111
Views
13
CrossRef citations to date
0
Altmetric
Original Research

Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH

, , , , , , , & show all
Pages 141-150 | Published online: 20 Dec 2012

References

  • Neuschwander-TetriBAClarkJMBassNMNASH Clinical Research NetworkClinical, laboratory and histological associations in adults with nonalcoholic fatty liver diseaseHepatology201052391392420648476
  • DanielSBen-MenachemTVasudevanGMaCKBlumenkehlMProspective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patientsAm J Gastroenterol199994103010301410520861
  • ClarkJMBrancatiFLDiehlAMNonalcoholic fatty liver diseaseGastroenterology200212261649165712016429
  • SorbiDMcGillDBThistleJLTherneauTMHenryJLindorKDAn assessment of the role of liver biopsies in asymptomatic patients with chronic liver test abnormalitiesAm J Gastroenterol200095113206321011095343
  • ByronDMinukGYClinical hepatology: profile of an urban, hospital-based practiceHepatology19962448138158855181
  • Neuschwander-TetriBACaldwellSHNonalcoholic steatohepatitis: summary of an AASLD Single Topic ConferenceHepatology20033751202121912717402
  • Almeda-ValdésPCuevas-RamosDAguilar-SalinasCAMetabolic syndrome and non-alcoholic fatty liver diseaseAnn Hepatol20098Suppl 1S18S2419381120
  • ClarkJMThe epidemiology of nonalcoholic fatty liver disease in adultsJ Clin Gastroenterol200640Suppl 1S5S1016540768
  • SanyalAJCampbell-SargentCMirshahiFNonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalitiesGastroenterology200112051183119211266382
  • MarchesiniGBriziMBianchiGNonalcoholic fatty liver disease: a feature of the metabolic syndromeDiabetes20015081844185011473047
  • MeroAMiikkulainenHRiskiJPakkanenRAaltoJTakalaTEffects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during trainingJ Appl Physiol1997834114411519338422
  • SéverinSWenshuiXMilk biologically active components as nutraceuticals: reviewCrit Rev Food Sci Nutr2005457–864565616371332
  • StruffWGSprotteGBovine colostrum as a biologic in clinical medicine: a review – Part II: clinical studiesInt J Clin Pharmacol Ther200846521122518538107
  • StruffWGSprotteGBovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatmentInt J Clin Pharmacol Ther200745419320217474538
  • LoimarantaVTenovuoJVirtanenSGeneration of bovine immune colostrum against Streptococcus mutans and Streptococcus sobrinus and its effect on glucose uptake and extracellular polysaccharide formation by mutans streptococciVaccine19971511126112689286054
  • LoimarantaVNuutilaJMarnilaPTenovuoJKorhonenHLiliusEMColostral proteins from cows immunised with Streptococcus mutans/S. sobrinus support the phagocytosis and killing of mutans streptococci by human leucocytesJ Med Microbiol1999481091792610510968
  • HowardANMarksJHypocholesterolaemic effect of milkLancet19772803125525669869
  • MalinowMRMcLaughlinPThe effect of skim milk on plasma cholesterol in ratsExperientia1975319101210131175732
  • GolayAFerraraJMFelberJPSchneiderHCholesterol-lowering effect of skim milk from immunized cows in hypercholesterolemic patientsAm J Clin Nutr1990526101410192239776
  • WinerSChanYPaltserGNormalization of obesity-associated insulin resistance through immunotherapyNat Med200915892192919633657
  • FeuererMHerreroLCipollettaDLean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersNat Med200915893093919633656
  • AdarTBen Ya’acovALalazarGOral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cellsClin Exp Immunol2012167225226022236001
  • DeFronzoRAStonehouseAHHanJWintleMERelationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trialsDiabet Med201027330931720536494
  • IlanYMaronRTukpahAMInduction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob miceProc Natl Acad Sci U S A2010107219765977020445103
  • KjemsLLHolstJJVølundAMadsbadSThe influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjectsDiabetes200352238038612540611
  • NevilleMCAnatomy and physiology of lactationPediatr Clin North Am2001481133411236721
  • BuescherESMcWilliams-KoeppenPSoluble tumor necrosis factor-alpha (TNF-alpha) receptors in human colostrum and milk bind to TNF-alpha and neutralize TNF-alpha bioactivityPediatr Res199844137429667368
  • GarofaloRPGoldmanASCytokines, chemokines, and colony-stimulating factors in human milk: the 1997 updateBiol Neonate19987421341429691155
  • DohmGLEltonCWRajuMSIGF-I – stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDMDiabetes1990399102810322166697
  • NathanDMBuseJBDavidsonMBAmerican Diabetes Association; European Association for Study of DiabetesMedical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of DiabetesDiabetes Care200932119320318945920
  • KorhonenHMarnilaPGillHSMilk immunoglobulins and complement factorsBr J Nutr200084Suppl 1S75S8011242450
  • HammarströmLWeinerCKTargeted antibodies in dairy-based productsAdv Exp Med Biol200860632134318183936
  • HilpertHBrüssowHMietensCSidotiJLernerLWerchauHUse of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infantsJ Infect Dis198715611581663110303
  • MieleLValenzaVLa TorreGIncreased intestinal permeability and tight junction alterations in nonalcoholic fatty liver diseaseHepatology20094961877188719291785
  • LiraFSRosaJCPimentelGDEndotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjectsLipids Health Dis201098220684772
  • EwaschukJEndersbyRThielDProbiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsisHepatology200746384185017659579
  • HotamisligilGSInflammation and metabolic disordersNature2006444712186086717167474
  • IlanYZigmondELalazarGOral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cellsJ Clin Immunol201030116717719756989