ATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production

References

• Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237–241.
   PubMed Web of Science ®Google Scholar
• Martin WJ, Harper JL. Innate Inflammation and Resolution in Acute Gout. Immunol Cell Biol. 2010;88(1):15–19.
   PubMed Web of Science ®Google Scholar
• Martin WJ, Walton M, Harper J. Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum. 2009;60(1):281–289.
   PubMed Web of Science ®Google Scholar
• Tao JH, Chen M, Tang JP, et al. Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis. PLoS One. 2017;12(8):e0181685. doi:10.1371/journal.pone.0181685
   PubMed Web of Science ®Google Scholar
• Tao JH, Zhang Y, Li XP. P2X7R: a potential key regulator of acute gouty arthritis. Semin Arthritis Rheu. 2013;43(3):376. doi:10.1016/j.semarthrit.2013.04.007
   PubMed Web of Science ®Google Scholar
• Barbera-Cremades M, Baroja-Mazo A, Gomez AI, Machado F, Di virgilio F, Pelegrı´n P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1b release. FASEB J. 2012;26:2951–2962.
   PubMed Web of Science ®Google Scholar
• Iyer SS, Pulskens WP, Sadler JJ, et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A. 2009;106(48):20388–20393. doi:10.1073/pnas.0908698106
   PubMed Web of Science ®Google Scholar
• Jacob F, Perez Novo C, Bachert C, Van Crombruggen K. Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal. 2013;9(3):285e306.
   Web of Science ®Google Scholar
• Riteau N, Baron L, Villeret B, et al. ATP release and purinergic signaling: a common pathway for particIe—mediated inflammasome activation. Cell Death Dis. 2012;3(10):e403. doi:10.1038/cddis.2012.114
   PubMed Web of Science ®Google Scholar
• Hechler B, Gachet C. Purinergic receptors in thrombosis and inflammation. Arterioscler Thromb VascBiol. 2015;35:2307–2315.
   PubMed Web of Science ®Google Scholar
• Morandini AC, Savio LE, Coutinho-Silva R. The role of P2X7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases. Biomed J. 2014;37(4):169–177.
   PubMedGoogle Scholar
• Hoffmeister C, Trevisan G, Rossato MF, de Oliveira SM, Gomez MV, Ferreira J. Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats. Pain. 2011;152(8):1777–1788.
   PubMed Web of Science ®Google Scholar
• Coderre TJ, Wall PD. Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund’s adjuvant. Pain. 1987;28(3):379–393.
   PubMed Web of Science ®Google Scholar
• Dai XJ, Tao JH, Xuan F, et al. Changes of Treg/Th17 Ratio in Spleen of Acute Gouty Arthritis Rat Induced by MSU Crystals. Inflammation. 2018;41(5):1–10.
   PubMed Web of Science ®Google Scholar
• Park JS, Oh Y, Park O, et al. PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells. J Controlled Release. 2017;1:731.
   Google Scholar
• Hartmann P, Szabó A, Eros G, et al. Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats. Eur J Pharmacol. 2009;622(1–3):58.
   PubMed Web of Science ®Google Scholar
• Rouault T, Caldwell DS, Holmes EW. Aspiration of the asymptomatic metatarsophalangeal joint in gout patients and hyperuricemic controls. Arthritis Rheum. 1982;25(2):209–212.
   PubMed Web of Science ®Google Scholar
• Gombault A, Baron L, Couillin I. ATP release and purinergic signaling in NLRP3 inflammasome activation. Front Immunol. 2013;3:414.
   PubMed Web of Science ®Google Scholar
• Lee H, Lim Y. Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated withNLRP3 inflammasome in alloxan-induced diabetic mice. Nutr Res Pract. 2019;13(5):377–383.
   PubMed Web of Science ®Google Scholar
• Rajamäki K, Lappalainen J, Oörni K, et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One. 2010;5(7):e11765.
   PubMed Web of Science ®Google Scholar
• Lenertz LY, Gavala ML, Zhu Y, et al. Transcriptional Control Mechanisms Associated with the Nucleotide Receptor P2X7, a Critical Regulator of Immunologic, Osteogenic and Neurologic Functions. Immunol Res. 2011;50(1):22–38. doi:10.1007/s12026-011-8203-4
   PubMed Web of Science ®Google Scholar
• Ferrari D, Pizzirani C, Adinolfi E, et al. The P2X7 receptor: a key player in IL-1 processing and release. J Immunol. 2006;176:3877–3883.
   PubMed Web of Science ®Google Scholar
• Aga M, Johnson CJ, Hart AP, et al. Modulation of monocyte signaling and pore formation in response to agonists of the nucleotide receptor P2X(7). J Geophysical Res Space Phys. 2002;93(A11):12893–12900.
   Google Scholar
• Gicquel T, Robert S, Loyer P, et al. IL-1β production is dependent of the activation of purinergic receptors and NLRP3 pathway in human macrophages. FASEB J. 2015;29:4162–4173.
   PubMed Web of Science ®Google Scholar
• Schett AG, Dayer JM, Manger B, et al. Mechanisms of inflammation in gout. Rheumatology. 2015;12(2):1090–1096.
   Google Scholar
• Yue N, Huang H, Zhu X, et al. Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. Neuroinflammation. 2017;14(1):102. doi:10.1186/s12974-017-0865-y
   PubMed Web of Science ®Google Scholar
• Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010;40(7):1830–1835.
   PubMed Web of Science ®Google Scholar
• Scanu A, Oliviero F, Ramonda R, Frallonardo P, Dayer JM, Punzi L. Cytokine levels in human synovial fluid during the different stages of acute gout: role of transforming growth factor β1 in the resolution phase. Ann Rheum Dis. 2012;71(4):621–624.
   PubMed Web of Science ®Google Scholar
• Schenk U, Frascoli M, Proietti M, et al. ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors. Sci Signal. 2011;4(162):ra12.
   PubMed Web of Science ®Google Scholar
• Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediatesimmune suppression. J Exp Med. 2007;204:1257–1265.
   PubMed Web of Science ®Google Scholar
• Trautmann A. Extracellular ATP in the immune system: more than just a ”danger signal”. Sci Signal. 2009;2(56):pe6.
   PubMed Web of Science ®Google Scholar
• Piconese S, Gri G, Tripodo C, et al. Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40 /OX40L axis toward Th17-cell differentiation. Blood. 2009;114:2639–2648.
   PubMed Web of Science ®Google Scholar