Oxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging?

References

• Davalli P, Mitic T, Caporali A, Lauriola A, D’Arca D. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev. 2016;2016:1–18. doi:10.1155/2016/3565127
   Web of Science ®Google Scholar
• El Assar M, Angulo J, Rodríguez-Mañas L. Oxidative stress and vascular inflammation in aging. Free Radic Biol Med. 2013;65:380–401. doi:10.1016/j.freeradbiomed.2013.07.003
   PubMed Web of Science ®Google Scholar
• Guo Z, Wang G, Wu B, et al. DCAF1 regulates Treg senescence via the ROS axis during immunological aging. J Clin Invest. 2020;130(11):5893–5908. doi:10.1172/JCI136466
   PubMed Web of Science ®Google Scholar
• Annesley SJ, Fisher PR. Mitochondria in Health and Disease. Cells. 2019;8(7):680. doi:10.3390/cells8070680
   PubMed Web of Science ®Google Scholar
• Cordani M, Donadelli M, Strippoli R, Bazhin AV, Sánchez-álvarez M. Interplay between ROS and Autophagy in Cancer and Aging: from Molecular Mechanisms to Novel Therapeutic Approaches. Oxid Med Cell Longev. 2019;2019:1–3. doi:10.1155/2019/8794612
   Web of Science ®Google Scholar
• Kudryavtseva AV, Krasnov GS, Dmitriev AA, et al. Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget. 2016;7(29):44879–44905. doi:10.18632/oncotarget.9821
   PubMedGoogle Scholar
• Baranov S, Baranova E. Aging and Ambiguous ROS. System Genetics Analysis. Curr Aging Sci. 2017;10(1):6–11. doi:10.2174/1874609809666160921114504
   PubMedGoogle Scholar
• Gella A, Durany N. Oxidative stress in Alzheimer disease. Cell Adh Migr. 2009;3(1):88–93. doi:10.4161/cam.3.1.7402
   PubMed Web of Science ®Google Scholar
• Ahmad S, Khan MS, Akhter F, et al. Glycoxidation of biological macromolecules: a critical approach to halt the menace of glycation. Glycobiology. 2014;24(11):979–990. doi:10.1093/glycob/cwu057
   PubMed Web of Science ®Google Scholar
• Yang K, Wang XQ, He YS, et al. Advanced glycation end products induce chemokine/cytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow mesenchymal stem cells. Cardiovasc Diabetol. 2010;9(1):66. doi:10.1186/1475-2840-9-66
   PubMed Web of Science ®Google Scholar
• Moldogazieva NT, Mokhosoev IM, Melnikova TI, Porozov YB, Terentiev AA. Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases. Oxid Med Cell Longev. 2019;2019:1–14. doi:10.1155/2019/3085756
   Web of Science ®Google Scholar
• Yuan T, Yang T, Chen H, et al. New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. Redox Biol. 2019;20:247–260. doi:10.1016/j.redox.2018.09.025
   PubMed Web of Science ®Google Scholar
• Shen C-Y, Lu C-H, Wu C-H, et al. The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases. Molecules. 2020;25(23):5591. doi:10.3390/molecules25235591
   PubMed Web of Science ®Google Scholar
• Yamagishi S, Matsui T, Ishibashi Y, et al. Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System. Curr Pharm Des. 2017;23(8):1135–1141. doi:10.2174/1381612822666161021155502
   PubMed Web of Science ®Google Scholar
• Omolaoye TS, du Plessis SS. Male infertility: a proximate look at the advanced glycation end products. Reprod Toxicol. 2020;93:169–177. doi:10.1016/j.reprotox.2020.02.002
   PubMed Web of Science ®Google Scholar
• Saeed M, Kausar MA, Singh R, Siddiqui AJ, Akhter A. The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders. Curr Protein Pept Sci. 2020;21(9):846–859. doi:10.2174/1389203721666200505101734
   PubMed Web of Science ®Google Scholar
• Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian J Endocrinol Metab. 2016;20(4):546. doi:10.4103/2230-8210.183480
   PubMedGoogle Scholar
• Chen J, Tan W. Platelet activation and immune response in diabetic microangiopathy. Clin Chim Acta. 2020;507:242–247. doi:10.1016/j.cca.2020.04.042
   PubMed Web of Science ®Google Scholar
• Madonna R, Balistreri CR, Geng Y-J, De Caterina R. Diabetic microangiopathy: pathogenetic insights and novel therapeutic approaches. Vascul Pharmacol. 2017;90:1–7. doi:10.1016/j.vph.2017.01.004
   PubMed Web of Science ®Google Scholar
• Nedić O, Rattan SIS, Grune T, Trougakos IP. Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology. Free Radic Res. 2013;47(sup1):28–38. doi:10.3109/10715762.2013.806798
   PubMed Web of Science ®Google Scholar
• Filošević Vujnović A, Jović K, Pištan E, Andretić Waldowski R. Influence of Dopamine on Fluorescent Advanced Glycation End Products Formation Using Drosophila melanogaster. Biomolecules. 2021;11(3):453. doi:10.3390/biom11030453
   PubMed Web of Science ®Google Scholar
• Desai KM, Chang T, Wang H, et al. Oxidative stress and aging: is methylglyoxal the hidden enemy?This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease. Can J Physiol Pharmacol. 2010;88(3):273–284. doi:10.1139/Y10-001
   PubMed Web of Science ®Google Scholar
• Bejarano E, Taylor A. Too sweet: problems of protein glycation in the eye. Exp Eye Res. 2019;178:255–262. doi:10.1016/j.exer.2018.08.017
   PubMed Web of Science ®Google Scholar
• Zhang C-Z, Cheng X-Q, Li J-Y, et al. Saliva in the diagnosis of diseases. Int J Oral Sci. 2016;8(3):133–137. doi:10.1038/ijos.2016.38
   PubMed Web of Science ®Google Scholar
• Maciejczyk M, Bielas M, Zalewska A, Gerreth K. Salivary Biomarkers of Oxidative Stress and Inflammation in Stroke Patients: from Basic Research to Clinical Practice. Oxid Med Cell Longev. 2021;2021:5545330. doi:10.1155/2021/5545330
   PubMed Web of Science ®Google Scholar
• Pereira JAM, Porto-Figueira P, Taware R, Sukul P, Rapole S, Câmara JS. Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review. Molecules. 2020;25(13):3098. doi:10.3390/molecules25133098
   PubMed Web of Science ®Google Scholar
• Carpenter GH. The Secretion, Components, and Properties of Saliva. Annu Rev Food Sci Technol. 2013;4(1):267–276. doi:10.1146/annurev-food-030212-182700
   PubMed Web of Science ®Google Scholar
• Porcheri C, Mitsiadis TA. Physiology, Pathology and Regeneration of Salivary Glands. Cells. 2019;8(9):976. doi:10.3390/cells8090976
   PubMed Web of Science ®Google Scholar
• Proctor GB. The physiology of salivary secretion. Periodontol. 2016;70(1):11–25. doi:10.1111/prd.12116
   Web of Science ®Google Scholar
• Matczuk J, Żendzian-piotrowska M, Maciejczyk M, Kurek K. Salivary lipids: a review. Adv Clin Exp Med. 2017;26(6):1023–1031. doi:10.17219/acem/63030
   Web of Science ®Google Scholar
• Kaneko C, Kobayashi T, Ito S, et al. Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: a pilot case-control study. PLoS One. 2018;13(2):e0192365–e0192365. doi:10.1371/journal.pone.0192365
   PubMed Web of Science ®Google Scholar
• Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DTW. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013;26(4):781–791. doi:10.1128/CMR.00021-13
   PubMed Web of Science ®Google Scholar
• Malathi N, Mythili S, Vasanthi HR. Salivary Diagnostics: a Brief Review. ISRN Dent. 2014;2014:1–8. doi:10.1155/2014/158786
   Google Scholar
• Pfaffe T, Cooper-White J, Beyerlein P, Kostner K, Punyadeera C. Diagnostic potential of saliva: current state and future applications. Clin Chem. 2011;57(5):675–687. doi:10.1373/clinchem.2010.153767
   PubMed Web of Science ®Google Scholar
• Pesce MA, Spitalnik SL. Saliva and the Clinical Pathology Laboratory. Ann N Y Acad Sci. 2007;1098(1):192–199. doi:10.1196/annals.1384.032
   PubMed Web of Science ®Google Scholar
• Maciejczyk M, Zalewska A, Ładny JR. Salivary Antioxidant Barrier, Redox Status, and Oxidative Damage to Proteins and Lipids in Healthy Children, Adults, and the Elderly. Oxid Med Cell Longev. 2019;2019:1–12. doi:10.1155/2019/4393460
   Web of Science ®Google Scholar
• Choromańska M, Klimiuk A, Kostecka-Sochoń P, et al. Antioxidant defence, oxidative stress and oxidative damage in saliva, plasma and erythrocytes of dementia patients. Can salivary AGE be a marker of dementia? Int J Mol Sci. 2017;18(10):873w4. doi:10.3390/ijms18102205
   Web of Science ®Google Scholar
• Zalewska A, Klimiuk A, Zięba S, et al. Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer’s disease. Sci Rep. 2021;11(1):23904. doi:10.1038/s41598-021-03456-9
   PubMed Web of Science ®Google Scholar
• Klimiuk A, Zalewska A, Knapp M, Sawicki R, Ładny JR, Maciejczyk M. Salivary gland dysfunction in patients with chronic heart failure is aggravated by nitrosative stress, as well as oxidation and glycation of proteins. Biomolecules. 2021;11(1):1–27. doi:10.3390/biom11010119
   Web of Science ®Google Scholar
• Maciejczyk M, Mil KM, Gerreth P, Hojan K, Zalewska A, Gerreth K. Salivary cytokine profile in patients with ischemic stroke. Sci Rep. 2021;11(1):17185. doi:10.1038/s41598-021-96739-0
   PubMed Web of Science ®Google Scholar
• Morawska K, Maciejczyk M, Zięba S, et al. Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients. Mediators Inflamm. 2021;2021:3192409. doi:10.1155/2021/3192409
   PubMed Web of Science ®Google Scholar
• World Health Organization. Surveys: Basic Methods - World Health Organization. World Health Organization; 2017.
   Google Scholar
• Choromańska B, Myśliwiec P, Kozłowski T, et al. Antioxidant Barrier and Oxidative Damage to Proteins, Lipids, and DNA/RNA in Adrenal Tumor Patients. Oxid Med Cell Longev. 2021;2021:5543531. doi:10.1155/2021/5543531
   PubMed Web of Science ®Google Scholar
• Walker JM. The Bicinchoninic Acid (BCA) Assay for Protein Quantitation. In: Basic Protein and Peptide Protocols. Vol. 32. New Jersey: Humana Press;1994:5–8. doi:10.1385/0-89603-268-X:5
   Google Scholar
• Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70–77. doi:10.1016/0003-9861(59)90090-6
   PubMed Web of Science ®Google Scholar
• Reznick AZ, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 1994;233(C):357–363. doi:10.1016/S0076-6879(94)33041-7
   PubMed Web of Science ®Google Scholar
• Cabello-Verrugio C, Simon F, Trollet C, Santibañez JF. Oxidative Stress in Disease and Aging: mechanisms and Therapies 2016. Oxid Med Cell Longev. 2017;2017:1–2. doi:10.1155/2017/4310469
   Web of Science ®Google Scholar
• Monnier VM, Taniguchi N. Advanced glycation in diabetes, aging and age-related diseases: conclusions. Glycoconj J. 2016;33(4):691–692. doi:10.1007/s10719-016-9711-1
   PubMed Web of Science ®Google Scholar
• Suji G, Sivakami S. Glucose, glycation and aging. Biogerontology. 2004;5(6):365–373. doi:10.1007/s10522-004-3189-0
   PubMed Web of Science ®Google Scholar
• Nicolas C, Jaisson S, Gorisse L, et al. Carbamylation and glycation compete for collagen molecular aging in vivo. Sci Rep. 2019;9(1):18291. doi:10.1038/s41598-019-54817-4
   PubMed Web of Science ®Google Scholar
• Gorisse L, Pietrement C, Vuiblet V, et al. Protein carbamylation is a hallmark of aging. Proc Natl Acad Sci. 2016;113(5):1191–1196. doi:10.1073/pnas.1517096113
   PubMed Web of Science ®Google Scholar
• Bedard K, Krause K-H. The NOX Family of ROS-Generating NADPH Oxidases: physiology and Pathophysiology. Physiol Rev. 2007;87(1):245–313. doi:10.1152/physrev.00044.2005
   PubMed Web of Science ®Google Scholar
• Simpson DSA, Oliver PL. ROS Generation in Microglia: understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. Antioxidants. 2020;9(8):743. doi:10.3390/antiox9080743
   Web of Science ®Google Scholar
• Wu Y, Chen M, Jiang J. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion. 2019;49:35–45. doi:10.1016/j.mito.2019.07.003
   PubMed Web of Science ®Google Scholar
• Singh A, Kukreti R, Saso L, Kukreti S. Oxidative Stress: a Key Modulator in Neurodegenerative Diseases. Molecules. 2019;24(8):1583. doi:10.3390/molecules24081583
   PubMed Web of Science ®Google Scholar
• Dąbrowska Z, Bijowski K, Dąbrowska E, Pietruska M. Effect of oxidants and antioxidants on oral health. Med Ogólna i Nauk o Zdrowiu. 2020;26(2):87–93. doi:10.26444/monz/122255
   Google Scholar
• Battino M, Ferreiro MS, Gallardo I, Newman HN, Bullon P. The antioxidant capacity of saliva. J Clin Periodontol. 2002;29(3):189–194. doi:10.1034/j.1600-051X.2002.290301x.x
   PubMed Web of Science ®Google Scholar
• Eichler J. Protein glycosylation. Curr Biol. 2019;29(7):R229–R231. doi:10.1016/j.cub.2019.01.003
   PubMed Web of Science ®Google Scholar
• Zińczuk J, Zaręba K, Kamińska J, et al. Association of Tumour Microenvironment with Protein Glycooxidation, DNA Damage, and Nitrosative Stress in Colorectal Cancer. Cancer Manag Res. 2021;13:6329–6348. doi:10.2147/CMAR.S314940
   PubMedGoogle Scholar
• Klimiuk A, Maciejczyk M, Choromańska M, Fejfer K, Waszkiewicz N, Zalewska A. Salivary Redox Biomarkers in Different Stages of Dementia Severity. J Clin Med. 2019;8(6). doi:10.3390/jcm8060840
   PubMed Web of Science ®Google Scholar
• Walton EL. Saliva biomarkers in neurological disorders: a “spitting image” of brain health? Biomed J. 2018;41(2):59–62. doi:10.1016/j.bj.2018.04.005
   PubMed Web of Science ®Google Scholar
• Krahel A, Paszynska E, Slopien A, et al. Stress/Immune Biomarkers in Saliva among Children with ADHD Status. Int J Environ Res Public Health. 2021;18(2):769. doi:10.3390/ijerph18020769
   PubMed Web of Science ®Google Scholar
• Mehta T, Fayyaz M, Giler GE, et al. Current Trends in Biomarkers for Traumatic Brain Injury. Open Access J Neurol Neurosurg. 2020;12(4):86–94.
   PubMedGoogle Scholar
• Maciejczyk M, Zalewska A, Gerreth K. Salivary Redox Biomarkers in Selected Neurodegenerative Diseases. J Clin Med. 2020;9(2):497. doi:10.3390/jcm9020497
   PubMed Web of Science ®Google Scholar
• Risso FM, Sannia A, Gavilanes DAW, et al. Biomarkers of brain damage in preterm infants. J Matern Neonatal Med. 2012;25(sup4):93–96. doi:10.3109/14767058.2012.715024
   PubMed Web of Science ®Google Scholar
• Wormwood KL, Aslebagh R, Channaveerappa D, et al. Salivary proteomics and biomarkers in neurology and psychiatry. Clin Appl. 2015;9(9–10):899–906. doi:10.1002/prca.201400153
   PubMed Web of Science ®Google Scholar
• François M, Bull CF, Fenech MF, Leifert WR. Current State of Saliva Biomarkers for Aging and Alzheimer’s Disease. Curr Alzheimer Res. 2018;16(1):56–66. doi:10.2174/1567205015666181022094924
   Web of Science ®Google Scholar
• Fan AP, An H, Moradi F, et al. Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: a technical review in the era of PET/MRI. Neuroimage. 2020;220:117136. doi:10.1016/j.neuroimage.2020.117136
   PubMed Web of Science ®Google Scholar
• Falkowska A, Gutowska I, Goschorska M, Nowacki P, Chlubek D, Baranowska-Bosiacka I. Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism. Int J Mol Sci. 2015;16(11):25959–25981. doi:10.3390/ijms161125939
   PubMed Web of Science ®Google Scholar
• Maciejczyk M, Żebrowska E, Chabowski A. Insulin resistance and oxidative stress in the brain: what’s new? Int J Mol Sci. 2019;20(4):634. doi:10.3390/ijms20040874
   PubMed Web of Science ®Google Scholar
• Castellani R, Smith MA, Richey GL, Perry G. Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res. 1996;737(1–2):195–200. doi:10.1016/0006-8993(96
   PubMed Web of Science ®Google Scholar
• Facheris M, Beretta S, Ferrarese C. Peripheral markers of oxidative stress and excitotoxicity in neurodegenerative disorders: tools for diagnosis and therapy? Polidori MC. J Alzheimer’s Dis. 2004;6(2):177–184. doi:10.3233/JAD-2004-6210
   PubMed Web of Science ®Google Scholar
• Sayre L, Smith M, Perry G. Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease. Curr Med Chem. 2001;8(7):721–738. doi:10.2174/0929867013372922
   PubMed Web of Science ®Google Scholar
• Pukhalskaia AE, Dyatlova AS, Linkova NS, et al. Sirtuins as Possible Predictors of Aging and Alzheimer’s Disease Development: verification in the Hippocampus and Saliva. Bull Exp Biol Med. 2020;169(6):821–824. doi:10.1007/s10517-020-04986-4
   PubMed Web of Science ®Google Scholar
• Jaisson S, Pietrement C, Gillery P. Protein Carbamylation: chemistry, Pathophysiological Involvement, and Biomarkers. Advances in Clinical Chemistry. 2018;84:1–38. doi:10.1016/bs.acc.2017.12.001
   PubMed Web of Science ®Google Scholar
• Delanghe S, Delanghe JR, Speeckaert R, Van Biesen W, Speeckaert MM. Mechanisms and consequences of carbamoylation. Nat Rev Nephrol. 2017;13(9):580–593. doi:10.1038/nrneph.2017.103
   PubMed Web of Science ®Google Scholar
• Qiu G-H, Zheng X, Fu M, Huang C, Yang X. The protective function of non-coding DNA in DNA damage accumulation with age and its roles in age-related diseases. Biogerontology. 2019;20(6):741–761. doi:10.1007/s10522-019-09832-3
   PubMed Web of Science ®Google Scholar
• Babbar M, Basu S, Yang B, Croteau DL, Bohr VA. Mitophagy and DNA damage signaling in human aging. Mech Ageing Dev. 2020;186:111207. doi:10.1016/j.mad.2020.111207
   PubMed Web of Science ®Google Scholar
• Agathangelou K, Apostolou Z, Garinis GA. Nuclear DNA Damage and Ageing. In:. 2018;309–322. doi:10.1007/978-981-13-2835-0_10
   PubMedGoogle Scholar
• da Silva PFL, Schumacher B. DNA damage responses in ageing. Open Biol. 2019;9(11):190168. doi:10.1098/rsob.190168
   PubMed Web of Science ®Google Scholar
• Kowalska M, Piekut T, Prendecki M, Sodel A, Kozubski W, Dorszewska J. Mitochondrial and Nuclear DNA Oxidative Damage in Physiological and Pathological Aging. DNA Cell Biol. 2020;39(8):1410–1420. doi:10.1089/dna.2019.5347
   PubMed Web of Science ®Google Scholar
• Nissanka N, Moraes CT. Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. FEBS Lett. 2018;592(5):728–742. doi:10.1002/1873-3468.12956
   PubMed Web of Science ®Google Scholar
• Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging. Science. 2005;309(5733):481–484. doi:10.1126/science.1112125
   PubMed Web of Science ®Google Scholar
• Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev. 1998;7(1):9–16.
   PubMed Web of Science ®Google Scholar
• Han Y, Chen JZ. Oxidative Stress Induces Mitochondrial DNA Damage and Cytotoxicity through Independent Mechanisms in Human Cancer Cells. Biomed Res Int. 2013;2013:1–8. doi:10.1155/2013/825065
   Web of Science ®Google Scholar
• Zińczuk J, Maciejczyk M, Zaręba K, et al. Pro-Oxidant Enzymes, Redox Balance and Oxidative Damage to Proteins, Lipids and DNA in Colorectal Cancer Tissue. Is Oxidative Stress Dependent on Tumour Budding and Inflammatory Infiltration? Cancers. 2020;12(6):523. doi:10.3390/cancers12061636
   PubMed Web of Science ®Google Scholar
• Kaur J, Politis C, Jacobs R. Salivary 8-hydroxy-2-deoxyguanosine, malondialdehyde, vitamin C, and vitamin E in oral pre-cancer and cancer: diagnostic value and free radical mechanism of action. Clin Oral Investig. 2016;20(2):315–319. doi:10.1007/s00784-015-1506-4
   PubMed Web of Science ®Google Scholar
• Adeoye J, Brennan PA, Thomson P. “Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection. J Oral Pathol Med. 2020;49(8):711–719. doi:10.1111/jop.13003
   PubMed Web of Science ®Google Scholar
• Wagner K-H, Cameron-Smith D, Wessner B, Franzke B. Biomarkers of Aging: from Function to Molecular Biology. Nutrients. 2016;8(6):338. doi:10.3390/nu8060338
   PubMed Web of Science ®Google Scholar
• Bai X. Biomarkers of Aging. In:. 2018;217–234. doi:10.1007/978-981-13-1117-8_14
   Web of Science ®Google Scholar
• Ahmed MS, Ikram S, Bibi N, Mir A. Hutchinson–Gilford Progeria Syndrome: a Premature Aging Disease. Mol Neurobiol. 2017. doi:10.1007/s12035-017-0610-7
   Web of Science ®Google Scholar
• Foo MXR, Ong PF, Dreesen O. Premature aging syndromes: from patients to mechanism. J Dermatol Sci. 2019;96(2):58–65. doi:10.1016/j.jdermsci.2019.10.003
   PubMed Web of Science ®Google Scholar
• Schnabel F, Kornak U, Wollnik B. Premature aging disorders: a clinical and genetic compendium. Clin Genet. 2021;99(1):3–28. doi:10.1111/cge.13837
   PubMed Web of Science ®Google Scholar
• Leopold JA. Editorial commentary: premature peripheral arterial disease: a consequence of accelerated vascular aging due to less than ideal cardiovascular health? Trends Cardiovasc Med. 2021;31(6):359–360. doi:10.1016/j.tcm.2020.06.011
   PubMed Web of Science ®Google Scholar
• Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Akazawa H, Komuro I. Understanding Vascular Diseases: lessons From Premature Aging Syndromes. Can J Cardiol. 2016;32(5):650–658. doi:10.1016/j.cjca.2015.12.003
   PubMed Web of Science ®Google Scholar
• Huebschmann AG, Kohrt WM, Regensteiner JG. Exercise attenuates the premature cardiovascular aging effects of type 2 diabetes mellitus. Vasc Med. 2011;16(5):378–390. doi:10.1177/1358863X11419996
   PubMed Web of Science ®Google Scholar
• Burton DGA, Faragher RGA. Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing. Biogerontology. 2018;19(6):447–459. doi:10.1007/s10522-018-9763-7
   PubMed Web of Science ®Google Scholar
• Maciejczyk M, Heropolitanska-Pliszka E, Pietrucha B, et al. Antioxidant defense, redox homeostasis, and oxidative damage in children with ataxia telangiectasia and Nijmegen breakage syndrome. Front Immunol. 2019;10(SEP):365. doi:10.3389/fimmu.2019.02322
   PubMed Web of Science ®Google Scholar
• Pietrucha B, Heropolitanska-Pliszka E, Maciejczyk M, et al. Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome. Oxid Med Cell Longev. 2017;2017:1–8. doi:10.1155/2017/6745840
   Web of Science ®Google Scholar
• Skirbekk VF, Staudinger UM, Cohen JE. How to Measure Population Aging? The Answer Is Less than Obvious: a Review. Gerontology. 2019;65(2):136–144. doi:10.1159/000494025
   PubMed Web of Science ®Google Scholar
• Xu F, Laguna L, Sarkar A. Aging-related changes in quantity and quality of saliva: where do we stand in our understanding? J Texture Stud. 2019;50(1):27–35. doi:10.1111/jtxs.12356
   PubMed Web of Science ®Google Scholar
• Bel’skaya LV, Sarf EA, Solomatin DV. Age and Gender Characteristics of the Infrared Spectra of Normal Human Saliva. Appl Spectrosc. 2020;74(5):536–543. doi:10.1177/0003702819885958
   PubMed Web of Science ®Google Scholar
• Avezov K, Reznick AZ, Aizenbud D. Oxidative stress in the oral cavity: sources and pathological outcomes. Respir Physiol Neurobiol. 2015;209:91–94. doi:10.1016/j.resp.2014.10.007
   PubMed Web of Science ®Google Scholar
• Żukowski P, Maciejczyk M, Waszkiel D. Sources of free radicals and oxidative stress in the oral cavity. Arch Oral Biol. 2018;92:8–17. doi:10.1016/j.archoralbio.2018.04.018
   PubMed Web of Science ®Google Scholar
• Zieniewska I, Maciejczyk M, Zalewska A. The effect of selected dental materials used in conservative dentistry, endodontics, surgery, and orthodontics as well as during the periodontal treatment on the redox balance in the oral cavity. Int J Mol Sci. 2020;21(24):9684. doi:10.3390/ijms21249684
   PubMed Web of Science ®Google Scholar