The role of the NLRP3 inflammasome in gout

References

• ScheeleCarl Wilhelm1742–1786Swedish apothecaryJAMA19702121322582259
   Google Scholar
• FreudweilerMStudies on the nature of gouty tophiDtsch Arch Klin Med189963266
   Google Scholar
• LandisRCHaskardDOPathogenesis of crystal-induced inflammationCurr Rheumatol Rep200131364111177769
   PubMedGoogle Scholar
• MartinWJWaltonMHarperJResident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute goutArthritis Rheum200960128128919116939
   PubMed Web of Science ®Google Scholar
• TorresRMacdonaldLCrollSDHyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritisAnn Rheum Dis200968101602160819528034
   PubMed Web of Science ®Google Scholar
• TerkeltaubRSundyJSSchumacherHRThe interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot studyAnn Rheum Dis200968101613161719635719
   PubMed Web of Science ®Google Scholar
• McGonagleDTanALShankaranarayanaSMaddenJEmeryPMcDermottMFManagement of treatment resistant inflammation of acute on chronic tophaceous gout with anakinraAnn Rheum Dis200766121683168417998217
   PubMed Web of Science ®Google Scholar
• SoADe SmedtTRevazSTschoppJA pilot study of IL-1 inhibition by anakinra in acute goutArthritis Res Ther200792R2817352828
   PubMed Web of Science ®Google Scholar
• SoADe MeulemeesterMPikhlakACanakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: results of a multicenter, phase II, dose-ranging studyArthritis Rheum201062103064307620533546
   PubMed Web of Science ®Google Scholar
• PelegrinPSurprenantAPannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathwayJ Biol Chem200728242386239417121814
   PubMed Web of Science ®Google Scholar
• MaitraRClementCCScharfBEndosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysisMol Immunol2009472–317518419804908
   PubMed Web of Science ®Google Scholar
• HornungVBauernfeindFHalleASilica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationNat Immunol20089884785618604214
   PubMed Web of Science ®Google Scholar
• HackerHVabulasRMTakeuchiOHoshinoKAkiraSWagnerHImmune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6J Exp Med2000192459560010952730
   PubMed Web of Science ®Google Scholar
• MariathasanSWeissDSNewtonKCryopyrin activates the inflammasome in response to toxins and ATPNature2006440708122823216407890
   PubMed Web of Science ®Google Scholar
• MartinonFPetrilliVMayorATardivelATschoppJGout-associated uric acid crystals activate the NALP3 inflammasomeNature2006440708123724116407889
   PubMed Web of Science ®Google Scholar
• ZhangFXKirschningCJMancinelliRBacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytesJ Biol Chem1999274127611761410075645
   PubMed Web of Science ®Google Scholar
• SchwandnerRDziarskiRWescheHRotheMKirschningCJPeptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2J Biol Chem199927425174061740910364168
   PubMed Web of Science ®Google Scholar
• MoorsMALiLMizelSBActivation of interleukin-1 receptor-associated kinase by gram-negative flagellinInfect Immun20016974424442911401982
   PubMed Web of Science ®Google Scholar
• FrendeusBWachtlerCHedlundMEscherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activationMol Microbiol2001401375111298274
   PubMed Web of Science ®Google Scholar
• HedlundMFrendeusBWachtlerCHangLFischerHSvanborgCType 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cellsMol Microbiol200139354255211169097
   PubMed Web of Science ®Google Scholar
• NociariMOcheretinaOSchogginsJWFalck-PedersenESensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulatorJ Virol20078184145415717251283
   PubMed Web of Science ®Google Scholar
• LinYLeeHBergAHLisantiMPShapiroLSchererPEThe lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytesJ Biol Chem200027532242552426310823826
   PubMed Web of Science ®Google Scholar
• KawaiTAkiraSAntiviral signaling through pattern recognition receptorsJ Biochem2007141213714517190786
   PubMed Web of Science ®Google Scholar
• MartinonFAgostiniLMeylanETschoppJIdentification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasomeCurr Biol200414211929193415530394
   PubMed Web of Science ®Google Scholar
• CravenRRGaoXAllenICStaphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cellsPLoS One2009410e744619826485
   PubMed Web of Science ®Google Scholar
• KannegantiTDOzorenNBody-MalapelMBacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3Nature2006440708123323616407888
   PubMed Web of Science ®Google Scholar
• MuruveDAPetrilliVZaissAKThe inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune responseNature2008452718310310718288107
   PubMed Web of Science ®Google Scholar
• EisenbarthSCColegioORO’ConnorWSutterwalaFSFlavellRACrucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvantsNature200845371981122112618496530
   PubMed Web of Science ®Google Scholar
• CasselSLEisenbarthSCIyerSSThe Nalp3 inflammasome is essential for the development of silicosisProc Natl Acad Sci U S A2008105269035904018577586
   PubMed Web of Science ®Google Scholar
• DostertCPetrilliVVan BruggenRSteeleCMossmanBTTschoppJInnate immune activation through Nalp3 inflammasome sensing of asbestos and silicaScience2008320587667467718403674
   PubMed Web of Science ®Google Scholar
• InoharaNChamaillardMMcDonaldCNunezGNOD-LRR proteins: role in host-microbial interactions and inflammatory diseaseAnnu Rev Biochem20057435538315952891
   PubMed Web of Science ®Google Scholar
• MartinonFBurnsKTschoppJThe inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaMol Cell200210241742612191486
   PubMed Web of Science ®Google Scholar
• MartinonFTschoppJInflammatory caspases and inflammasomes: master switches of inflammationCell Death Differ2007141102216977329
   PubMed Web of Science ®Google Scholar
• PetrilliVPapinSDostertCMayorAMartinonFTschoppJActivation of the NALP3 inflammasome is triggered by low intracellular potassium concentrationCell Death Differ20071491583158917599094
   PubMed Web of Science ®Google Scholar
• KahlenbergJMDubyakGRMechanisms of caspase-1 activation by P2X7 receptor-mediated K+ releaseAm J Physiol Cell Physiol20042865C1100110815075209
   PubMed Web of Science ®Google Scholar
• FranchiLKannegantiTDDubyakGRNunezGDifferential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteriaJ Biol Chem200728226188101881817491021
   PubMed Web of Science ®Google Scholar
• HalleAHornungVPetzoldGCThe NALP3 inflammasome is involved in the innate immune response to amyloid-betaNat Immunol20089885786518604209
   PubMed Web of Science ®Google Scholar
• ChuSCYangSFTzangBSHsiehYSLueKHLuKHCathepsin B and cystatin C play an inflammatory role in gouty arthritis of the kneeClin Chim Acta201041121–221788179220699092
   PubMed Web of Science ®Google Scholar
• MeissnerFMolawiKZychlinskyASuperoxide dismutase 1 regulates caspase-1 and endotoxic shockNat Immunol20089886687218604212
   PubMed Web of Science ®Google Scholar
• NeteaMGNold-PetryCANoldMFDifferential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophagesBlood2009113102324233519104081
   PubMed Web of Science ®Google Scholar
• RobertsTLIdrisADunnJAHIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNAScience200932359171057106019131592
   PubMed Web of Science ®Google Scholar
• Fernandes-AlnemriTYuJWDattaPWuJAlnemriESAIM2 activates the inflammasome and cell death in response to cytoplasmic DNANature2009458723750951319158676
   PubMed Web of Science ®Google Scholar
• HornungVAblasserACharrel-DennisMAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCNature2009458723751451819158675
   PubMed Web of Science ®Google Scholar
• BurckstummerTBaumannCBlumlSAn orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeNat Immunol200910326627219158679
   PubMed Web of Science ®Google Scholar
• HumkeEWShriverSKStarovasnikMAFairbrotherWJDixitVMICEBERG: a novel inhibitor of interleukin-1beta generationCell200010319911111051551
   PubMed Web of Science ®Google Scholar
• DruilheASrinivasulaSMRazmaraMAhmadMAlnemriESRegulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteinsCell Death Differ20018664965711536016
   PubMed Web of Science ®Google Scholar
• LamkanfiMDeneckerGKalaiMINCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generationJ Biol Chem200427950517295173815383541
   PubMed Web of Science ®Google Scholar
• ScottAMSalehMThe inflammatory caspases: guardians against infections and sepsisCell Death Differ2007141233116977333
   PubMed Web of Science ®Google Scholar
• SalehMMathisonJCWolinskiMKEnhanced bacterial clearance and sepsis resistance in caspase-12-deficient miceNature200644070871064106816625199
   PubMed Web of Science ®Google Scholar
• SalehMVaillancourtJPGrahamRKDifferential modulation of endotoxin responsiveness by human caspase-12 polymorphismsNature20044296987757915129283
   PubMed Web of Science ®Google Scholar
• GuardaGDostertCStaehliFT cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomesNature2009460725226927319494813
   PubMed Web of Science ®Google Scholar
• HoffmanHMMuellerJLBroideDHWandererAAKolodnerRDMutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndromeNat Genet200129330130511687797
   PubMed Web of Science ®Google Scholar
• FeldmannJPrieurAMQuartierPChronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytesAm J Hum Genet200271119820312032915
   PubMed Web of Science ®Google Scholar
• AgannaEMartinonFHawkinsPNAssociation of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosisArthritis Rheum20024692445245212355493
   PubMed Web of Science ®Google Scholar
• AgostiniLMartinonFBurnsKMcDermottMFHawkinsPNTschoppJNALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderImmunity200420331932515030775
   PubMed Web of Science ®Google Scholar
• AksentijevichINowakMMallahMDe novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseasesArthritis Rheum200246123340334812483741
   PubMed Web of Science ®Google Scholar
• BrydgesSDMuellerJLMcGeoughMDInflammasome-mediated disease animal models reveal roles for innate but not adaptive immunityImmunity200930687588719501000
   PubMed Web of Science ®Google Scholar
• HoffmanHMFiresteinGSAnakinra for the treatment of neonatal-onset multisystem inflammatory diseaseNat Clin Pract Rheumatol200621264664717133246
   PubMedGoogle Scholar
• Goldbach-ManskyRDaileyNJCannaSWNeonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibitionN Engl J Med2006355658159216899778
   PubMed Web of Science ®Google Scholar
• HawkinsPNLachmannHJMcDermottMFInterleukin-1-receptor antagonist in the Muckle-Wells syndromeN Engl J Med2003348252583258412815153
   PubMed Web of Science ®Google Scholar
• Goldbach-ManskyRShroffSDWilsonMA pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndromeArthritis Rheum20085882432244218668591
   PubMed Web of Science ®Google Scholar
• HoffmanHMThroneMLAmarNJEfficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studiesArthritis Rheum20085882443245218668535
   PubMed Web of Science ®Google Scholar
• LachmannHJKone-PautIKuemmerle-DeschnerJBUse of canakinumab in the cryopyrin-associated periodic syndromeN Engl J Med2009360232416242519494217
   PubMed Web of Science ®Google Scholar
• LachmannHJLowePFelixSDIn vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromesJ Exp Med200920651029103619364880
   PubMed Web of Science ®Google Scholar
• HoffmanHMRilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)Expert Opin Biol Ther20099451953119344287
   PubMed Web of Science ®Google Scholar
• StackJHBeaumontKLarsenPDIL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patientsJ Immunol200517542630263416081838
   PubMed Web of Science ®Google Scholar
• MastersSLSimonAAksentijevichIKastnerDLHorror autoinflammaticus: the molecular pathophysiology of autoinflammatory diseaseAnnu Rev Immunol20092762166819302049
   PubMed Web of Science ®Google Scholar
• WiseCAGillumJDSeidmanCEMutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorderHum Mol Genet200211896196911971877
   PubMed Web of Science ®Google Scholar
• ShohamNGCentolaMMansfieldEPyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathwayProc Natl Acad Sci U S A200310023135011350614595024
   PubMed Web of Science ®Google Scholar
• VermaDLermMBlomgran JulinderRErikssonPSoderkvistPSarndahlEGene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?Arthritis Rheum200858388889418311798
   PubMed Web of Science ®Google Scholar
• KastbomAVermaDErikssonPSkoghTWingrenGSoderkvistPGenetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project)Rheumatology (Oxford)200847441541718263599
   PubMed Web of Science ®Google Scholar
• SchoultzIVermaDHalfvarssonJCombined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn’s disease in Swedish menAm J Gastroenterol200910451180118819319132
   PubMed Web of Science ®Google Scholar
• MiaoZMZhaoSHYanSLNALP3 inflammasome functional polymorphisms and gout susceptibilityCell Cycle200981273019106604
   PubMed Web of Science ®Google Scholar
• AksentijevichIMastersSLFergusonPJAn autoinflammatory disease with deficiency of the interleukin-1-receptor antagonistN Engl J Med2009360232426243719494218
   PubMed Web of Science ®Google Scholar
• MastersSLDunneASubramanianSLActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetesNat Immunol2010111089790420835230
   PubMed Web of Science ®Google Scholar
• DuewellPKonoHRaynerKJNLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsNature201046472931357136120428172
   PubMed Web of Science ®Google Scholar
• RajamakiKLappalainenJOorniKCholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammationPLoS One201057e1176520668705
   PubMed Web of Science ®Google Scholar
• OkamotoMLiuWLuoYConstitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1betaJ Biol Chem201028596477648820038581
   PubMed Web of Science ®Google Scholar
• VilaysaneAChunJSeamoneMEThe NLRP3 inflammasome promotes renal inflammation and contributes to CKDJ Am Soc Nephrol201021101732174420688930
   PubMed Web of Science ®Google Scholar
• KannegantiTDBody-MalapelMAmerACritical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNAJ Biol Chem200628148365603656817008311
   PubMed Web of Science ®Google Scholar
• AllenICScullMAMooreCBThe NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNAImmunity200930455656519362020
   PubMed Web of Science ®Google Scholar
• IchinoheTLeeHKOguraYFlavellRIwasakiAInflammasome recognition of influenza virus is essential for adaptive immune responsesJ Exp Med20092061798719139171
   PubMed Web of Science ®Google Scholar
• KannegantiTDCentral roles of NLRs and inflammasomes in viral infectionNat Rev Immunol2010101068869820847744
   PubMed Web of Science ®Google Scholar
• AllenICTeKippeEMWoodfordRMThe NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancerJ Exp Med201020751045105620385749
   PubMed Web of Science ®Google Scholar
• YagnikDRHillyerPMarshallDNoninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages. Implications for the control of joint inflammation in goutArthritis Rheum20004381779178910943868
   PubMed Web of Science ®Google Scholar
• LandisRCYagnikDRFloreyOSafe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophagesArthritis Rheum200246113026303312428246
   PubMed Web of Science ®Google Scholar
• ShiYEvansJERockKLMolecular identification of a danger signal that alerts the immune system to dying cellsNature2003425695751652114520412
   PubMed Web of Science ®Google Scholar
• JoostenLANeteaMGMylonaEEngagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritisArthritis Rheum201062113237324820662061
   PubMed Web of Science ®Google Scholar
• Liu-BryanRScottPSydlaskeARoseDMTerkeltaubRInnate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammationArthritis Rheum20055292936294616142712
   PubMed Web of Science ®Google Scholar
• ChenCJShiYHearnAMyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystalsJ Clin Invest200611682262227116886064
   PubMed Web of Science ®Google Scholar
• ScottPMaHViriyakosolSTerkeltaubRLiu-BryanREngagement of CD14 mediates the inflammatory potential of monosodium urate crystalsJ Immunol200617796370637817056568
   PubMed Web of Science ®Google Scholar
• TerkeltaubRCurtissLKTennerAJGinsbergMHLipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystalsJ Clin Invest1984736171917306725556
   PubMed Web of Science ®Google Scholar
• TerkeltaubRADyerCAMartinJCurtissLKApolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivoJ Clin Invest199187120261985096
   PubMed Web of Science ®Google Scholar
• Ortiz-BravoESieckMSSchumacherHRJrChanges in the proteins coating monosodium urate crystals during active and subsiding inflammation. Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch modelArthritis Rheum1993369127412858216421
   PubMed Web of Science ®Google Scholar
• LioteFPrudhommeauxFSchiltzCInhibition and prevention of monosodium urate monohydrate crystal-induced acute inflammation in vivo by transforming growth factor beta1Arthritis Rheum1996397119211988670330
   PubMed Web of Science ®Google Scholar
• RediniFMauvielAPronostSLoyauGPujolJPTransforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expressionArthritis Rheum199336144508424835
   PubMed Web of Science ®Google Scholar
• FadokVABrattonDLKonowalAFreedPWWestcottJYHensonPMMacrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFJ Clin Invest199810148908989466984
   PubMed Web of Science ®Google Scholar
• BellinganGJCaldwellHHowieSEDransfieldIHaslettCIn vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodesJ Immunol19961576257725858805660
   PubMed Web of Science ®Google Scholar
• JordanKMCameronJSSnaithMBritish Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of goutRheumatology (Oxford)20074681372137417522099
   PubMed Web of Science ®Google Scholar
• McGonagleDTanALMaddenJEmeryPMcDermottMFSuccessful treatment of resistant pseudogout with anakinraArthritis Rheum200858263163318240249
   PubMed Web of Science ®Google Scholar
• LaskoBSheedyBHingoraniVRDEA594, a novel uricosuric agent, significantly reduced serum urate levels and was well tolerated in a phase 2a pilot study in hyperuricemic gout patientsArthritis Rheum200960S413414
   Google Scholar