No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

References

• WHO. WHO coronavirus disease (COVID-19) dashboard. Available from: https://covid19.who.int/. Accessed October 3, 2021.
   Google Scholar
• Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320. doi:10.1136/bmj.m3320
   PubMed Web of Science ®Google Scholar
• Chmielewska B, Barratt I, Townsend R, et al. Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis. Lancet Glob Health. 2021;9(6):e759–e772.
   PubMed Web of Science ®Google Scholar
• Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ. 2021;193(16):E540–E548. doi:10.1503/cmaj.202604
   PubMed Web of Science ®Google Scholar
• National Health Commission of the People’s Republic of China. COVID-19 vaccination status. Available from: http://www.nhc.gov.cn/. Accessed October 3, 2021.
   Google Scholar
• Callaway E. The race for coronavirus vaccines: a graphical guide. Nature. 2020;580(7805):576–577. doi:10.1038/d41586-020-01221-y
   PubMed Web of Science ®Google Scholar
• Al Kaabi N, Zhang Y, Xia S, et al. Effect of 2 inactivated SARS-CoV-2 vaccines on symptomatic COVID-19 infection in adults: a randomized clinical trial. JAMA. 2021;326(1):35–45. doi:10.1001/jama.2021.8565
   PubMed Web of Science ®Google Scholar
• Sadoff J, Gray G, Vandebosch A, et al. Safety and efficacy of single-dose Ad26.COV2.S vaccine against Covid-19. N Engl J Med. 2021;384(23):2187–2201. doi:10.1056/NEJMoa2101544
   PubMed Web of Science ®Google Scholar
• Thomas SJ, Moreira ED Jr, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine through 6 months. N Engl J Med. 2021;385(19):1761–1773. doi:10.1056/NEJMoa2110345
   PubMed Web of Science ®Google Scholar
• Blake Evans M, Alexander C, Barnard E, et al. COVID-19 vaccine and infertility: baseless claims and unfounded social media panic. ASRM, Fertility and Sterility; 2021. Available from: https://www.fertstertdialog.com/posts/covid-19-vaccine-and-infertility-baseless-claims-and-unfounded-social-media-panic. Accessed January 26, 2022.
   Google Scholar
• Iacobucci G. Covid-19: no evidence that vaccines can affect fertility, says new guidance. BMJ. 2021;372:n509. doi:10.1136/bmj.n509
   PubMed Web of Science ®Google Scholar
• Flynn AC, Kavanagh K, Smith AD, Poston L, White SL. The impact of the COVID-19 pandemic on pregnancy planning behaviors. Women’s Health Rep. 2021;2(1):71–77.
   Google Scholar
• Skjefte M, Ngirbabul M, Akeju O, et al. COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries. Eur J Epidemiol. 2021;36(2):197–211. doi:10.1007/s10654-021-00728-6
   PubMed Web of Science ®Google Scholar
• Bentov Y, Beharier O, Moav-Zafrir A, et al. Ovarian follicular function is not altered by SARS-CoV-2 infection or BNT162b2 mRNA COVID-19 vaccination. Hum Reprod. 2021;36(9):2506–2513. doi:10.1093/humrep/deab182
   PubMed Web of Science ®Google Scholar
• Orvieto R, Noach-Hirsh M, Segev-Zahav A, Haas J, Nahum R, Aizer A. Does mRNA SARS-CoV-2 vaccine influence patients’ performance during IVF-ET cycle? Reprod Biol Endocrinol. 2021;19(1):69. doi:10.1186/s12958-021-00757-6
   PubMed Web of Science ®Google Scholar
• Zhu FC, Guan XH, Li YH, et al. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, Phase 2 trial. Lancet. 2020;396(10249):479–488. doi:10.1016/S0140-6736(20)31605-6
   PubMed Web of Science ®Google Scholar
• Yang S, Li Y, Dai L, et al. Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, Phase 1 and 2 trials. Lancet Infect Dis. 2021;21(8):1107–1119. doi:10.1016/S1473-3099(21)00127-4
   PubMed Web of Science ®Google Scholar
• Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J Vitro Fert Embryo Transfer. 1986;3(5):284–295. doi:10.1007/BF01133388
   PubMedGoogle Scholar
• Gardner DK, Schoolcraft WB. In vitro culture of human blastocyst. In: Jansen R, Mortimer D, editors. Towards Reproductive Certainty: Infertility and Genetics Beyond 1999. Carnforth: Parthenon Press; 1999:378–388.
   Google Scholar
• Gleicher N, Barad D. Unexplained infertility: does it really exist? Hum Reprod. 2006;21(8):1951–1955. doi:10.1093/humrep/del135
   PubMed Web of Science ®Google Scholar
• Mohr-Sasson A, Haas J, Abuhasira S, et al. The effect of Covid-19 mRNA vaccine on serum anti-Müllerian hormone levels. Hum Reprod. 2021. doi:10.1093/humrep/deab282
   Web of Science ®Google Scholar
• Naleway AL, Mittendorf KF, Irving SA, et al. Primary ovarian insufficiency and adolescent vaccination. Pediatrics. 2018;142(3):e20180943. doi:10.1542/peds.2018-0943
   PubMed Web of Science ®Google Scholar
• Chandi A, Jain N. State of ART in the COVID-19 era and consequences on human reproductive system. Biol Reprod. 2021;105(4):808–821. doi:10.1093/biolre/ioab122
   PubMed Web of Science ®Google Scholar
• Li K, Chen G, Hou H, et al. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 2021;42(1):260–267. doi:10.1016/j.rbmo.2020.09.020
   PubMed Web of Science ®Google Scholar
• Orvieto R, Segev-Zahav A, Aizer A. Does COVID-19 infection influence patients’ performance during IVF-ET cycle?: an observational study. Gynecol Endocrinol. 2021;37(10):895–897. doi:10.1080/09513590.2021.1918080
   PubMed Web of Science ®Google Scholar
• Wang M, Yang Q, Ren X, et al. Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: a retrospective cohort study. EClinicalMedicine. 2021;38:101013. doi:10.1016/j.eclinm.2021.101013
   PubMedGoogle Scholar
• Kollmann Z, Schneider S, Fux M, Bersinger NA, von Wolff M. Gonadotrophin stimulation in IVF alters the immune cell profile in follicular fluid and the cytokine concentrations in follicular fluid and serum. Hum Reprod. 2017;32(4):820–831. doi:10.1093/humrep/dex005
   PubMed Web of Science ®Google Scholar
• Lachapelle MH, Hemmings R, Roy DC, Falcone T, Miron P. Flow cytometric evaluation of leukocyte subpopulations in the follicular fluids of infertile patients. Fertil Steril. 1996;65(6):1135–1140. doi:10.1016/S0015-0282(16)58327-7
   PubMed Web of Science ®Google Scholar
• Gallinelli A, Roncaglia R, Matteo ML, Ciaccio I, Volpe A, Facchinetti F. Immunological changes and stress are associated with different implantation rates in patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2001;76(1):85–91. doi:10.1016/S0015-0282(01)01826-X
   PubMed Web of Science ®Google Scholar
• Yang KM, Ntrivalas E, Cho HJ, et al. Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation. Am J Reprod Immunol. 2010;63(5):370–378. doi:10.1111/j.1600-0897.2010.00811.x
   PubMed Web of Science ®Google Scholar
• Soleimanpour S, Yaghoubi A. COVID-19 vaccine: where are we now and where should we go? Expert Rev Vaccines. 2021;20(1):23–44. doi:10.1080/14760584.2021.1875824
   PubMed Web of Science ®Google Scholar
• Cruz-Tapias P, Blank M, Anaya JM, Shoenfeld Y. Infections and vaccines in the etiology of antiphospholipid syndrome. Curr Opin Rheumatol. 2012;24(4):389–393. doi:10.1097/BOR.0b013e32835448b8
   PubMed Web of Science ®Google Scholar
• Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A. Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review. J Neurol Sci. 2021;428:117607. doi:10.1016/j.jns.2021.117607
   PubMed Web of Science ®Google Scholar
• Liu T, Dai J, Yang Z, et al. Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort. Sci Bull. 2021;66(22):2312–2319. doi:10.1016/j.scib.2021.07.033
   PubMed Web of Science ®Google Scholar
• Backos M, Rai R, Regan L. Antiphospholipid antibodies and infertility. Hum Fertil. 2002;5(1):30–34. doi:10.1080/1464727992000199731
   Google Scholar
• Expert Group for Beijing Human Assisted Reproductive Technology Center For Quality Control and Improvement. COVID-19 vaccination strategy for planning pregnancy and assisted reproductive technology treatment: expert recommendations [In Chinese]. Chin J Reprod Contracep. 2021;41(4):296–299.
   Google Scholar
• ESHRE COVID-19 Working Group. ESHRE STATEMENT ON COVID-19 vaccination and medically assisted reproduction. Available from: https://www.eshre.eu/Europe/Position-statements/COVID19/vaccination. Accessed October 3, 2021.
   Google Scholar
• Coronavirus/COVID-19 Task Force of the American Society for Reproductive Medicine. ASRM patient management and clinical recommendations during the (coronavirus COVID-19)pandemic: update no. 13—variants, vaccines, and vaccination; February 22, 2021. Available from: https://www.asrm.org/globalassets/asrm/asrm-content/news-and-publications/covid-19/covidtaskforceupdate13.pdf. Accessed October 3, 2021.
   Google Scholar
• Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivariate Behav Res. 2011;46(3):399–424. doi:10.1080/00273171.2011.568786
   PubMed Web of Science ®Google Scholar
• Lifshitz D, Haas J, Lebovitz O, Raviv G, Orvieto R, Aizer A. Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis? Reprod Biomed Online. 2021. doi:10.1016/j.rbmo.2021.09.021
   PubMed Web of Science ®Google Scholar