Probiotic Combination CBLEB Alleviates Streptococcus pneumoniae Infection Through Immune Regulation in Immunocompromised Rats

References

• Welte T, Torres A, Nathwani D. Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax. 2012;67(1):71–79. doi:10.1136/thx.2009.129502
   PubMed Web of Science ®Google Scholar
• WHO fact sheet on pneumonia provides key facts and information on causes, presenting features, economic costs, treatment, prevention and WHO response. Available from: https://www.who.int/news-room/fact-sheets/detail/pneumonia. Accessed February 1, 2022.
   Google Scholar
• O’Brien KL, Wolfson LJ, Watt JP, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet. 2009;374(9693):893–902.
   PubMed Web of Science ®Google Scholar
• Wang Y, Jiang B, Guo Y, et al. Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection. Mucosal Immunol. 2017;10(1):250–259. doi:10.1038/mi.2016.41
   PubMed Web of Science ®Google Scholar
• Yan R, Wang K, Wang Q, et al. Probiotic Lactobacillus casei Shirota prevents acute liver injury by reshaping the gut microbiota to alleviate excessive inflammation and metabolic disorders. Microb Biotechnol. 2021;15(1):247–261. doi:10.1111/1751-7915.13750
   PubMed Web of Science ®Google Scholar
• Hussain M, Melegaro A, Pebody RG, et al. A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting. Epidemiol Infect. 2005;133(5):891–898. doi:10.1017/S0950268805004012
   PubMed Web of Science ®Google Scholar
• Hyams C, Camberlein E, Cohen JM, Bax K, Brown JS. The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms. Infect Immun. 2010;78(2):704–715. doi:10.1128/IAI.00881-09
   PubMed Web of Science ®Google Scholar
• Ivanov S, Paget C, Trottein F. Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus. PLoS Pathog. 2014;10(10):e1004300. doi:10.1371/journal.ppat.1004300
   PubMed Web of Science ®Google Scholar
• Pilishvili T, Lexau C, Farley MM, et al. Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine. J Infect Dis. 2010;201(1):32–41. doi:10.1086/648593
   PubMed Web of Science ®Google Scholar
• Bonten MJ, Huijts SM, Bolkenbaas M, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015;372(12):1114–1125. doi:10.1056/NEJMoa1408544
   PubMed Web of Science ®Google Scholar
• Jose RJ, Brown JS. Adult pneumococcal vaccination: advances, impact, and unmet needs. Curr Opin Pulm Med. 2017;23(3):225–230. doi:10.1097/MCP.0000000000000369
   PubMed Web of Science ®Google Scholar
• Yahiaoui RY, Heijer CDD, Bijnen EMV, et al. Prevalence and antibiotic resistance of commensal Streptococcus pneumoniae in nine European countries. Future Microbiol. 2016;11(6):737–744. doi:10.2217/fmb-2015-0011
   PubMed Web of Science ®Google Scholar
• Barbieri N, Herrera M, Salva S, Villena J, Alvarez S. Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice. Benef Microbes. 2017;8(3):393–405. doi:10.3920/BM2016.0152
   PubMed Web of Science ®Google Scholar
• Vintini EO, Medina MS. Host immunity in the protective response to nasal immunization with a pneumococcal antigen associated to live and heat-killed Lactobacillus casei. BMC Immunol. 2011;12:46. doi:10.1186/1471-2172-12-46
   PubMed Web of Science ®Google Scholar
• Lv L, Mu D, Du Y, Yan R, Jiang H. Mechanism of the Immunomodulatory Effect of the Combination of Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus on Immunocompromised Rats. Front Immunol. 2021;12:694344. doi:10.3389/fimmu.2021.694344
   PubMed Web of Science ®Google Scholar
• Tzanakaki G, Tsopanomichalou M, Kesanopoulos K, et al. Simultaneous single-tube PCR assay for the detection of Neisseria meningitidis, Haemophilus influenzae type b and Streptococcus pneumoniae. Clin Microbiol Infect. 2005;11(5):386–390. doi:10.1111/j.1469-0691.2005.01109.x
   PubMed Web of Science ®Google Scholar
• Matute-Bello G, Downey G, Moore BB, et al. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 2011;44(5):725–738. doi:10.1165/rcmb.2009-0210ST
   PubMed Web of Science ®Google Scholar
• Xiping Z, Ruiping Z, Binyan Y, et al. Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis. J Gastroenterol Hepatol. 2010;25(2):302–308. doi:10.1111/j.1440-1746.2009.05999.x
   PubMed Web of Science ®Google Scholar
• Lv L, Jiang H, Chen Y, et al. The faecal metabolome in COVID-19 patients is altered and associated with clinical features and gut microbes. Anal Chim Acta. 2021;1152:338267. doi:10.1016/j.aca.2021.338267
   PubMed Web of Science ®Google Scholar
• Lv L, Jiang H, Chen X, et al. The Salivary Microbiota of Patients With Primary Biliary Cholangitis Is Distinctive and Pathogenic. Front Immunol. 2021;12:2950. doi:10.3389/fimmu.2021.713647
   Web of Science ®Google Scholar
• Tanaka A, Seki M, Yamahira S, et al. Lactobacillus pentosus strain b240 suppresses pneumonia induced by Streptococcus pneumoniae in mice. Lett Appl Microbiol. 2011;53(1):35–43. doi:10.1111/j.1472-765X.2011.03079.x
   PubMed Web of Science ®Google Scholar
• Zelaya H, Laino J, Villena J, Marranzino G, Alvarez S, Aguero G. Lactobacillus casei CRL431 modulates hemostatic activation induced by protein malnourishment and pneumococcal respiratory infection. Appl Microbiol Biotechnol. 2020;104(24):10669–10683. doi:10.1007/s00253-020-10957-6
   PubMed Web of Science ®Google Scholar
• Zelaya H, Laino J, Villena J, Alvarez S, Aguero G. Lactobacillus rhamnosus CRL1505 beneficially modulates the immuno-coagulative response after pneumococcal infection in immunocompromised malnourished mice. Can J Microbiol. 2013;59(10):684–693. doi:10.1139/cjm-2013-0361
   PubMed Web of Science ®Google Scholar
• Gluck U, Gebbers JO. Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic streptococci). Am J Clin Nutr. 2003;77(2):517–520. doi:10.1093/ajcn/77.2.517
   PubMed Web of Science ®Google Scholar
• Schluter J, Peled JU, Taylor BP, et al. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020;588(7837):303–307. doi:10.1038/s41586-020-2971-8
   PubMed Web of Science ®Google Scholar
• Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9(5):313–323. doi:10.1038/nri2515
   PubMed Web of Science ®Google Scholar
• Schuijt TJ, Lankelma JM, Scicluna BP, et al. The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut. 2016;65(4):575–583. doi:10.1136/gutjnl-2015-309728
   PubMed Web of Science ®Google Scholar
• Mukherjee A, Lordan C, Ross RP, Cotter PD. Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health. Gut Microbes. 2020;12(1):1802866. doi:10.1080/19490976.2020.1802866
   PubMed Web of Science ®Google Scholar
• Lv L, Gu S, Jiang H, et al. Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features. Commun Biol. 2021;4(1):480. doi:10.1038/s42003-021-02036-x
   PubMed Web of Science ®Google Scholar
• Jin Z, Wu K, Hou J, Yu K, Shen Y, Guo S. A PTX/nitinol stent combination with temperature-responsive phase-change 1-hexadecanol for magnetocaloric drug delivery: magnetocaloric drug release and esophagus tissue penetration. Biomaterials. 2018;153:49–58. doi:10.1016/j.biomaterials.2017.10.040
   PubMed Web of Science ®Google Scholar
• Fox KJ, Prather KLJ. Production of D-Glyceric acid from D-Galacturonate in Escherichia coli. J Ind Microbiol Biotechnol. 2020;47(12):1075–1081. doi:10.1007/s10295-020-02323-2
   PubMed Web of Science ®Google Scholar
• Su H, Liu R, Chang M, Huang J, Wang X. Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Food Funct. 2017;8(9):3091–3103. doi:10.1039/C7FO00433H
   PubMed Web of Science ®Google Scholar
• Huang J, Chen Z, Zhang W, Zhang T, Mu W. D-lyxose isomerase and its application for functional sugar production. Appl Microbiol Biotechnol. 2018;102(5):2051–2062. doi:10.1007/s00253-018-8746-6
   PubMed Web of Science ®Google Scholar
• Tong W, Xu Y, Xian M, et al. Biosynthetic pathway for acrylic acid from glycerol in recombinant Escherichia coli. Appl Microbiol Biotechnol. 2016;100(11):4901–4907. doi:10.1007/s00253-015-7272-z
   PubMed Web of Science ®Google Scholar
• Mishra R, Kushveer JS, Khan MIK, et al. 2,4-Di-Tert-Butylphenol Isolated From an Endophytic Fungus, Daldinia eschscholtzii, Reduces Virulence and Quorum Sensing in Pseudomonas aeruginosa. Front Microbiol. 2020;11:1668. doi:10.3389/fmicb.2020.01668
   PubMed Web of Science ®Google Scholar
• Api AM, Belsito D, Biserta S, et al. RIFM fragrance ingredient safety assessment, m-cresol, CAS Registry Number 108-39-4. Food Chem Toxicol. 2021;149(Suppl 1):112043. doi:10.1016/j.fct.2021.112043
   PubMed Web of Science ®Google Scholar
• Musie E, Moore CC, Martin EN, Scheld WM. Toll-Like Receptor 4 Stimulation before or after Streptococcus pneumonia e Induced Sepsis Improves Survival and Is Dependent on T-Cells. PLoS One. 2014;9(1):e86015. doi:10.1371/journal.pone.0086015
   PubMed Web of Science ®Google Scholar
• Zhou A, Ni J, Xu Z, et al. Application of (1)h NMR spectroscopy-based metabolomics to sera of tuberculosis patients. J Proteome Res. 2013;12(10):4642–4649. doi:10.1021/pr4007359
   PubMed Web of Science ®Google Scholar
• Choi I, Son H, Baek JH. Tricarboxylic Acid (TCA) Cycle Intermediates: regulators of Immune Responses. Life. 2021;11(1):69. doi:10.3390/life11010069
   PubMedGoogle Scholar
• Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Nunez G. Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol. 2009;183(9):5823–5829. doi:10.4049/jimmunol.0900444
   PubMed Web of Science ®Google Scholar
• Brown RL, Sequeira RP, Clarke TB. The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017;8(1):1512. doi:10.1038/s41467-017-01803-x
   PubMed Web of Science ®Google Scholar
• Baranek T, Morello E, Valayer A, et al. FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection. Front Immunol. 2017;8:123. doi:10.3389/fimmu.2017.00123
   PubMed Web of Science ®Google Scholar
• Mohan T, Zhu W, Wang Y, Wang BZ. Applications of chemokines as adjuvants for vaccine immunotherapy. Immunobiology. 2018;223(6–7):477–485. doi:10.1016/j.imbio.2017.12.001
   PubMed Web of Science ®Google Scholar
• Raasch CE, Zhang P, Siggins RW, LaMotte LR, Nelson S, Bagby GJ. Acute alcohol intoxication impairs the hematopoietic precursor cell response to pneumococcal pneumonia. Alcohol Clin Exp Res. 2010;34(12):2035–2043. doi:10.1111/j.1530-0277.2010.01291.x
   PubMed Web of Science ®Google Scholar
• Cheng Y, Yang C, Tan Z, He Z. Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Diarrhoea Kids. Front Veterinary Sci. 2021;8:598691. doi:10.3389/fvets.2021.598691
   PubMed Web of Science ®Google Scholar
• Hanna VS, Hafez EAA. Synopsis of arachidonic acid metabolism: a review. J Adv Res. 2018;11:23–32. doi:10.1016/j.jare.2018.03.005
   PubMed Web of Science ®Google Scholar
• Vernon HJ, Manoli I. Milestones in treatments for inborn errors of metabolism: reflections on Where chemistry and Medicine meet. Am J Med Genet A. 2021;185(11):3350–3358. doi:10.1002/ajmg.a.62385
   PubMed Web of Science ®Google Scholar
• Butman HS, Kotze TJ, Dowd CS, Strauss E. Vitamin in the Crosshairs: targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents. Front Cell Infect Microbiol. 2020;10:605662. doi:10.3389/fcimb.2020.605662
   PubMed Web of Science ®Google Scholar
• Garg M, Angus PW, Burrell LM, Herath C, Gibson PR, Lubel JS. Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract. Aliment Pharmacol Ther. 2012;35(4):414–428. doi:10.1111/j.1365-2036.2011.04971.x
   PubMed Web of Science ®Google Scholar
• Zhao B, Rothenberg E, Ramsden DA, Lieber MR. The molecular basis and disease relevance of non-homologous DNA end joining. Nat Rev Mol Cell Biol. 2020;21(12):765–781. doi:10.1038/s41580-020-00297-8
   PubMed Web of Science ®Google Scholar
• Yusta B, Holland D, Koehler JA, et al. ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut. Gastroenterology. 2009;137(3):986–996. doi:10.1053/j.gastro.2009.05.057
   PubMed Web of Science ®Google Scholar
• Nguyen T, Deenick EK, Tangye SG. Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications. Expert Rev Clin Immunol. 2021;1–10.
   Web of Science ®Google Scholar
• Harjunpaa H, Llort Asens M, Guenther C, Fagerholm SC. Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment. Front Immunol. 2019;10:1078. doi:10.3389/fimmu.2019.01078
   PubMed Web of Science ®Google Scholar