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ORIGINAL RESEARCH

Tumor Necrosis Factor-α Gene Polymorphism is Associated with Short- and Long-Term Kidney Allograft Outcomes

ORCID Icon, , , , &
Pages 2243-2254 | Published online: 05 Apr 2022

References

  • Wekerle T, Segev D, Lechler R, Oberbauer R. Strategies for long-term preservation of kidney graft function. Lancet. 2017;389(10084):2152–2162. doi:10.1016/S0140-673617
  • Breyer MD, Susztak K. The next generation of therapeutics for chronic kidney disease. Nat Rev Drug Discov. 2016;15(8):568–588. doi:10.1038/nrd.2016.67
  • Stegall MD, Troy Somerville K, Everly MJ, et al. The importance of drug safety and tolerability in the development of new immunosuppressive therapy for transplant recipients: the Transplant Therapeutics Consortium’s position statement. Am J Transplant. 2019;19(3):625–632. doi:10.1111/ajt.15214
  • Edmonston DL, Roe MT, Block G, et al. Drug Development in Kidney Disease: proceedings From a Multistakeholder Conference. Am J Kidney Dis. 2020;76(6):842–850. doi:10.1053/J.AJKD.2020.05.026
  • Rudrapal M, Khairnar S J, Jadhav A G. Drug Repurposing (DR): an emerging approach in drug discovery. In: Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications. IntechOpen; 2020. doi10.5772/intechopen.93193
  • Holdsworth SR, Can PY. Cytokines: names and numbers you should care about. Clin J Am Soc Nephrol. 2015;10(12):2243–2254. doi:10.2215/CJN.07590714
  • Brenner D, Blaser H, Mak TW. Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol. 2015;15(6):362–374. doi:10.1038/nri3834
  • Lim H, Lee SH, Lee HT, et al. Structural biology of the TNFα antagonists used in the treatment of rheumatoid arthritis. Int J Mol Sci. 2018;19(3):768. doi:10.3390/ijms19030768
  • Jang D, Lee A-H, Shin H-Y, et al. The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. Int J Mol Sci. 2021;22(5):1–16. doi:10.3390/IJMS22052719
  • Kalliolias GD, Ivashkiv LB. TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat Rev Rheumatol. 2016;12(1):49–62. doi:10.1038/nrrheum.2015.169
  • Feldmann M, Pusey CD. Is there a role for TNF-α in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases. J Am Soc Nephrol. 2006;17(5):1243–1252. doi:10.1681/ASN.2005121359
  • Nagata Y, Fujimoto M, Nakamura K, et al. Anti-TNF-α agent infliximab and splenectomy are protective against renal ischemia-reperfusion injury. Transplantation. 2016;100(8):1675–1682. doi:10.1097/TP.0000000000001222
  • Di Paola R, Genovese T, Impellizzeri D, Ahmad A, Cuzzocrea S, Esposito E. The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-αR1: a comparison with infliximab treatment. Eur J Pharmacol. 2013;700(1–3):134–146. doi:10.1016/j.ejphar.2012.11.066
  • Tasdemir C, Tasdemir S, Vardi N, et al. Protective effect of infliximab on ischemia/reperfusion-induced damage in rat kidney. Ren Fail. 2012;34(9):1144–1149. doi:10.3109/0886022X.2012.717490
  • Moers C, Pol RA, De Borst MH. Tumor necrosis factor a blockade to ameliorate renal ischemia reperfusion injury: potential implications for kidney transplantation. Transplantation. 2016;100(8):1601–1602. doi:10.1097/TP.0000000000001221
  • King EA, Wade DJ, Degner JF, Marchini J. Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval. PLoS Genet. 2019;15(12):e1008489. doi:10.1371/journal.pgen.1008489
  • Nelson MR, Tipney H, Painter JL, et al. The support of human genetic evidence for approved drug indications. Nat Genet. 2015;47(8):856–860. doi:10.1038/ng.3314
  • Zhang S, Zhan L, Zhu Y, Sun H, Xu X. Tumor necrosis factor alpha gene polymorphisms increase susceptibility to adenovirus infection in children and are correlated with severity of adenovirus-associated pneumonia. Genet Test Mol Biomarkers. 2020;24(12):761–770. doi:10.1089/gtmb.2020.0122
  • Khan S, Mandal RK, Jawed A, et al. TNF-α −308 G > A (rs1800629) polymorphism is associated with celiac disease: a meta-analysis of 11 case-control studies. Sci Rep. 2016;6(1):1–10. doi:10.1038/srep32677
  • Dessing MC, Kers J, Damman J, Navis GJ, Florquin S, Leemans JC. Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation. Sci Rep. 2016;6. doi:10.1038/srep36315
  • Damman J, Daha MR, Leuvenink HG, et al. Association of complement C3 gene variants with renal transplant outcome of deceased cardiac dead donor kidneys. Am J Transplant. 2012;12(3):660–668. doi:10.1111/j.1600-6143.2011.03880.x
  • Damman J, Kok JL, Snieder H, et al. Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation. Mol Immunol. 2012;50(1–2):1–8. doi:10.1016/j.molimm.2011.11.009
  • Poppelaars F, Gaya Da Costa M, Eskandari SK, Damman J, Seelen MA. Donor genetic variants in interleukin-6 and interleukin-6 receptor associate with biopsy-proven rejection following kidney transplantation. medRxiv. 2021;11:1–4. doi:10.1101/2021.04.17.21255669
  • Poppelaars F, Gaya da Costa M, Faria B, Eskandari SK, Damman J, Seelen MA. A functional TGFB1 polymorphism in the donor associates with long-term graft survival after kidney transplantation. Clin Kidney J. 2021;15:278–286. doi:10.1093/ckj/sfab175
  • Chen G, Liu B, Li H, et al. Ethnicity-stratified analysis of the association between TNF- α genetic polymorphisms and acute kidney injury: a systematic review and meta-analysis. Biomed Res Int. 2020;2020. doi:10.1155/2020/5262351
  • Israni AK, Li N, Cizman BB, et al. Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function After kidney transplantation. Am J Kidney Dis. 2008;52(2):331–339. doi:10.1053/j.ajkd.2008.05.006
  • Auton A, Abecasis GR, Altshuler DM, et al. A global reference for human genetic variation. Nature. 2015;526(7571):68–74. doi:10.1038/nature15393
  • Tang R, Sinnwell JP, Li J, Rider DN, de Andrade M, Biernacka JM. Identification of genes and haplotypes that predict rheumatoid arthritis using random forests. BMC Proc. 2009;3(Suppl 7):S68. doi:10.1186/1753-6561-3-s7-s68
  • Kühl T, Behrens S, Jung AY, et al. Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort. Brain Behav Immun. 2018;73:252–260. doi:10.1016/j.bbi.2018.05.009
  • van Meeteren MJW, Hayee B, Inderson A, et al. Safety of anti-TNF treatment in liver transplant recipients: a systematic review and metaanalysis. J Crohn’s Colitis. 2017;11(9):1146–1151. doi:10.1093/ecco-jcc/jjx057
  • Quinn CS, Jorgenson MR, Descourouez JL, Muth BL, Astor BC, Mandelbrot DA. Management of tumor necrosis factor α inhibitor therapy after renal transplantation: a comparative analysis and associated outcomes. Ann Pharmacother. 2019;53(3):268–275. doi:10.1177/1060028018802814
  • Diuwe P, Domagala P, Durlik M, Trzebicki J, Chmura A, Kwiatkowski A. The effect of the use of a TNF-alpha inhibitor in hypothermic machine perfusion on kidney function after transplantation. Contemp Clin Trials. 2017;59:44–50. doi:10.1016/j.cct.2017.05.013
  • Gareb B, Otten AT, Frijlink HW, Dijkstra G, Kosterink JGW. Review: local tumor necrosis factor-α inhibition in inflammatory bowel disease. Pharmaceutics. 2020;12(6):1–31. doi:10.3390/pharmaceutics12060539
  • de Vries DK, Wijermars LGM, Reinders MEJ, Lindeman JHN, Schaapherder AFM. Donor pre-treatment in clinical kidney transplantation: a critical appraisal. Clin Transplant. 2013;27(6):799–808. doi:10.1111/ctr.12261
  • O’Neill S, Oniscu GC. Donor pretreatment and machine perfusion: current views. Curr Opin Organ Transplant. 2020;25(1):59–65. doi:10.1097/MOT.0000000000000725