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ORIGINAL RESEARCH

Beta2-Microglobulin as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram

ORCID Icon, , , , ORCID Icon, , , & ORCID Icon show all
Pages 1813-1825 | Received 29 Jun 2023, Accepted 04 Oct 2023, Published online: 11 Oct 2023

References

  • Yang C, Zhang H, Zhang L, et al. Evolving therapeutic landscape of advanced hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2023;20(4):203–222.
  • Lee HM, Lidofsky SD, Taddei TH, Townshend-Bulson LJ. Attacking the public health crisis of hepatocellular carcinoma at its roots. Hepatology. 2023;77(4):1456–1459. doi:10.1002/hep.32741
  • Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma. Nat RevDis Prim. 2021;7(1):6. doi:10.1038/s41572-020-00240-3
  • Kim H, Ahn SW, Hong SK, et al. Survival benefit of liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma. Br J Surg. 2017;104(8):1045–1052. doi:10.1002/bjs.10541
  • Zhong JH, Lu SD, Wang YY, Ma L, Li LQ. Intermediate-stage HCC--upfront resection can be feasible. Nat Rev Clin Oncol. 2015;12(5):295. doi:10.1038/nrclinonc.2014.122-c3
  • Zhong JH, Ke Y, Gong WF, et al. Hepatic resection associated with good survival for selected patients with intermediate and advanced-stage hepatocellular carcinoma. Ann Surg. 2014;260(2):329–340. doi:10.1097/SLA.0000000000000236
  • Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 Edition). Liver Cancer. 2020;9(6):682–720. doi:10.1159/000509424
  • Nakayama H, Okamura Y, Higaki T, Moriguchi M, Takayama T. Effect of blood product transfusion on the prognosis of patients undergoing hepatectomy for hepatocellular carcinoma: a propensity score matching analysis. J Gastroenterol. 2023;58(2):171–181. doi:10.1007/s00535-022-01946-9
  • Jeng LB, Li TC, Wang J, Teng CF. Increased plasma levels of monocyte chemoattractant protein-1 in patients with hepatitis B virus pre-S2 gene deletion mutation predict a higher risk of hepatocellular carcinoma recurrence after curative surgical resection. Cancer. 2023;129(17):2621–2636. doi:10.1002/cncr.34815
  • Lin WP, Xing KL, Fu JC, et al. Development and validation of a model including distinct vascular patterns to estimate survival in hepatocellular carcinoma. JAMA network open. 2021;4(9):e2125055. doi:10.1001/jamanetworkopen.2021.25055
  • He Z, She X, Liu Z, et al. Advances in post-operative prognostic models for hepatocellular carcinoma. J Zhejiang Univ Sci B. 2023;24(3):191–206. doi:10.1631/jzus.B2200067
  • Golfieri R, Bargellini I, Spreafico C, Trevisani F. Patients with Barcelona clinic liver cancer stages B and C hepatocellular carcinoma: time for a subclassification. Liver Cancer. 2019;8(2):78–91. doi:10.1159/000489791
  • Dupuy M, Iltache S, Rivière B, et al. Plasma hPG(80) (Circulating Progastrin) as a novel prognostic biomarker for hepatocellular carcinoma. Cancers. 2022;14(2):402. doi:10.3390/cancers14020402
  • Liu L, Wang Q, Zhao X, et al. Establishment and validation of nomogram model for the diagnosis of AFP-negative hepatocellular carcinoma. Front Oncol. 2023;13:1131892. doi:10.3389/fonc.2023.1131892
  • Huang C, Fang M, Feng H, et al. N-glycan fingerprint predicts alpha-fetoprotein negative hepatocellular carcinoma: a large-scale multicenter study. Int J Cancer. 2021;149(3):717–727. doi:10.1002/ijc.33564
  • Kristiansson A, Davidsson S, Johansson ME, et al. α(1)-Microglobulin (A1M) protects human proximal tubule epithelial cells from heme-induced damage in vitro. Int J Mol Sci. 2020;21(16):5825. doi:10.3390/ijms21165825
  • Bergwik J, Kristiansson A, Welinder C, et al. Knockout of the radical scavenger α(1)-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight. Free Radic Biol Med. 2021;162:160–170. doi:10.1016/j.freeradbiomed.2020.02.019
  • Gao Y, Hong Y, Huang L, et al. β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell. 2023;186(5):1026–1038.e1020. doi:10.1016/j.cell.2023.01.021
  • Sivanathan PC, Ooi KS, Mohammad Haniff MAS, et al. Lifting the veil: characteristics, clinical significance, and application of β-2-microglobulin as biomarkers and its detection with biosensors. ACS Biomater Sci Eng. 2022;8(8):3142–3161. doi:10.1021/acsbiomaterials.2c00036
  • Josson S, Nomura T, Lin JT, et al. β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res. 2011;71(7):2600–2610. doi:10.1158/0008-5472.CAN-10-3382
  • Huang WC, Wu D, Xie Z, et al. beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res. 2006;66(18):9108–9116. doi:10.1158/0008-5472.CAN-06-1996
  • Li D, Zhang Q, Li L, et al. β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages. Cancer Res. 2022;82(18):3321–3334. doi:10.1158/0008-5472.CAN-22-0507
  • Huang WC, Havel JJ, Zhau HE, et al. Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells. Clin Cancer Res. 2008;14(17):5341–5347. doi:10.1158/1078-0432.CCR-08-0793
  • Bunning RA, Haworth SL, Cooper EH. Serum beta-2-microglobulin levels in urological cancer. J Urol. 1979;121(5):624–625. doi:10.1016/S0022-5347(17)56910-4
  • Nomura T, Huang WC, Zhau HE, et al. Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis. Clin Cancer Res. 2006;12(24):7294–7305. doi:10.1158/1078-0432.CCR-06-2060
  • Li K, Du H, Lian X, et al. Characterization of β2-microglobulin expression in different types of breast cancer. BMC Cancer. 2014;14(1):750. doi:10.1186/1471-2407-14-750
  • Chai D, Li K, Du H, et al. β2-microglobulin has a different regulatory molecular mechanism between ER(+) and ER(-) breast cancer with HER2(). BMC Cancer. 2019;19(1):223. doi:10.1186/s12885-019-5410-1
  • Jung SH, Kim K, Yoon SE, et al. Validation of the revised diagnostic criteria for primary plasma cell leukemia by the Korean Multiple Myeloma Working Party. Blood Cancer J. 2022;12(11):157. doi:10.1038/s41408-022-00755-w
  • Pedersen AG, Bach FW, Nissen M, Bach F. Creatine kinase BB and beta-2-microglobulin as markers of CNS metastases in patients with small-cell lung cancer. J Clin Oncol. 1985;3(10):1364–1372. doi:10.1200/JCO.1985.3.10.1364
  • Heimbach JK, Kulik LM, Finn RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67(1):358–380. doi:10.1002/hep.29086
  • EAftSot L. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236.
  • Cong WM, Bu H, Chen J, et al. Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update. World J Gastroenterol. 2016;22(42):9279–9287. doi:10.3748/wjg.v22.i42.9279
  • Zhou Y, Tang L, Chen Y, Zhang Y, Zhuang W. An immune panel signature predicts prognosis of lung adenocarcinoma patients and correlates with immune microenvironment. Front Cell Dev Biol. 2021;9:797984. doi:10.3389/fcell.2021.797984
  • Yoo C, Yoon DH, Yoon S, et al. Prognostic impact of β2-microglobulin in patients with non-gastric mucosa-associated lymphoid tissue lymphoma. Leuk Lymphoma. 2015;56(3):688–693. doi:10.3109/10428194.2014.917640
  • Udzura M, Kobayashi H, Taguchi Y, Sekino H. Intrasellar intercarotid communicating artery associated with agenesis of the right internal carotid artery: case report. Neurosurgery. 1988;23(6):770–773. doi:10.1227/00006123-198812000-00019
  • Takeuchi M, Miyoshi H, Asano N, et al. Human leukocyte antigen class II expression is a good prognostic factor in adult T-cell leukemia/lymphoma. Haematologica. 2019;104(8):1626–1632. doi:10.3324/haematol.2018.205567
  • Li H, Shao G, Zhang Y, et al. Nomograms based on SUVmax of (18)F-FDG PET/CT and clinical parameters for predicting progression-free and overall survival in patients with newly diagnosed extranodal natural killer/T-cell lymphoma. Cancer Imaging. 2021;21(1):9. doi:10.1186/s40644-020-00379-y
  • Vassilakopoulos TP, Nadali G, Angelopoulou MK, et al. The prognostic significance of beta(2)-microglobulin in patients with Hodgkin’s lymphoma. Haematologica. 2002;87(7):701–708; discussion 708.
  • Federico M, Bellei M, Marcheselli L, et al. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J Clin Oncol. 2009;27(27):4555–4562. doi:10.1200/JCO.2008.21.3991
  • Chen Y, Neelapu S, Feng L, et al. Prognostic significance of baseline peripheral absolute neutrophil, monocyte and serum β2-microglobulin level in patients with diffuse large b-cell lymphoma: a new prognostic model. Br J Haematol. 2016;175(2):290–299. doi:10.1111/bjh.14237
  • López-Guillermo A, Colomo L, Jiménez M, et al. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol. 2005;23(12):2797–2804. doi:10.1200/JCO.2005.07.155
  • Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised international staging system for multiple myeloma: a report from International Myeloma Working Group. J Clin Oncol. 2015;33(26):2863–2869. doi:10.1200/JCO.2015.61.2267
  • Hofbauer D, Mougiakakos D, Broggini L, et al. β(2)-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Immunity. 2021;54(8):1772–1787.e1779. doi:10.1016/j.immuni.2021.07.002
  • Erstad DJ, Tanabe KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma. Ann Surg Oncol. 2019;26(5):1474–1493. doi:10.1245/s10434-019-07227-9
  • Ren L, Chen D, Xu W, et al. Predictive potential of Nomogram based on GMWG for patients with hepatocellular carcinoma after radical resection. BMC Cancer. 2021;21(1):817. doi:10.1186/s12885-021-08565-2
  • Mo Q, Liu Y, Zhou Z, et al. Prognostic value of aspartate transaminase/alanine transaminase ratio in patients with hepatitis B virus-related hepatocellular carcinoma undergoing hepatectomy. Front Oncol. 2022;12:876900. doi:10.3389/fonc.2022.876900
  • Shim JH, Jun MJ, Han S, et al. Prognostic nomograms for prediction of recurrence and survival after curative liver resection for hepatocellular carcinoma. Ann Surg. 2015;261(5):939–946. doi:10.1097/SLA.0000000000000747
  • Long J, Zhang L, Wan X, et al. A four-gene-based prognostic model predicts overall survival in patients with hepatocellular carcinoma. J Cell Mol Med. 2018;22(12):5928–5938. doi:10.1111/jcmm.13863
  • Tang B, Zhu J, Li J, et al. The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma. Cell Commun Signal. 2020;18(1):174. doi:10.1186/s12964-020-00663-1
  • Chen B, Yang Z, Lang Z, et al. M6A-related lncRNAs predict clinical outcome and regulate the tumor immune microenvironment in hepatocellular carcinoma. BMC Cancer. 2022;22(1):867. doi:10.1186/s12885-022-09925-2