepatocellular carcinoma patients with microvascular invasion after R0 resection could be benefited from prophylactic transarterial chemoembolization: a propensity score matching study. Cancer Manag Res. 2020;12:3815–3825. doi:10.2147/CMAR.S251605
   PubMed Web of Science ®Google Scholar
• Dai XM, Xiang ZQ, Wang Q, Li HJ, Zhu Z. Oncological outcomes of anatomic versus non-anatomic resections for small hepatocellular carcinoma: systematic review and meta-analysis of propensity-score matched studies. World J Surg Oncol. 2022;20(1):299. doi:10.1186/s12957-022-02770-4
   PubMed Web of Science ®Google Scholar
• Liu L, Shui Y, Yu Q, et al. Narrow-margin hepatectomy resulted in higher recurrence and lower overall survival for R0 resection hepatocellular carcinoma. Front Oncol. 2021;10:610636. doi:10.3389/fonc.2020.610636
   PubMed Web of Science ®Google Scholar
• Field W, Rostas JW, Philps P, Scoggins CR, Mcmasters KM, Martin RN. Wide versus narrow margins after partial hepatectomy for hepatocellular carcinoma: balancing recurrence risk and liver function. Am J Surg. 2017;214(2):273–277. doi:10.1016/j.amjsurg.2017.06.002
   PubMed Web of Science ®Google Scholar
• Nitta H, Allard MA, Sebagh M, et al. Ideal surgical margin to prevent early recurrence after hepatic resection for hepatocellular carcinoma. World J Surg. 2021;45(4):1159–1167. doi:10.1007/s00268-020-05881-9
   PubMed Web of Science ®Google Scholar
• Marques F, Ghallab M, Vibert E, et al. Prognostic impact of surgical margins for hepatocellular carcinoma according to preoperative alpha-fetoprotein level. HPB. 2022;24(6):848–856. doi:10.1016/j.hpb.2021.10.012
   PubMed Web of Science ®Google Scholar
• Lee JC, Cheng CH, Wang YC, et al. Clinical relevance of alpha-fetoprotein in determining resection margin for hepatocellular carcinoma. Medicine. 2019;98(11):e14827. doi:10.1097/MD.0000000000014827
   PubMed Web of Science ®Google Scholar
• Aoki T, Kubota K, Hasegawa K, et al. Significance of the surgical hepatic resection margin in patients with a single hepatocellular carcinoma. Br J Surg. 2020;107(1):113–120. doi:10.1002/bjs.11329
   PubMed Web of Science ®Google Scholar
• Fukutomi S, Nomura Y, Nakashima O, et al. Evaluation of hepatocellular carcinoma spread via the portal system by 3-dimensional mapping. HPB. 2017;19(12):1119–1125. doi:10.1016/j.hpb.2017.08.011
   PubMed Web of Science ®Google Scholar
• Huang J, Li L, Liu FC, et al. Prognostic analysis of single large hepatocellular carcinoma following radical resection: a single-center study. J Hepatocell Carcinoma. 2023;10:573–586. doi:10.2147/JHC.S404895
   PubMed Web of Science ®Google Scholar
• Zheng Z, Guan R, Jianxi W, et al. Microvascular invasion in hepatocellular carcinoma: a review of its definition, clinical significance, and comprehensive management. J Oncol. 2022;2022:9567041. doi:10.1155/2022/9567041
   PubMedGoogle Scholar
• Rodriguez-Peralvarez M, Luong TV, Andreana L, Meyer T, Dhillon AP, Burroughs AK. A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability. Ann Surg Oncol. 2013;20(1):325–339. doi:10.1245/s10434-012-2513-1
   PubMed Web of Science ®Google Scholar
• Nakashima Y, Nakashima O, Tanaka M, Okuda K, Nakashima M, Kojiro M. Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type. Hepatol Res. 2003;26(2):142–147. doi:10.1016/s1386-6346(03)00007-x
   PubMed Web of Science ®Google Scholar
• Lin WD, Ye LN, Song ZS, Wang KP, Feng YF, Pan CY. Wide surgical margins improve prognosis for HCC with microvascular invasion. Eur Rev Med Pharmacol Sci. 2023;27(5):2052–2059. doi:10.26355/eurrev_202303_31576
   PubMed Web of Science ®Google Scholar
• Cai R, Song R, Pang P, et al. Transcatheter arterial chemoembolization plus sorafenib versus transcatheter arterial chemoembolization alone to treat advanced hepatocellular carcinoma: a meta-analysis. BMC Cancer. 2017;17(1):714. doi:10.1186/s12885-017-3707-5
   PubMedGoogle Scholar
• Peng Z, Fan W, Zhu B, et al. Lenvatinib combined with transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma: a Phase III, randomized clinical trial (LAUNCHl). J Clin Oncol. 2023;41(1):117–127. doi:10.1200/JCO.22.00392
   PubMed Web of Science ®Google Scholar
• Wang L, Ke Q, Deng M, et al. Adjuvant transarterial chemoembolization for patients with hepatocellular carcinoma after radical hepatectomy: a real world study. Scand J Gastroenterol. 2019;54(11):1403–1411. doi:10.1080/00365521.2019
   PubMed Web of Science ®Google Scholar
• Lin K, Wei F, Huang Q, et al. Postoperative adjuvant transarterial chemoembolization plus tyrosine kinase inhibitor for hepatocellular carcinoma: a multicentre retrospective study. J Hepatocell Carcinoma. 2022;9:127–140. doi:10.2147/JHC.S352480
   PubMed Web of Science ®Google Scholar
• Wang L, Qiu L, Ke Q, Ji H, Wu J. Systematic review of adjuvant external beam radiotherapy for hepatocellular carcinoma following radical hepatectomy. Radiother Oncol. 2022;175:101–111. doi:10.1016/j.radonc.2022.08.019
   PubMed Web of Science ®Google Scholar
• Chen W, Hu S, Liu Z, et al. Adjuvant anti-PD-1 antibody for hepatocellular carcinoma with high recurrence risks after hepatectomy. Hepatol Int. 2023;17(2):406–416. doi:10.1007/s12072-022-10478-6
   PubMed Web of Science ®Google Scholar