Health and Environmental Risks of Incense Smoke: Mechanistic Insights and Cumulative Evidence

References

• Jetter JJ, Guo Z, McBrian JA, Flynn MR. Characterization of emissions from burning incense. Sci Total Environ. 2002;295:51–67. doi:10.1016/S0048-9697(02)00043-8
   PubMed Web of Science ®Google Scholar
• Cai WH, Wong PPY. Associations between incense-burning temples and respiratory mortality in Hong Kong. Atmosphere. 2021;12:774. doi:10.3390/atmos12060774
   Web of Science ®Google Scholar
• Bureau KHCEP. Reduction of pollutants in temples. In: Total Inventory Control of Air Pollutants and the Guidance Program for Reduction. Kao-Hsiong, Taiwan: Bureau KHCEP; 2003:6–9.7.
   Google Scholar
• Lin TC, Krishnaswamy G, Chi DS. Incense smoke: clinical, structural and molecular effects on airway disease. Clin Mol Allergy. 2008;6:1–9. doi:10.1186/1476-7961-6-3
   PubMedGoogle Scholar
• Apte K, Salvi S. Household air pollution and its effects on health. F1000Res. 2016;5:F1000 Faculty Rev–2593. doi:10.12688/f1000research.7552.1
   PubMedGoogle Scholar
• Moeran B. Making scents of smell: manufacturing and consuming incense in Japan. Hum Organ. 2009;68:439–450. doi:10.17730/humo.68.4.q570w7g1684u412t
   Web of Science ®Google Scholar
• Lin JM, Tang CS. Characterization and aliphatic aldehyde content of particulates in Chinese c. Bulletin of Environ Contam Toxicol. 1994;53:895–901. doi:10.1007/BF00196221
   PubMed Web of Science ®Google Scholar
• Shrestha O. Incense stick: an overlooked source of health hazard. JNMA J Nepal Med Assoc. 2020;58:823–825. doi:10.31729/jnma.5286
   PubMed Web of Science ®Google Scholar
• Zhang J, Chen W, Li J, Yu S, Zhao W. VOCs and particulate pollution due to incense burning in temples, China. Procedia Eng. 2015;121:992–1000. doi:10.1016/j.proeng.2015.09.067
   Google Scholar
• Bootdee S, Chantara S, Prapamontol T. Determination of PM2.5 and polycyclic aromatic hydrocarbons from incense burning emission at shrine for health risk assessment. Atmos Pollut Res. 2016;7:680–689. doi:10.1016/j.apr.2016.03.002
   Web of Science ®Google Scholar
• Goel A, Wathore R, Chakraborty T, Agrawal M. Characteristics of exposure to particles due to incense burning inside temples in Kanpur, India. Aerosol Air Qual Res. 2017;17:608–615. doi:10.4209/aaqr.2016.04.0146
   Web of Science ®Google Scholar
• Wang IJ, Tsai CH, Chen CH, Tung KY, Lee YL. Glutathione S-transferase, incense burning and asthma in children. Eur Resp J. 2011;37:1371. doi:10.1183/09031936.00137210
   PubMed Web of Science ®Google Scholar
• Ji X, Bihan OL, Ramalho O, et al. Characterization of particles emitted by incense burning in an experimental house. Indoor Air. 2010;20:147–158.
   PubMed Web of Science ®Google Scholar
• Chen YC, Ho WC, Yu YH. Adolescent lung function associated with incense burning and other environmental exposures at home. Indoor Air. 2017;27:746–752. doi:10.1111/ina.1235513
   PubMed Web of Science ®Google Scholar
• Pan A, Clark ML, Ang LW, Yu MC, Yuan JM, Koh WP. Incense use and cardiovascular mortality among Chinese in Singapore: the Singapore Chinese Health Study. Environ Health Perspect. 2014;122:1279–1284. doi:10.1289/ehp.1307662
   PubMed Web of Science ®Google Scholar
• Chang HL, Kuo ML, Lin JM. Mutagenic activity of incense smoke in comparison to formaldehyde and acetaldehyde in Salmonella typhimurium TA102. Bull Environ Contam Toxicol. 1997;58:394–401. doi:10.1007/s00128990034781
   PubMed Web of Science ®Google Scholar
• Navasumrit P, ArayAsiri M, Hiang OM, et al. Potential health effects of exposure to carcinogenic compounds in incense smoke in temple workers. Chem Biol Interact. 2008;173:19–31. doi:10.1016/j.cbi.2008.02.004119
   PubMed Web of Science ®Google Scholar
• Lin TC, Chang FH, Hsieh JH, Chao HR, Chao MR. Environmental exposure to polycyclic aromatic hydrocarbons and total suspended particulates in a Taiwanese temple. Bull Environ Contam Toxicol. 2001;67:332–338. doi:10.1007/s001280129
   PubMed Web of Science ®Google Scholar
• Lin TC, Chang FH, Hsieh JH, Chao HR, Chao MR. Characteristics of polycyclic aromatic hydrocarbons and total suspended particulate in indoor and outdoor atmosphere of a Taiwanese temple. J Hazardous Mater A. 2002;95:1–12. doi:10.1016/S0304-3894(02)00146-2
   Google Scholar
• Lin TC, Yang CR, Chang FH. Burning characteristics and emission products related to metallic content in incense. J Hazardous Mater. 2007;140:165–172. doi:10.1016/j.jhazmat.2006.06.052
   PubMed Web of Science ®Google Scholar
• Pastor-Nieto MA, Gatica-Ortega ME. Ubiquity, hazardous effects, and risk assessment of fragrances in consumer products. Curr Treat Options Allergy. 2021;8:21–41. doi:10.1007/s40521-020-00275-7
   PubMedGoogle Scholar
• Wong A, Lou W, Ho KF, et al. Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults. Sci Rep. 2020;10:7090. doi:10.1038/s41598-020-63568-6
   PubMed Web of Science ®Google Scholar
• Friborg JT, Yuan JM, Wang R, Koh WP, Lee HP, Yu MC. Incense use and respiratory tract carcinomas. Cancer. 2008;113:1676–1684. doi:10.1002/cncr.23788
   PubMed Web of Science ®Google Scholar
• Nor NSM, Yip CW, Ibrahim N, et al. Particulate matter (PM2.5) as a potential SARS-CoV-2 carrier. Sci Rep. 2021;2508. doi:10.1038/s41598-021-81935-9
   Web of Science ®Google Scholar
• Czwojdzinska M, Terpinska M, Kuzniarski A, Placzkowska S, Piwowar A. Exposure to PM2.5 and PM10 and COVID-19 infection rates and mortality: a one-year observational study in Poland. Biomed J. 2021. doi:10.1016/j.bj.2021.11.006
   PubMed Web of Science ®Google Scholar
• Schraufnagel DE. The health effects of ultrafine particles. Exp Mol Med. 2020;52:311–317. doi:10.1038/s12276-020-0403-3
   PubMed Web of Science ®Google Scholar
• Illegal mosquito repellent incense sticks are dangerous and poisonous. Think before you buy them!!!! (Article discusses the regulations of Central Insecticide board (CIB) and Home Insect Control Association (HICA)). Available from: https://www.hindustantimes.com/brand-post/illegal-mosquito-repellent-incense-sticks-are-dangerous-and-poisonous-think-before-you-buy-them/story-X5f7B6XiGeFa7XMUmdSckM.html. Accessed March 29, 2022.
   Google Scholar
• Sturton SD, Wen HL, Sturton OG. Etiology of cancer of the nasopharynx. Cancer. 1966;19:1666–1669. doi:10.1002/1097-0142(196611)19:11<1666::AID-CNCR2820191135>3.0.CO;2-H
   PubMed Web of Science ®Google Scholar
• Yang CY, Chiu JF, Cheng MF, Lin MC. Effects of indoor environmental factors on respiratory health of children in a subtropical climate. Environ Res. 1997;75:49–55. doi:10.1006/enrs.1997.3774
   PubMed Web of Science ®Google Scholar
• Ho CK, Tseng WR, Yang CY. Adverse respiratory and irritant health effects in temple workers in Taiwan. J Toxicol Environ Health A. 2005;68:1465–1470. doi:10.1080/15287390590967405
   PubMed Web of Science ®Google Scholar
• Alarifi SA, Mubarak MM, Alokail MS. Ultrastructure of the pulmonary alveolar cells of rats exposed to Arabian mix incense (Ma`amoul). J Biol Sci. 2004;4:694–699. doi:10.3923/jbs.2004.694.69963
   Google Scholar
• Alarifi SA, Mubarak MM, Alokail MS. Ultrastructural changes of pneumocytes of rat exposed to Arabian incense (Bakhour). Saudi Med J. 2004;25:1689–1693.
   PubMed Web of Science ®Google Scholar
• Wang B, Lee SC, Ho KF, Kang YM. Characteristics of emissions of air pollutants from burning of incense in temples. Hong Kong Sci Tot Env. 2007;377:52–60. doi:10.1016/j.scitotenv.2007.01.099
   PubMed Web of Science ®Google Scholar
• Sholih M, Perwitasari D, Hendriani R, et al. Knowledge, attitudes, and practices of lung cancer risk factors in West Bandung Society. J Pharm Bioallied Sci. 2019;11:574–579. doi:10.4103/jpbs.JPBS_213_19
   Web of Science ®Google Scholar
• Löfroth G, Stensman C, Brandhorst-Satzkorn M. Indoor sources of mutagenic aerosol particulate matter: smoking, cooking and incense burning. Mutat Res. 1991;261:21–28. doi:10.1016/0165-1218(91)90094-3
   PubMed Web of Science ®Google Scholar
• Reddy KRBK, Gupta N, Bhattacharya BG, et al. Impact of air pollution on allergic rhinitis and asthma: consensus statement by Indian Academy of Pediatrics. Indian Pediatr. 2021;58:766–770. doi:10.1007/s13312-021-2288-1
   Web of Science ®Google Scholar
• Chuang HC, Jones T, Berube K. Combustion particles emitted during church services: implication for human respiratory health. Environ Int. 2012;40:137–142. doi:10.1016/j.envint.2011.07.009
   PubMed Web of Science ®Google Scholar
• Yamamoto N, Kan-o K, Tatsuta M, et al. Incense smoke-induced oxidative stress disrupts tight junctions and bronchial epithelial barrier integrity and induces airway hyperresponsiveness in mouse lungs. Sci Rep. 2021;11:7222. doi:10.1038/s41598-021-86745-7
   PubMed Web of Science ®Google Scholar
• Guo SE, Chi MC, Lin CM, Yang TM. Contributions of burning incense on indoor air pollution levels and on the health status of patients with chronic obstructive pulmonary disease. Peer J. 2020;8:e9768–e9768. doi:10.7717/peerj.9768
   PubMed Web of Science ®Google Scholar
• Laniado-Laborín R. Smoking and chronic obstructive pulmonary disease (COPD). Parallel epidemics of the 21 century. Int J Env Res Public Health. 2009;6:209–224. doi:10.3390/ijerph6010209
   PubMed Web of Science ®Google Scholar
• Alokail MS, Al-Daghri NM, Alarifi SA, Draz HM, Hussain T, Yakout SM. Long-term exposure to incense smoke alters metabolism in Wistar albino rats. Cell Biochem Funct. 2011;29:96–101. doi:10.1002/cbf.1726
   PubMed Web of Science ®Google Scholar
• Weber LP, Al-Diss A, Marit JS, German TN, Terletski SD. Role of carbon monoxide in impaired endothelial function mediated by acute second-hand tobacco, incense, and candle smoke exposures. Environ Toxicol Pharmacol. 2011;31:453–459.
   PubMed Web of Science ®Google Scholar
• Lin LY, Lin HY, Chen HW, Su TL, Huang LC, Chuang KJ. Effects of temple particles on inflammation and endothelial cell response. Sci Total Environ. 2012;414:68–72. doi:10.1016/j.scitotenv.2011.08.05071
   PubMed Web of Science ®Google Scholar
• Huang YL, Chen HW, Han BC, et al. Personal exposure to household particulate matter, household activities and heart rate variability among housewives. PLoS One. 2014;9:e89969. doi:10.1371/journal.pone.008996967
   PubMed Web of Science ®Google Scholar
• Al-Attas OS, Hussain T, Ahmed M, et al. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Environ Sci Pollut Res Int. 2015;22:10083–10093. doi:10.1007/s11356-015-4212-569
   PubMed Web of Science ®Google Scholar
• Kammoolkon R, Taneepanichskul N, Pitaknoppakul N, Lertmaharit S, Lohsoonthorn V. Incense smoke and increasing carotid intima media thickness: a cross-sectional study of the Thai-Vietnamese community. Asia Pac J Public Health. 2018;30:178–187. doi:10.1177/101053951775393065
   PubMed Web of Science ®Google Scholar
• Hayakawa R, Matsunaga K, Arima Y. Depigmented contact dermatitis due to incense. Contact Dermatitis. 1987;16:272–274. doi:10.1111/j.1600-0536.1987.tb01451.x
   PubMed Web of Science ®Google Scholar
• Hayakawa R, Matsunaga K, Arima Y. Airborne pigmented contact dermatitis due to musk ambrette in incense. Contact Dermatitis. 1987;16:96–98. doi:10.1111/j.1600-0536.1987
   PubMed Web of Science ®Google Scholar
• Lin CY, Wen HJ, Lee YL, Guo YL. Are maternal psychosocial factors associated with cord immunoglobulin E in addition to family atopic history and mother immunoglobulin E? Clin Exp Allergy. 2004;34:548–554. doi:10.1111/j.1365-2222.2004.1928.x
   PubMed Web of Science ®Google Scholar
• Hsu NY, Wang JY, Wu PC, Su HJ. Paternal heredity and housing characteristics affect childhood asthma and allergy morbidity. Arch Environ Occup Health. 2012;67:155–162. doi:10.1080/19338244.2011.598890
   PubMed Web of Science ®Google Scholar
• Norbäck D, Zhang X, Fan Q, et al. Home environment and health: domestic risk factors for rhinitis, throat symptoms and non-respiratory symptoms among adults across China. Sci Tot Environ. 2019;681:320–330. doi:10.1016/j.scitotenv.2019.05.08454
   PubMed Web of Science ®Google Scholar
• Fang XY, Strodl E, Liu BQ, et al. Association between prenatal exposure to household inhalants exposure and ADHD-like behaviors at around 3 years of age: findings from Shenzhen Longhua Child Cohort Study. Environ Res. 2019;177:108612. doi:10.1016/j.envres.2019.108612
   PubMed Web of Science ®Google Scholar
• Wei CF, Chen MH, Lin CC, et al. Household incense burning and infant gross motor development: results from the Taiwan Birth Cohort Study. Environ Int. 2018;115:110–116.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Health effects of particulate matter, Policy Implications for countries in Eastern Europe, Caucasus and Central Asia; 2013. ISBN: 9789289000017.
   Google Scholar
• Yamamoto Y, Isoyama E, Sofikitis N, Miyagawa I. Effects of smoking on testicular function and fertilizing potential in rats. Urol Res. 1998;26:45–48. doi:10.1007/s002400050022
   PubMedGoogle Scholar
• Kapawa A, Giannakis D, Tsoukanelis K, et al. Effects of paternal cigarette smoking on testicular function, sperm fertilizing capacity, embryonic development and blastocyst capacity for implantation in rats. Andrologia. 2004;36:57–68. doi:10.1111/j.1439-0272.2004.00605.x
   PubMed Web of Science ®Google Scholar
• Zhou R, An Q, Pan XW, Yang B, Hu J, Wang YH. Higher cytotoxicity and genotoxicity of burning incense than cigarette. Environ Chem Lett. 2015;13:465–471. doi:10.1007/s10311-015-0521-7
   Web of Science ®Google Scholar
• Akingbade AM, Saalu LC, Oyebanji OO, Oyeniran DA, AKande OO, Akunna GG. Rhodinol-based incense testiculotoxicity in Albino rats: testicular histology, spermatogenic and biochemical evaluations. J Pharmacol Toxicol. 2014;9:68–81. doi:10.3923/jpt.2014.68.81
   Google Scholar
• Chen LY, Ho C. Incense burning during pregnancy and birth weight and head circumference among term births: the Taiwan Birth Cohort Study. Env Health Persp. 2016;124:1487–1492. doi:10.1289/ehp.1509922
   PubMed Web of Science ®Google Scholar
• He JR, Wei DM, Chan FF, et al. Associations between maternal exposure to incense burning and blood pressure during pregnancy. Sci Tot Env. 2018;610-611:1421–1427. doi:10.1016/j.scitotenv.2017.08.134
   PubMed Web of Science ®Google Scholar
• Sastry J, Agawane S, Rajan M, Black K, Laumbach R, Ramagopal M. The effect of the indoor environment on wheeze- and sleep-related symptoms in young Indian children. Lung India. 2021;38:307.
   PubMed Web of Science ®Google Scholar
• Vallès Y, Inman CK, Peters BA, et al. Incense burning is associated with human oral microbiota composition. Sci Rep. 2019;9:10039. doi:10.1038/s41598-019-46353-y
   PubMed Web of Science ®Google Scholar
• Hussain T, Al-Attas OS, Alrokayan SA, et al. Deleterious effects of incense smoke exposure on kidney function and architecture in male albino rats. Inhal Toxicol. 2016;28:364–373. doi:10.1080/08958378.2016.1179372
   PubMed Web of Science ®Google Scholar
• Geng TT, Jafar TH, Yuan JM, Koh WP. Long-term incense use and the risk of end-stage renal disease among Chinese in Singapore: the Singapore Chinese health study. BMC Nephrol. 2019;20. doi:10.1186/s12882-018-1186-9
   PubMed Web of Science ®Google Scholar
• Yadav VK, Singh B, Choudhary N. Characterization of Indian incense stick powders for their physical, chemical and mineralogical properties. World J Environ Biosci. 2020;9:39–43.
   Google Scholar
• Balasubramanian N. Scented oils and perfumes chemical technology in antiquity. Am Chem Soc. 2015;1211:219–244.
   Google Scholar
• Jain SN, Tamboli SR, Sutar DS, Mawal VN, Shaikh AA, Prajapati AA. Incense stick ash as a novel and sustainable adsorbent for sequestration of Victoria Blue from aqueous phase. Sustainable Chem Pharm. 2020;15:100199. doi:10.1016/j.scp.2019.100199
   Web of Science ®Google Scholar
• Mishra S, Singh AL, Tiwary D. Studies of physico-chemical status of the ponds at Varanasi Holy City under anthropogenic influences. Int J Environ Res Dev. 2018;4:261–268.
   Google Scholar
• Yadav VK, Yadav KK, Ahmed EM, et al. Transformation of hazardous sacred incense sticks ash waste into less toxic product by sequential approach prior to their disposal into the water bodies. Env Sc Pollut Res Int. 2021. doi:10.1007/s11356-021-15009-8
   Web of Science ®Google Scholar
• Khezri B, Chan YY, Tiong LYD, Webster RD. Annual air pollution caused by the Hungry Ghost Festival. Environ Sci Process Impacts. 2015;17:1578–1586. doi:10.1039/c5em00312a
   PubMed Web of Science ®Google Scholar
• Fang GC, Chang CN, Chu CC, et al. Fine (PM2.5), coarse (PM2.5-10), and metallic elements of suspended particulates for incense burning at Tzu Yun Yen temple in central Taiwan. Chemosphere. 2003;51:983–991. doi:10.1016/S0045-6535(03)00124-3
   PubMed Web of Science ®Google Scholar
• Balaram V. Rare earth elements: a review of applications, occurrence, exploration, analysis, recycling, and environmental impact. Geosci Front. 2019;10:1285–1303. doi:10.1016/j.gsf.2018.12.005
   Web of Science ®Google Scholar
• Yadav VK, Gnanamoorthy G, Cabral-Pinto MMS, et al. Variations and similarities in structural, chemical, and elemental properties on the ashes derived from the coal due to their combustion in open and controlled manner. Environ Sci Pollut Res Int. 2021;28:32609–32625. doi:10.1007/s11356-021-12989-5
   Web of Science ®Google Scholar
• Mesallam TA, Farahat M, Shoeib R, et al. Acute effects of inhaling Oud incense on voice of Saudi adults. Ann Saudi Med. 2015;35:111–119. doi:10.5144/0256-4947.2015.111
   PubMed Web of Science ®Google Scholar
• Yang TT, Ho SC, Chuang LT, Chuang HC, Li YT, Wu JJ. Characterization of particulate-phase polycyclic aromatic hydrocarbons emitted from incense burning and their bioreactivity in RAW264.7 macrophage. Env Pollut. 2017;220:1190–1198. doi:10.1016/j.envpol.2016.11.016
   PubMed Web of Science ®Google Scholar
• Elsayed Y, Dalibalta S, Gomes I, Fernandes N, Alqtaishat F. Chemical composition and potential health risks of raw Arabian incense (Bakhour). J Saudi Chem Soc. 2016;20:465–473. doi:10.1016/j.jscs.2014.10.005
   Web of Science ®Google Scholar
• Tung JC, Huang WC, Yang JC, et al. an incense smoke ingredient, promotes lung cancer malignancy. Envir Toxicol. 2017;32:2379–2391. doi:10.1002/tox.22451
   PubMed Web of Science ®Google Scholar
• Lin CH, Lo PY, Wu HD, Chang C, Wang LC. Association between indoor air pollution and respiratory disease in companion dogs and cats. J Vet Int Med. 2018;32:1259–1267. doi:10.1111/jvim.15143
   PubMed Web of Science ®Google Scholar
• Kaizaki-Mitsumoto A, Hataoka K, Funada M, Odanaka Y, Kumamoto H, Numazawa S. Pyrolysis of UR-144, a synthetic cannabinoid, augments an affinity to human CB1 receptor and cannabimimetic effects in mice. J Toxicol Sci. 2017;42:335–341. doi:10.2131/jts.42.335
   PubMed Web of Science ®Google Scholar
• Lu Y, Lin S, Lawrence WR, et al. Evidence from SINPHONIE project: impact of home environmental exposures on respiratory health among school-age children in Romania. Sc Tot Environ. 2018;621:75–84. doi:10.1016/j.scitotenv.2017.11.157
   PubMed Web of Science ®Google Scholar
• Lung SC, Wang WV, Wen TJ, Liu C, Hu S. A versatile low-cost sensing device for assessing PM2.5 spatiotemporal variation and quantifying source contribution. Sci Tot Environ. 2020;716:137145. doi:10.1016/j.scitotenv.2020.137145
   PubMed Web of Science ®Google Scholar
• Niu X, Jones T, BéruBé K, Chuang HC, Sun J, Ho KF. The oxidative capacity of indoor source combustion derived particulate matter and resulting respiratory toxicity. Sci Tot Environ. 2021;767:144391. doi:10.1016/j.scitotenv.2020.144391
   PubMed Web of Science ®Google Scholar
• Manoukian A, Buiron D, Temime-Roussel B, Wortham H, Quivet E. Measurements of VOC/SVOC emission factors from burning incenses in an environmental test chamber: influence of temperature, relative humidity, and air exchange rate. Environ Sci Pollut Res. 2016;23:6300–6311. doi:10.1007/s11356-015-5819-2
   PubMed Web of Science ®Google Scholar
• Lu F, Li S, Shen B, et al. The emission characteristic of VOCs and the toxicity of BTEX from different mosquito-repellent incenses. J Hazard Mater. 2020;384:121428. doi:10.1016/j.jhazmat.2019.121428
   PubMed Web of Science ®Google Scholar