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ORIGINAL RESEARCH

Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling Against Candida albicans Infection

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Pages 1797-1810 | Published online: 11 Mar 2022

References

  • Hansen S, Thiel S, Willis A, Holmskov U, Jensenius JC. Purification and characterization of two mannan-binding lectins from mouse serum. J Immunol. 2000;164(5):2610–2618. doi:10.4049/jimmunol.164.5.2610
  • Wang M, Chen Y, Zhang Y, Zhang L, Lu X, Chen Z. Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells. Cell Mol Immunol. 2011;8(3):265–275. doi:10.1038/cmi.2011.1
  • Wang M, Wang F, Yang J, et al. Mannan-binding lectin inhibits Candida albicans-induced cellular responses in PMA-activated THP-1 cells through Toll-like receptor 2 and Toll-like receptor 4. PLoS One. 2013;8(12):e83517. doi:10.1371/journal.pone.0083517
  • Wang F, Li Y, Yang C, et al. Mannan-binding lectin suppresses peptidoglycan-induced TLR2 activation and inflammatory responses. Mediators Inflamm. 2019;2019:1349784. doi:10.1155/2019/1349784
  • Juul-Madsen HR, Norup LR, Jorgensen PH, Handberg KJ, Wattrang E, Dalgaard TS. Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations. Vaccine. 2011;29(51):9499–9507. doi:10.1016/j.vaccine.2011.10.016
  • Ip WK, Takahashi K, Ezekowitz RA, Stuart LM. Mannose-binding lectin and innate immunity. Immunol Rev. 2009;230(1):9–21. doi:10.1111/j.1600-065X.2009.00789.x
  • Guttormsen HK, Stuart LM, Shi L, et al. Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination. Clin Immunol. 2009;130(3):264–271.
  • Muller S, Schaffer T, Flogerzi B, et al. Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens. Gut. 2010;59(11):1493–1500. doi:10.1136/gut.2010.208348
  • Ruseva M, Kolev M, Dagnaes-Hansen F, et al. Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment. Immunology. 2009;127(2):279–288. doi:10.1111/j.1365-2567.2008.03016.x
  • Schoepfer AM, Flogerzi B, Seibold-Schmid B, et al. Low Mannan-binding lectin serum levels are associated with complicated Crohn’s disease and reactivity to oligomannan (ASCA). Am J Gastroenterol. 2009;104(10):2508–2516. doi:10.1038/ajg.2009.315
  • Ho J, Camilli G, Griffiths JS, Richardson JP, Kichik N, Naglik JR. Candida albicans and candidalysin in inflammatory disorders and cancer. Immunology. 2021;162(1):11–16. doi:10.1111/imm.13255
  • Fiane AE, Videm V, Lingaas PS, et al. Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair. Circulation. 2003;108(7):849–856. doi:10.1161/01.CIR.0000084550.16565.01
  • Pandiyan P, Conti HR, Zheng L, et al. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 2011;34(3):422–434. doi:10.1016/j.immuni.2011.03.002
  • Conti HR, Shen F, Nayyar N, et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med. 2009;206(2):299–311. doi:10.1084/jem.20081463
  • Bhaskaran N, Weinberg A, Pandiyan P. Th17 inflammation model of oropharyngeal candidiasis in immunodeficient mice. JoVE. 2015;96:56.
  • Shen Z, Chen L, Hao F, Wu J. Transcriptional regulation of Foxp3 gene: multiple signal pathways on the road. Med Res Rev. 2009;29(5):742–766. doi:10.1002/med.20152
  • Pang N, Zhang F, Ma X. TGF-beta/Smad signaling pathway regulates Th17/Treg balance during Echinococcus multilocularis infection. Int Immunopharmacol. 2014;20(1):248–257. doi:10.1016/j.intimp.2014.02.038
  • Lee S, Kim J, Min H, Seong RH. RORgammat-driven TH17 cell differentiation requires epigenetic control by the Swi/Snf chromatin remodeling complex. iScience. 2020;23(5):101106. doi:10.1016/j.isci.2020.101106
  • Lin XL, Lv JJ, Lv J, et al. Heme oxygenase-1 directly binds STAT3 to control the generation of pathogenic Th17 cells during neutrophilic airway inflammation. Allergy. 2017;72(12):1972–1987. doi:10.1111/all.13216
  • Taylor PR, Roy S, Meszaros EC, et al. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. J Leukoc Biol. 2016;100(1):213–222. doi:10.1189/jlb.4A1015-483R
  • Voisinne G, Kersse K, Chaoui K, et al. Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics. Nat Immunol. 2019;20(11):1530–1541. doi:10.1038/s41590-019-0489-8
  • Ashkanane A, Gomez GF, Levon J, Windsor LJ, Eckert GJ, Gregory RL. Nicotine upregulates coaggregation of candida albicans and streptococcus mutans. J Prosthodontics. 2019;28(7):790–796. doi:10.1111/jopr.12643
  • Carlson E. Effect of strain of Staphylococcus aureus on synergism with Candida albicans resulting in mouse mortality and morbidity. Infect Immun. 1983;42(1):285–292. doi:10.1128/iai.42.1.285-292.1983
  • Wu M, Wang F, Yang J, et al. The responses of the gut microbiota to MBL deficiency. Mol Immunol. 2020;122:99–108. doi:10.1016/j.molimm.2020.03.008
  • Yasmin S, Dixon B, Olivares-Villagomez D, Algood HMS. Interleukin-21 (IL-21) downregulates dendritic cell cytokine responses to helicobacter pylori and modulates T Lymphocyte IL-17A expression in Peyer’s patches during Infection. Infect Immun. 2019;87(11). doi:10.1128/IAI.00237-19
  • Net EMG, Sutmuller R, Hermann C, et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol. 2004;172(6):3712–3718. doi:10.4049/jimmunol.172.6.3712
  • Spaccapelo R, Del Sero G, Mosci P, Bistoni F, Romani L. Early T cell unresponsiveness in mice with candidiasis and reversal by IL-2: effect on T helper cell development. J Immunol. 1997;158(5):2294–2302.
  • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010;40(7):1830–1835. doi:10.1002/eji.201040391
  • Durant L, Watford WT, Ramos HL, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 2010;32(5):605–615. doi:10.1016/j.immuni.2010.05.003
  • Zhang S, Zhang G, Wan YY. SKI and SMAD4 are essential for IL-21-induced Th17 differentiation. Mol Immunol. 2019;114:260–268. doi:10.1016/j.molimm.2019.07.029
  • Li MZ, Lai DH, Zhao HB, Chen Z, Huang QX, Situ J. SOCS3 overexpression enhances ADM resistance in bladder cancer T24 cells. Eur Rev Med Pharmacol Sci. 2017;21(13):3005–3011.
  • Malonis RJ, Fu W, Jelcic MJ, et al. RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor beta signaling. J Biol Chem. 2017;292(18):7435–7451. doi:10.1074/jbc.M117.783662
  • Hammad NM, El Badawy NE, Ghramh HA, Al Kady LM. Mannose-binding lectin: a potential therapeutic candidate against candida infection. Biomed Res Int. 2018;2018:2813737. doi:10.1155/2018/2813737
  • Hsueh PR, Graybill JR, Playford EG, et al. Consensus statement on the management of invasive candidiasis in intensive care units in the Asia-Pacific region. Int J Antimicrob Agents. 2009;34(3):205–209. doi:10.1016/j.ijantimicag.2009.03.014
  • Bichele R, Karner J, Truusalu K, et al. IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model. Eur J Immunol. 2018;48(3):464–470. doi:10.1002/eji.201747209
  • Gil ML, Gozalbo D. Role of Toll-like receptors in systemic Candida albicans infections. Front Biosci. 2009;14:570–582. doi:10.2741/3263
  • Kong X, Leng D, Liang G, et al. Paeoniflorin augments systemic Candida albicans infection through inhibiting Th1 and Th17 cell expression in a mouse model. Int Immunopharmacol. 2018;60:76–83. doi:10.1016/j.intimp.2018.03.001
  • Luisa gil M, Murciano C, Yanez A, Gozalbo D. Role of Toll-like receptors in systemic Candida albicans infections. Front Biosci. 2016;21:278–302. doi:10.2741/4388
  • Saijo S, Ikeda S, Yamabe K, et al. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 2010;32(5):681–691. doi:10.1016/j.immuni.2010.05.001
  • Cheng SC, Chai LY, Joosten LA, et al. Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway. Infect Immun. 2010;78(1):393–399. doi:10.1128/IAI.01041-09
  • Zhu LL, Zhao XQ, Jiang C, et al. C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013;39(2):324–334. doi:10.1016/j.immuni.2013.05.017
  • Feldhoff LM, Rueda CM, Moreno-Fernandez ME, et al. IL-1beta induced HIF-1alpha inhibits the differentiation of human FOXP3(+) T cells. Sci Rep. 2017;7(1):465. doi:10.1038/s41598-017-00508-x
  • Wei F, Zhang Y, Zhao W, Yu X, Liu CJ. Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions. PLoS One. 2014;9(11):e112110. doi:10.1371/journal.pone.0112110
  • Malhotra N, Robertson E, Kang J. SMAD2 is essential for TGF beta-mediated Th17 cell generation. J Biol Chem. 2010;285(38):29044–29048. doi:10.1074/jbc.C110.156745
  • Yang EJ, Lee J, Lee SY, et al. EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control. PLoS One. 2014;9(2):e86062. doi:10.1371/journal.pone.0086062
  • Yao R, Ma YL, Liang W, et al. MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS One. 2012;7(10):e46082. doi:10.1371/journal.pone.0046082