90
Views
16
CrossRef citations to date
0
Altmetric
Original Research

PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case–Control Study

, ORCID Icon, , , , ORCID Icon & ORCID Icon show all
Pages 301-308 | Published online: 03 Dec 2019

References

  • McNees AL, Markesich D, Zayyani NR, Graham DY. Mycobacterium paratuberculosis as a cause of Crohn’s disease. Expert Rev Gastroenterol Hepatol. 2015;9(12):1523–1534. doi:10.1586/17474124.2015.109393126474349
  • Kuenstner JT, Naser S, Chamberlin W, et al. The consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017. Front Public Health. 2017;5:208. doi:10.3389/fpubh.2017.0020829021977
  • Feller M, Huwiler K, Stephan R, et al. Mycobacterium avium subspecies paratuberculosis and Crohn’s disease: a systematic review and meta-analysis. Lancet Infect Dis. 2007;7(9):607–613. doi:10.1016/S1473-3099(07)70211-617714674
  • Sechi LA, Dow CT. Mycobacterium avium ss. paratuberculosis Zoonosis – the hundred year war – beyond Crohn’s disease. Front Immunol. 2015;6:96. doi:10.3389/fimmu.2015.0009625788897
  • Eslami M, Shafiei M, Ghasemian A, et al. Mycobacterium avium paratuberculosis and Mycobacterium avium complex and related subspecies as causative agents of zoonotic and occupational diseases. J Cell Physiol. 2019;234(8):12415–12421. doi:10.1002/jcp.2807630673126
  • Waddell LA, Rajić A, Stärk KD, McEWEN SA. The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence. Epidemiol Infect. 2015;143(15):3135–3157. doi:10.1017/S095026881500076X25989710
  • Fawzy A, Zschöck M, Ewers C, Eisenberg T. Genotyping methods and molecular epidemiology of Mycobacterium avium subsp. paratuberculosis (MAP). Int J Vet Sci Med. 2018;6(2):258–264. doi:10.1016/j.ijvsm.2018.08.00130564606
  • Sergeant ESG, McAloon CG, Tratalos JA, Citer LR, Graham DA, More SJ. Evaluation of national surveillance methods for detection of Irish dairy herds infected with Mycobacterium avium subspecies paratuberculosis. J Dairy Sci. 2019;102(3):2525–2538. doi:10.3168/jds.2018-1569630692009
  • Yokoyama K, Cossu D, Hoshino Y, Tomizawa Y, Momotani E, Hattori N. Anti-mycobacterial antibodies in paired cerebrospinal fluid and serum samples from Japanese patients with multiple sclerosis or neuromyelitis optica spectrum disorder. J Clin Med. 2018;7:12. doi:10.3390/jcm7120522
  • Cossu D, Yokoyama K, Tomizawa Y, Momotani E, Hattori N. Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system. Sci Rep. 2017;7(1):3179. doi:10.1038/s41598-017-03370-z28600575
  • Mameli G, Cocco E, Frau J, Marrosu MG, Sechi LA. Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of MS patients. Sci Rep. 2016;6:22401. doi:10.1038/srep2240126956729
  • Slavin YN, Bo M, Caggiu E, et al. High levels of antibodies against PtpA and PknG secreted by Mycobacterium avium ssp. paratuberculosis are present in neuromyelitis optica spectrum disorder and multiple sclerosis patients. J Neuroimmunol. 2018;323:49–52. doi:10.1016/j.jneuroim.2018.07.00730196833
  • Bo M, Niegowska M, Arru G, et al. Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder. J Neuroimmunol. 2018;318:97–102. doi:10.1016/j.jneuroim.2018.02.01329519720
  • Dow CT. M. paratuberculosis and Parkinson’s disease – is this a trigger. Med Hypotheses. 2014;83(6):709–712. doi:10.1016/j.mehy.2014.09.02525459140
  • Arru G, Caggiu E, Paulus K, Sechi GP, Mameli G, Sechi LA. Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson’s disease? J Neuroimmunol. 2016;293:86–90. doi:10.1016/j.jneuroim.2016.02.01627049567
  • Niegowska M, Rapini N, Piccinini S, et al. Type 1 diabetes at-risk children highly recognize Mycobacterium avium subspecies paratuberculosis epitopes homologous to human Znt8 and proinsulin. Sci Rep. 2016;6:22266. doi:10.1038/srep2226626923214
  • Niegowska M, Wajda-Cuszlag M, Stępień-Ptak G, et al. Anti-HERV-WEnv antibodies are correlated with seroreactivity against Mycobacterium avium subsp. paratuberculosis in children and youths at T1D risk. Sci Rep. 2019;9(1):6282. doi:10.1038/s41598-019-42788-531000760
  • Cossu D, Yokoyama K, Sakanishi T, Momotani E, Hattori N. Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. J Neuroimmunol. 2019;330:174–177. doi:10.1016/j.jneuroim.2019.01.01330738572
  • Bo M, Erre GL, Niegowska M, et al. Interferon regulatory factor 5 is a potential target of autoimmune response triggered by Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis in rheumatoid arthritis: investigating a mechanism of molecular mimicry. Clin Exp Rheumatol. 2018;36(3):376–381.29352853
  • Bo M, Niegowska M, Erre GL, et al. Rheumatoid arthritis patient antibodies highly recognize IL-2 in the immune response pathway involving IRF5 and EBV antigens. Sci Rep. 2018;8(1):1789. doi:10.1038/s41598-018-19957-z29379122
  • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205–2219. doi:10.1056/NEJMra100496522150039
  • Isaacs JD. The changing face of rheumatoid arthritis: sustained remission for all? Nat Rev Immunol. 2010;10(8):605–611. doi:10.1038/nri280420651747
  • Stahl EA, Raychaudhuri S, Remmers EF, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42(6):508–514. doi:10.1038/ng.58220453842
  • Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003;34(4):395–402. doi:10.1038/ng120612833157
  • Olsen I, Singhrao SK, Potempa J. Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer’s disease. J Oral Microbiol. 2018;10(1):1487742. doi:10.1080/20002297.2018.148774229963294
  • Engström M, Eriksson K, Lee L, et al. Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis. J Transl Med. 2018;16(1):214. doi:10.1186/s12967-018-1588-230064459
  • Lloyd KA, Wigerblad G, Sahlström P, et al. Differential ACPA binding to nuclear antigens reveals a PAD-Independent pathway and a distinct subset of acetylation cross-reactive autoantibodies in rheumatoid arthritis. Front Immunol. 2019;9:3033. doi:10.3389/fimmu.2018.0303330662440
  • Udalova IA, Mantovani A, Feldmann M. Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol. 2016;12(8):472–485. doi:10.1038/nrrheum.2016.9127383913
  • Weiss M, Blazek K, Byrne AJ, Perocheau DP, Udalova IA. IRF5 is a specific marker of inflammatory macrophages in vivo. Mediators Inflamm. 2013;2013:245804. doi:10.1155/2013/24580424453413
  • Saliba DG, Heger A, Eames HL, et al. IRF5: relA interaction targets inflammatory genes in macrophages. Cell Rep. 2014;8(5):1308–1317. doi:10.1016/j.celrep.2014.07.03425159141
  • Chaubey KK, Singh SV, Gupta S, et al. Mycobacterium avium subspecies paratuberculosis – an important food borne pathogen of high public health significance with special reference to India: an update. Vet Q. 2017;37(1):282–399. doi:10.1080/01652176.2017.139730129090657
  • Aletaha D, Neogi T, Silman AJ, et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–2581. doi:10.1002/art.2758420872595
  • Bach H, Sun J, Hmama Z, Av-Gay Y. Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection. Infect Immun. 2006;74(12):6540–6546. doi:10.1128/IAI.01106-0616982836
  • Xia A, Stempak JM, Grist J, Bressler B, Silverberg MS, Bach H. Effect of inflammatory bowel disease therapies on immunogenicity of Mycobacterium paratuberculosis proteins. Scand J Gastroenterol. 2104;49(2):157–163. doi:10.3109/00365521.2013.857713
  • Gurung RB, Begg DJ, Purdie AC, Bach H, Whittington RJ. Immunoreactivity of protein tyrosine phosphatase A (PtpA) in sera from sheep infected with Mycobacterium avium subspecies paratuberculosis. Vet Immunol Immunopathol. 2014;160(1–2):129–132. doi:10.1016/j.vetimm.2014.03.01324788024
  • Bach E, Raizman EA, Vanderwal R, et al. Immunogenicity of PtpA secreted during Mycobacterium avium ssp. paratuberculosis infection in cattle. Vet Immunol Immunopathol. 2018;198:1–5. doi:10.1016/j.vetimm.2018.02.00629571512
  • Smolen JS, Aletaha D, Barton A, et al. Rheumatoid arthritis. Nat Rev Dis Primers. 2018;4:18001.29417936
  • Trouw LA, Rispens T, Toes REM. Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(6):331–339. doi:10.1038/nrrheum.2017.1528275265
  • Jung H, Jung SM, Rim YA, et al. Arthritic role of Porphyromonas gingivalis in collagen-induced arthritis mice. PLoS One. 2017;12(11):e0188698. doi:10.1371/journal.pone.018869829190705
  • Mukherjee A, Jantsch V, Khan R, et al. Rheumatoid arthritis-associated autoimmunity due to aggregatibacter actinomycetemcomitans and its resolution with antibiotic therapy. Front Immunol. 2018;9:2352. doi:10.3389/fimmu.2018.0235230459755
  • Mameli G, Erre GL, Caggiu E, et al. Identification of a HERV-K env surface peptide highly recognized in Rheumatoid Arthritis (RA) patients: a cross-sectional case-control study. Clin Exp Immunol. 2017;189(1):127–131. doi:10.1111/cei.2017.189.issue-128324619
  • McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007;7(6):429–442. doi:10.1038/nri209417525752
  • O’Neil LJ, Kaplan MJ. Neutrophils in rheumatoid arthritis: breaking immune tolerance and fueling disease. Trends Mol Med. 2019;25(3):215–227. doi:10.1016/j.molmed.2018.12.00830709614
  • Weiss M, Byrne AJ, Blazek K, et al. IRF5 controls both acute and chronic inflammation. Proc Natl Acad Sci U S A. 2015;112(35):11001–11006. doi:10.1073/pnas.150625411226283380
  • Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol. 2014;10(10):593–601. doi:10.1038/nrrheum.2014.8024914698
  • Almuttaqi H, Udalova IA. Advances and challenges in targeting IRF5, a key regulator of inflammation. Febs J. 2019;286(9):1624–1637. doi:10.1111/febs.2019.286.issue-930199605
  • Khoyratty TE, Udalova IA. Diverse mechanisms of IRF5 action in inflammatory responses. Int J Biochem Cell Biol. 2018;99:38–42. doi:10.1016/j.biocel.2018.03.01229578052
  • Moon YM, Lee SY, Kwok SK, et al. The Fos-related antigen 1-JUNB/activator protein 1 transcription complex, a downstream target of signal transducer and activator of transcription 3, induces T helper 17 differentiation and promotes experimental autoimmune arthritis. Front Immunol. 2017;8:1793. doi:10.3389/fimmu.2017.0179329326694
  • Arsenault RJ, Maattanen P, Daigle J, Potter A, Griebel P, Napper S. From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis. Vet Res. 2014;45(1):54. doi:10.1186/1297-9716-45-5424885748