The role of neuroinflammation and neurovascular dysfunction in major depressive disorder

References

• KelleyKWBluthéRMDantzerRCytokine-induced sickness behaviorBrain Behav Immun200317S112S11812615196
   PubMed Web of Science ®Google Scholar
• AizensteinHJBaskysABoldriniMVascular depression consensus report: a critical updateBMC Med20161416127806704
   PubMed Web of Science ®Google Scholar
• AlexopoulosGSMeyersBSYoungRCCampbellSSilbersweigDCharlsonM‘Vascular depression’ hypothesisArch Gen Psychiatry1997549159229337771
   PubMed Web of Science ®Google Scholar
• SneedJRCulang-ReinliebMEThe vascular depression hypothesis: an updateAm J Geriatr psychiatry2011199910321328801
   PubMed Web of Science ®Google Scholar
• AnismanHMeraliZCytokines, stress and depressive illness: brainimmune interactionsAnn Med20033521112693607
   PubMed Web of Science ®Google Scholar
• RaisonCLCapuronLMillerAHCytokines sing the blues: inflammation and the pathogenesis of depressionTrends Immunol200627243116316783
   PubMed Web of Science ®Google Scholar
• MillerAHMaleticVRaisonCLInflammation and its discontents: the role of cytokines in the pathophysiology of major depressionBiol Psychiatry20096573274119150053
   PubMed Web of Science ®Google Scholar
• LanquillonSKriegJCBening-Abu-ShachUVedderHCytokine production and treatment response in major depressive disorderNeuropsychopharmacology20002237037910700656
   PubMed Web of Science ®Google Scholar
• HowrenMBLamkinDMSulsJAssociations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysisPsychosom Med20097117118619188531
   PubMed Web of Science ®Google Scholar
• DowlatiYHerrmannNSwardfagerWA meta-analysis of cytokines in major depressionBiol Psychiatry20106744645720015486
   PubMed Web of Science ®Google Scholar
• AlesciSMartinezPEKelkarSMajor depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implicationsJ Clin Endocrinol Metab2005902522253015705924
   PubMed Web of Science ®Google Scholar
• YangKXieGZhangZLevels of serum interleukin (IL)-6, IL-1β, tumour necrosis factor-α and leptin and their correlation in depressionAust N Z J Psychiatry20074126627317464708
   PubMed Web of Science ®Google Scholar
• SuSMillerAHSniederHCommon genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart studyPsychosom Med20097115215819073752
   PubMed Web of Science ®Google Scholar
• ClericiMArosioBMundoECytokine polymorphisms in the pathophysiology of mood disordersCNS Spectr20091441942519890236
   PubMed Web of Science ®Google Scholar
• WongMLDongCMaestre-MesaJLicinioJPolymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant responseMol Psychiatry20081380081218504423
   PubMed Web of Science ®Google Scholar
• TuğluCKaraSHCaliyurtOVardarEAbayEIncreased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorderPsychopharmacology200317042943312955291
   PubMed Web of Science ®Google Scholar
• ChrousosGPStressors, stress, and neuroendocrine integration of the adaptive response: the 1997 Hans Selye Memorial LectureAnn N Y Acad Sci19988513113359668623
   PubMed Web of Science ®Google Scholar
• WangXWuHMillerAHInterleukin 1α (IL-1α) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor functionMol Psychiatry20049657514699442
   PubMed Web of Science ®Google Scholar
• PaceTWHuFMillerAHCytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depressionBrain Behav Immun20072191917070667
   PubMed Web of Science ®Google Scholar
• SongCMeraliZAnismanHVariations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatmentNeuroscience19998882383610363820
   PubMed Web of Science ®Google Scholar
• PaceTWMletzkoTCAlagbeOIncreased stress-induced inflammatory responses in male patients with major depression and increased early life stressAm J Psychiatry20061631630163316946190
   PubMed Web of Science ®Google Scholar
• FrankMGBarattaMVSprungerDBWatkinsLRMaierSFMicroglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responsesBrain Behav Immun200721475916647243
   PubMed Web of Science ®Google Scholar
• BarrientosRMSprungerDBCampeauSWatkinsLRRudyJWMaierSFBDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administrationJ Neuroimmunol200415511912615342202
   PubMed Web of Science ®Google Scholar
• JeonSWKimYKInflammation-induced depression: Its pathophysiology and therapeutic implicationsJ Neuroimmunol2017313929829153615
   PubMed Web of Science ®Google Scholar
• JeonSWKimYKNeuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?World J Psychiatry2016628329327679767
   PubMed Web of Science ®Google Scholar
• KimYKNaKSMyintAMLeonardBEThe role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depressionProg Neuropsychopharmacol Biol Psychiatry20166427728426111720
   PubMed Web of Science ®Google Scholar
• JunTYPaeCUHoonHPossible association between –G308A tumour necrosis factor-α gene polymorphism and major depressive disorder in the Korean populationPsychiatr Genet20031317918112960751
   PubMed Web of Science ®Google Scholar
• FertuzinhosSMOliveiraJRNishimuraALAnalysis of IL-1α, IL-1β, and IL-1RA [correction of IL-RA] polymorphisms in dysthy-miaJ Mol Neurosci20042225125614997019
   PubMed Web of Science ®Google Scholar
• AdinolfiLENevolaRRinaldiLRomanoCGiordanoMChronic hepatitis C virus infection and depressionClin Liver Dis20172151753428689590
   PubMed Web of Science ®Google Scholar
• PollakYYirmiyaRCytokine-induced changes in mood and behaviour: implications for ‘depression due to a general medical condition’, immunotherapy and antidepressive treatmentInt J Neuropsychophar-macol20025389399
   PubMed Web of Science ®Google Scholar
• YirmiyaRWeidenfeldJPollakYCytokines, “depression due to a general medical condition”, and antidepressant drugsAdv Exp Med Biol199946128331610442179
   PubMed Web of Science ®Google Scholar
• DantzerRAubertABluthéRMMechanisms of the behavioural effects of cytokinesAdv Exp Med Biol19994618310510442169
   PubMed Web of Science ®Google Scholar
• al-HuthailYRNeuropsychiatric side-effects of interferon alfa therapy for hepatitis C and their management: a reviewSaudi J Gastroenterol200612596719858587
   PubMedGoogle Scholar
• KrausMRSchäferAScheurlenMParoxetine for the prevention of depression induced by interferon alfaN Engl J Med2001345375376
   PubMed Web of Science ®Google Scholar
• SavitzJDrevetsWCSmithCMPutative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorderNeuropsychopharmacology20154046347125074636
   PubMed Web of Science ®Google Scholar
• RéusGZJansenKTitusSCarvalhoAFGabbayVQuevedoJKynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences [sic] from animal and human studiesJ Psychiatr Res20156831632826028548
   PubMed Web of Science ®Google Scholar
• HolsboerFCorticotropin-releasing hormone modulators and depressionCurr Opin Investig Drugs200344650
   PubMedGoogle Scholar
• de SouzaEBCorticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disordersPsychoneuroendocrinology1995207898198834089
   PubMed Web of Science ®Google Scholar
• Yurgelun-ToddDASavaSDahlgrenMKMood disordersNeuroimaging Clin N Am20071751152117983967
   PubMed Web of Science ®Google Scholar
• GongQHeYDepression, neuroimaging and connectomics: a selective overviewBiol Psychiatry20157722323525444171
   PubMed Web of Science ®Google Scholar
• PaulusMPFeinsteinJSSimmonsASteinMBAnterior cingulate activation in high trait anxious subjects is related to altered error processing during decision makingBiol Psychiatry2004551179118715184037
   PubMed Web of Science ®Google Scholar
• CapuronLRavaudADantzerRTiming and specificity of the cognitive changes induced by interleukin-2 and interferon-α treatments in cancer patientsPsychosom Med20016337638611382265
   PubMed Web of Science ®Google Scholar
• EischAJPetrikDDepression and hippocampal neurogenesis: a road to remission?Science2012338727523042885
   PubMed Web of Science ®Google Scholar
• MaharIBambicoFRMechawarNNobregaJNStress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effectsNeurosci Biobehav Rev20143817319224300695
   PubMed Web of Science ®Google Scholar
• EkdahlCTKokaiaZLindvallOBrain inflammation and adult neurogenesis: the dual role of microgliaNeuroscience20091581021102918662748
   PubMed Web of Science ®Google Scholar
• KanekoNKudoKMabuchiTSuppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrusNeuropsychopharmacology2006312619262616823390
   PubMed Web of Science ®Google Scholar
• KooJWDumanRSIL-1β is an essential mediator of the antineurogenic and anhedonic effects of stressProc Natl Acad Sci U S A200810575175618178625
   PubMed Web of Science ®Google Scholar
• JeonSWKimYKMolecular neurobiology and promising new treatment in depressionInt J Mol Sci20161738126999106
   PubMed Web of Science ®Google Scholar
• KempermannGKrebsJFabelKThe contribution of failing adult hippocampal neurogenesis to psychiatric disordersCurr Opin Psychiatry20082129029518382230
   PubMed Web of Science ®Google Scholar
• RevestJMDupretDKoehlMAdult hippocampal neurogenesis is involved in anxiety-related behaviorsMol Psychiatry20091495996719255582
   PubMed Web of Science ®Google Scholar
• ThompsonABoekhoornKvan DamAMChanges in adult neurogenesis in neurodegenerative diseases: cause or consequence?Genes Brain Behav20087284218184368
   PubMed Web of Science ®Google Scholar
• SolomonMBHermanJPSex differences in psychopathology: of gonads, adrenals and mental illnessPhysiol Behav20099725025819275906
   PubMed Web of Science ®Google Scholar
• McCormickCMMathewsIZHPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressorsPharmacol Biochem Behav20078622023316901532
   PubMed Web of Science ®Google Scholar
• NaninckEFLucassenPJBakkerJSex differences in adolescent depression: do sex hormones determine vulnerability?J Neuroendocrinol20112338339221418338
   PubMed Web of Science ®Google Scholar
• BaleTLNeuroendocrine and immune influences on the CNS: it’s a matter of sexNeuron200964131619840541
   PubMed Web of Science ®Google Scholar
• HanamsagarRBilboSDSex differences in neurodevelopmental and neurodegenerative disorders: focus on microglial function and neuroinflammation during developmentJ Steroid Biochem Mol2016160127133
   PubMed Web of Science ®Google Scholar
• KippMBeyerCImpact of sex steroids on neuroinflammatory processes and experimental multiple sclerosisFront Neuroendocrinol20093018820019393685
   PubMed Web of Science ®Google Scholar
• SoucyGBoivinGLabrieFRivestSEstradiol is required for a proper immune response to bacterial and viral pathogens in the female brainJ Immunol20051746391639815879140
   PubMed Web of Science ®Google Scholar
• MayerEAGut feelings: the emerging biology of gut-brain communicationNat Rev Neurosci20111245346621750565
   PubMed Web of Science ®Google Scholar
• TheoharidesTCWeinkaufCContiPBrain cytokines and neuropsychiatric disordersJ Clin Psychopharmacol20042457758115538117
   PubMed Web of Science ®Google Scholar
• KoopmanMel AidySDepressed gut? The microbiota-diet-inflammation trialogue in depressionCurr Opin Psychiatry20173036937728654462
   PubMed Web of Science ®Google Scholar
• PetraAIPanagiotidouSHatziagelakiEStewartJMContiPTheoharidesTCGut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulationClin Ther20153798499526046241
   PubMed Web of Science ®Google Scholar
• KrebsMLeopoldKHinzpeterASchaeferMNeuroprotective agents in schizophrenia and affective disordersExpert Opin Pharmacother2006783784816634707
   PubMed Web of Science ®Google Scholar
• NajjarSPearlmanDMAlperKNajjarADevinskyONeuroinflammation and psychiatric illnessJ Neuroinflammation2013104323547920
   PubMed Web of Science ®Google Scholar
• KöhlerOBenrosMENordentoftMEffect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trialsJAMA Psychiatry2014711381139125322082
   PubMed Web of Science ®Google Scholar
• EyreHAAirTProctorSBauneBTA critical review of the efficacy of non-steroidal anti-inflammatory drugs in depressionProg Neuropsychopharmacol Biol Psychiatry201557111625455584
   PubMed Web of Science ®Google Scholar
• Garcia-BuenoBPerez-NievasBGLezaJCIs there a role for the nuclear receptor PPARγ in neuropsychiatric diseases?Int J Neuropsychopharmacol2010131411142920800014
   PubMed Web of Science ®Google Scholar
• JohanssonDFalkAMarcusMMSvenssonTHCelecoxib enhances the effect of reboxetine and fluoxetine on cortical noradrenaline and serotonin output in the ratProg Neuropsychopharmacol Biol Psychiatry20123914314822691715
   PubMed Web of Science ®Google Scholar
• MüllerNSchwarzMJDehningSThe cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetineMol Psychiatry20061168068416491133
   PubMed Web of Science ®Google Scholar
• NeryFGMonkulESHatchJPCelecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled studyHum Psychopharmacol200823879418172906
   PubMed Web of Science ®Google Scholar
• WangYYangFLiuYFGaoFJiangWAcetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive ratsNeurosci Lett2011499747921640159
   PubMed Web of Science ®Google Scholar
• SchmidtFMKirkbyKCHimmerichHThe TNF-alpha inhibitor etanercept as monotherapy in treatment-resistant depression: report of two casesPsychiatr Danub20142628829025191779
   PubMed Web of Science ®Google Scholar
• Warner-SchmidtJLVanoverKEChenEYMarshallJJGreengardPAntidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humansProc Natl Acad Sci U S A20111089262926721518864
   PubMed Web of Science ®Google Scholar
• HowlandRHSequenced treatment alternatives to relieve depression (STAR*D): part 2 – study outcomesJ Psychosoc Nurs Ment Health Serv2008462124
   Web of Science ®Google Scholar
• UherRCarverSPowerRANon-steroidal anti-inflammatory drugs and efficacy of antidepressants in major depressive disorderPsychol Med2012422027203522391106
   PubMed Web of Science ®Google Scholar
• LinPYMischoulonDFreemanMPAre omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depressionMol Psychiatry2012171161116722824812
   PubMed Web of Science ®Google Scholar
• DaviesNMKehoePGBen-ShlomoYAssociations of antihypertensive treatments with Alzheimer’s disease, vascular dementia, and other dementiasJ Alzheimers Dis20112669970821709373
   PubMed Web of Science ®Google Scholar
• BrietzkeEKapczinskiFTNF-α as a molecular target in bipolar disorderProg Neuropsychopharmacol Biol Psychiatry2008321355136118316149
   PubMed Web of Science ®Google Scholar
• HannestadJDellaGioiaNBlochMThe effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysisNeuropsychopharmacology2011362452245921796103
   PubMed Web of Science ®Google Scholar
• JanssenDGCaniatoRNVersterJCBauneBTA psychoneuroimmunological review on cytokines involved in antidepressant treatment responseHum Psychopharmacol20102520121520373471
   PubMed Web of Science ®Google Scholar
• McNallyLBhagwagarZHannestadJInflammation, glutamate, and glia in depression: a literature reviewCNS Spectr20081350151018567974
   PubMed Web of Science ®Google Scholar
• ZoumakisEChrousosGPCorticotropin-releasing hormone receptor antagonists: an updateEndocr Dev201017364319955754
   PubMedGoogle Scholar
• UherRGenes, environment, and individual differences in responding to treatment for depressionHarv Rev Psychiatry20111910912421631158
   PubMed Web of Science ®Google Scholar
• MaesMBosmansEde JonghRIncreased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depressionCytokine199798538589367546
   PubMed Web of Science ®Google Scholar
• MaesMThe immunoregulatory effects of antidepressantsHum Psychopharmacol2001169510312404604
   PubMed Web of Science ®Google Scholar
• CattaneoAGennarelliMUherRCandidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline ‘predictors’ and longitudinal ‘targets’Neuropsychopharmacology20133837738522990943
   PubMed Web of Science ®Google Scholar
• PowellTRSchalkwykLCHeffernanALTumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram responseEur Neuropsychopharmacol2013231105111423142150
   PubMed Web of Science ®Google Scholar
• TsaoCWLinYSChenCCCytokines and serotonin transporter in patients with major depressionProg Neuropsychopharmacol Biol Psychiatry20063089990516616982
   PubMed Web of Science ®Google Scholar
• EllerTVasarVShlikJPro-inflammatory cytokines and treatment response to escitalopram in major depressive disorderProg Neuropsychopharmacol Biol Psychiatry20083244545017976882
   PubMed Web of Science ®Google Scholar
• RobinsonRGJorgeREPost-stroke depression: a reviewAm J Psychiatry201617322123126684921
   PubMed Web of Science ®Google Scholar
• HouseADennisMMogridgeLWarlowCHawtonKJonesLMood disorders in the year after first strokeBr J Psychiatry199115883922015456
   PubMed Web of Science ®Google Scholar
• RobinsonRGPriceTRPost-stroke depressive disorders: a follow-up study of 103 patientsStroke1982136356417123596
   PubMed Web of Science ®Google Scholar
• RobinsonRGKubosKLStarrLBRaoKPriceTRMood disorders in stroke patients: importance of location of lesionBrain198410781936697163
   PubMed Web of Science ®Google Scholar
• CarsonAJMacHaleSAllenKDepression after stroke and lesion location: a systematic reviewLancet200035612212610963248
   PubMed Web of Science ®Google Scholar
• AströmMAdolfssonRAsplundKMajor depression in stroke patients: a 3-year longitudinal studyStroke1993249769828322398
   PubMed Web of Science ®Google Scholar
• FengCFangMLiuXYThe neurobiological pathogenesis of post-stroke depressionScientificWorldJournal2014201452134924744682
   PubMed Web of Science ®Google Scholar
• FujikawaTYokotaNMuraokaMYamawakiSResponse of patients with major depression and silent cerebral infarction to antidepressant drug therapy, with emphasis on central nervous system adverse reactionsStroke199627204020428898812
   PubMed Web of Science ®Google Scholar
• BryanRNManolioTASchertzLDA method for using MR to evaluate the effects of cardiovascular disease on the brain: the cardiovascular health studyAJNR Am J Neuroradiol199415162516337847205
   PubMed Web of Science ®Google Scholar
• ThomasAJFerrierINKalariaRNPerryRHBrownAO’BrienJTA neuropathological study of vascular factors in late-life depressionJ Neurol Neurosurg Psychiatry200170838711118253
   PubMed Web of Science ®Google Scholar
• KhalafAEdelmanKTudorascuDAndreescuCReynoldsCFAizensteinHWhite matter hyperintensity accumulation during treatment of late-life depressionNeuropsychopharmacology2015403027303526058663
   PubMed Web of Science ®Google Scholar
• BryerJBStarksteinSEVotypkaVParikhRMPriceTRRobinsonRGReduction of CSF monoamine metabolites in poststroke depression: a preliminary reportJ Neuropsychiatry Clin Neurosci199244404421384852
   PubMed Web of Science ®Google Scholar
• MaybergHSRobinsonRGWongDFPET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depressionAm J Psychiatry19881459379433394877
   PubMed Web of Science ®Google Scholar
• FinklesteinSCampbellABaldessariniRJMoyaKLHaberSNLate changes in cerebral monoamine metabolism following focal ventrolateral cerebrocortical lesions in ratsBrain Res19853442052102412650
   PubMed Web of Science ®Google Scholar
• SantosMKövariEGoldGThe neuroanatomical model of post-stroke depression: towards a change of focus?J Neurol Sci200928315816219264329
   PubMed Web of Science ®Google Scholar
• BertrandNIshiiHBeleyASpatzMBiphasic striatal acetylcholine release during and after transient cerebral ischemia in gerbilsJ Cereb Blood Flow Metab1993137897958360285
   PubMed Web of Science ®Google Scholar
• KurodaHBaskinDSMatsuiTLohHHHosobuchiYLeeNMEffects of dynorphin1–13 on opiate binding and dopamine and GABA uptake in stroked cat brainBrain Res198637968742874866
   PubMed Web of Science ®Google Scholar
• FolsteinMFMaibergerRMcHughPRMood disorder as a specific complication of strokeJ Neurol Neurosurg Psychiatry19774010181020591971
   PubMed Web of Science ®Google Scholar
• BooneKBMillerBLLesserIMNeuropsychological correlates of white-matter lesions in healthy elderly subjects: a threshold effectArch Neurol1992495495541580819
   PubMed Web of Science ®Google Scholar
• YangSHuaPShangXA significant risk factor for poststroke depression: the depression-related subnetworkJ Psychiatry Neurosci20154025926825871495
   PubMed Web of Science ®Google Scholar
• FirbankMJLloydAJFerrierNO’BrienJTA volumetric study of MRI signal hyperintensities in late-life depressionAm J Geriatr Psychiatry20041260661215545328
   PubMed Web of Science ®Google Scholar
• de GrootJCde LeeuwFEOudkerkMHofmanAJollesJBretelerMMCerebral white matter lesions and depressive symptoms in elderly adultsArch Gen Psychiatry2000571071107611074873
   PubMed Web of Science ®Google Scholar
• KrishnanMSO’BrienJTFirbankMJRelationship between periventricular and deep white matter lesions and depressive symptoms in older people: the LADIS studyInt J Geriatr Psychiatry20062198398916955428
   PubMed Web of Science ®Google Scholar
• JormAFAnsteyKJChristensenHMRI hyperintensities and depressive symptoms in a community sample of individuals 60–64 years oldAm J Psychiatry200516269970515800141
   PubMed Web of Science ®Google Scholar
• IidakaTNakajimaTKawamotoKSignal hyperintensities on brain magnetic resonance imaging in elderly depressed patientsEur Neurol1996362932998864711
   PubMed Web of Science ®Google Scholar
• BaldwinRJeffriesSJacksonATreatment response in late-onset depression: relationship to neuropsychological, neuroradiological and vascular risk factorsPsychol Med20043412513614971633
   PubMed Web of Science ®Google Scholar
• BarberRGholkarAScheltensPBallardCMcKeithIGO’BrienJTMRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer’s diseaseInt J Geriatr Psychiatry20001591191611044873
   PubMed Web of Science ®Google Scholar
• ThomasAJO’BrienJTDavisSIschemic basis for deep white matter hyperintensities in major depression: a neuropathological studyArch Gen Psychiatry20025978579212215077
   PubMed Web of Science ®Google Scholar
• HerrmannLLle MasurierMEbmeierKPWhite matter hyperintensities in late life depression: a systematic reviewJ Neurol Neurosurg Psychiatry20087961962417717021
   PubMed Web of Science ®Google Scholar
• BaeJNMacFallJRKrishnanKRPayneMESteffensDCTaylorWDDorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depressionBiol Psychiatry2006601356136316876144
   PubMed Web of Science ®Google Scholar
• TaylorWDMacFallJRPayneMELate-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matterAm J Psychiatry20041611293129615229065
   PubMed Web of Science ®Google Scholar
• ConnorTJLeonardBEDepression, stress and immunological activation: the role of cytokines in depressive disordersLife Sci1998625836069472719
   PubMed Web of Science ®Google Scholar
• DimopoulosNPiperiCSaloniciotiAElevation of plasma concentration of adhesion molecules in late-life depressionInt J Geriatr200621965971
   Web of Science ®Google Scholar
• HickieIScottEMitchellPWilhelmKAustinMPBennettBSubcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depressionBiol Psychiatry1995371511607727623
   PubMed Web of Science ®Google Scholar
• AlexopoulosGSMurphyCFGunning-DixonFMMicrostructural white matter abnormalities and remission of geriatric depressionAm J Psychiatry200816523824418172016
   PubMed Web of Science ®Google Scholar
• KrishnanKRHaysJCGeorgeLKBlazerDGSix-month outcomes for MRI-related vascular depressionDepress Anxiety199881421469871815
   PubMedGoogle Scholar
• NavarroVGastóCLomeñaFPrognostic value of frontal functional neuroimaging in late-onset severe major depressionBr J Psychiatry200418430631115056574
   PubMed Web of Science ®Google Scholar
• HickieIScottEWilhelmKBrodatyHSubcortical hyperintensities on magnetic resonance imaging in patients with severe depression: a longitudinal evaluationBiol Psychiatry1997423673749276077
   PubMed Web of Science ®Google Scholar
• O’BrienJAmesDChiuESchweitzerIDesmondPTressBSevere deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up studyBMJ19983179829849765166
   PubMed Web of Science ®Google Scholar
• SteffensDCBosworthHBProvenzaleJMMacFallJRSubcortical white matter lesions and functional impairment in geriatric depressionDepress Anxiety200215232811816049
   PubMed Web of Science ®Google Scholar
• JorgeREMoserDJAcionLRobinsonRTreatment of vascular depression using repetitive transcranial magnetic stimulationArch Gen Psychiatry20086526827618316673
   PubMed Web of Science ®Google Scholar
• TaraganoFEBagnattiPAllegriRFA double-blind, randomized clinical trial to assess the augmentation with nimodipine of antidepressant therapy in the treatment of “vascular depression”Int Psychogeriatr20051748749816252380
   PubMed Web of Science ®Google Scholar
• AlexopoulosGSRauePJKiossesDNProblem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disabilityArch Gen Psychiatry201168334121199963
   PubMed Web of Science ®Google Scholar
• GoldsteinLBBasic and clinical studies of pharmacologic effects on recovery from brain injuryJ Neural Transplant Plast199341751928018750
   PubMed Web of Science ®Google Scholar
• GoldsteinLBCommon drugs may influence motor recovery after strokeNeurology1995458658717746398
   PubMed Web of Science ®Google Scholar
• CholletFTardyJAlbucherJFFluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trialLancet Neurol20111012313021216670
   PubMed Web of Science ®Google Scholar
• RedingMJOrtoLAWinterSWFortunaIMDi PontePMcDowellFHAntidepressant therapy after stroke: a double-blind trialArch Neurol1986437637653729755
   PubMed Web of Science ®Google Scholar
• PedeltyLGorelickPBManagement of hypertension and cerebrovascular disease in the elderlyAm J Med20081212331
   Web of Science ®Google Scholar
• BellavanceAEfficacy of ticlopidine and aspirin for prevention of reversible cerebrovascular ischemic events: the Ticlopidine Aspirin Stroke StudyStroke199324145214578378945
   PubMed Web of Science ®Google Scholar
• SiveniusJRiekkinenPJLaaksoMSmetsPLowenthalAEuropean Stroke Prevention Study (ESPS): antithrombotic therapy is also effective in the elderlyActa Neurol Scand1993871111148442393
   PubMed Web of Science ®Google Scholar
• TaraganoFEAllegriRVicarioABagnattiPLyketsosCGA double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of ‘vascular depression’Int J Geriatr Psychiatry20011625426011288158
   PubMed Web of Science ®Google Scholar
• BeeversDGBeta-blockers for hypertension: time to call a haltJ Hum Hypertens1998128078109883700
   PubMed Web of Science ®Google Scholar
• KoDTHebertPRCoffeyCSSedrakyanACurtisJPKrumholzHMβ-Blocker therapy and symptoms of depression, fatigue, and sexual dysfunctionJAMA200228835135712117400
   PubMed Web of Science ®Google Scholar
• RiedLDTuethMJHandbergEKupferSPepineCJA study of antihypertensive drugs and depressive symptoms (SADD-Sx) in patients treated with a calcium antagonist versus an atenolol hypertension treatment strategy in the International Verapamil SR-Trandolapril Study (INVEST)Psychosom Med20056739840615911902
   PubMed Web of Science ®Google Scholar
• JeonSWKimYKNeuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?World J Psychiatry20166284293
   Google Scholar