Neutrophil Ratio of White Blood Cells as a Prognostic Predictor of Clostridioides difficile Infection

References

• Hung YP, Tsai CS, Tsai BY, et al. Clostridioides difficile infection in patients with hematological malignancy: a multicenter study in Taiwan. J Microbiol Immunol Infect. 2021;54:1101–1110.
   PubMedGoogle Scholar
• Lai YH, Tsai BY, Hsu CY, et al. The role of toll-like receptor-2 in Clostridioides difficile infection: evidence from a mouse model and clinical patients. Front Immunol. 2021;12:691039.
   PubMed Web of Science ®Google Scholar
• Blumenreich MS. The white blood cell and differential count. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. Boston; 1990.
   Google Scholar
• Bauer MP, Hensgens MP, Miller MA, et al. Renal failure and leukocytosis are predictors of a complicated course of Clostridium difficile infection if measured on day of diagnosis. Clin Infect Dis. 2012;55(Suppl 2):S149–53.
   PubMed Web of Science ®Google Scholar
• Reigadas E, Alcala L, Marin M, Martin A, Bouza E. Clinical, immunological and microbiological predictors of poor outcome in Clostridium difficile infection. Diagn Microbiol Infect Dis. 2017;88:330–334.
   PubMed Web of Science ®Google Scholar
• McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66:987–994.
   PubMed Web of Science ®Google Scholar
• Tahir N, Zahra F. Neutrophilia. Treasure Island (FL): StatPearls; 2021.
   Google Scholar
• Jose S, Madan R. Neutrophil-mediated inflammation in the pathogenesis of Clostridium difficile infections. Anaerobe. 2016;41:85–90.
   PubMed Web of Science ®Google Scholar
• Haddad FG, Zaidan J, Polavarapu A, et al. An insight into Clostridium difficile infection: a single-center retrospective case-control study. Z Gastroenterol. 2019;57:1183–1195.
   PubMed Web of Science ®Google Scholar
• Tieu JD, Schmidt SA, Miller JL, et al. Clostridium difficile treatment in neutropenic patients: clinical outcomes of metronidazole, vancomycin, combinations, and switch therapy. J Oncol Pharm Pract. 2019;25:520–528.
   PubMed Web of Science ®Google Scholar
• Kulaylat AS, Buonomo EL, Scully KW, et al. Development and validation of a prediction model for mortality and adverse outcomes among patients with peripheral eosinopenia on admission for Clostridium difficile infection. JAMA Surg. 2018;153:1127–1133.
   PubMed Web of Science ®Google Scholar
• Loo VG, Bourgault AM, Poirier L, et al. Host and pathogen factors for Clostridium difficile infection and colonization. N Engl J Med. 2011;365:1693–1703.
   PubMed Web of Science ®Google Scholar
• Lee CC, Lee JC, Chiu CW, Tsai PJ, Ko WC, Hung YP. Clinical significance of toxigenic Clostridioides difficile growth in stool cultures during the era of nonculture methods for the diagnosis of C. difficile infection. Microbiol Spectr. 2021;1:e0079921.
   Google Scholar
• Hung YP, Cia CT, Tsai BY, et al. The first case of severe Clostridium difficile ribotype 027 infection in Taiwan. J Infect. 2015;70:98–101.
   PubMed Web of Science ®Google Scholar
• Levey AS, Eckardt KU, Tsukamoto Y, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: improving Global Outcomes (KDIGO). Kidney Int. 2005;67:2089–2100.
   PubMed Web of Science ®Google Scholar
• Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis. 2007;45:302–307.
   PubMed Web of Science ®Google Scholar
• McDermott AJ, Falkowski NR, McDonald RA, Pandit CR, Young VB, Huffnagle GB. Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice. Immunology. 2016;147:114–124.
   PubMed Web of Science ®Google Scholar
• Abernathy-Close L, Dieterle MG, Vendrov KC, Bergin IL, Rao K, Young VB. Aging dampens the intestinal innate immune response during severe Clostridioides difficile infection and is associated with altered cytokine levels and granulocyte mobilization. Infect Immun. 2020;88:e00960–19.
   PubMed Web of Science ®Google Scholar
• McDermott AJ, Frank CR, Falkowski NR, McDonald RA, Young VB, Huffnagle GB. Role of GM-CSF in the inflammatory cytokine network that regulates neutrophil influx into the colonic mucosa during Clostridium difficile infection in mice. Gut Microbes. 2014;5:476–484.
   PubMed Web of Science ®Google Scholar
• Donlan A, Petri WA. The inflammasome and type-2 immunity in Clostridium difficile infection. Clin Colon Rectal Surg. 2020;33:67–72.
   PubMed Web of Science ®Google Scholar
• Carlson TJ, Endres BT, Le Pham J, et al. Eosinopenia and binary toxin increase mortality in hospitalized patients with Clostridioides difficile infection. Open Forum Infect Dis. 2020;7:ofz552.
   PubMed Web of Science ®Google Scholar
• Kelly CP, LaMont JT. Clostridium difficile–more difficult than ever. N Engl J Med. 2008;359:1932–1940.
   PubMed Web of Science ®Google Scholar
• Verdoorn BP, Orenstein R, Rosenblatt JE, et al. High prevalence of tcdC deletion-carrying Clostridium difficile and lack of association with disease severity. Diagn Microbiol Infect Dis. 2010;66:24–28.
   PubMed Web of Science ®Google Scholar
• Hung YP, Tsai PJ, Lee YT, et al. Nationwide surveillance of ribotypes and antimicrobial susceptibilities of toxigenic Clostridium difficile isolates with an emphasis on reduced doxycycline and tigecycline susceptibilities among ribotype 078 lineage isolates in Taiwan. Infect Drug Resist. 2018;11:1197–1203.
   PubMed Web of Science ®Google Scholar
• Tschudin-Sutter S, Braissant O, Erb S, et al. Growth patterns of Clostridium difficile - correlations with strains, binary toxin and disease severity: a prospective cohort study. PLoS One. 2016;11:e0161711.
   PubMed Web of Science ®Google Scholar
• Martin JSH, Eyre DW, Fawley WN, et al. Patient and strain characteristics associated with Clostridium difficile transmission and adverse outcomes. Clin Infect Dis. 2018;67:1379–1387.
   PubMed Web of Science ®Google Scholar