Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression

References

• Lewis CM Jr., Obregón -tito A, Tito RY, Foster MW, Spicer PG. The human microbiome project: lessons from human genomics. Trends Microbiol. 2012;20(1):1–4. doi:10.1016/j.tim.2011.10.004
   PubMed Web of Science ®Google Scholar
• Kitamoto S, Nagao-Kitamoto H, Hein R, Schmidt TM, Kamada N. The bacterial connection between the oral cavity and the gut diseases. J Dent Res. 2020;99(9):1021–1029. doi:10.1177/0022034520924633
   PubMed Web of Science ®Google Scholar
• Pandya G, Kirtonia A, Singh A, et al. A comprehensive review of the multifaceted role of the microbiota in human pancreatic carcinoma. Semin Cancer Biol. 2021. doi:10.1016/j.semcancer.2021.05.027
   Web of Science ®Google Scholar
• Sureda A, Daglia M, Argüelles Castilla S, et al. Oral microbiota and Alzheimer’s disease: Do all roads lead to Rome? Pharmacol Res. 2020;151(104582):104582. doi:10.1016/j.phrs.2019.104582
   PubMed Web of Science ®Google Scholar
• Hunt RH, Camilleri M, Crowe SE, et al. The stomach in health and disease. Gut. 2015;64(10):1650–1668. doi:10.1136/gutjnl-2014-307595
   PubMed Web of Science ®Google Scholar
• Jia W, Xie G, Jia W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol. 2018;15(2):111–128. doi:10.1038/nrgastro.2017.119
   PubMed Web of Science ®Google Scholar
• Ducarmon QR, Zwittink RD, Hornung BVH, van Schaik W, Young VB, Kuijper EJ. Gut microbiota and colonization resistance against bacterial enteric infection. Microbiol Mol Biol Rev. 2019;83(3):e00007–19. doi:10.1128/mmbr.00007-19
   PubMed Web of Science ®Google Scholar
• Soderholm AT, Pedicord VA. Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity. Immunology. 2019;158(4):267–280. doi:10.1111/imm.13117
   PubMed Web of Science ®Google Scholar
• Kim S, Covington A, Pamer EG. The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017;279(1):90–105. doi:10.1111/imr.12563
   PubMed Web of Science ®Google Scholar
• Weersma RK, Zhernakova A, Fu J. Interaction between drugs and the gut microbiome. Gut. 2020;69(8):1510–1519. doi:10.1136/gutjnl-2019-320204
   PubMed Web of Science ®Google Scholar
• Brown EM, Kenny DJ, Xavier RJ. Gut microbiota regulation of T cells during inflammation and autoimmunity. Annu Rev Immunol. 2019;37(1):599–624. doi:10.1146/annurev-immunol-042718-041841
   PubMed Web of Science ®Google Scholar
• Byrd KM, Gulati AS. The “Gum-Gut” axis in inflammatory bowel diseases: a hypothesis-driven review of associations and advances. Front Immunol. 2021;12:620124. doi:10.3389/fimmu.2021.620124
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16(12):713–732. doi:10.1038/s41575-019-0189-8
   PubMed Web of Science ®Google Scholar
• Murphy N, Moreno V, Hughes DJ, et al. Lifestyle and dietary environmental factors in colorectal cancer susceptibility. Mol Aspects Med. 2019;69:2–9. doi:10.1016/j.mam.2019.06.005
   PubMed Web of Science ®Google Scholar
• Yang L, Wang S, Lee JJ, et al. An enhanced genetic model of colorectal cancer progression history. Genome Biol. 2019;20(1):168. doi:10.1186/s13059-019-1782-4
   PubMed Web of Science ®Google Scholar
• Janney A, Powrie F, Mann EH. Host-microbiota maladaptation in colorectal cancer. Nature. 2020;585(7826):509–517. doi:10.1038/s41586-020-2729-3
   PubMed Web of Science ®Google Scholar
• Grazioso TP, Brandt M, Djouder N. Diet, microbiota, and colorectal cancer. iScience. 2019;21:168–187. doi:10.1016/j.isci.2019.10.011
   PubMed Web of Science ®Google Scholar
• Imai S, Ooki T, Murata-Kamiya N, et al. Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis. Cell Host Microbe. 2021;29(6):941–958.e10. doi:10.1016/j.chom.2021.04.006
   PubMed Web of Science ®Google Scholar
• Flemer B, Warren RD, Barrett MP, et al. The oral microbiota in colorectal cancer is distinctive and predictive. Gut. 2018;67(8):1454–1463. doi:10.1136/gutjnl-2017-314814
   PubMed Web of Science ®Google Scholar
• Hong J, Guo F, Lu SY, et al. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 2020;70(11):2123–2137. doi:10.1136/gutjnl-2020-322780
   PubMed Web of Science ®Google Scholar
• Gao R, Zhu Y, Kong C, et al. Alterations, interactions, and diagnostic potential of gut bacteria and viruses in colorectal cancer. Front Cell Infect Microbiol. 2021;11:657867. doi:10.3389/fcimb.2021.657867
   PubMed Web of Science ®Google Scholar
• Blasco-Baque V, Garidou L, Pomié C, et al. Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut. 2017;66(5):872–885. doi:10.1136/gutjnl-2015-309897
   PubMed Web of Science ®Google Scholar
• Esberg A, Haworth S, Kuja-Halkola R, Magnusson PKE, Johansson I. Heritability of oral microbiota and immune responses to oral bacteria. Microorganisms. 2020;8(8):1126. doi:10.3390/microorganisms8081126
   PubMed Web of Science ®Google Scholar
• Kim YK, Shin C. The microbiota-gut-brain axis in neuropsychiatric disorders: pathophysiological mechanisms and novel treatments. Curr Neuropharmacol. 2018;16(5):559–573. doi:10.2174/1570159x15666170915141036
   PubMed Web of Science ®Google Scholar
• Tranah TH, Edwards LA, Schnabl B, Shawcross DL. Targeting the gut-liver-immune axis to treat cirrhosis. Gut. 2021;70(5):982–994. doi:10.1136/gutjnl-2020-320786
   PubMed Web of Science ®Google Scholar
• Kitamoto S, Nagao-Kitamoto H, Jiao Y, et al. The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis. Cell. 2020;182(2):447–462. e14. doi:10.1016/j.cell.2020.05.048
   PubMed Web of Science ®Google Scholar
• Mark Welch JL, Ramírez -puebla ST, Borisy GG. Oral microbiome geography: micron-scale habitat and niche. Cell Host Microbe. 2020;28(2):160–168. doi:10.1016/j.chom.2020.07.009
   PubMed Web of Science ®Google Scholar
• Human Microbiome Project C. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207–214. doi:10.1038/nature11234.
   PubMed Web of Science ®Google Scholar
• Utter DR, Borisy GG, Eren AM, Cavanaugh CM, Mark Welch JL. Metapangenomics of the oral microbiome provides insights into habitat adaptation and cultivar diversity. Genome Biol. 2020;21(1):293. doi:10.1186/s13059-020-02200-2
   PubMed Web of Science ®Google Scholar
• Gao L, Xu T, Huang G, Jiang S, Gu Y, Chen F. Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell. 2018;9(5):488–500. doi:10.1007/s13238-018-0548-1
   PubMed Web of Science ®Google Scholar
• Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018;16(12):745–759. doi:10.1038/s41579-018-0089-x
   PubMed Web of Science ®Google Scholar
• Dinakaran V, Mandape SN, Shuba K, et al. Identification of specific oral and gut pathogens in full thickness colon of colitis patients: implications for colon motility. Front Microbiol. 2018;9:3220. doi:10.3389/fmicb.2018.03220
   PubMed Web of Science ®Google Scholar
• Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. 2019;76(3):473–493. doi:10.1007/s00018-018-2943-4
   PubMed Web of Science ®Google Scholar
• Magne F, Gotteland M, Gauthier L, et al. The Firmicutes/Bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients? Nutrients. 2020;12(5):1474. doi:10.3390/nu12051474
   PubMed Web of Science ®Google Scholar
• Stojanov S, Berlec A, Štrukelj B. The influence of probiotics on the Firmicutes/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms. 2020;8(11):1715. doi:10.3390/microorganisms8111715
   PubMed Web of Science ®Google Scholar
• Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174–180. doi:10.1038/nature09944
   PubMed Web of Science ®Google Scholar
• Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017;20(2):145–155. doi:10.1038/nn.4476
   PubMed Web of Science ®Google Scholar
• Gomes AC, Hoffmann C, Mota JF. The human gut microbiota: metabolism and perspective in obesity. Gut Microbes. 2018;9(4):308–325. doi:10.1080/19490976.2018.1465157
   PubMed Web of Science ®Google Scholar
• Makki K, Deehan EC, Walter J, Bäckhed F. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe. 2018;23(6):705–715. doi:10.1016/j.chom.2018.05.012
   PubMed Web of Science ®Google Scholar
• Salazar N, Valdés-Varela L, González S, Gueimonde M, de Los Reyes- Gavilán CG. Nutrition and the gut microbiome in the elderly. Gut Microbes. 2017;8(2):82–97. doi:10.1080/19490976.2016.1256525
   PubMed Web of Science ®Google Scholar
• Pickard JM, Zeng MY, Caruso R, Nunez G. Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease. Immunol Rev. 2017;279(1):70–89. doi:10.1111/imr.12567
   PubMed Web of Science ®Google Scholar
• Oliveira RA, Ng KM, Correia MB, et al. Klebsiella michiganensis transmission enhances resistance to Enterobacteriaceae gut invasion by nutrition competition. Nat Microbiol. 2020;5(4):630–641. doi:10.1038/s41564-019-0658-4
   PubMed Web of Science ®Google Scholar
• Kamada N, Chen GY, Inohara N, Núñez G. Control of pathogens and pathobionts by the gut microbiota. Nat Immunol. 2013;14(7):685–690. doi:10.1038/ni.2608
   PubMed Web of Science ®Google Scholar
• Pickard JM, Nunez G. Pathogen colonization resistance in the gut and its manipulation for improved health. Am J Pathol. 2019;189(7):1300–1310. doi:10.1016/j.ajpath.2019.03.003
   PubMed Web of Science ®Google Scholar
• Yang Y, Misra BB, Liang L, et al. Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer. Theranostics. 2019;9(14):4101–4114. doi:10.7150/thno.35186
   PubMed Web of Science ®Google Scholar
• Dai Z, Coker OO, Nakatsu G, et al. Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers. Microbiome. 2018;6(1):70. doi:10.1186/s40168-018-0451-2
   PubMed Web of Science ®Google Scholar
• Li S, Konstantinov SR, Smits R, Peppelenbosch MP. Bacterial biofilms in colorectal cancer initiation and progression. Trends Mol Med. 2017;23(1):18–30. doi:10.1016/j.molmed.2016.11.004
   PubMed Web of Science ®Google Scholar
• Russo E, Bacci G, Chiellini C, et al. Preliminary comparison of oral and intestinal human microbiota in patients with colorectal cancer: a pilot study. Front Microbiol. 2017;8:2699. doi:10.3389/fmicb.2017.02699
   PubMed Web of Science ®Google Scholar
• Komiya Y, Shimomura Y, Higurashi T, et al. Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity. Gut. 2019;68(7):1335–1337. doi:10.1136/gutjnl-2018-316661
   PubMed Web of Science ®Google Scholar
• Yachida S, Mizutani S, Shiroma H, et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat Med. 2019;25(6):968–976. doi:10.1038/s41591-019-0458-7
   PubMed Web of Science ®Google Scholar
• Kaci G, Goudercourt D, Dennin V, et al. Anti-inflammatory properties of Streptococcus salivarius, a commensal bacterium of the oral cavity and digestive tract. Appl Environ Microbiol. 2014;80(3):928–934. doi:10.1128/aem.03133-13
   PubMed Web of Science ®Google Scholar
• Said HS, Suda W, Nakagome S, et al. Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA Res. 2014;21(1):15–25. doi:10.1093/dnares/dst037
   PubMed Web of Science ®Google Scholar
• Kostic AD, Chun E, Robertson L, et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013;14(2):207–215. doi:10.1016/j.chom.2013.07.007
   PubMed Web of Science ®Google Scholar
• Yang J, Li D, Yang Z, et al. Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families. Gut Microbes. 2020;11(4):918–929. doi:10.1080/19490976.2020.1712986
   PubMed Web of Science ®Google Scholar
• Allali I, Delgado S, Marron PI, et al. Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain. Gut Microbes. 2015;6(3):161–172. doi:10.1080/19490976.2015.1039223
   PubMed Web of Science ®Google Scholar
• Koliarakis I, Messaritakis I, Nikolouzakis TK, Hamilos G, Souglakos J, Tsiaoussis J. Oral bacteria and intestinal dysbiosis in colorectal cancer. Int J Mol Sci. 2019;20(17):4146. doi:10.3390/ijms20174146
   PubMed Web of Science ®Google Scholar
• Olsen I, Yamazaki K. Can oral bacteria affect the microbiome of the gut? J Oral Microbiol. 2019;11(1):1586422. doi:10.1080/20002297.2019.1586422
   PubMed Web of Science ®Google Scholar
• Casasanta MA, Yoo CC, Udayasuryan B, et al. Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration. Sci Signal. 2020;13(641):eaba9157. doi:10.1126/scisignal.aba9157
   PubMed Web of Science ®Google Scholar
• Bullman S, Pedamallu CS, Sicinska E, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017;358(6369):1443–1448. doi:10.1126/science.aal5240
   PubMed Web of Science ®Google Scholar
• Ianiro G, Tilg H, Gasbarrini A. Antibiotics as deep modulators of gut microbiota: between good and evil. Gut. 2016;65(11):1906–1915. doi:10.1136/gutjnl-2016-312297
   PubMed Web of Science ®Google Scholar
• Scott NA, Andrusaite A, Andersen P, et al. Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Sci Transl Med. 2018;10(464):eaao4755. doi:10.1126/scitranslmed.aao4755
   PubMed Web of Science ®Google Scholar
• Atarashi K, Suda W, Luo C, et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science. 2017;358(6361):359–365. doi:10.1126/science.aan4526
   PubMed Web of Science ®Google Scholar
• Jackson MA, Goodrich JK, Maxan ME, et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut. 2016;65(5):749–756. doi:10.1136/gutjnl-2015-310861
   PubMed Web of Science ®Google Scholar
• Takashima S, Tanaka F, Kawaguchi Y, et al. Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice. Neurogastroenterol Motil. 2020;32(7):e13841. doi:10.1111/nmo.13841
   PubMed Web of Science ®Google Scholar
• Morgan AP, Crowley JJ, Nonneman RJ, et al. The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse. PLoS One. 2014;9(12):e115225. doi:10.1371/journal.pone.0115225
   PubMed Web of Science ®Google Scholar
• Cussotto S, Strain CR, Fouhy F, et al. Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function. Psychopharmacology. 2019;236(5):1671–1685. doi:10.1007/s00213-018-5006-5
   PubMed Web of Science ®Google Scholar
• Sokol H, Seksik P, Rigottier-Gois L, et al. Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis. 2006;12(2):106–111. doi:10.1097/01.MIB.0000200323.38139.c6
   PubMed Web of Science ®Google Scholar
• Morgan XC, Tickle TL, Sokol H, et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 2012;13(9):R79. doi:10.1186/gb-2012-13-9-r79
   PubMed Web of Science ®Google Scholar
• Larabi A, Barnich N, Nguyen HTT. New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy. 2020;16(1):38–51. doi:10.1080/15548627.2019.1635384
   PubMed Web of Science ®Google Scholar
• Kitamoto S, Alteri CJ, Rodrigues M, et al. Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut. Nat Microbiol. 2020;5(1):116–125. doi:10.1038/s41564-019-0591-6
   PubMed Web of Science ®Google Scholar
• Stecher B, Conway T, Cohen P. The roles of inflammation, nutrient availability and the commensal microbiota in enteric pathogen infection. Microbiol Spectr. 2015;3(3). doi:10.1128/microbiolspec.MBP-0008-2014
   PubMed Web of Science ®Google Scholar
• Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018;67(6):1024–1032. doi:10.1136/gutjnl-2017-314281
   PubMed Web of Science ®Google Scholar
• Gourley CR, Negretti NM, Konkel ME. The food-borne pathogen Campylobacter jejuni depends on the AddAB DNA repair system to defend against bile in the intestinal environment. Sci Rep. 2017;7(1):14777. doi:10.1038/s41598-017-14646-9
   PubMed Web of Science ®Google Scholar
• Boll EJ, Nielsen LN, Krogfelt KA, Struve C. Novel screening assay for in vivo selection of Klebsiella pneumoniae genes promoting gastrointestinal colonisation. BMC Microbiol. 2012;12(1):201. doi:10.1186/1471-2180-12-201
   PubMed Web of Science ®Google Scholar
• Ullman TA, Itzkowitz SH. Intestinal inflammation and cancer. Gastroenterology. 2011;140(6):1807–1816. doi:10.1053/j.gastro.2011.01.057
   PubMed Web of Science ®Google Scholar
• Wang G, Huang S, Wang Y, et al. Bridging intestinal immunity and gut microbiota by metabolites. Cell Mol Life Sci. 2019;76(20):3917–3937. doi:10.1007/s00018-019-03190-6
   PubMed Web of Science ®Google Scholar
• Bauer C, Duewell P, Mayer C, et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 2010;59(9):1192–1199. doi:10.1136/gut.2009.197822
   PubMed Web of Science ®Google Scholar
• Peng C, Ouyang Y, Lu N, Li LN. The NF-κB signaling pathway, the microbiota, and gastrointestinal tumorigenesis: recent advances. Front Immunol. 2020;11:1387. doi:10.3389/fimmu.2020.01387
   PubMed Web of Science ®Google Scholar
• Engevik MA, Danhof HA, Ruan W, et al. Fusobacterium nucleatum secretes outer membrane vesicles and promotes intestinal inflammation. mBio. 2021;12(2):e02706–02720. doi:10.1128/mBio.02706-20
   PubMed Web of Science ®Google Scholar
• Hayden MS, Ghosh S. NF-κB in immunobiology. Cell Res. 2011;21(2):223–244. doi:10.1038/cr.2011.13
   PubMed Web of Science ®Google Scholar
• Jia YP, Wang K, Zhang ZJ, et al. TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation caused by Fusobacterium nucleatum in vivo. PLoS One. 2017;12(10):e0186179. doi:10.1371/journal.pone.0186179
   PubMed Web of Science ®Google Scholar
• Yang Y, Weng W, Peng J, et al. Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-н╨B, and up-regulating expression of microRNA-21. Gastroenterology. 2017;152(4):851–866.e24. doi:10.1053/j.gastro.2016.11.018
   PubMed Web of Science ®Google Scholar
• Shi C, Yang Y, Xia Y, et al. Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer. Gut. 2016;65(9):1470–1481. doi:10.1136/gutjnl-2014-308455
   PubMed Web of Science ®Google Scholar
• Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013;13(11):759–771. doi:10.1038/nrc3611
   PubMed Web of Science ®Google Scholar
• Atanasova K, Lee J, Roberts J, Lee K, Ojcius DM, Yilmaz Ö. Nucleoside-diphosphate-kinase of p. gingivalis is secreted from epithelial cells in the absence of a leader sequence through a pannexin-1 interactome. Sci Rep. 2016;6(1):37643. doi:10.1038/srep37643
   PubMed Web of Science ®Google Scholar
• Wang X, Jia Y, Wen L, et al. Porphyromonas gingivalis promotes colorectal carcinoma by activating the hematopoietic NLRP3 inflammasome. Cancer Res. 2021;81(10):2745–2759. doi:10.1158/0008-5472.CAN-20-3827
   PubMed Web of Science ®Google Scholar
• Park E, Na HS, Song YR, Shin SY, Kim YM, Chung J. Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection. Infect Immun. 2014;82(1):112–123. doi:10.1128/iai.00862-13
   PubMed Web of Science ®Google Scholar
• Khan AA, Khan Z, Warnakulasuriya S. Cancer-associated toll-like receptor modulation and insinuation in infection susceptibility: association or coincidence? Ann Oncol. 2016;27(6):984–997. doi:10.1093/annonc/mdw053
   PubMed Web of Science ®Google Scholar
• Burgueño JF, Abreu MT. Epithelial Toll-like receptors and their role in gut homeostasis and disease. Nat Rev Gastroenterol Hepatol. 2020;17(5):263–278. doi:10.1038/s41575-019-0261-4
   PubMed Web of Science ®Google Scholar
• Chen T, Li Q, Wu J, et al. Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism. Cancer Immunol Immunother. 2018;67(10):1635–1646. doi:10.1007/s00262-018-2233-x
   PubMed Web of Science ®Google Scholar
• Hu L, Liu Y, Kong X, et al. Fusobacterium nucleatum facilitates M2 macrophage polarization and colorectal carcinoma progression by activating TLR4/NF-κB/S100A9 cascade. Front Immunol. 2021;12:658681. doi:10.3389/fimmu.2021.658681
   PubMed Web of Science ®Google Scholar
• Holden JA, Attard TJ, Laughton KM, Mansell A, O’Brien-Simpson NM, Reynolds EC. Porphyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines. Infect Immun. 2014;82(10):4190–4203. doi:10.1128/iai.02325-14
   PubMed Web of Science ®Google Scholar
• Zhang Q, Bi J, Zheng X, et al. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018;19(7):723–732. doi:10.1038/s41590-018-0132-0
   PubMed Web of Science ®Google Scholar
• Gur C, Ibrahim Y, Isaacson B, et al. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity. 2015;42(2):344–355. doi:10.1016/j.immuni.2015.01.010
   PubMed Web of Science ®Google Scholar
• Gur C, Maalouf N, Shhadeh A, et al. Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1. Oncoimmunology. 2019;8(6):e1581531. doi:10.1080/2162402x.2019.1581531
   PubMed Web of Science ®Google Scholar
• Kim WM, Huang YH, Gandhi A, Blumberg RS. CEACAM1 structure and function in immunity and its therapeutic implications. Semin Immunol. 2019;42:101296. doi:10.1016/j.smim.2019.101296
   PubMed Web of Science ®Google Scholar
• Nakatsu G, Li X, Zhou H, et al. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 2015;6(1):8727. doi:10.1038/ncomms9727
   PubMed Web of Science ®Google Scholar
• Uchino Y, Goto Y, Konishi Y, et al. Colorectal cancer patients have four specific bacterial species in oral and gut microbiota in common-a metagenomic comparison with healthy subjects. Cancers. 2021;13(13):3332. doi:10.3390/cancers13133332
   PubMed Web of Science ®Google Scholar
• Fan X, Alekseyenko AV, Wu J, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2018;67(1):120–127. doi:10.1136/gutjnl-2016-312580
   PubMed Web of Science ®Google Scholar
• Li D, Xi W, Zhang Z, et al. Oral microbial community analysis of the patients in the progression of liver cancer. Microb Pathog. 2020;149:104479. doi:10.1016/j.micpath.2020.104479
   PubMed Web of Science ®Google Scholar
• Tjalsma H, Boleij A, Marchesi JR, Dutilh BE. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol. 2012;10(8):575–582. doi:10.1038/nrmicro2819
   PubMed Web of Science ®Google Scholar
• Guilloux CA, Lamoureux C, Beauruelle C, Héry-Arnaud G. Porphyromonas: a neglected potential key genus in human microbiomes. Anaerobe. 2021;68:102230. doi:10.1016/j.anaerobe.2020.102230
   PubMed Web of Science ®Google Scholar
• Zeller G, Tap J, Voigt AY, et al. Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol Syst Biol. 2014;10(11):766. doi:10.15252/msb.20145645
   PubMed Web of Science ®Google Scholar
• Singh UP, Singh NP, Murphy EA, et al. Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine. 2016;77:44–49. doi:10.1016/j.cyto.2015.10.008
   PubMed Web of Science ®Google Scholar
• Sasidharan Nair V, Toor SM, Taha RZ, Shaath H, Elkord E. DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer. Clin Epigenetics. 2018;10(1):104. doi:10.1186/s13148-018-0539-3
   PubMed Web of Science ®Google Scholar
• Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell. 2014;26(6):923–937. doi:10.1016/j.ccell.2014.10.018
   PubMed Web of Science ®Google Scholar
• Li Y, Liu H, Qi H, et al. Probiotic fermentation of Ganoderma lucidum fruiting body extracts promoted its immunostimulatory activity in mice with dexamethasone-induced immunosuppression. Biomed Pharmacother. 2021;141:111909. doi:10.1016/j.biopha.2021.111909
   PubMed Web of Science ®Google Scholar