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REVIEW

Topical Anti-Inflammatory Agents for Non-Infectious Uveitis: Current Treatment and Perspectives

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Pages 6439-6451 | Received 16 May 2022, Accepted 12 Nov 2022, Published online: 28 Nov 2022

References

  • Williams GS, Westcott M. Practical Uveitis: Understanding the Grape. CRC Press; 2017.
  • Mackenzie W. A Practical Treatise on the Diseases of the Eye. Forgotten Books; 1855.
  • Forrester JV. New concepts on the role of autoimmunity in the pathogenesis of uveitis. Eye. 1992;6(5):433–446. doi:10.1038/eye.1992.93
  • Bloch-Michel E. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol. 1987;103:234–235. doi:10.1016/S0002-9394(14)74235-7
  • Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005;140(3):509–516.
  • Hogan MJ, Kimura SJ, Thygeson P. Signs and symptoms of uveitis: i. Anterior uveitis. Am J Ophthalmol. 1959;47(5):155–170. doi:10.1016/S0002-9394(14)78239-X
  • Nussenblatt RB, Palestine AG, Chan CC, Roberge F. Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology. 1985;92(4):467–471. doi:10.1016/S0161-6420(85)34001-0
  • Deschenes J, Murray PI, Rao NA, Nussenblatt RB. International uveitis study group (IUSG) clinical classification of uveitis. Ocul Immunol Inflamm. 2008;16(1–2):1–2. doi:10.1080/09273940801899822
  • Miserocchi E, Fogliato G, Modorati G, Bandello F. Review on the worldwide epidemiology of uveitis. Eur J Ophthalmol. 2013;23(5):705–717. doi:10.5301/ejo.5000278
  • Durrani OM, Tehrani NN, Marr JE, Moradi P, Stavrou P, Murray PI. Degree, duration, and causes of visual loss in uveitis. Br J Ophthalmol. 2004;88(9):1159–1162. doi:10.1136/bjo.2003.037226
  • Thorne JE, Suhler E, Skup M, et al. Prevalence of noninfectious uveitis in the United States: a claims-based analysis. JAMA Ophthalmol. 2016;134(11):1237–1245. doi:10.1001/jamaophthalmol.2016.3229
  • Hsu YR, Huang JCC, Tao Y, et al. Noninfectious uveitis in the Asia–Pacific region. Eye. 2019;33(1):66–77. doi:10.1038/s41433-018-0223-z
  • García-Aparicio Á, García de Yébenes MJ, Otón T, Muñoz-Fernández S. Prevalence and incidence of uveitis: a systematic review and meta-analysis. Ophthalmic Epidemiol. 2021;28(6):461–468. doi:10.1080/09286586.2021.1882506
  • Rosenbaum JT, Bodaghi B, Couto C, et al. New observations and emerging ideas in diagnosis and management of non-infectious uveitis: a review. Semin Arthritis Rheum. 2019;49(3):438–445. doi:10.1016/j.semarthrit.2019.06.004
  • Tsirouki T, Dastiridou A, Symeonidis C, et al. A focus on the epidemiology of uveitis. Ocul Immunol Inflamm. 2018;26(1):2–16. doi:10.1080/09273948.2016.1196713
  • Nalcacioglu-Yuksekkaya P, Ozdal PC, Yazici A, Tirhis H. Clinical and demographic characteristics of patients with uveitis starting later in life. Ocul Immunol Inflamm. 2015;23(4):304–310. doi:10.3109/09273948.2014.938761
  • Tallouzi MO, Moore DJ, Bucknall N, et al. Outcomes important to patients with non-infectious posterior segment-involving uveitis: a qualitative study. BMJ Open Ophthalmol. 2020;5(1):e000481. doi:10.1136/bmjophth-2020-000481
  • Barry RJ, Nguyen QD, Lee RW, Murray PI, Denniston AK. Pharmacotherapy for uveitis: current management and emerging therapy. Clin Ophthalmol Auckl NZ. 2014;22(8):1891–1911.
  • Barry RJ, Sutcliffe N, Isenberg DA, et al. The Sjögren’s Syndrome Damage Index--a damage index for use in clinical trials and observational studies in primary Sjögren’s syndrome. Rheumatol Oxf Engl. 2008;47(8):1193–1198. doi:10.1093/rheumatology/ken164
  • Skopouli FN, Dafni U, Ioannidis JP, Moutsopoulos HM. Clinical evolution, and morbidity and mortality of primary Sjögren’s syndrome. Semin Arthritis Rheum. 2000;29(5):296–304. doi:10.1016/S0049-0172(00)80016-5
  • Jones J, Francis P. Ophthalmic utility of topical bromfenac, a twice-daily nonsteroidal anti-inflammatory agent. Expert Opin Pharmacother. 2009;10(14):2379–2385. doi:10.1517/14656560903188425
  • Woods AC. Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease. Am J Ophthalmol. 1950;33(9):1325–1351. doi:10.1016/0002-9394(50)91827-7
  • Watson D, Noble MJ, Dutton GN, Midgley JM, Healey TM. Penetration of topically applied dexamethasone alcohol into human aqueous humor. Arch Ophthalmol. 1988;106(5):686–687. doi:10.1001/archopht.1988.01060130748037
  • Watson DG, McGhee CNJ, Midgley JM, Dutton GN, Noble MJ. Penetration of topically applied betamethasone sodium phosphate into human aqueous humour. Eye. 1990;4(4):603–606. doi:10.1038/eye.1990.84
  • McGhee CNJ, Noble MJ, Watson DG, et al. Penetration of topically applied prednisolone sodium phosphate into human aqueous humour. Eye. 1989;3(4):463–467. doi:10.1038/eye.1989.69
  • Sulaiman RS, Kadmiel M, Cidlowski JA. Glucocorticoid receptor signaling in the eye. Steroids. 2018;133:60–66. doi:10.1016/j.steroids.2017.11.002
  • Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. N Engl J Med. 2005;353(16):1711–1723. doi:10.1056/NEJMra050541
  • Saklatvala J, Nagase H, Salvesen G, Dean J, Clark A. Control of the expression of inflammatory response genes. In: Biochemical Society Symposia. Portland Press; 2003:95–106.
  • Gille J, Reisinger K, Westphal-Varghese B, Kaufmann R. Decreased mRNA stability as a mechanism of glucocorticoid-mediated inhibition of vascular endothelial growth factor gene expression by cultured keratinocytes. J Invest Dermatol. 2001;117(6):1581–1587. doi:10.1046/j.0022-202x.2001.01573.x
  • Hafezi-Moghadam A, Simoncini T, Yang Z, et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med. 2002;8(5):473–479. doi:10.1038/nm0502-473
  • Airody A, Heath G, Lightman S, Gale R. Non-infectious uveitis: optimising the therapeutic response. Drugs. 2016;76(1):27–39. doi:10.1007/s40265-015-0502-y
  • Phulke S, Kaushik S, Kaur S, Pandav SS. Steroid-induced glaucoma: an avoidable irreversible blindness. J Curr Glaucoma Pract. 2017;11(2):67. doi:10.5005/jp-journals-10028-1226
  • Raizman M. Corticosteroid therapy of eye disease: fifty years later. Arch Ophthalmol. 1996;114(8):1000–1001. doi:10.1001/archopht.1996.01100140208016
  • Pleyer U, Ursell PG, Rama P. Intraocular pressure effects of common topical steroids for post-cataract inflammation: are they all the same? Ophthalmol Ther. 2013;2(2):55–72. doi:10.1007/s40123-013-0020-5
  • Daniel E, Pistilli M, Kothari S, et al. Risk of ocular hypertension in adults with noninfectious uveitis. Ophthalmology. 2017;124(8):1196–1208. doi:10.1016/j.ophtha.2017.03.041
  • Din NM, Isa H, Taylor SR, Barton K, Lightman SL. Intraocular pressure elevation in uveitis. Expert Rev Ophthalmol. 2012;7(1):45–59. doi:10.1586/eop.11.75
  • Cantrill HL, Palmberg PF, Zink HA, Waltman SR, Podos SM, Becker B. Comparison of in vitro potency of corticosteroids with ability to raise intraocular pressure. Am J Ophthalmol. 1975;79(6):1012–1017. doi:10.1016/0002-9394(75)90687-X
  • Loteprednol Etabonate US Uveitis Study Group. Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis. Am J Ophthalmol. 1999;127(5):537–544. doi:10.1016/S0002-9394(99)00034-3
  • Sallam A, Sheth HG, Habot-Wilner Z, Lightman S. Outcome of raised intraocular pressure in uveitic eyes with and without a corticosteroid-induced hypertensive response. Am J Ophthalmol. 2009;148(2):207–213.e1. doi:10.1016/j.ajo.2009.02.032
  • Basilious A, Lloyd JC. Posterior subcapsular cataracts and hypotony secondary to severe pembrolizumab induced uveitis: case report. Can J Ophthalmol J Can Ophtalmol. 2016;51(1):e4–e6. doi:10.1016/j.jcjo.2015.09.008
  • Dikshit SK, Avasthi PN. Posterior lenticular opacities in children on corticosteroid therapy. Indian J Pediatr. 1965;32(3):93–96. doi:10.1007/BF02756568
  • Jobling AI, Augusteyn RC. What causes steroid cataracts? A review of steroid-induced posterior subcapsular cataracts. Clin Exp Optom. 2002;85(2):61–75. doi:10.1111/j.1444-0938.2002.tb03011.x
  • Dick AD, Tundia N, Sorg R, et al. Risk of ocular complications in patients with noninfectious intermediate uveitis, posterior uveitis, or panuveitis. Ophthalmology. 2016;123(3):655–662. doi:10.1016/j.ophtha.2015.10.028
  • Blum-Hareuveni T, Seguin-Greenstein S, Kramer M, et al. Risk factors for the development of cataract in children with uveitis. Am J Ophthalmol. 2017;177:139–143. doi:10.1016/j.ajo.2017.02.023
  • Thorne JE, Woreta FA, Dunn JP, Jabs DA. Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids. Ophthalmology. 2010;117(7):1436–1441. doi:10.1016/j.ophtha.2009.12.003
  • Schallhorn JM, Niemeyer KM, Browne EN, Chhetri P, Acharya NR. Difluprednate for the treatment of uveitic cystoid macular edema. Am J Ophthalmol. 2018;191:14–22. doi:10.1016/j.ajo.2018.03.027
  • Petrushkin H, Rogers D, Pavesio C. The use of topical non-steroidal anti-inflammatory drugs for uveitic cystoid macular edema. Ocul Immunol Inflamm. 2018;26(5):795–797. doi:10.1080/09273948.2016.1269931
  • Sheppard JD. Topical bromfenac for prevention and treatment of cystoid macular edema following cataract surgery: a review. Clin Ophthalmol Auckl NZ. 2016;10:2099. doi:10.2147/OPTH.S86971
  • Ahuja M, Dhake AS, Sharma SK, Majumdar DK. Topical ocular delivery of NSAIDs. AAPS J. 2008;10(2):229–241. doi:10.1208/s12248-008-9024-9
  • Waterbury L, Kunysz EA, Beuerman R. Effects of steroidal and non-steroidal anti-inflammatory agents on corneal wound healing. J Ocul Pharmacol. 1987;3(1):43–54. doi:10.1089/jop.1987.3.43
  • Radwan AE, Arcinue CA, Yang P, Artornsombudh P, Abu Al-Fadl EM, Foster CS. Bromfenac alone or with single intravitreal injection of bevacizumab or triamcinolone acetonide for treatment of uveitic macular edema. Graefes Arch Clin Exp Ophthalmol. 2013;251(7):1801–1806. doi:10.1007/s00417-013-2309-4
  • Al-Ani HH, Sims JL, Tomkins-Netzer O, Lightman S, Niederer RL. Vision loss in anterior uveitis. Br J Ophthalmol. 2020;104(12):1652–1657. doi:10.1136/bjophthalmol-2019-315551
  • Loh AR, Acharya NR. Incidence rates and risk factors for ocular complications and vision loss in HLA-B27-associated uveitis. Am J Ophthalmol. 2010;150(4):534–542. doi:10.1016/j.ajo.2010.04.031
  • Gregory AC, Kempen JH, Daniel E, et al. Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the SITE study. Ophthalmology. 2013;120(1):186–192. doi:10.1016/j.ophtha.2012.07.052
  • Rothova A, Suttorp-van Schulten MS, Treffers WF, Kijlstra A. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol. 1996;80(4):332–336. doi:10.1136/bjo.80.4.332
  • Eperjesi F, Jones K. Cycloplegic refraction in optometric practice. Optom Pract. 2005;6(3):107.
  • Ihekaire DE. The comparative efficacy of Cycloplegic drugs–Tropicamide and Cyclopentolate on school children. Int J Sci Res Educ. 2012;5(3):223–246.
  • Shah SM, Spalton DJ, Smith SE. Measurement of aqueous cells and flare in normal eyes. Br J Ophthalmol. 1991;75(6):348–352. doi:10.1136/bjo.75.6.348
  • Ikeji F, Pavesio C, Bunce C, White E. Quantitative assessment of the effects of pupillary dilation on aqueous flare in eyes with chronic anterior uveitis using laser flare photometry. Int Ophthalmol. 2010;30(5):491–494. doi:10.1007/s10792-010-9373-0
  • Yilmaz M, Guven Yilmaz S, Palamar M, Ates H, Yagci A. The effects of tropicamide and cyclopentolate hydrochloride on laser flare meter measurements in uveitis patients: a comparative study. Int Ophthalmol. 2021;41(3):853–857. doi:10.1007/s10792-020-01639-3
  • Kalogeropoulos D, Sung VC. Pathogenesis of uveitic glaucoma. J Curr Glaucoma Pract. 2018;12(3):125. doi:10.5005/jp-journals-10078-1236
  • Sng CC, Ang M, Barton K. Uveitis and glaucoma: new insights in the pathogenesis and treatment. Prog Brain Res. 2015;221:243–269.
  • Becker HI, Walton RC, Diamant JI, Zegans ME. Anterior uveitis and concurrent allergic conjunctivitis associated with long-term use of topical 0.2% brimonidine tartrate. Arch Ophthalmol. 2004;122(7):1063–1066. doi:10.1001/archopht.122.7.1063
  • Byles DB, Frith P, Salmon JF. Anterior uveitis as a side effect of topical brimonidine. Am J Ophthalmol. 2000;130(3):287–291. doi:10.1016/S0002-9394(00)00491-8
  • Cates CA, Jeffrey MN. Granulomatous anterior uveitis associated with 0.2% topical brimonidine. Eye. 2003;17(5):670–671. doi:10.1038/sj.eye.6700392
  • Hopf S, Mercieca K, Pfeiffer N, Prokosch-Willing V. Brimonidine-associated uveitis–a descriptive case series. BMC Ophthalmol. 2020;20(1):1–7. doi:10.1186/s12886-020-01762-w
  • Bito LZ. Prostaglandins: a new approach to glaucoma management with a new, intriguing side effect. Surv Ophthalmol. 1997;41:S1–S14. doi:10.1016/S0039-6257(97)80002-1
  • Holló G. The side effects of the prostaglandin analogues. Expert Opin Drug Saf. 2007;6(1):45–52. doi:10.1517/14740338.6.1.45
  • Warwar RE, Bullock JD, Ballal D. Cystoid macular edema and anterior uveitis associated with latanoprost use: experience and incidence in a retrospective review of 94 patients. Ophthalmology. 1998;105(2):263–268. doi:10.1016/S0161-6420(98)92977-3
  • Fechtner RD, Khouri AS, Zimmerman TJ, et al. Anterior uveitis associated with latanoprost. Am J Ophthalmol. 1998;126(1):37–41. doi:10.1016/S0002-9394(98)00071-3
  • Hu J, Vu JT, Hong B, Gottlieb C. Uveitis and cystoid macular oedema secondary to topical prostaglandin analogue use in ocular hypertension and open angle glaucoma. Br J Ophthalmol. 2020;104(8):1040–1044. doi:10.1136/bjophthalmol-2019-315280
  • Baudouin C, Labbé A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29(4):312–334. doi:10.1016/j.preteyeres.2010.03.001
  • Aguayo Bonniard A, Yeung JY, Chan CC, Birt CM. Ocular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK). Expert Opin Drug Metab Toxicol. 2016;12(11):1279–1289. doi:10.1080/17425255.2016.1209481
  • Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi GA. The eye drop preservative benzalkonium chloride potently induces mitochondrial dysfunction and preferentially affects LHON mutant cells. Invest Ophthalmol Vis Sci. 2017;58(4):2406–2412. doi:10.1167/iovs.16-20903
  • Dart J. Corneal toxicity: the epithelium and stroma in iatrogenic and factitious disease. Eye. 2003;17(8):886–892. doi:10.1038/sj.eye.6700576
  • Korenfeld MS, Silverstein SM, Cooke DL, Vogel R, Crockett RS, Emulsion DO. Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. J Cataract Refract Surg. 2009;35(1):26–34. doi:10.1016/j.jcrs.2008.09.024
  • Smith S, Lorenz D, Peace J, McLeod K, Crockett RS, Vogel R. Difluprednate ophthalmic emulsion 0.05%(Durezol®) administered two times daily for managing ocular inflammation and pain following cataract surgery. Clin Ophthalmol Auckl NZ. 2010;4:983. doi:10.2147/OPTH.S10696
  • Slabaugh MA, Herlihy E, Ongchin S, Van Gelder RN. Efficacy and potential complications of difluprednate use for pediatric uveitis. Am J Ophthalmol. 2012;153(5):932–938. doi:10.1016/j.ajo.2011.10.008
  • Kakimoto H, Takamura Y, Arimura S, et al. Effect of 0.05% difluprednate ophthalmic emulsion on proinflammatory cytokine levels after retinal laser photocoagulation in rabbits. J Ocul Pharmacol Ther. 2018;34(5):410–415. doi:10.1089/jop.2017.0109
  • Kersey JP, Broadway DC. Corticosteroid-induced glaucoma: a review of the literature. Eye. 2006;20(4):407–416. doi:10.1038/sj.eye.6701895
  • Armaly MF. Effect of corticosteroids on intraocular pressure and fluid dynamics: i. The effect of dexamethasone* in the normal eye. Arch Ophthalmol. 1963;70(4):482–491. doi:10.1001/archopht.1963.00960050484010
  • Kawamura M, Zako M. Long-term stability of uveitis with faint anterior chamber flare treated with once-daily topical ophthalmic betamethasone. Inflammation. 2014;37(2):417–425. doi:10.1007/s10753-013-9754-4
  • Fairbairn WD, Thorson JC. Fluorometholone: anti-inflammatory and intraocular pressure effects. Arch Ophthalmol. 1971;86(2):138–141. doi:10.1001/archopht.1971.01000010140004
  • Shokoohi-Rad S, Daneshvar R, Jafarian-Shahri M, Rajaee P. Comparison between Betamethasone, Fluorometholone and Loteprednol Etabonate on intraocular pressure in patients after keratorefractive surgery. J Curr Ophthalmol. 2018;30(2):130–135. doi:10.1016/j.joco.2017.11.008
  • Stewart R, Horwitz B, Howes J, Novack GD, Hart K. Double-masked, placebo-controlled evaluation of loteprednol etabonate 0.5 for postoperative inflammation. J Cataract Refract Surg. 1998;24(11):1480–1489. doi:10.1016/S0886-3350(98)80170-3
  • Lane SS, Holland EJ. Loteprednol etabonate 0.5% versus prednisolone acetate 1.0% for the treatment of inflammation after cataract surgery. J Cataract Refract Surg. 2013;39(2):168–173. doi:10.1016/j.jcrs.2012.10.039
  • Filippelli M, Gelso A, Rinaldi M, et al. Effects of topical low-dose preservative-free hydrocortisone on intraocular pressure in patients affected by ocular surface disease with and without glaucoma. Graefes Arch Clin Exp Ophthalmol. 2022;260(1):247–253. doi:10.1007/s00417-021-05345-3
  • Feiler DL, Srivastava SK, Pichi F, Bena J, Lowder CY. Resolution of noninfectious uveitic cystoid macular edema with topical difluprednate. Retina. 2017;37(5):844–850. doi:10.1097/IAE.0000000000001243
  • Symes RJ, Forooghian F. Topical difluprednate monotherapy for uveitic macular edema. Can J Ophthalmol. 2016;51(1):47–49. doi:10.1016/j.jcjo.2015.10.007
  • Onishi SM, Asahi MG, Chou C, Gallemore RP. Topical difluprednate for the treatment of Harada’s disease. Clin Ophthalmol Auckl NZ. 2015;9:157.
  • Hariprasad SM, Callanan D. Topical nepafenac 0.1% for treatment of chronic uveitic cystoid macular edema. Retin Cases Brief Rep. 2008;2(4):304–308. doi:10.1097/ICB.0b013e31809ed9db
  • Saade JS, Istambouli R, AbdulAal M, Antonios R, Hamam RN. Bromfenac 0.09% for the treatment of macular edema secondary to noninfectious uveitis. Middle East Afr J Ophthalmol. 2021;28(2):98. doi:10.4103/meajo.meajo_134_21
  • Gallenga PE, Mastropasqua L, Lobefolo L, et al. Efficacy of diclofenac eyedrops in preventing postoperative inflammation and long-term cystoid macular edema. J Cataract Refract Surg. 1997;23(8):1183–1189. doi:10.1016/S0886-3350(97)80313-6
  • Heier J, Cheetham JK, DeGryse R, et al. Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: a randomized, vehicle-controlled clinical trial. Am J Ophthalmol. 1999;127(3):253–259. doi:10.1016/S0002-9394(98)00413-9
  • Suzuki T, Hayakawa K, Nakagawa Y, Onouchi H, Ogata M, Kawai K. Topical dorzolamide for macular edema in the early phase after vitrectomy and epiretinal membrane removal. Clin Ophthalmol Auckl NZ. 2013;7:549. doi:10.2147/OPTH.S42188
  • Grover S, Apushkin MA, Fishman GA. Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa. Am J Ophthalmol. 2006;141(5):850–858. doi:10.1016/j.ajo.2005.12.030
  • Mazet R, Yaméogo JBG, Wouessidjewe D, Choisnard L, Gèze A. Recent advances in the design of topical ophthalmic delivery systems in the treatment of ocular surface inflammation and their biopharmaceutical evaluation. Pharmaceutics. 2020;12(6). doi:10.3390/pharmaceutics12060570
  • Kim SJ, Flach AJ, Jampol LM. Nonsteroidal anti-inflammatory drugs in ophthalmology. Surv Ophthalmol. 2010;55(2):108–133. doi:10.1016/j.survophthal.2009.07.005