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ORIGINAL RESEARCH

Associations Among Disseminated Intravascular Coagulation, Thrombocytopenia Cytokines/Chemokines and Genetic Polymorphisms of Toll-Like Receptor 2/4 in Chinese Patients with Sepsis

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Pages 1-15 | Published online: 04 Jan 2022

References

  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
  • Huang M, Cai S, Su J. The pathogenesis of sepsis and potential therapeutic targets. Int J Mol Sci. 2019;20(21):5376. doi:10.3390/ijms20215376
  • Guo L, Rondina MT. The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases. Front Immunol. 2019;10:2204. doi:10.3389/fimmu.2019.02204
  • Claushuis TA, van Vught LA, Scicluna BP, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood. 2016;127(24):3062–3072. doi:10.1182/blood-2015-11-680744
  • Manne BK, Denorme F, Middleton EA, et al. Platelet gene expression and function in patients with COVID-19. Blood. 2020;136(11):1317–1329. doi:10.1182/blood.2020007214
  • Yang X, Yang Q, Wang Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020;18(6):1469–1472. doi:10.1111/jth.14848
  • Rondina MT, Carlisle M, Fraughton T, et al. Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. J Gerontol A Biol Sci Med Sci. 2015;70(2):225–231. doi:10.1093/gerona/glu082
  • van den Boogaard FE, Schouten M, de Stoppelaar SF, et al. Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia. Crit Care Med. 2015;43(3):e75–e83. doi:10.1097/CCM.0000000000000853
  • de Stoppelaar SF, van ‘t Veer C, Claushuis TA, et al. Thrombocytopenia Impairs Host Defense in Gram-Negative Pneumonia-Derived Sepsis in Mice. Blood. 2014;124(25):3781–3790.
  • Hottz ED, Bozza FA, Bozza PT. Platelets in immune response to virus and immunopathology of viral infections. Front Med. 2018;5:121. doi:10.3389/fmed.2018.00121
  • Carestia A, Kaufman T, Schattner M. Platelets: new bricks in the building of neutrophil extracellular traps. Front Immunol. 2016;7:271. doi:10.3389/fimmu.2016.00271
  • Levi M, Schultz M, van der Poll T. Sepsis and thrombosis. Semin Thromb Hemost. 2013;39(5):559–566. doi:10.1055/s-0033-1343894
  • Vallance TM, Zeuner MT, Williams HF, Widera D, Vaiyapuri S. Toll-like receptor 4 signalling and its impact on platelet function, thrombosis, and haemostasis. Mediators Inflamm. 2017;2017:9605894. doi:10.1155/2017/9605894
  • Trugilho MRO, Hottz ED, Brunoro GVF, et al. Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue. PLoS Pathog. 2017;13(5):e1006385. doi:10.1371/journal.ppat.1006385
  • Ding N, Chen G, Hoffman R, et al. Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Circ Cardiovasc Genet. 2014;7(5):615–624. doi:10.1161/CIRCGENETICS.113.000398
  • Kapur R, Semple JW. The nonhemostatic immune functions of platelets. Semin Hematol. 2016;53(Suppl 1):S2–S6. doi:10.1053/j.seminhematol.2016.04.002
  • Cognasse F, Nguyen KA, Damien P, et al. The inflammatory role of platelets via their TLRs and siglec receptors. Front Immunol. 2015;6:83. doi:10.3389/fimmu.2015.00083
  • Aslam R, Speck ER, Kim M, et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo. Blood. 2006;107(2):637–641. doi:10.1182/blood-2005-06-2202
  • Funayama H, Huang L, Sato T, et al. Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide. Int Immunopharmacol. 2009;9(13–14):1518–1524. doi:10.1016/j.intimp.2009.09.006
  • Mukherjee S, Huda S, Sinha Babu S. Toll-like receptor polymorphism in host immune response to infectious diseases: a review. Scand J Immunol. 2019;90(1):e12771. doi:10.1111/sji.12771
  • Joosten LA, Abdollahi-Roodsaz S, Dinarello CA, O’Neill L, Netea MG. Toll-like receptors and chronic inflammation in rheumatic diseases: new developments. Nat Rev Rheumatol. 2016;12(6):344–357. doi:10.1038/nrrheum.2016.61
  • Schmitt C, Humeny A, Becker CM, Brune K, Pahl A. Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles. Clin Chem. 2002;48(10):1661–1667. doi:10.1093/clinchem/48.10.1661
  • Shashkin PN, Brown GT, Ghosh A, Marathe GK, McIntyre TM. Lipopolysaccharide is a direct agonist for platelet RNA splicing. J Immunol. 2008;181(5):3495–3502. doi:10.4049/jimmunol.181.5.3495
  • Patrignani P, Di Febbo C, Tacconelli S, et al. Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo. Blood. 2006;107(9):3572–3574. doi:10.1182/blood-2005-12-4811
  • Gando S, Iba T, Eguchi Y, et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. 2006;34(3):625–631. doi:10.1097/01.CCM.0000202209.42491.38
  • Taylor FB, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327–1330. doi:10.1055/s-0037-1616068
  • Vincent JL, de Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study.. Crit Care Med. 1998;26(11):1793–1800.
  • Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II a severity of disease classification system. Crit Care Med. 1985;13(10):818–829. doi:10.1097/00003246-198510000-00009
  • Huang Z, Fu Z, Huang W, Huang K. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: a meta-analysis. Am J Emerg Med. 2020;38(3):641–647. doi:10.1016/j.ajem.2019.10.023
  • Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34–45. doi:10.1038/nri3345
  • Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38–44. doi:10.1016/j.thromres.2016.11.007
  • Weyrich AS, Zimmerman GA. Platelets: signaling cells in the immune continuum. Trends Immunol. 2004;25(9):489–495. doi:10.1016/j.it.2004.07.003
  • Romagnani P, Lasagni L, Annunziato F, Serio M, Romagnani S. CXC chemokines: the regulatory link between inflammation and angiogenesis. Trends Immunol. 2004;25(4):201–209. doi:10.1016/j.it.2004.02.006
  • McIntyre TM, Prescott SM, Weyrich AS, Zimmerman GA. Cell-cell interactions: leukocyte-endothelial interactions. Curr Opin Hematol. 2003;10(2):150–158. doi:10.1097/00062752-200303000-00009
  • Schober A, Manka D, von Hundelshausen P, et al. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation. 2002;106(12):1523–1529. doi:10.1161/01.CIR.0000028590.02477.6F
  • Boehlen F, Clemetson KJ. Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfus Med. 2001;11(6):403–417. doi:10.1046/j.1365-3148.2001.00340.x
  • Berthet J, Damien P, Hamzeh-Cognasse H, Pozzetto B, Garraud O, Cognasse F. Toll-like receptor 4 signal transduction in platelets: novel pathways. Br J Haematol. 2010;151(1):89–92. doi:10.1111/j.1365-2141.2010.08292.x
  • Jayachandran M, Brunn GJ, Karnicki K, Miller RS, Owen WG, Miller VM. In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk. J Appl Physiol. 2007;102(1):429–433. doi:10.1152/japplphysiol.01576.2005
  • Andonegui G, Kerfoot SM, McNagny K, Ebbert KV, Patel KD, Kubes P. Platelets express functional Toll-like receptor-4. Blood. 2005;106(7):2417–2423. doi:10.1182/blood-2005-03-0916
  • Clark SR, Ma AC, Tavener SA, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med. 2007;13(4):463–469. doi:10.1038/nm1565
  • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373–384. doi:10.1038/ni.1863
  • Vijay K. Toll-like receptors in immunity and inflammatory diseases: past, present, and future. Int Immunopharmacol. 2018;59:391–412. doi:10.1016/j.intimp.2018.03.002
  • Blair P, Rex S, Vitseva O, et al. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009;104(3):346–354.
  • Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE. Regulatory effects of TLR2 on megakaryocytic cell function. Blood. 2011;117(22):5963–5974. doi:10.1182/blood-2010-09-304949
  • Szilágyi B, Fejes Z, Póliska S, et al. Reduced miR-26b expression in megakaryocytes and platelets contributes to elevated level of platelet activation status in sepsis. Int J Mol Sci. 2020;21(3):866. doi:10.3390/ijms21030866
  • Middleton EA, Rowley JW, Campbell RA, et al. Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood. 2019;134(12):911–923. doi:10.1182/blood.2019000067
  • Gao JW, Zhang AQ, Wang X, et al. Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis. Crit Care. 2015;19:416. doi:10.1186/s13054-015-1130-3
  • Smeland TE, Muller F, Blomfeldt A, Stavem K, Aamot HV. No associations established between single nucleotide polymorphisms in human Toll-like receptor 2 and Toll-interacting protein and Staphylococcus aureus bloodstream infections. APMIS 2017;125(10):927–932.
  • Rodriguez-Osorio CA, Lima G, Herrera-Caceres JO, et al. Genetic variations in toll-like receptor 4 in Mexican-Mestizo patients with intra-abdominal infection and/or pneumonia. Immunol Lett. 2013;153(1–2):41–46. doi:10.1016/j.imlet.2013.07.002
  • Rallabhandi P, Bell J, Boukhvalova MS, et al. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol. 2006;177(1):322–332. doi:10.4049/jimmunol.177.1.322
  • Sato K, Yoshimura A, Kaneko T, et al. A single nucleotide polymorphism in 3ʹ-untranslated region contributes to the regulation of Toll-like receptor 4 translation. J Biol Chem. 2012;287(30):25163–25172. doi:10.1074/jbc.M111.338426
  • Mansur A, von Gruben L, Popov AF, et al. The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients. J Transl Med. 2014;12:177. doi:10.1186/1479-5876-12-177