Investigation of chronic efficacy and safety profile of two potential anti-inflammatory bipyrazole-based compounds in experimental animals

References

• OngCKSLirkPTanCHSeymourRAAn evidence-based update on nonsteroidal anti-inflammatory drugsClin Med Res200751193417456832
   PubMedGoogle Scholar
• GrosserTSmythEFitzGeraldGAAnti-inflammatory, antipyretic and analgesic agents; pharmacotherapy of goutBruntonLLChabnerBAKnollmannBCGoodman & Gilman’s The Pharmacological Basis of Therapeutics12th edCaliforniaMcGraw-Hill Education20119591004
   Google Scholar
• RaoPKnausEEEvolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyondJ Pharm Pharm Sci20081181110s
   PubMed Web of Science ®Google Scholar
• FrölichJCA classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymesTrends Pharmacol Sci19971830349114728
   PubMed Web of Science ®Google Scholar
• ShahAAFitzgeraldDJMurrayFENon-steroidal anti-inflammatory drugs (NSAIDs) and gastro-intestinal toxicity: current issuesIr J Med Sci1999168424224510624361
   PubMed Web of Science ®Google Scholar
• HiguchiKUmegakiEWatanabeTPresent status and strategy of NSAIDs-induced small bowel injuryJ Gastroenterol200944987988819568687
   PubMed Web of Science ®Google Scholar
• SostresCGargalloCJArroyoMTLanasAAdverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tractBest Pract Res Clin Gastroenterol201024212113220227026
   PubMed Web of Science ®Google Scholar
• LaineLThe gastrointestinal effects of nonselective NSAIDs and COX-2-selective inhibitorsSemin Arthritis Rheum2002323253212528071
   PubMed Web of Science ®Google Scholar
• WheltonANephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implicationsAm J Med1999106513S24S10390124
   PubMedGoogle Scholar
• WheltonARenal and related cardiovascular effects of conventional and COX-2-specific NSAIDs and non-NSAID analgesicsAm J Ther200072637411319575
   PubMedGoogle Scholar
• CarsonJLStromBLDuffADasKSafety of nonsteroidal anti-inflammatory drugs with respect to acute liver diseaseArch Intern Med199315311133113368507123
   PubMedGoogle Scholar
• RubensteinJHLaineLThe hepatotoxicity of non-steroidal anti-inflammatory drugsAliment Pharmacol Ther200420437338015298630
   PubMed Web of Science ®Google Scholar
• Garcia-RodriguezLAWilliamsRDerbyLEDeanADJickHAcute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factorsArch Int Med199415433113168297198
   PubMedGoogle Scholar
• AntmanEMBennettJSDaughertyAAmerican Heart AssociationUse of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart AssociationCirculation2007115121634164217325246
   PubMed Web of Science ®Google Scholar
• CaugheyGEClelandLGPenglisPSGambleJRJamesMJRoles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2J Immunol200116752831283811509629
   PubMed Web of Science ®Google Scholar
• TrelleSReichenbachSWandelSCardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysisBMJ2011342c708621224324
   PubMed Web of Science ®Google Scholar
• JohnsenSPLarssonHTaroneRERisk of hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control studyArch Int Med2005165997898415883235
   PubMed Web of Science ®Google Scholar
• HuangLMackenzieGOuyangNThe novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in ratsBr J Pharmacol201116271521153321175575
   PubMed Web of Science ®Google Scholar
• PanLHangNZhangCSynthesis and biological evaluation of novel benzimidazole derivatives and analogs targeting the NLRP3 inflammasomeMolecules2017222213
   Web of Science ®Google Scholar
• FaourWHMrouehMDaherCFSynthesis of some new amide-linked bipyrazoles and their evaluation as anti-inflammatory and analgesic agentsJ Enzyme Inhib Med Chem20163161079109426482802
   PubMed Web of Science ®Google Scholar
• MorrisCJCarrageenan-induced edema in the rat and mouseWinyardPGWilloughbyDAMethods in Molecular Biology: Inflammation Protocols225New JerseyHumana Press2003115
   Google Scholar
• VogelGHAnalgesic, anti-inflammatory, and anti-pyretic activityDrug Discovery and Evaluation: Pharmacologic Assays3rd edBerlin, GermanySpringer20089831116
   Google Scholar
• BaileyPJSturmALopez-RamosBA biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indomethacinInflammation: Mechanisms and Treatment4DordrechtSpringer1981345346
   Google Scholar
• GazeDCCollinsonPOCardiac troponins as biomarkers of drug- and toxin-induced cardiac toxicity and cardioprotectionExpert Opin Drug Metab Toxicol20051471572516863435
   PubMedGoogle Scholar
• LermaEVBlood urea nitrogen (BUN)2012 Available from: http://emed-icine.medscape.com/article/2073979-overviewAccessed May 1, 2016
   Google Scholar
• SeoPJKimNKimJ-HComparison of indomethacin, diclofenac and aspirin-induced gastric damage according to age in ratsGut Liver20126221021722570750
   PubMed Web of Science ®Google Scholar
• KhalidUPino-ChavezGNesargikarPKidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessmentJournal of Histology and Histopathology201631
   Google Scholar
• BehrendsMMartinez-PalliGNiemannCUCohenSRamachandranRHiroseRAcute hyperglycemia worsens hepatic ischemia/reperfusion injury in ratsJ Gastrointest Surg201014352853519997981
   PubMed Web of Science ®Google Scholar
• AmacherDESerum transaminase elevations as indicators of hepatic injury following the administration of drugsRegul Toxicol Pharmacol19982721191309671567
   PubMed Web of Science ®Google Scholar
• GandhiMNChallaSRPrasanthPGandhiTRRole of leukotrienes in NSAID induced gastric ulceration and inflammation in wistar ratsAsian Pac J Trop Dis201223215219
   Google Scholar
• Van WalsemAPandhiSNixonRMGuyotPKarabisAMooreRARelative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysisArthritis Res Ther20151716625879879
   PubMed Web of Science ®Google Scholar
• ChalasaniNPHayashiPHBonkovskyHLNavarroVJLeeWMFontanaRJACG Clinical guideline: the diagnosis and management of idiosyncratic drug-induced liver injuryAm J Gastroenterol201410995096624935270
   PubMed Web of Science ®Google Scholar
• LewisJHStineJGNonsteroidal anti-inflammatory drugs and leukotriene receptor antagonists: pathology and clinical presentation of hepatotoxicityKaplowitzNDeLeveLDDrug-Induced Liver Disease3rd edAmsterdamElsevier2013370402
   Google Scholar
• BessoneFNon-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?World J Gastroenterol201016455651566121128314
   PubMed Web of Science ®Google Scholar