P2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet

References

• Nishida K, Otsu K. Inflammation and metabolic cardiomyopathy. Cardiovasc Res. 2017;113:389–398. doi:10.1093/cvr/cvx012
   PubMed Web of Science ®Google Scholar
• Luc K, Schramm-Luc A, Guzik TJ, Mikolajczyk TP. Oxidative stress and inflammatory markers in prediabetes and diabetes. J Physiol Pharmacol. 2019;70:809–824.
   Web of Science ®Google Scholar
• Crewe C, An YA, Scherer PE. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. J Clin Invest. 2017;127:74–82. doi:10.1172/JCI88883
   PubMed Web of Science ®Google Scholar
• Singh M, Benencia F. Inflammatory processes in obesity: focus on endothelial dysfunction and the role of adipokines as inflammatory mediators. Int Rev Immunol. 2019;38:157–171. doi:10.1080/08830185.2019.1638921
   PubMed Web of Science ®Google Scholar
• Chen M, Li Y, Sun Q, et al. Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults. Am J Clin Nutr. 2016;104:1209–1217. doi:10.3945/ajcn.116.134460
   PubMed Web of Science ®Google Scholar
• Liu XM, Liu YJ, Huang Y, et al. Dietary total flavonoids intake and risk of mortality from all causes and cardiovascular disease in the general population: a systematic review and meta-analysis of cohort studies. Mol Nutr Food Res. 2017;61(6):1601003. doi:10.1002/mnfr.201601003
   Web of Science ®Google Scholar
• Gonçalves N, Silva AF, Rodrigues PG, et al. Early cardiac changes induced by a hypercaloric Western-type diet in “subclinical” obesity. Am J Physiol Heart Circ Physiol. 2016;310:H655–H666. doi:10.1152/ajpheart.00684.2015
   PubMed Web of Science ®Google Scholar
• Carbone S, Canada JM, Buckley LF, et al. Dietary fat, sugar consumption, and cardiorespiratory fitness in patients with heart failure with preserved ejection fraction. JACC Basic Transl Sci. 2017;2(1):30513–30525.
   Google Scholar
• Poret JM, Souza-Smith F, Marcell SJ, et al. Primeaux, high fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes. 2018;42:535–541. doi:10.1038/ijo.2017.280
   Web of Science ®Google Scholar
• Avtanski D, Pavlov VA, Tracey KJ, Poretsky L. Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL/6J mouse model of obesity. Animal Model Exp Med. 2019;25:252–258. doi:10.1002/ame2.12084
   Google Scholar
• Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S. The P2X7 receptor in infection and inflammation. Immunity. 2017;47:15–31. doi:10.1016/j.immuni.2017.06.020
   PubMed Web of Science ®Google Scholar
• Solini A, Menini S, Rossi C, et al. The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation. J Pathol. 2013;231:342–353. doi:10.1002/path.4237
   PubMed Web of Science ®Google Scholar
• Ward JR, West PW, Ariaans MP, et al. Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms. J Biol Chem. 2010;23:23147–23158. doi:10.1074/jbc.M109.072793
   Web of Science ®Google Scholar
• Zhang X, Fu Y, Li H, et al. H3 relaxin inhibits the collagen synthesis via ROS- and P2X7R-mediated NLRP3 inflammasome activation in cardiac fibroblasts under high glucose. J Cell Mol Med. 2018;22:1816–1825. doi:10.1111/jcmm.13464
   PubMed Web of Science ®Google Scholar
• Mezzaroma E, Toldo S, Farkas D, et al. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci USA. 2011;108:19725–19730. doi:10.1073/pnas.1108586108
   PubMed Web of Science ®Google Scholar
• Thum T, Condorelli G. Long noncoding RNAs and microRNAs in cardiovascular pathophysiology. Circ Res. 2015;116:751–762. doi:10.1161/CIRCRESAHA.116.303549
   PubMed Web of Science ®Google Scholar
• Zheng Z, Ge Y, Zhang J, et al. PUFA diets alter the microRNA expression profiles in an inflammation rat model. Mol Med Rep. 2015;11:4149–4157. doi:10.3892/mmr.2015.3318
   PubMed Web of Science ®Google Scholar
• Alehagen U, Johansson P, Aaseth J, Alexander J, Wågsäter D. Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. PLoS One. 2017;12:1–18.
   Web of Science ®Google Scholar
• Guedes EC, França GS, Lino CA, et al. MicroRNA expression signature is altered in the cardiac remodeling induced by high fat diets. J Cell Physiol. 2016;231:1771–1783. doi:10.1002/jcp.25280
   PubMed Web of Science ®Google Scholar
• Rahman OA, Sasvari-Szekely M, Szekely A, Faludi G, Guttman A, Nemoda Z. Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene. Electrophoresis. 2010;31:1790–1795. doi:10.1002/elps.200900664
   PubMed Web of Science ®Google Scholar
• Huang S, Chen Y, Wu W, et al. miR-150 promotes human breast cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7 receptor. PLoS One. 2013;8:e80707. doi:10.1371/journal.pone.0080707
   PubMed Web of Science ®Google Scholar
• Killeen ME, Ferris L, Kupetsky EA, Falo LJ, Mathers AR. Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis. J Immunol. 2013;190:4324–4336. doi:10.4049/jimmunol.1202045
   PubMed Web of Science ®Google Scholar
• Faita F, Di Lascio N, Rossi C, Kusmic C, Solini A. Ultrasonographic characterization of the db/db mouse: an animal model of metabolic abnormalities. J Diabetes Res. 2018;8:4561309.
   Google Scholar
• Hein SJ, Lehmann LH, Kossack M, et al. Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury. PLoS One. 2015;10:e0122665. doi:10.1371/journal.pone.0122665
   PubMed Web of Science ®Google Scholar
• Wadsworth MP, Sobel BE, Schneider DJ, Tra W, Hirtum HV, Taatjes DJ. Quantitative analysis of atherosclerotic lesion composition in mice. In: Cell Imaging Techniques. Humana Press; 2006:137–152.
   Google Scholar
• Solini A, Rossi C, Duranti E, Taddei S, Natali A, Virdis A. Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase. Vascul Pharmacol. 2016;76:62–71. doi:10.1016/j.vph.2015.10.002
   PubMed Web of Science ®Google Scholar
• Peltier HJ, Latham GJ. Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 2008;14:844–852. doi:10.1261/rna.939908
   PubMed Web of Science ®Google Scholar
• Ono K, Kuwabara Y, Han J. MicroRNA and cardiovascular diseases. FEBS J. 2011;278:1619–1633. doi:10.1111/j.1742-4658.2011.08090.x
   PubMed Web of Science ®Google Scholar
• Liu D, Zeng X, Li X, et al. Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators. Biochem Pharmacol. 2020;175:113863. doi:10.1016/j.bcp.2020.113863
   PubMed Web of Science ®Google Scholar
• Cheng W, Sun Y, Wu Q, et al. Paraventricular nucleus P2X7 receptors aggravate acute myocardial infarction injury via ROS-induced vasopressin-V1b activation in rats. Neurosci Bull. 2021;37:641–656. doi:10.1007/s12264-021-00641-8
   PubMed Web of Science ®Google Scholar
• Zhou J, Tian G, Quan Y, et al. Inhibition of P2X7 purinergic receptor ameliorates cardiac fibrosis by suppressing NLRP3/IL-1β pathway. Oxid Med Cell Longev. 2020;2020:7956274. doi:10.1155/2020/7956274
   PubMed Web of Science ®Google Scholar
• Zhou J, Zhou Z, Liu X, Yin HY, Tang Y, Cao X. P2X7 receptor-mediated inflammation in cardiovascular disease. Front Pharmacol. 2021;12:654425. doi:10.3389/fphar.2021.654425
   PubMed Web of Science ®Google Scholar
• Tu G, Li G, Peng H, et al. P2X(7) inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury. Brain Res Bull. 2013;96:71–85. doi:10.1016/j.brainresbull.2013.05.004
   PubMed Web of Science ®Google Scholar
• Liu J, Li G, Peng H, et al. Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor. Purinergic Signal. 2013;9:463–479. doi:10.1007/s11302-013-9367-2
   PubMed Web of Science ®Google Scholar
• Chen X, Li H, Wang K, et al. Aerobic exercise ameliorates myocardial inflammation, fibrosis and apoptosis in high-fat-diet rats by inhibiting P2X7 purinergic receptors. Front Physiol. 2019;10:1286. doi:10.3389/fphys.2019.01286
   PubMed Web of Science ®Google Scholar
• Fernández-Sada E, Torres-Quintanilla A, Silva-Platas C, et al. Proinflammatory cytokines are soluble mediators linked with ventricular arrhythmias and contractile dysfunction in a rat model of metabolic syndrome. Oxid Med Cell Longev. 2017;2017:7682569. doi:10.1155/2017/7682569
   PubMed Web of Science ®Google Scholar
• Toldo S, Mezzaroma E, Bressi E, et al. Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse. J Cardiovasc Pharmacol. 2014;64:1–6. doi:10.1097/FJC.0000000000000106
   PubMed Web of Science ®Google Scholar
• Meléndez GC, McLarty JL, Levick SP, Du Y, Janicki JS, Brower GL. Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension. 2010;56:225–231. doi:10.1161/HYPERTENSIONAHA.109.148635
   PubMed Web of Science ®Google Scholar
• Vessey DA, Li L, Kelley M. P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X7 channels. Am J Physiol Heart Circ Physiol. 2011;301:H881–H887. doi:10.1152/ajpheart.00305.2011
   PubMed Web of Science ®Google Scholar
• Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005;15:11–18. doi:10.1038/sj.cr.7290257
   PubMed Web of Science ®Google Scholar
• Liu ZF, Ji JJ, Zheng D, Su L, Peng T. Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation. J Cell Physiol. 2019;234:10761–10770. doi:10.1002/jcp.27750
   PubMed Web of Science ®Google Scholar
• Gentile D, Natale M, Lazzerini PE, Capecchi PL, Laghi-Pasini F. The role of P2X7 receptors in tissue fibrosis: a brief review. Purinergic Signal. 2015;11:435–440. doi:10.1007/s11302-015-9466-3
   PubMed Web of Science ®Google Scholar
• Gorabi AM, Kiaiem N, Sathyapalan T, Al-Rasadi K, Jamialahmadi T, Sahebkar A. The role of MicroRNAs in regulating cytokines and growth factors in coronary artery disease: the ins and outs. J Immunol Res. 2020;2020:5193036. doi:10.1155/2020/5193036
   PubMed Web of Science ®Google Scholar
• Zheng D, Zang Y, Xu H, et al. MicroRNA-214 promotes the calcification of human aortic valve interstitial cells through the acceleration of inflammatory reactions with activated MyD88/NF-κB signaling. Clin Res Cardiol. 2019;108:691–702. doi:10.1007/s00392-018-1398-9
   PubMed Web of Science ®Google Scholar
• Chen ZG, Liu H, Zhang JB, Zhang SL, Zhao LH, Liang WQ. Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection. Mol Med Rep. 2015;12:1258–1264. doi:10.3892/mmr.2015.3539
   PubMed Web of Science ®Google Scholar
• Li Y, Zhou Q, Zhe Pei C, et al. Hyperglycemia and advanced glycation end products regulate miR-126 expression in endothelial progenitor cells. J Vasc Res. 2016;53:94–104. doi:10.1159/000448713
   PubMed Web of Science ®Google Scholar
• Luo Q, Guo D, Liu G, Chen G, Hang M, Jin M. Exosomes from MiR-126-overexpressing adscs are therapeutic in relieving acute myocardial ischaemic injury. Cell Physiol Biochem. 2017;44:2105–2116. doi:10.1159/000485949
   PubMedGoogle Scholar
• Beaucage KL, Xiao A, Pollmann SI, et al. Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice. Purinergic Signal. 2014;10:291–304. doi:10.1007/s11302-013-9388-x
   PubMed Web of Science ®Google Scholar
• Rayner JJ, Banerjee R, Holloway CJ, et al. The relative contribution of metabolic and structural abnormalities to diastolic dysfunction in obesity. Int J Obes. 2018;42:441–447. doi:10.1038/ijo.2017.239
   PubMed Web of Science ®Google Scholar
• Hao X-Z, Fan H-M. Identification of miRNAs as atherosclerosis biomarkers and functional role of miR-126 in atherosclerosis progression through MAPK signalling pathway. Eur Rev Med Pharmacol Sci. 2017;21:2725–2733.
   PubMed Web of Science ®Google Scholar