Inflammasomes: Pandora’s box for sepsis

References

• GeroulanosSDoukaETHistorical perspective of the word “sepsis”Intensive Care Med200632207717131165
   PubMed Web of Science ®Google Scholar
• FunkDJParrilloJEKumarASepsis and septic shock: a historyCrit Care Clin2009258310119268796
   PubMed Web of Science ®Google Scholar
• RittirschDFlierlMAWardPAHarmful molecular mechanisms in sepsisNat Rev Immunol200881077678718802444
   PubMed Web of Science ®Google Scholar
• BudelmannGHugo Schottmuller, 1867–1936. The problem of sepsisInternist196910921014903434
   PubMedGoogle Scholar
• BoneRCDefinitions for sepsis and organ failureCrit Care Med1992207247261597021
   PubMed Web of Science ®Google Scholar
• BoneRCBalkRACerraFBDefinitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care MedicineChest1992101164416551303622
   PubMed Web of Science ®Google Scholar
• SingerMDeutschmanCSSeymourCWThe third international consensus definitions for sepsis and septic shock (sepsis-3)JAMA2016315880181026903338
   PubMed Web of Science ®Google Scholar
• HotchkissRSMonneretGPayenDImmunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approachLancet Infect Dis2013a1326026823427891
   PubMed Web of Science ®Google Scholar
• HotchkissRSMonneretGPayenDSepsis-induced immunosuppression: from cellular dysfunctions to immunotherapyNat Rev Immunol2013131286287424232462
   PubMed Web of Science ®Google Scholar
• HotchkissRSMoldawerLLOpalSMReinhartKTurnbullIRVincentJLSepsis and septic shockNat Rev Dis Primers201621604528117397
   PubMed Web of Science ®Google Scholar
• GülFArslantaşMKCinelİKumarAChanging definitions of sepsisTurk J Anaesthesiol Reanim20174512913828752002
   PubMed Web of Science ®Google Scholar
• MartinGSSepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomesExpert Rev Anti Infect Ther201210670170622734959
   PubMed Web of Science ®Google Scholar
• AngusDCvan der PollTSevere sepsis and septic shockN Engl J Med201336984085123984731
   PubMed Web of Science ®Google Scholar
• CollingKPBantonKLBeilmanGJVasopressors in sepsisSurg Infect (Larchmt)20181920220729336676
   PubMed Web of Science ®Google Scholar
• Stearns-KurosawaDJOsuchowskiMFValentineCKurosawaSRemickDGThe pathogenesis of sepsisAnnu Rev Pathol20116194820887193
   PubMed Web of Science ®Google Scholar
• Cabrera-PerezJCondottaSABadovinacVPGriffithTSImpact of sepsis on CD4 T cell immunityJ Leukoc Biol20149676777724791959
   PubMed Web of Science ®Google Scholar
• WiersingaWJLeopoldSJCranendonkDRvan der PollTHost innate immune responses to sepsisVirulence201451364423774844
   PubMed Web of Science ®Google Scholar
• CaoCMaTChaiYFShouSTThe role of regulatory T cells in immune dysfunction during sepsisWorld J Emerg Med2015615925802559
   PubMedGoogle Scholar
• DelanoMJWardPAThe immune system’s role in sepsis progression, resolution, and long-term outcomeImmunol Rev2016274133035327782333
   PubMed Web of Science ®Google Scholar
• DelanoMJWardPASepsis-induced immune dysfunction: can immune therapies reduce mortality?J Clin Invest20161261233126727230
   PubMed Web of Science ®Google Scholar
• van der PollTvan de VeerdonkFLSciclunaBPNeteaMGThe immunopathology of sepsis and potential therapeutic targetsNat Rev Immunol201717740742028436424
   PubMed Web of Science ®Google Scholar
• KumarVT cells and their immunometabolism: a novel way to understanding sepsis immunopathogenesis and future therapeuticsEur J Cell Biol2018a
   Web of Science ®Google Scholar
• SundarKMSiresMSepsis induced immunosuppression: implications for secondary infections and complicationsIndian J Crit Care Med20131716216924082613
   PubMedGoogle Scholar
• DanahyDBStrotherRKBadovinacVPGriffithTSClinical and experimental sepsis impairs CD8 T-cell-mediated immunityCrit Rev Immunol201636577427480902
   PubMed Web of Science ®Google Scholar
• LamkanfiMDixitVMInflammasomes: guardians of cytosolic sanctityImmunol Rev20092279510519120479
   PubMed Web of Science ®Google Scholar
• FranchiLMunoz-PlanilloRReimerTEigenbrodTNunezGInflammasomes as microbial sensorsEur J Immunol20104061161520201013
   PubMed Web of Science ®Google Scholar
• LamkanfiMvande WalleLKannegantiTDDeregulated inflammasome signaling in diseaseImmunol Rev201124316317321884175
   PubMed Web of Science ®Google Scholar
• FranchiLMunoz-PlanilloRNunezGSensing and reacting to microbes through the inflammasomesNat Immunol20121332533222430785
   PubMed Web of Science ®Google Scholar
• ZmoraNLevyMPevsner-FishcerMElinavEInflammasomes and intestinal inflammationMucosal Immunol20171086588328401932
   PubMed Web of Science ®Google Scholar
• AlhallafRAghaZMillerCMThe NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infectionCell Rep2018231085109829694887
   PubMed Web of Science ®Google Scholar
• KayagakiNWarmingSLamkanfiMNon-canonical inflammasome activation targets caspase-11Nature201147911712122002608
   PubMed Web of Science ®Google Scholar
• BrozPMonackDMNoncanonical inflammasomes: caspase-11 activation and effector mechanismsPLoS Pathog20139e100314423468620
   PubMed Web of Science ®Google Scholar
• LatzEXiaoTSStutzAActivation and regulation of the inflammasomesNat Rev Immunol201313639741123702978
   PubMed Web of Science ®Google Scholar
• von MoltkeJAyresJSKofoedEMChavarría-SmithJVanceRERecognition of bacteria by inflammasomesAnnu Rev Immunol2013317310623215645
   PubMed Web of Science ®Google Scholar
• MonieTPThe canonical inflammasome: a macromolecular complex driving inflammationSubcell Biochem201783437328271472
   PubMedGoogle Scholar
• PellegriniCAntonioliLLopez-CastejonGBlandizziCFornaiMCanonical and non-canonical activation of NLRP3 inflammasome at the crossroad between immune tolerance and intestinal inflammationFront Immunol2017883628179906
   PubMed Web of Science ®Google Scholar
• PróchnickiTLatzEInflammasomes on the crossroads of innate immune recognition and metabolic controlCell Metab2017261719328683296
   PubMed Web of Science ®Google Scholar
• KerurNFukudaSBanerjeeDcGAS drives noncanonical-inflammasome activation in age-related macular degenerationNat Med201824506129176737
   PubMed Web of Science ®Google Scholar
• MartinonFBurnsKTschoppJThe inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaMol Cell20021041742612191486
   PubMed Web of Science ®Google Scholar
• SinghalGJaehneEJCorriganFTobenCBauneBTInflammasomes in neuroinflammation and changes in brain function: a focused reviewFront Neurosci201483
   Google Scholar
• FreemanLCTingJPThe pathogenic role of the inflammasome in neurodegenerative diseasesJ Neurochem2016136Suppl 1293826119245
   PubMed Web of Science ®Google Scholar
• GuoBFuSZhangJLiuBLiZTargeting inflammasome/IL-1 pathways for cancer immunotherapySci Rep201663610727786298
   PubMed Web of Science ®Google Scholar
• NikolettLDavidBÁdámDInflammasomes link vascular disease with neuroinflammation and brain disordersJ Cereb Blood Flow Metab2016361668168527486046
   PubMed Web of Science ®Google Scholar
• SaresellaMLa RosaFPianconeFThe NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s diseaseMol Neurodegener20161112326939933
   PubMed Web of Science ®Google Scholar
• KantonoMGuoBInflammasomes and cancer: the dynamic role of the inflammasome in tumor developmentFront Immunol20178113228955343
   PubMed Web of Science ®Google Scholar
• LinCZhangJInflammasomes in inflammation-induced cancerFront Immunol20178Pt 127128360909
   PubMed Web of Science ®Google Scholar
• MamikMKPowerCInflammasomes in neurological diseases: emerging pathogenic and therapeutic conceptsBrain201714092273228529050380
   PubMed Web of Science ®Google Scholar
• ElinavEThaissCAFlavellRAAnalysis of microbiota alterations in inflammasome-deficient miceMethods Mol Biol2013104018519423852605
   PubMedGoogle Scholar
• SesterDPSagulenkoVThygesenSJDeficient NLRP3 and AIM2 inflammasome function in autoimmune NZB miceJ Immunol201519531233124126116505
   PubMed Web of Science ®Google Scholar
• ThygesenSJSesterDPCridlandSOWiltonSDStaceyKJCorrecting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotidesImmunol Cell Biol201694552026833024
   PubMed Web of Science ®Google Scholar
• KimYMBrinkmannMMPaquetMEPloeghHLUNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomesNature200845223423818305481
   PubMed Web of Science ®Google Scholar
• MogensenTHPathogen recognition and inflammatory signaling in innate immune defensesClin Microbiol Rev200922224027319366914
   PubMed Web of Science ®Google Scholar
• TakeuchiOAkiraSPattern recognition receptors and inflammationCell2010140680582020303872
   PubMed Web of Science ®Google Scholar
• WangYYangCMaoKChenSMengGSunBCellular localization of NLRP3 inflammasomeProtein Cell20134642543123609011
   PubMed Web of Science ®Google Scholar
• LamkanfiMDixitVMMechanisms and functions of inflammasomesCell20141571013102224855941
   PubMed Web of Science ®Google Scholar
• ManSMKannegantiT-DRegulation of inflammasome activationImmunol Rev2015265162125879280
   PubMed Web of Science ®Google Scholar
• de ZoeteMRPalmNWZhuSFlavellRAInflammasomesCold Spring Harb Perspect Biol20146a01628725324215
   PubMed Web of Science ®Google Scholar
• RathinamVAKFitzgeraldKAinflammasome complexes: emerging mechanisms and effector functionsCell2016165479280027153493
   PubMed Web of Science ®Google Scholar
• Lopez-CastejonGBroughDUnderstanding the mechanism of IL-1β secretionCytokine Growth Factor Rev201122418919522019906
   PubMed Web of Science ®Google Scholar
• KangSFernandes-AlnemriTRogersCCaspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3Nat Commun20156751526104484
   PubMed Web of Science ®Google Scholar
• ZhangXFanCZhangHMLKL and FADD are critical for suppressing progressive lymphoproliferative disease and activating the NLRP3 inflammasomeCell Rep201616123247325927498868
   PubMed Web of Science ®Google Scholar
• ConosSAChenKWde NardoDActive MLKL triggers the NLRP3 inflammasome in a cell-intrinsic mannerProc Natl Acad Sci U S A2017114E961e96928096356
   PubMed Web of Science ®Google Scholar
• GutierrezKDDavisMADanielsBPMLKL activation triggers NLRP3-mediated processing and release of IL-1beta independently of gasdermin-DJ Immunol20171982156216428130493
   PubMed Web of Science ®Google Scholar
• WeinlichROberstABeereHMGreenDRNecroptosis in development, inflammation and diseaseNat Rev Mol Cell Biol201718212713627999438
   PubMed Web of Science ®Google Scholar
• SharmaAAJenRKanBImpaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytesEur J Immunol201545123824925311115
   PubMed Web of Science ®Google Scholar
• StouchANMccoyAMGreerRMIL-1β and inflammasome activity link inflammation to abnormal fetal airway developmentJ Immunol201619683411342026951798
   PubMed Web of Science ®Google Scholar
• Arango DuqueGDescoteauxAMacrophage cytokines: involvement in immunity and infectious diseasesFront Immunol2014549125339958
   PubMed Web of Science ®Google Scholar
• DinarelloCACannonJGMierJWMultiple biological activities of human recombinant interleukin 1J Clin Invest198677173417393519678
   PubMed Web of Science ®Google Scholar
• RadekeHHMartinMTopleyNKaeverVReschKDifferential biological activities of human interleukin-1 alpha and interleukin-1 betaEur Cytokine Netw1991251591873492
   PubMedGoogle Scholar
• ReznikovLLKimS-HWestcottJYIL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gammaProc Natl Acad Sci U S A20009752174217910681439
   PubMed Web of Science ®Google Scholar
• LeeJKKimSHLewisECAzamTReznikovLLDinarelloCADifferences in signaling pathways by IL-1beta and IL-18Proc Natl Acad Sci U S A20041018815882015161979
   PubMed Web of Science ®Google Scholar
• KeyelPAHow is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1Cytokine20146913614524746243
   PubMed Web of Science ®Google Scholar
• GattiSBeckJFantuzziGBartfaiTDinarelloCAEffect of interleukin-18 on mouse core body temperatureAm J Physiol Regul Integr Comp Physiol2002282R70270911832389
   PubMed Web of Science ®Google Scholar
• Komai-KomaMGracieJAWeiX-QChemoattraction of human T cells by IL-18J Immunol20031701084109012517977
   PubMed Web of Science ®Google Scholar
• GutcherIBecherBAPC-derived cytokines and T cell polarization in autoimmune inflammationJ Clin Invest20071171119112717476341
   PubMed Web of Science ®Google Scholar
• NeteaMGJoostenLABLewisEDeficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistanceNat Med200612665065616732281
   PubMed Web of Science ®Google Scholar
• ZorrillaEPSanchez-AlavezMSugamaSInterleukin-18 controls energy homeostasis by suppressing appetite and feed efficiencyProc Natl Acad Sci U S A2007104110971110217578927
   PubMed Web of Science ®Google Scholar
• GaglianiNPalmNWde ZoeteMRFlavellRAInflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiotaInt Immunol20142649549924948595
   PubMed Web of Science ®Google Scholar
• RathinamVAKChanFK-MInflammasome, inflammation, and tissue homeostasisTrends Mol Med201824330431829433944
   PubMed Web of Science ®Google Scholar
• ElinavEStrowigTKauALNLRP6 inflammasome regulates colonic microbial ecology and risk for colitisCell201114574575721565393
   PubMed Web of Science ®Google Scholar
• LevyMThaissCAZeeviDMicrobiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signalingCell20151631428144326638072
   PubMed Web of Science ®Google Scholar
• LoboLABenjamimCFOliveiraACThe interplay between micro-biota and inflammation: lessons from peritonitis and sepsisClin Transl Immunology201657e9027525063
   PubMed Web of Science ®Google Scholar
• Cabrera-PerezJBadovinacVPGriffithTSEnteric immunity, the gut microbiome, and sepsis: rethinking the germ theory of diseaseExp Biol Med (Maywood)201724212713927633573
   PubMed Web of Science ®Google Scholar
• Lei-LestonACMurphyAGMaloyKJEpithelial cell inflammasomes in intestinal immunity and inflammationFront Immunol20178
   Web of Science ®Google Scholar
• MedzhitovRPattern recognition theory and the launch of modern innate immunityJ Immunol201319194473447424141853
   PubMed Web of Science ®Google Scholar
• JanewayCAJrApproaching the asymptote? Evolution and revolution in immunologyCold Spring Harb Symp Quant Biol198954Pt1113
   Google Scholar
• HartSPSmithJRDransfieldIPhagocytosis of opsonized apoptotic cells: roles for ‘old-fashioned’ receptors for antibody and complementClin Exp Immunol200413518118514738443
   PubMed Web of Science ®Google Scholar
• TaylorPRMartinez-PomaresLStaceyMLinHHBrownGDGordonSMacrophage receptors and immune recognitionAnnu Rev Immunol20052390194415771589
   PubMed Web of Science ®Google Scholar
• ChenGShawMHKimYGNunezGNOD-like receptors: role in innate immunity and inflammatory diseaseAnnu Rev Pathol2009436539818928408
   PubMed Web of Science ®Google Scholar
• MartinonFMayorATschoppJThe inflammasomes: guardians of the bodyAnnu Rev Immunol200927122926519302040
   PubMed Web of Science ®Google Scholar
• NakhaeiPGeninPCivasAHiscottJRIG-I-like receptors: sensing and responding to RNA virus infectionSemin Immunol200921421522219539500
   PubMed Web of Science ®Google Scholar
• JacobsSRDamaniaBNLRs, inflammasomes, and viral infectionJ Leukoc Biol20129246947722581934
   PubMed Web of Science ®Google Scholar
• SchmidtARothenfusserSHopfnerK-PSensing of viral nucleic acids by RIG-I: from translocation to translationEur J Cell Biol2012911788521496944
   PubMed Web of Science ®Google Scholar
• BauernfeindFHornungVOf inflammasomes and pathogens – sensing of microbes by the inflammasomeEMBO Mol Med2013581482623666718
   PubMed Web of Science ®Google Scholar
• TakedaKAkiraSToll-like receptorsCurr Protoc Immunol201510912141110
   Google Scholar
• SatohTAkiraSToll-like receptor signaling and its inducible proteinsMicrobiol Spectr20164
   Web of Science ®Google Scholar
• TarteySTakeuchiOPathogen recognition and Toll-like receptor targeted therapeutics in innate immune cellsInt Rev Immunol2017362577328060562
   PubMed Web of Science ®Google Scholar
• ZhangHLuoJAlcornJFAIM2 inflammasome is critical for influenza-induced lung injury and mortalityJ Immunol2017198114383439328424239
   PubMed Web of Science ®Google Scholar
• KumarVSharmaANeutrophils: Cinderella of innate immune systemInt Immunopharmacol201010111325133420828640
   PubMed Web of Science ®Google Scholar
• KumarVSharmaAMast cells: emerging sentinel innate immune cells with diverse role in immunityMol Immunol2010a48142520678798
   PubMed Web of Science ®Google Scholar
• KumarVAhmadARole of MAIT cells in the immunopathogenesis of inflammatory diseases: new players in old gameInt Rev Immunol2018379011029106304
   PubMed Web of Science ®Google Scholar
• BoydJHDivangahiMYahiaouiLGvozdicDQureshiSPetrofBJToll-like receptors differentially regulate CC and CXC chemokines in skeletal muscle via NF-κB and calcineurinInfect Immun2006746829683816982839
   PubMed Web of Science ®Google Scholar
• SalomãoRMartinsPSBrunialtiMKCTLR signaling pathway in patients with sepsisShock200830Suppl 1737718704004
   PubMed Web of Science ®Google Scholar
• TsujimotoHOnoSEfronPAScumpiaPOMoldawerLLMochizukiHRole of Toll-like receptors in the development of sepsisShock200829331532118277854
   PubMed Web of Science ®Google Scholar
• SavvaARogerTTargeting Toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseasesFront Immunol2013184387
   Google Scholar
• TurnerMDNedjaiBHurstTPenningtonDJCytokines and chemokines: at the crossroads of cell signalling and inflammatory diseaseBiochim Biophys Acta20141843112563258224892271
   PubMed Web of Science ®Google Scholar
• FranchiLEigenbrodTMuñoz-PlanilloRNuñezGThe inflammasome: a caspase-1 activation platform regulating immune responses and disease pathogenesisNat Immunol20091024119221555
   PubMed Web of Science ®Google Scholar
• TaxmanDJHuangMTTingJPInflammasome inhibition as a pathogenic stealth mechanismCell Host Microbe20108171120638636
   PubMed Web of Science ®Google Scholar
• MenuPVinceJEThe NLRP3 inflammasome in health and disease: the good, the bad and the uglyClin Exp Immunol2011166111521762124
   PubMed Web of Science ®Google Scholar
• Chavarria-SmithJVanceREThe NLRP1 inflammasomesImmunol Rev2015265223425879281
   PubMed Web of Science ®Google Scholar
• ZhaoYShaoFThe NAIP–NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatusImmunol Rev20152658510225879286
   PubMed Web of Science ®Google Scholar
• KruegerMHeinzmannANauckMAdhesion molecules in pediatric intensive care patients with organ dysfunction syndromeIntensive Care Med20073335936317124613
   PubMed Web of Science ®Google Scholar
• ZonneveldRMartinelliRShapiroNIKuijpersTWPlötzFBCarmanCVSoluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adultsCrit Care20141820420424602331
   PubMed Web of Science ®Google Scholar
• AmalakuhanBHabibSAMangatMEndothelial adhesion molecules and multiple organ failure in patients with severe sepsisCytokine20168826727327701021
   PubMed Web of Science ®Google Scholar
• WhalenMJDoughtyLACarlosTMWisniewskiSRKochanekPMCarcilloJAIntercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are increased in the plasma of children with sepsis-induced multiple organ failureCrit Care Med20002872600260710921602
   PubMed Web of Science ®Google Scholar
• Sosa-BustamanteGPAmador-LiconaNBarbosa-SabaneroGIntercellular adhesion molecules and mortality for sepsis in infants younger than 1 year of lifeRev Invest Clin20116360160623650672
   PubMedGoogle Scholar
• SuCMChengHHTsaiTCElevated serum vascular cell adhesion molecule-1 is associated with septic encephalopathy in adult community-onset severe sepsis patientsBiomed Res Int2014201410
   Web of Science ®Google Scholar
• SagerHBDuttaPDahlmanJERNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarctionSci Transl Med20168342342ra380
   Google Scholar
• HildebrandFPapeH-CHarwoodPRole of adhesion molecule ICAM in the pathogenesis of polymicrobial sepsisExp Toxicol Pathol20055628129015816357
   PubMedGoogle Scholar
• ChiZMelendezAJRole of cell adhesion molecules and immune-cell migration in the initiation, onset and development of atherosclerosisCell Adh Migr2007117117519262139
   PubMed Web of Science ®Google Scholar
• ChaeYKChoiWMBaeWHOverexpression of adhesion molecules and barrier molecules is associated with differential infiltration of immune cells in non-small cell lung cancerSci Rep20188102329348685
   PubMed Web of Science ®Google Scholar
• BauerPRMicrovascular responses to sepsis: clinical significancePathophysiology2002814114812039645
   PubMedGoogle Scholar
• ReinhartKBayerOBrunkhorstFMeisnerMMarkers of endothelial damage in organ dysfunction and sepsisCrit Care Med200230SupplementS302S31212004252
   PubMed Web of Science ®Google Scholar
• InoueMWilliamsKLGunnMDShinoharaMLNLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitisProc Natl Acad Sci U S A2012109104801048522699511
   PubMed Web of Science ®Google Scholar
• WangJGWilliamsJCDavisBKMonocytic microparticles activate endothelial cells in an IL-1β-dependent mannerBlood201111882366237421700772
   PubMed Web of Science ®Google Scholar
• Boisrame-HelmsJKremerHSchini-KerthVMezianiFEndothelial dysfunction in sepsisCurr Vasc Pharmacol20131115016023506494
   PubMed Web of Science ®Google Scholar
• InceCMayeuxPRNguyenTThe endothelium in sepsisShock20164525927026871664
   PubMed Web of Science ®Google Scholar
• ChenYLiXBoiniKMEndothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritisBiochim Biophys Acta2015185339640825450976
   PubMed Web of Science ®Google Scholar
• LuoS-FChinC-YHoL-JTsengW-YKuoC-FLaiJHMonosodium urate crystals induced ICAM-1 expression and cell–cell adhesion in renal mesangial cells: implications for the pathogenesis of gouty nephropathyJ Microbiol Immunol Infect2018S16841182(18)30003
   Google Scholar
• HewettJASchultzeAEVanciseSRothRANeutrophil depletion protects against liver injury from bacterial endotoxinLab Invest1992663473611538588
   PubMed Web of Science ®Google Scholar
• TsujiCMinhazMUShioyaSFukahoriMTanigakiTNakazawaHThe importance of polymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production and lung injury: ex vivo observation in rat lungsLung199817611139436173
   PubMed Web of Science ®Google Scholar
• RaeburnCDCalkinsCMZimmermanMAICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulationAm J Physiol Regul Integr Comp Physiol20022832R477R48612121861
   PubMed Web of Science ®Google Scholar
• YangLFroioRMSciutoTEDvorakAMAlonRLuscinskasFWICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flowBlood2005106258459215811956
   PubMed Web of Science ®Google Scholar
• XuRHuangHZhangZWangFSThe role of neutrophils in the development of liver diseasesCell Mol Immunol201411322423124633014
   PubMed Web of Science ®Google Scholar
• WoodfinABeyrauMVoisinMBICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemiaBlood2016127789890726647392
   PubMed Web of Science ®Google Scholar
• van der HeijdenTKritikouEVenemaWNLRP3 inflammasome inhibition by MCC950 reduces atherosclerotic lesion development in apolipoprotein E–deficient miceArterioscler Thromb Vasc Biol20173781457146128596375
   PubMed Web of Science ®Google Scholar
• BakeleMJoosMBurdiSLocalization and functionality of the inflammasome in neutrophilsJ Biol Chem20142895320532924398679
   PubMed Web of Science ®Google Scholar
• Pérez-FigueroaETorresJSánchez-ZaucoNContreras-RamosAAlvarez-ArellanoLMaldonado-BernalCActivation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infectionInnate Immun201622210311226610398
   PubMed Web of Science ®Google Scholar
• Alfonso-LoechesSUreña-PeraltaJRMorillo-BarguesMJOliver-de La CruzJGuerriCRole of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cellsFront Cell Neurosci201418216
   Google Scholar
• HarijithAEbenezerDLNatarajanVReactive oxygen species at the crossroads of inflammasome and inflammationFront Physiol2014535225324778
   PubMed Web of Science ®Google Scholar
• AbaisJMXiaMZhangYBoiniKMLiP-LRedox regulation of NLRP3 inflammasomes: ROS as trigger or effector?Antioxid Redox Signal2015221111112925330206
   PubMed Web of Science ®Google Scholar
• AnderssonUTraceyKJHMGB1 in sepsisScand J Infect Dis20033557758414620138
   PubMed Web of Science ®Google Scholar
• HuangWTangYLiLHMGB1, a potent proinflammatory cytokine in sepsisCytokine20105111912620347329
   PubMed Web of Science ®Google Scholar
• KaczmarekAVandenabeelePKryskoDVNecroptosis: the release of damage-associated molecular patterns and its physiological relevanceImmunity20133820922323438821
   PubMed Web of Science ®Google Scholar
• ZhaoHJafferTEguchiSWangZLinkermannAMaDRole of necroptosis in the pathogenesis of solid organ injuryCell Death Dis20156e197526583318
   PubMed Web of Science ®Google Scholar
• FiuzaCBustinMTalwarSInflammation-promoting activity of HMGB1 on human microvascular endothelial cellsBlood20031012652266012456506
   PubMed Web of Science ®Google Scholar
• AsavarutPZhaoHGuJMaDThe role of HMGB1 in inflammation-mediated organ injuryActa Anaesthesiol Taiwan201351283323711603
   PubMedGoogle Scholar
• LuiGWongCKIpMHMGB1/RAGE signaling and pro-inflammatory cytokine responses in non-HIV adults with active pulmonary tuberculosisPLoS One2016117e015913227434276
   PubMed Web of Science ®Google Scholar
• AbdulmahdiWPatelDRabadiMMHMGB1 redox during sepsisRedox Biol20171360060728806702
   PubMed Web of Science ®Google Scholar
• StevensNEChapmanMJFraserCKKuchelTRHayballJDDienerKRTherapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomesSci Rep201771585028724977
   PubMed Web of Science ®Google Scholar
• WillinghamSBAllenICBergstralhDTNLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathwaysJ Immunol200918332008201519587006
   PubMed Web of Science ®Google Scholar
• LamkanfiMSarkarAvande WalleLInflammasome-dependent release of the alarmin HMGB1 in endotoxemiaJ Immunol20101854385439220802146
   PubMed Web of Science ®Google Scholar
• vande WalleLKannegantiTDLamkanfiMHMGB1 release by inflammasomesVirulence20112216216521422809
   PubMed Web of Science ®Google Scholar
• LeblancPMDoggettTAChoiJAn immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptorJ Biol Chem20142897777778624474694
   PubMed Web of Science ®Google Scholar
• LuBWangHAnderssonUTraceyKJRegulation of HMGB1 release by inflammasomesProtein Cell20134316316723483477
   PubMed Web of Science ®Google Scholar
• ScaffidiPMisteliTBianchiMERelease of chromatin protein HMGB1 by necrotic cells triggers inflammationNature2002418689419119512110890
   PubMed Web of Science ®Google Scholar
• LuBNakamuraTInouyeKNovel role of PKR in inflammasome activation and HMGB1 releaseNature2012488741367067422801494
   PubMed Web of Science ®Google Scholar
• BonaldiTTalamoFScaffidiPMonocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretionEMBO J2003225551556014532127
   PubMed Web of Science ®Google Scholar
• EvankovichJChoSWZhangRHigh mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activityJ Biol Chem2010285398883989720937823
   PubMed Web of Science ®Google Scholar
• ChiWChenHLiFZhuYYinWZhuoYHMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-kappaB pathway in acute glaucomaJ Neuroinflammation20151213726224068
   PubMed Web of Science ®Google Scholar
• Abu El-AsrarAMAlamKGarcia-RamirezMAssociation of HMGB1 with oxidative stress markers and regulators in PDRMol Vis20172385387129259392
   PubMed Web of Science ®Google Scholar
• WatsonRWRedmondHPWangJHCondronCBouchier-HayesDNeutrophils undergo apoptosis following ingestion of Escherichia coliJ Immunol199615610398639928621940
   PubMed Web of Science ®Google Scholar
• DeleoFRModulation of phagocyte apoptosis by bacterial pathogensApoptosis2004939941315192322
   PubMed Web of Science ®Google Scholar
• WilkieRPVissersMCDragunowMHamptonMBA functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophilsInfect Immun20077573256326317438039
   PubMed Web of Science ®Google Scholar
• VictorVMRochaMde La FuenteMImmune cells: free radicals and antioxidants in sepsisInt Immunopharmacol20044332734715037211
   PubMed Web of Science ®Google Scholar
• VíctorVMEspulguesJVHernández-MijaresARochaMOxidative stress and mitochondrial dysfunction in sepsis: a potential therapy with mitochondria-targeted antioxidantsInfect Disord Drug Targets20099437638919689380
   PubMedGoogle Scholar
• BimeCZhouTWangTSlepianMJGarciaJGNHeckerLReactive oxygen species–associated molecular signature predicts survival in patients with sepsisPulm Circ2016619620127252846
   PubMed Web of Science ®Google Scholar
• OliveiraYpadePontes-de-CarvalhoLCCoutoRDNoronha-DutraAAOxidative stress in sepsis. Possible production of free radicals through an erythrocyte-mediated positive feedback mechanismBraz J Infect Dis2017211192627916603
   PubMed Web of Science ®Google Scholar
• CepinskasGWilsonJXInflammatory response in microvascular endothelium in sepsis: role of oxidantsJ Clin Biochem Nutr20084217518418545638
   PubMed Web of Science ®Google Scholar
• HuetODupicLHarroisADuranteauJOxidative stress and endothelial dysfunction during sepsisFront Biosci (Landmark Ed)1620111986199521196278
   PubMed Web of Science ®Google Scholar
• PotzBASellkeFWAbidMREndothelial ROS and impaired myocardial oxygen consumption in sepsis-induced cardiac dysfunctionJ Intensive Crit Care2016020120
   Google Scholar
• LégerTCharrierAMoreauCEarly sepsis does not stimulate reactive oxygen species production and does not reduce cardiac function despite an increased inflammation statusPhysiol Rep20175e1323128684640
   PubMed Web of Science ®Google Scholar
• HoetzeneckerWEchtenacherBGuenovaEROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppressionNat Med20111812822179317
   PubMed Web of Science ®Google Scholar
• CruzCMRinnaAFormanHJVenturaALPersechiniPMOjciusDMATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophagesJ Biol Chem20072822871287917132626
   PubMed Web of Science ®Google Scholar
• MartinonFSignaling by ROS drives inflammasome activationEur J Immunol201040361661920201014
   PubMed Web of Science ®Google Scholar
• HeYHaraHNúñezGMechanism and regulation of NLRP3 inflammasome activationTrends Biochem Sci2016411012102127669650
   PubMed Web of Science ®Google Scholar
• KumarVTargeting macrophage immunometabolism: dawn in the darkness of sepsisInt Immunopharmacol20185817318529625385
   PubMed Web of Science ®Google Scholar
• AbaisJMZhangCXiaMNADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemiaAntioxid Redox Signal2013181537154823088210
   PubMed Web of Science ®Google Scholar
• BoiniKMXiaMAbaisJMActivation of inflammasomes in podocyte injury of mice on the high fat diet: effects of ASC gene deletion and silencingBiochim Biophys Acta2014184383684524508291
   PubMed Web of Science ®Google Scholar
• HanSCaiWYangXROS-mediated NLRP3 inflammasome activity is essential for burn-induced acute lung injuryMediators Inflamm2015201516
   Web of Science ®Google Scholar
• SumiYWoehrleTChenYPlasma ATP is required for neutrophil activation in a mouse sepsis modelShock201442214214724675414
   PubMed Web of Science ®Google Scholar
• LedderoseCLiXBaoYSumiYShapiroNJungerWSystemic ATP levels suppress the function of CD4+ T cells in sepsis by impairing autocrine purinergic signalingFASEB J201529972976
   Web of Science ®Google Scholar
• LedderoseCBaoYKondoYPurinergic signaling and immune responses in sepsisClin Ther2016381054106527156007
   PubMed Web of Science ®Google Scholar
• SueyoshiKSumiYInoueYFluorescence imaging of ATP in neutrophils from patients with sepsis using organelle-localizable fluorescent chemosensorsAnn Intensive Care2016616427422255
   PubMed Web of Science ®Google Scholar
• LiXKondoYBaoYSystemic adenosine triphosphate impairs neutrophil chemotaxis and host defense in sepsisCrit Care Med2017451e97e10427548819
   PubMedGoogle Scholar
• DubyakGRSignal transduction by P2-purinergic receptors for extracellular ATPAm J Respir Cell Mol Biol199142953001707633
   PubMed Web of Science ®Google Scholar
• BuzziNBilbaoPSBolandRde BolandARExtracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell lineBiochim Biophys Acta200917901651165919836435
   PubMed Web of Science ®Google Scholar
• SäveSPerssonKExtracellular ATP and P2Y receptor activation induce a proinflammatory host response in the human urinary tractInfect Immun20107883609361520515921
   PubMed Web of Science ®Google Scholar
• RiteauNGassePFauconnierLExtracellular ATP is a danger signal activating P2X 7 receptor in lung inflammation and fibrosisAm J Respir Crit Care Med2010182677478320522787
   PubMed Web of Science ®Google Scholar
• GargADKryskoDVVandenabeelePAgostinisPExtracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell deathCell Death Dis20167e209726890136
   PubMed Web of Science ®Google Scholar
• di VirgilioFdal BenDSartiACGiulianiALFalzoniSThe P2X7 receptor in infection and inflammationImmunity201747153128723547
   PubMed Web of Science ®Google Scholar
• KarmakarMKatsnelsonMADubyakGRPearlmanENeutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATPNat Commun201671055526877061
   PubMed Web of Science ®Google Scholar
• di VirgilioFLiaisons dangereuses: P2X(7) and the inflammasomeTrends Pharmacol Sci20072846547217692395
   PubMed Web of Science ®Google Scholar
• Coutinho-SilvaROjciusDMRole of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasitesMicrobes Infect2012141271127722634346
   PubMed Web of Science ®Google Scholar
• GombaultABaronLCouillinIATP release and purinergic signaling in NLRP3 inflammasome activationFront Immunol2012341423316199
   PubMed Web of Science ®Google Scholar
• IdzkoMFerrariDEltzschigHKNucleotide signalling during inflammationNature201450931031724828189
   PubMed Web of Science ®Google Scholar
• CsokaBNemethZHToroGExtracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killingFASEB J2015293626363726060214
   PubMed Web of Science ®Google Scholar
• WuXRenJChenGSystemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruptionSci Rep201771436428663567
   PubMed Web of Science ®Google Scholar
• NicholsRDvon MoltkeJVanceRENAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory diseaseNat Commun201781220929263322
   PubMed Web of Science ®Google Scholar
• KumarVSharmaAAdenosine: an endogenous modulator of innate immune system with therapeutic potentialEur J Pharmacol200961671519464286
   PubMed Web of Science ®Google Scholar
• KumarVAdenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?Purinergic Signal2013914516523271562
   PubMed Web of Science ®Google Scholar
• BaoRHouJLiYAdenosine promotes Foxp3 expression in Treg cells in sepsis model by activating JNK/AP-1 pathwayAm J Transl Res201682284229227347335
   PubMed Web of Science ®Google Scholar
• MartinCLeoneMViviandXAyemM-LGuieuRHigh adenosine plasma concentration as a prognostic index for outcome in patients with septic shockCrit Care Med20002893198320211008982
   PubMed Web of Science ®Google Scholar
• SperlaghBDodaMBaranyiMHaskoGIschemic-like condition releases norepinephrine and purines from different sources in super-fused rat spleen stripsJ Neuroimmunol2000111455411063820
   PubMed Web of Science ®Google Scholar
• OuyangXGhaniAMalikAAdenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathwayNat Commun201341290924352507
   PubMed Web of Science ®Google Scholar
• KumarVChhibberSIntravenous 2-chloroadenosine protects BALB/c mice from Klebsiella pneumoniae B5055-induced sepsis by modulating the pro-inflammatory immune responseJ Chemother20092163964520071287
   PubMed Web of Science ®Google Scholar
• CsokaBNemethZHRosenbergerPA2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammationJ Immunol201018554255020505145
   PubMed Web of Science ®Google Scholar
• KumarVHarjaiKChhibberS2-Chloroadenosine (2-CADO) treatment modulates the pro-inflammatory immune response to prevent acute lung inflammation in BALB/c mice suffering from Klebsiella pneumoniae B5055-induced pneumoniaInt J Antimicrob Agents201035659960220189776
   PubMed Web of Science ®Google Scholar
• SivakKVVasinAVEgorovVVAdenosine A2A receptor as a drug target for treatment of sepsisMol Biol2016502200212
   Web of Science ®Google Scholar
• NonakaMKimuraAGenomic view of the evolution of the complement systemImmunogenetics200658970171316896831
   PubMed Web of Science ®Google Scholar
• NonakaMEvolution of the complement systemSubcell Biochem201480314324798006
   PubMedGoogle Scholar
• MerleNSChurchSEFremeaux-BacchiVRoumeninaLTComplement system part I – molecular mechanisms of activation and regulationFront Immunol20156426226082779
   PubMed Web of Science ®Google Scholar
• MerleNSNoeRHalbwachs-MecarelliLFremeaux-BacchiVRoumeninaLTComplement system part II: role in immunityFront Immunol2015618025726074922
   PubMed Web of Science ®Google Scholar
• WardPAThe dark side of C5a in sepsisNat Rev Immunol20044213315040586
   PubMed Web of Science ®Google Scholar
• GressnerOAKochASansonETrautweinCTackeFHigh C5a levels are associated with increased mortality in sepsis patients-no enhancing effect by actin-free Gc-globulinClin Biochem20084197498018538666
   PubMed Web of Science ®Google Scholar
• MarkiewskiMMDeangelisRALambrisJDComplexity of complement activation in sepsisJ Cell Mol Med2008126a2245225418798865
   PubMed Web of Science ®Google Scholar
• CharchafliehJWeiJLabazeGThe role of complement system in septic shockClin Dev Immunol201220128
   Google Scholar
• YanCGaoHNew insights for C5a and C5a receptors in sepsisFront Immunol2012336823233853
   PubMed Web of Science ®Google Scholar
• RicklinDReisESLambrisJDComplement in disease: a defence system turning offensiveNat Rev Nephrol201612738340127211870
   PubMed Web of Science ®Google Scholar
• SureshRChandrasekaranPSutterwalaFSMosserDMComplement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activationJ Cell Sci201612991928193927006116
   PubMed Web of Science ®Google Scholar
• LaudisiFSpreaficoREvrardMCutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β releaseJ Immunol20131911006101023817414
   PubMed Web of Science ®Google Scholar
• TriantafilouMHughesTRMorganBPTriantafilouKComplementing the inflammasomeImmunology2016147215216426572245
   PubMed Web of Science ®Google Scholar
• MurakamiTOckingerJYuJCritical role for calcium mobilization in activation of the NLRP3 inflammasomeProc Natl Acad Sci U S A201210928112821128722733741
   PubMed Web of Science ®Google Scholar
• HorngTCalcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasomeTrends Immunol20143525326124646829
   PubMed Web of Science ®Google Scholar
• ShimadaKCrotherTRKarlinJOxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosisImmunity201236340141422342844
   PubMed Web of Science ®Google Scholar
• LuanY-YYaoY-MXiaoX-ZShengZ-YInsights into the apoptotic death of immune cells in sepsisJ Interferon Cytokine Res2015351172225007137
   PubMed Web of Science ®Google Scholar
• FangCWeiXWeiYMitochondrial DNA in the regulation of innate immune responsesProtein Cell20167111626498951
   PubMed Web of Science ®Google Scholar
• LiszewskiMKKolevMLeFriecGIntracellular complement activation sustains T cell homeostasis and mediates effector differentiationImmunity20133961143115724315997
   PubMed Web of Science ®Google Scholar
• ArboreGWestEESpolskiRT helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsScience20163526292aad1210aad121027313051
   PubMed Web of Science ®Google Scholar
• IwasakaHNoguchiTTh1/Th2 balance in systemic inflammatory response syndrome (SIRS)Nihon Rinsho2004622237224315597790
   PubMedGoogle Scholar
• KalbitzMFattahiFGrailerJJComplement-induced activation of the cardiac NLRP3 inflammasome in sepsisFASEB J2016303997400627543123
   PubMed Web of Science ®Google Scholar
• AsgariELe FriecGYamamotoHC3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activationBlood20131223473348123878142
   PubMed Web of Science ®Google Scholar
• DinarelloCAThe C3a receptor, caspase-1, and release of IL-1betaBlood20131223394339524235127
   PubMed Web of Science ®Google Scholar
• BenoitMEClarkeEVMorgadoPFraserDATennerAJComplement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cellsJ Immunol20121885682569322523386
   PubMed Web of Science ®Google Scholar
• NakagawaIAmanoAMizushimaNAutophagy defends cells against invading group A StreptococcusScience200430656981037104015528445
   PubMed Web of Science ®Google Scholar
• Matsuzawa-IshimotoYHwangSCadwellKAutophagy and inflammationAnnu Rev Immunol20183617310129144836
   PubMed Web of Science ®Google Scholar
• Djavaheri-MergnyMAmelottiMMathieuJBesanconFBauvyCCodognoPRegulation of autophagy by NFkappaB transcription factor and reactive oxygen speciesAutophagy2007339039217471012
   PubMed Web of Science ®Google Scholar
• XuYJagannathCLiuXDSharafkhanehAKolodziejskaKEEissaNTToll-like receptor 4 is a sensor for autophagy associated with innate immunityImmunity200727113514417658277
   PubMed Web of Science ®Google Scholar
• WuHMWangJZhangBFangLXuKLiuRYCpG-ODN promotes phagocytosis and autophagy through JNK/P38 signal pathway in Staphylococcus aureus-stimulated macrophageLife Sci2016161515927476088
   PubMed Web of Science ®Google Scholar
• PiquereauJGodinRDeschênesSProtective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunctionAutophagy20139111837185124121678
   PubMed Web of Science ®Google Scholar
• TakahashiWWatanabeEFujimuraLKinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsisCrit Care2013174R16023883625
   PubMed Web of Science ®Google Scholar
• YenYTYangHRLoHCEnhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injurySurgery2013153568969823434181
   PubMed Web of Science ®Google Scholar
• HoJYuJWongSHAutophagy in sepsis: degradation into exhaustion?Autophagy2016121073108227172163
   PubMed Web of Science ®Google Scholar
• HsiaoHWTsaiKLWangLFThe decline of autophagy contributes to proximal tubular dysfunction during sepsisShock20123728929622089196
   PubMed Web of Science ®Google Scholar
• SuYQuYZhaoFLiHMuDLiXRegulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsisJ Neuroinflammation20151211626067996
   PubMed Web of Science ®Google Scholar
• KimuraTWatanabeESakamotoTAutophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsisPLoS One20149e9152224626347
   PubMed Web of Science ®Google Scholar
• LinC-WLoSPerngD-SComplete activation of autophagic process attenuates liver injury and improves survival in septic miceShock201441324124924365881
   PubMed Web of Science ®Google Scholar
• ZhangLAiYTsungAClinical application: restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsisExp Ther Med20161141159116727073416
   PubMed Web of Science ®Google Scholar
• RenCZhangHWuT-TYaoYMAutophagy: a potential therapeutic target for reversing sepsis-induced immunosuppressionFront Immunol20178
   Web of Science ®Google Scholar
• SaitohTFujitaNJangMHLoss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β productionNature2008456721926426818849965
   PubMed Web of Science ®Google Scholar
• ZhouRTardivelAThorensBChoiITschoppJThioredoxin-interacting protein links oxidative stress to inflammasome activationNat Immunol20101113614020023662
   PubMed Web of Science ®Google Scholar
• ZhouRYazdiASMenuPTschoppJA role for mitochondria in NLRP3 inflammasome activationNature201146922122521124315
   PubMed Web of Science ®Google Scholar
• KimuraTJainAChoiSWTRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunityJ Cell Biol201521097398926347139
   PubMed Web of Science ®Google Scholar
• HarrisJHartmanMRocheCAutophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradationJ Biol Chem20112869587959721228274
   PubMed Web of Science ®Google Scholar
• HarrisJLangTThomasJPWSukkarMBNabarNRKehrlJHAutophagy and inflammasomesMol Immunol201786101528249679
   PubMed Web of Science ®Google Scholar
• SuzukiTFranchiLTomaCDifferential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophagesPLoS Pathog200738e11117696608
   PubMed Web of Science ®Google Scholar
• JounaiNKobiyamaKShiinaMOgataKIshiiKJTakeshitaFNLRP4 negatively regulates autophagic processes through an association with beclin1J Immunol20111861646165521209283
   PubMed Web of Science ®Google Scholar
• ZhangYSaulerMShinnASEndothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injuryJ Immunol2014192115296530424778451
   PubMed Web of Science ®Google Scholar
• DengQWangYZhangYPseudomonas aeruginosa triggers macrophage autophagy to escape intracellular killing by activation of the NLRP3 inflammasomeInfect Immun201684566626467446
   PubMed Web of Science ®Google Scholar
• PuQGanCLiRAtg7 deficiency intensifies inflammasome activation and pyroptosis in Pseudomonas sepsisJ Immunol201719883205321328258192
   PubMed Web of Science ®Google Scholar
• WlodarskaMThaissCANowarskiRNLRP6 inflammasome orchestrates the colonic host–microbial interface by regulating goblet cell mucus secretionCell201415651045105924581500
   PubMed Web of Science ®Google Scholar
• KimMJBaeSHRyuJCSESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophagesAutophagy20161281272129127337507
   PubMed Web of Science ®Google Scholar
• MaoKChenSChenMNitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shockCell Res201323220121223318584
   PubMed Web of Science ®Google Scholar
• LupferCThomasPGAnandPKReceptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infectionNat Immunol201314548048823525089
   PubMed Web of Science ®Google Scholar
• SaitohTAkiraSRegulation of inflammasomes by autophagyJ Allergy Clin Immunol20161381283627373323
   PubMed Web of Science ®Google Scholar
• QianSFanJBilliarTRScottMJInflammasome and autophagy regulation: a two-way streetMol Med20172318819528741645
   PubMed Web of Science ®Google Scholar
• ShiC-SShenderovKHuangN-NActivation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destructionNat Immunol201213325526322286270
   PubMed Web of Science ®Google Scholar
• YukJMJoEKCrosstalk between autophagy and inflammasomesMol Cells201336539339924213677
   PubMed Web of Science ®Google Scholar
• TakahamaMAkiraSSaitohTAutophagy limits activation of the inflammasomesImmunol Rev20182811627329248000
   PubMed Web of Science ®Google Scholar
• ShibuyaNMikamiYKimuraYNagaharaNKimuraHVascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfideJ Biochem2009146562362619605461
   PubMed Web of Science ®Google Scholar
• WangRPhysiological implications of hydrogen sulfide: a whiff exploration that blossomedPhysiol Rev201292279189622535897
   PubMed Web of Science ®Google Scholar
• ElrodJWCalvertJWMorrisonJHydrogen sulfide attenuates myocardial ischemia–reperfusion injury by preservation of mitochondrial functionProc Natl Acad Sci U S A2007104155601556517878306
   PubMed Web of Science ®Google Scholar
• YangGWuLJiangBH2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyaseScience2008322590158759018948540
   PubMed Web of Science ®Google Scholar
• FernandesCJJrde AssuncaoMSMyocardial dysfunction in sepsis: a large, unsolved puzzleCrit Care Res Pract2012201289643022482045
   PubMedGoogle Scholar
• AntonucciEFiaccadoriEDonadelloKTacconeFSFranchiFScollettaSMyocardial depression in sepsis: from pathogenesis to clinical manifestations and treatmentJ Crit Care20142950051124794044
   PubMed Web of Science ®Google Scholar
• KakihanaYItoTNakaharaMYamaguchiKYasudaTSepsis-induced myocardial dysfunction: pathophysiology and managementJ Intensive Care201642227011791
   PubMed Web of Science ®Google Scholar
• LvXWangHPathophysiology of sepsis-induced myocardial dysfunctionMil Med Res2016313027708836
   PubMedGoogle Scholar
• VallabhajosyulaSPruthiSShahSWileyBMMankadSVJentzerJCBasic and advanced echocardiographic evaluation of myocardial dysfunction in sepsis and septic shockAnaesth Intensive Care2018461132429361252
   PubMed Web of Science ®Google Scholar
• LinZAltafNLiCHydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophagesBiochim Biophys Acta201818649 Pt B28902900
   PubMed Web of Science ®Google Scholar
• CastelblancoMLugrinJEhirchiouDHydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammationJ Biol Chem201829372546255729279328
   PubMed Web of Science ®Google Scholar
• HuangZZhuangXXieCExogenous hydrogen sulfide attenuates high glucose-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation by suppressing TLR4/NF-kappaB pathway in H9c2 CellsCell Physiol Biochem2016401578159027997926
   PubMedGoogle Scholar
• ZhangHZhiLMoorePKBhatiaMRole of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouseAm J Physiol Lung Cell Mol Physiol20062906L1193120116428267
   PubMed Web of Science ®Google Scholar
• SpillerFOrricoMINascimentoDCHydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activationAm J Respir Crit Care Med2010182336036820339148
   PubMed Web of Science ®Google Scholar
• LiXChengQLiJHeYTianPXuCSignificance of hydrogen sulfide in sepsis-induced myocardial injury in ratsExp Ther Med20171432153216128962136
   PubMed Web of Science ®Google Scholar
• OyadomariSMoriMRoles of CHOP/GADD153 in endoplasmic reticulum stressCell Death Differ200411438138914685163
   PubMed Web of Science ®Google Scholar
• TabasIRonDIntegrating the mechanisms of apoptosis induced by endoplasmic reticulum stressNat Cell Biol201113318419021364565
   PubMed Web of Science ®Google Scholar
• FerlitoMWangQFultonWBHydrogen sulfide increases survival during sepsis: protective effect of CHOP inhibitionJ Immunol20141921806181424403532
   PubMed Web of Science ®Google Scholar
• EndoMOyadomariSSugaMMoriMGotohTThe ER stress pathway involving CHOP is activated in the lungs of LPS-treated miceJ Biochem200513850150716272146
   PubMed Web of Science ®Google Scholar
• EndoMMoriMAkiraSGotohTC/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammationJ Immunol20061766245625316670335
   PubMed Web of Science ®Google Scholar
• HuiYduJTangCBinGJiangHChanges in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in ratsJ Infect20034715516012860150
   PubMed Web of Science ®Google Scholar
• NorrisENarasimhanSCulbersonCClemensMGThe liver is a critical site for hydrogen sulfide clearance in sepsisFASEB J20112511171118
   Web of Science ®Google Scholar
• ColettaCSzaboCPotential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shockCurr Vasc Pharmacol20131120822123506499
   PubMed Web of Science ®Google Scholar
• KimDAnantharamPVWhitleyEMAcute exposure to high level of hydrogen sulfide induces neurodegeneration via activation of inflammasomes in brainFASEB J2016a3011911195
   Web of Science ®Google Scholar
• GaddamRRChambersSMurdochDShawGBhatiaMCirculating levels of hydrogen sulfide and substance P in patients with sepsisJ Infect20177529330028760413
   PubMed Web of Science ®Google Scholar
• KoširMPodbregarMAdvances in the diagnosis of sepsis: hydrogen sulfide as a prognostic marker of septic shock severityEJIFCC20172813414128757821
   PubMedGoogle Scholar
• BeeNWhiteRPetrosAJHydrogen sulfide in exhaled gases from ventilated septic neonates and children: a preliminary reportPediatr Crit Care Med201718e327e33228622279
   PubMed Web of Science ®Google Scholar
• BeltowskiJHydrogen sulfide in pharmacology and medicine – an updatePharmacol Rep20156764765825933982
   PubMed Web of Science ®Google Scholar
• TilleySLCoffmanTMKollerBHMixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanesJ Clin Invest20011081152311435451
   PubMed Web of Science ®Google Scholar
• SmythEMGrosserTWangMYuYFitzgeraldGAProstanoids in health and diseaseJ Lipid Res200950SupplementS423S42819095631
   PubMed Web of Science ®Google Scholar
• KawabeTHarrisPDZakariaELGarrisonRNSepsis alters vessel contraction by adrenoceptor-induced nitric oxide and prostanoidJ Surg Res200311035235912788665
   PubMed Web of Science ®Google Scholar
• WangXShawDKHammondHLThe prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activationPLoS Pathog2016128e100580327482714
   PubMed Web of Science ®Google Scholar
• RicciottiEFitzgeraldGAProstaglandins and inflammationArterioscler Thromb Vasc Biol2011315986100021508345
   PubMed Web of Science ®Google Scholar
• von MoltkeJTrinidadNJMoayeriMRapid induction of inflammatory lipid mediators by the inflammasome in vivoNature2012490741810711122902502
   PubMed Web of Science ®Google Scholar
• ZoccalKFSorgiCAHoriJIOpposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortalityNat Commun201671076026907476
   PubMed Web of Science ®Google Scholar
• MaierNKLepplaSHMoayeriMThe cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomesJ Immunol201519462776278525681332
   PubMed Web of Science ®Google Scholar
• MortimerLMoreauFMacdonaldJAChadeeKNLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutationsNat Immunol201617101176118627548431
   PubMed Web of Science ®Google Scholar
• SokolowskaMChenL-YLiuYProstaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophagesJ Immunol2015194115472548725917098
   PubMed Web of Science ®Google Scholar
• TingJPDuncanJALeiYHow the noninflammasome NLRs function in the innate immune systemScience2010327596328629020075243
   PubMed Web of Science ®Google Scholar
• LiZZhangYLiuBLuoWLiHZhouYRole of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient miceSci Rep2017714216728165064
   PubMed Web of Science ®Google Scholar
• TunctanBKorkmazBSariANA novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acidAntiinflamm Antiallergy Agents Med Chem201211212115023013331
   PubMedGoogle Scholar
• TunctanBKorkmazBSariANContribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shockNitric Oxide201333184123684565
   PubMed Web of Science ®Google Scholar
• VijayRFehrARJanowskiAMVirus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signalingProc Natl Acad Sci U S A201711427E5444e545328630327
   PubMed Web of Science ®Google Scholar
• KhareSRatsimandresyRAde AlmeidaLThe PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA virusesNat Immunol20141534335324531343
   PubMed Web of Science ®Google Scholar
• de AlmeidaLKhareSMisharinAVThe PYRIN domain-only protein POP1 inhibits inflammasome assembly and ameliorates inflammatory diseaseImmunity20154326427626275995
   PubMed Web of Science ®Google Scholar
• AngusDCOpalSImmunosuppression and secondary infection in sepsis: part, not all, of the storyJAMA20163151457145926975243
   PubMed Web of Science ®Google Scholar
• FattahiFWardPAUnderstanding immunosuppression after sepsisImmunity2017473528723551
   PubMed Web of Science ®Google Scholar
• RoquillyAMcwilliamHEGJacquelineCLocal modulation of antigen-presenting cell development after resolution of pneumonia induces long-term susceptibility to secondary infectionsImmunity2017471e135147
   PubMed Web of Science ®Google Scholar
• JensenIJSjaastadFVGriffithTSBadovinacVPSepsis-induced T cell immunoparalysis: the ins and outs of impaired T cell immunityJ Immunol20182001543155329463691
   PubMed Web of Science ®Google Scholar
• CaoCMaTChaiY-FShouS-TThe role of regulatory T cells in immune dysfunction during sepsisWorld J Emerg Med2015a65925802559
   PubMedGoogle Scholar
• TaturaRZeschnigkMHansenWRelevance of Foxp3+ regulatory T cells for early and late phases of murine sepsisImmunology2015146114415626059660
   PubMed Web of Science ®Google Scholar
• YaoYVent-SchmidtJMcgeoughMDTr1 cells, but not Foxp3+ regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanismJ Immunol2015195248849726056255
   PubMed Web of Science ®Google Scholar
• FriedmanGJankowskiSMarchantAGoldmanMKahnRJVincentJLBlood interleukin 10 levels parallel the severity of septic shockJ Crit Care1997121831879459114
   PubMed Web of Science ®Google Scholar
• GogosCADrosouEBassarisHPSkoutelisAPro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic optionsJ Infect Dis200018117618010608764
   PubMed Web of Science ®Google Scholar
• PileriDAccardo PalomboAD’AmelioLConcentrations of cytokines Il-6 and Il-10 in plasma of burn patients: their relationship to sepsis and outcomeAnn Burns Fire Disasters20082118218521991134
   PubMedGoogle Scholar
• SurbatovicMPopovicNVojvodicDCytokine profile in severe Gram-positive and Gram-negative abdominal sepsisSci Rep201551135526079127
   PubMed Web of Science ®Google Scholar
• LatifiSQO’RiordanMALevineADInterleukin-10 controls the onset of irreversible septic shockInfect Immun2002704441444612117955
   PubMed Web of Science ®Google Scholar
• CayrolCGirardJ-PThe IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1Proc Natl Acad Sci U S A20091069021902619439663
   PubMed Web of Science ®Google Scholar
• MadouriFGuillouNFauconnierLCaspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammationJ Mol Cell Biol20157435136525714839
   PubMed Web of Science ®Google Scholar
• TominagaSIOhtaSTagoKSoluble form of the ST2 gene product exhibits growth promoting activity in NIH-3T3 cellsBiochem Biophys Rep2016581528955802
   PubMedGoogle Scholar
• GriesenauerBPaczesnySThe ST2/IL-33 axis in immune cells during inflammatory diseasesFront Immunol20178
   Web of Science ®Google Scholar
• KakkarRLeeRTThe IL-33/ST2 pathway: therapeutic target and novel biomarkerNat Rev Drug Discov2008782784018827826
   PubMed Web of Science ®Google Scholar
• EchtenacherBMannelDNHultnerLCritical protective role of mast cells in a model of acute septic peritonitisNature199638175778609992
   PubMed Web of Science ®Google Scholar
• HoogerwerfJJTanckMWTvan ZoelenMadWitteboleXLaterreP-Fvan der PollTSoluble ST2 plasma concentrations predict mortality in severe sepsisIntensive Care Med20103663063720151106
   PubMed Web of Science ®Google Scholar
• ParenicaJMalaskaJJarkovskyJSoluble ST2 levels in patients with cardiogenic and septic shock are not predictors of mortalityExp Clin Cardiol20121720520923592937
   PubMedGoogle Scholar
• HurMKimHKimHJSoluble ST2 has a prognostic role in patients with suspected sepsisAnn Lab Med20153557057726354344
   PubMed Web of Science ®Google Scholar
• SweetMJLeungBPKangDA novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expressionJ Immunol2001166116633663911359817
   PubMed Web of Science ®Google Scholar
• Alves-FilhoJCSônegoFSoutoFInterleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infectionNat Med2010
   Web of Science ®Google Scholar
• SutherlandREOlsenJSMckinstryAVillaltaSAWoltersPJMast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killingJ Immunol200818185598560518832718
   PubMed Web of Science ®Google Scholar
• DahdahAGautierGAttoutTMast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosisJ Clin Invest20141244577458925180604
   PubMed Web of Science ®Google Scholar
• NeteaMGJoostenLABInflammasome inhibition: putting out the fireCell Metab201521451351425863243
   PubMed Web of Science ®Google Scholar
• ShaoB-ZXuZ-QHanB-ZSuD-FLiuCNLRP3 inflammasome and its inhibitors: a reviewFront Pharmacol20156378
   Google Scholar
• JahanSKumarDChaturvediSTherapeutic targeting of NLRP3 inflammasomes by natural products and pharmaceuticals: a novel mechanistic approach for inflammatory diseasesCurr Med Chem2017241645167028245768
   PubMed Web of Science ®Google Scholar
• CollRCRobertsonAabChaeJJA small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesNat Med20152124825686105
   PubMed Web of Science ®Google Scholar
• YoumYHNguyenKYGrantRWThe ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory diseaseNat Med201521326325686106
   PubMed Web of Science ®Google Scholar
• NewmanJCVerdinEKetone bodies as signaling metabolitesTrends Endocrinol Metab2014251425224140022
   PubMed Web of Science ®Google Scholar
• GrabackaMPierzchalskaMDeanMReissKRegulation of ketone body metabolism and the role of PPARαInt J Mol Sci2016172093
   Web of Science ®Google Scholar
• OhtoshiMJikkoAAsanoMUchidaKOzawaKTobeTKetogenesis during sepsis in relation to hepatic energy metabolismRes Exp Med19841844209219
   Google Scholar
• Lanza-JacobySRosatoEBracciaGTabaresAAltered ketone body metabolism during gram-negative sepsis in the ratMetabolism199039115111572233276
   PubMed Web of Science ®Google Scholar
• LevyBSadouneLOGelotAMBollaertPENabetPLarcanAEvolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shockCrit Care Med20002811411910667509
   PubMed Web of Science ®Google Scholar
• GuanYBreyerMDPeroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal diseaseKidney Int200160143011422732
   PubMed Web of Science ®Google Scholar
• DengYHanXYaoZPPARalpha agonist stimulated angiogenesis by improving endothelial precursor cell function via a NLRP3 inflammasome pathwayCell Physiol Biochem2017422255226628817808
   PubMedGoogle Scholar
• WangYYuBWangLPioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitusPLoS One2017127e018124828708885
   PubMed Web of Science ®Google Scholar
• AronoffDMSerezaniCHCarstensJKStimulatory effects of peroxisome proliferator-activated receptor-γ on Fcγ receptor-mediated phagocytosis by alveolar macrophagesPPAR Res200720078
   Web of Science ®Google Scholar
• DrosatosKKhanRSTrentCMPPARγ activation prevents sepsis-related cardiac dysfunction and mortality in miceCirc Heart Fail2013655056223572494
   PubMed Web of Science ®Google Scholar
• KaplanJNowellMChimaRZingarelliBPioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsisInnate Immun20142051952824029145
   PubMed Web of Science ®Google Scholar
• ReddyATLakshmiSPReddyRCPPAR γ in bacterial infections: a friend or foe?PPAR Res2016379635407
   Google Scholar
• StandageSWCaldwellCCZingarelliBWongHRReduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsisShock201237216416922089192
   PubMed Web of Science ®Google Scholar
• KumarVChhibberSAnti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c miceEur J Pharmacol200859214615018662682
   PubMed Web of Science ®Google Scholar
• KumarVHarjaiKChhibberSA combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsisJ Chemother20092115916419423468
   PubMed Web of Science ®Google Scholar
• KumarVHarjaiKChhibberSThalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c miceInt Immunopharmacol201010777778320399910
   PubMed Web of Science ®Google Scholar
• KumarVChhibberSThalidomide: an old drug with new actionJ Chemother20112332633422233815
   PubMed Web of Science ®Google Scholar
• KellerMSollbergerGBeerHDThalidomide inhibits activation of caspase-1J Immunol20091835593559919843943
   PubMed Web of Science ®Google Scholar
• López-CastejónGPelegrínPCurrent status of inflammasome blockers as anti-inflammatory drugsExpert Opin Investig Drugs20122179951007
   PubMed Web of Science ®Google Scholar
• Ludwig-PortugallIBartokEDhanaEAn NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in miceKidney Int201690352553927262364
   PubMed Web of Science ®Google Scholar
• MarchettiCSwartzwelterBGamboniFOLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammationProc Natl Acad Sci U S A20181157E1530E153929378952
   PubMed Web of Science ®Google Scholar
• ZormanJSušjanPHafner-BratkovičIShikonin suppresses NLRP3 and AIM2 inflammasomes by direct inhibition of caspase-1PLoS One201611e015982627467658
   PubMed Web of Science ®Google Scholar
• HaraHTsuchiyaKKawamuraIPhosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activityNat Immunol2013141247125524185614
   PubMed Web of Science ®Google Scholar
• KwakS-BKoppulaSInE-JArtemisia extract suppresses NLRP3 and AIM2 inflammasome activation by inhibition of ASC phosphorylationMediators Inflamm20182018605406929686531
   PubMed Web of Science ®Google Scholar
• LeeJAhnHHongEJAnBSJeungEBLeeGSSulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasomeCell Immunol20163065330760
   Web of Science ®Google Scholar
• YendeSvan der PollTDiabetes and sepsis outcomes –it is not all bad newsCrit Care200913111719291261
   PubMed Web of Science ®Google Scholar
• KohGCKWPeacockSJvan der PollTWiersingaWJThe impact of diabetes on the pathogenesis of sepsisEur J Clin Microbiol Infect Dis20123137938821805196
   PubMed Web of Science ®Google Scholar
• KolyvaASZolotaVMpatsoulisDThe role of obesity in the immune response during sepsisNutr Diabetes20144e13725244356
   PubMed Web of Science ®Google Scholar
• Papadimitriou-OlivgerisMArethaDZotouAThe role of obesity in sepsis outcome among critically ill patients: a retrospective cohort analysisBiomed Res Int20162016599
   Google Scholar
• NgPYEikermannMThe obesity conundrum in sepsisBMC Anesthesiol201717114729070011
   PubMed Web of Science ®Google Scholar
• DixitVDNlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?Diabetes201362222423258906
   PubMed Web of Science ®Google Scholar
• LeeH-MKimJ-JKimHJShongMKuBJJoE-KUpregulated NLRP3 inflammasome activation in patients with type 2 diabetesDiabetes20136219420423086037
   PubMed Web of Science ®Google Scholar
• VolpeCMAnjosPMNogueira-MachadoJAInflammasome as a new therapeutic target for diabetic complicationsRecent Pat Endocr Metab Immune Drug Discov2016101566226899852
   PubMedGoogle Scholar
• RheinheimerJde SouzaBMCardosoNSBauerACCrispimDCurrent role of the NLRP3 inflammasome on obesity and insulin resistance: a systematic reviewMetabolism2017741928764843
   PubMed Web of Science ®Google Scholar
• SepehriZKianiZAfshariMKohanFDalvandAGhavamiSInflammasomes and type 2 diabetes: an updated systematic reviewImmunol Lett20171929710329079203
   PubMed Web of Science ®Google Scholar
• ZhangXDaiJLiLChenHChaiYNLRP3 inflammasome expression and signaling in human diabetic wounds and in high glucose induced macrophagesJ Diabetes Res 20172017b7
   Google Scholar
• FujitaniYKawamoriRWatadaHThe role of autophagy in pancreatic beta-cell and diabetesAutophagy2009528028219158492
   PubMed Web of Science ®Google Scholar
• NuñezCERodriguesVSGomesFSDefective regulation of adipose tissue autophagy in obesityInt J Obes2013371114731480
   Web of Science ®Google Scholar
• BarlowADThomasDCAutophagy in diabetes: beta-cell dysfunction, insulin resistance, and complicationsDNA Cell Biol20153425226025665094
   PubMed Web of Science ®Google Scholar
• SarparantaJGarcía-MaciaMSinghRAutophagy and mitochondria in obesity and type 2 diabetesCurr Diabetes Rev201713435236926900135
   PubMed Web of Science ®Google Scholar
• YangJSLuCCKuoSCAutophagy and its link to type II diabetes mellitusBiomedicine201772828612706
   PubMedGoogle Scholar
• HaoHCaoLJiangCFarnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsisCell Metab201725856–867e855
   Google Scholar
• de Magalhaes FilhoCDDownesMEvansRMFarnesoid X receptor an emerging target to combat obesityDig Dis20173518519028249279
   PubMed Web of Science ®Google Scholar
• XieSGuoCChiZA rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonismFEBS Lett2017591182836284728787755
   PubMed Web of Science ®Google Scholar
• LeeSNakahiraKDalliJNLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B4 synthesisAm J Respir Crit Care Med201719671372628245134
   PubMed Web of Science ®Google Scholar