Low Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD

References

• Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018;391(10131):1706–1717. doi:10.1016/S0140-6736(18)30841-9
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8(3):183–192. doi:10.1038/nri2254
   PubMed Web of Science ®Google Scholar
• Bafadhel M, McKenna S, Terry S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184(6):662–671. doi:10.1164/rccm.201104-0597OC
   PubMed Web of Science ®Google Scholar
• Tan WC, Bourbeau J, Nadeau G, et al. High eosinophil counts predict decline in FEV 1: results from the CanCOLD study. Eur Respir J. 2021;57(5):2000838. doi:10.1183/13993003.00838-2020
   PubMed Web of Science ®Google Scholar
• Park HY, Chang Y, Kang D, et al. Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study. Eur Respir J. 2021;58(4):2003823. doi:10.1183/13993003.03823-2020
   PubMed Web of Science ®Google Scholar
• Donaldson GC, Seemungal TA, Bhowmik A, et al. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57(10):847–852. doi:10.1136/thorax.57.10.847
   PubMed Web of Science ®Google Scholar
• Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(11):925–931. doi:10.1136/thx.2005.040527
   PubMed Web of Science ®Google Scholar
• MacDonald MI, Osadnik CR, Bulfin L, et al. Low and high blood eosinophil counts as biomarkers in hospitalized acute exacerbations of COPD. Chest. 2019;156(1):92–100. doi:10.1016/j.chest.2019.02.406
   PubMed Web of Science ®Google Scholar
• Couillard S, Larivée P, Courteau J, et al. Eosinophils in COPD exacerbations are associated with increased readmissions. Chest. 2017;151(2):366–373. doi:10.1016/j.chest.2016.10.003
   PubMed Web of Science ®Google Scholar
• Greulich T, Tüffers J, Mager S, et al. High eosinophil blood counts are associated with a shorter length of hospital stay in exacerbated COPD patients - a retrospective analysis. Respir Res. 2020;21(1):106. doi:10.1186/s12931-020-01365-5
   PubMed Web of Science ®Google Scholar
• Vedel-Krogh S, Nielsen SF, Lange P, et al. Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen General Population Study. Am J Respir Crit Care Med. 2016;193(9):965–974. doi:10.1164/rccm.201509-1869OC
   PubMed Web of Science ®Google Scholar
• Hegewald MJ, Horne BD, Trudo F, et al. Blood eosinophil count and hospital readmission in patients with acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2020;15:2629–2641. doi:10.2147/COPD.S251115
   PubMed Web of Science ®Google Scholar
• Pascoe S, Locantore N, Dransfield MT, et al. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015;3(6):435–442. doi:10.1016/S2213-2600(15)00106-X
   PubMed Web of Science ®Google Scholar
• Singh D, Agusti A, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Respir J. 2019;53(5):1900164. doi:10.1183/13993003.00164-2019
   PubMed Web of Science ®Google Scholar
• Schumann DM, Tamm M, Kostikas K, et al. Stability of the blood eosinophilic phenotype in stable and exacerbated COPD. Chest. 2019;156(3):456–465. doi:10.1016/j.chest.2019.04.012
   PubMed Web of Science ®Google Scholar
• Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187(4):347–365. doi:10.1164/rccm.201204-0596PP
   PubMed Web of Science ®Google Scholar
• Bafadhel M, Greening NJ, Harvey-Dunstan TC, et al. Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD. Chest. 2016;150(2):320–328. doi:10.1016/j.chest.2016.01.026
   PubMed Web of Science ®Google Scholar
• Choi J, Oh JY, Lee YS, et al. The association between blood eosinophil percent and bacterial infection in acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2019;14:953–959. doi:10.2147/COPD.S197361
   PubMed Web of Science ®Google Scholar
• Viniol C, Vogelmeier CF. Exacerbations of COPD. Eur Respir Rev. 2018;27:147. doi:10.1183/16000617.0103-2017
   Web of Science ®Google Scholar
• Jang JG, Ahn JH, Jin HJ. Incidence and prognostic factors of respiratory viral infections in severe acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2021;16:1265–1273. doi:10.2147/COPD.S306916
   PubMed Web of Science ®Google Scholar
• Rohde G, Wiethege A, Borg I, et al. Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Thorax. 2003;58(1):37–42. doi:10.1136/thorax.58.1.37
   PubMed Web of Science ®Google Scholar
• Du Y, Tu L, Zhu P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan. A retrospective observational study. Am J Respir Crit Care Med. 2020;201(11):1372–1379. doi:10.1164/rccm.202003-0543OC
   PubMed Web of Science ®Google Scholar
• Cameron RJ, de Wit D, Welsh TN, et al. Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation. Intensive Care Med. 2006;32(7):1022–1029. doi:10.1007/s00134-006-0202-x
   PubMed Web of Science ®Google Scholar
• Ko FW, Ip M, Chan PK, et al. Viral etiology of acute exacerbations of COPD in Hong Kong. Chest. 2007;132(3):900–908. doi:10.1378/chest.07-0530
   PubMed Web of Science ®Google Scholar
• Sasmita BR, Zhu Y, Gan H, et al. Leukocyte and its subtypes as predictors of short-term outcome in cardiogenic shock complicating acute myocardial infarction: a Cohort Study. Shock. 2021. doi:10.1097/SHK.0000000000001876
   Web of Science ®Google Scholar
• Abidi K, Khoudri I, Belayachi J, et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care. 2008;12(2):R59. doi:10.1186/cc6883
   PubMed Web of Science ®Google Scholar
• Steer J, Gibson J, Bourke SC. The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax. 2012;67(11):970–976. doi:10.1136/thoraxjnl-2012-202103
   PubMed Web of Science ®Google Scholar
• Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;9:Cd001288.
   Google Scholar
• Bafadhel M, McKenna S, Terry S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2012;186(1):48–55. doi:10.1164/rccm.201108-1553OC
   PubMed Web of Science ®Google Scholar
• Pavord ID, Lettis S, Locantore N, et al. Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD. Thorax. 2016;71(2):118–125. doi:10.1136/thoraxjnl-2015-207021
   PubMed Web of Science ®Google Scholar
• Siddiqui SH, Guasconi A, Vestbo J, et al. Blood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;192(4):523–525. doi:10.1164/rccm.201502-0235LE
   PubMed Web of Science ®Google Scholar
• Agboado G, Peters J, Donkin L. Factors influencing the length of hospital stay among patients resident in Blackpool admitted with COPD: a cross-sectional study. BMJ Open. 2012;2(5):e000869. doi:10.1136/bmjopen-2012-000869
   PubMed Web of Science ®Google Scholar
• Greening NJ, Harvey-Dunstan TC, Chaplin EJ, et al. Bedside assessment of quadriceps muscle by ultrasound after admission for acute exacerbations of chronic respiratory disease. Am J Respir Crit Care Med. 2015;192(7):810–816. doi:10.1164/rccm.201503-0535OC
   PubMed Web of Science ®Google Scholar
• Xiong G, Xu L, Wei L, et al. Atomization inhalation of terbutaline and budesonide efficiently improved immunity and lung function of AECOPD patients. Cell Mol Immunol. 2008;5(4):287–291. doi:10.1038/cmi.2008.35
   PubMed Web of Science ®Google Scholar
• Lugade AA, Bogner PN, Thatcher TH, et al. Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. J Immunol. 2014;192(11):5226–5235. doi:10.4049/jimmunol.1302584
   PubMed Web of Science ®Google Scholar
• Rovina N, Koutsoukou A, Koulouris NG. Inflammation and immune response in COPD: where do we stand? Mediators Inflamm. 2013;2013:413735. doi:10.1155/2013/413735
   PubMed Web of Science ®Google Scholar
• Takafuji S, Ohtoshi T, Takizawa H, et al. Eosinophil degranulation in the presence of bronchial epithelial cells. Effect of cytokines and role of adhesion. J Immunol. 1996;156(10):3980–3985.
   PubMed Web of Science ®Google Scholar
• Jones BE, Maerz MD, Buckner JH. IL-6: a cytokine at the crossroads of autoimmunity. Curr Opin Immunol. 2018;55:9–14. doi:10.1016/j.coi.2018.09.002
   PubMed Web of Science ®Google Scholar
• Freeman CM, Martinez CH, Todt JC, et al. Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood. Respir Res. 2015;16(1):94. doi:10.1186/s12931-015-0251-1
   PubMed Web of Science ®Google Scholar
• Ohkawara Y, Lei XF, Stämpfli MR, et al. Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation. Am J Respir Cell Mol Biol. 1997;16(5):510–520. doi:10.1165/ajrcmb.16.5.9160833
   PubMed Web of Science ®Google Scholar
• Gaspar Elsas MI, Joseph D, Elsas PX, et al. Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge. Am J Respir Cell Mol Biol. 1997;17(4):404–413. doi:10.1165/ajrcmb.17.4.2691
   PubMed Web of Science ®Google Scholar
• Geerdink JX, Simons SO, Pike R, et al. Differences in systemic adaptive immunity contribute to the “frequent exacerbator” COPD phenotype. Respir Res. 2016;17(1):140. doi:10.1186/s12931-016-0456-y
   PubMed Web of Science ®Google Scholar