Elevated TNF-α Induces Thrombophagocytosis by Mononuclear Cells in ex vivo Whole-Blood Co-Culture with Dengue Virus

References

• Billiau A, Matthys P. Interferon-gamma: a historical perspective. Cytokine Growth Factor Rev. 2009;20(2):97–113. doi:10.1016/j.cytogfr.2009.02.004
   PubMed Web of Science ®Google Scholar
• World Health Organization. Comprehensive guideline for prevention and control of dengue and dengue haemorrhagic fever; 2011.
   Google Scholar
• Vogt MB, Lahon A, Arya RP, Spencer Clinton JL, Rico-Hesse R. Dengue viruses infect human megakaryocytes, with probable clinical consequences. PLoS Negl Trop Dis. 2019;13(11):e0007837. doi:10.1371/journal.pntd.0007837
   PubMed Web of Science ®Google Scholar
• Basu A, Jain P, Gangodkar SV, Shetty S, Ghosh K. Dengue 2 virus inhibits in vitro megakaryocytic colony formation and induces apoptosis in thrombopoietin-inducible megakaryocytic differentiation from cord blood CD34+ cells. FEMS Immunol Med Microbiol. 2008;53:46–51. doi:10.1111/j.1574-695X.2008.00399.x
   PubMedGoogle Scholar
• Sridharan A, Chen Q, Tang KF, Ooi EE, Hibberd ML, Chen J. Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. J Virol. 2013;87(21):11648–11658. doi:10.1128/JVI.01156-13
   PubMed Web of Science ®Google Scholar
• Huang KJ, Lin YS, Liu HS, Yeh TM, Liu CC, Lei HY. Generation of anti-platelet autoantibody during dengue virus infection. Am J Infect Dis. 2008;4(1):50–59. doi:10.3844/ajidsp.2008.50.59
   Google Scholar
• Assinger A. Platelets and infection – an emerging role of platelets in viral infection. Front Immunol. 2014;5. doi:10.3389/fimmu.2014.00649
   PubMed Web of Science ®Google Scholar
• Mannaioni P, Di Bello M, Masini E. Platelets and inflammation: role of platelet-derived growth factor, adhesion molecules and histamine. Inflamm Res. 1997;46(1):4–18. doi:10.1007/PL00000158
   PubMed Web of Science ®Google Scholar
• Hottz ED, Medeiros-de-moraes IM, Vieira-de-abreu A, et al. Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue. J Immunol. 2014;193(4):1864–1872. doi:10.4049/jimmunol.1400091
   PubMed Web of Science ®Google Scholar
• Gawaz M, Fateh‐Moghadam S, Pilz G, Gurland HJ, Werdan K. Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure. Eur J Clin Invest. 1995;25(11):843–851. doi:10.1111/j.1365-2362.1995.tb01694.x
   PubMed Web of Science ®Google Scholar
• Dib PRB, Quirino‐Teixeira AC, Merij LB, et al. Innate immune receptors in platelets and platelet‐leukocyte interactions. J Leukoc Biol. 2020;108(4):1157–1182. doi:10.1002/JLB.4MR0620-701R
   PubMed Web of Science ®Google Scholar
• Cognasse F, Nguyen KA, Damien P, et al. The inflammatory role of platelets via their TLRs and Siglec receptors. Front Immunol. 2015;6:83. doi:10.3389/fimmu.2015.00083
   PubMed Web of Science ®Google Scholar
• Kou Z, Quinn M, Chen H, et al. Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells. J Med Virol. 2008;80(1):134–146. doi:10.1002/jmv.21051
   PubMed Web of Science ®Google Scholar
• Durbin AP, Vargas MJ, Wanionek K, et al. Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever. Virology. 2008;376(2):429–435. doi:10.1016/j.virol.2008.03.028
   PubMed Web of Science ®Google Scholar
• Alhoot MA, Wang SM, Sekaran SD. Inhibition of dengue virus entry and multiplication into monocytes using RNA interference. PLoS Negl Trop Dis. 2011;5(11):e1410. doi:10.1371/journal.pntd.0001410
   PubMed Web of Science ®Google Scholar
• Nikitina E, Larionova I, Choinzonov E, Kzhyshkowska J. Monocytes and macrophages as viral targets and reservoirs. Int J Mol Sci. 2018;19(9):2821. doi:10.3390/ijms19092821
   PubMed Web of Science ®Google Scholar
• Ong SP, Lee LM, Leong YFI, Ng ML, Chu JJH. Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells. PLoS One. 2012;7(7):e41932. doi:10.1371/journal.pone.0041932
   PubMed Web of Science ®Google Scholar
• Remy S, Gossez M, Belot A, et al. Massive increase in monocyte HLA-DR expression can be used to discriminate between septic shock and hemophagocytic lymphohistiocytosis-induced shock. Critl Care. 2018;22(1):1–2. doi:10.1186/s13054-018-2146-2
   PubMed Web of Science ®Google Scholar
• Pascarella A, Bracaglia C, Caiello I, et al. Monocytes from patients with macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis are hyperresponsive to interferon gamma. Front Immunol. 2021;12:801. doi:10.3389/fimmu.2021.663329
   Web of Science ®Google Scholar
• Ma T, Hudgins JP, Vergara‐Lluri M, Pham H, Brynes R, Shulman IA. Platelet transfusion refractoriness and thrombophagocytosis in an HIV/AIDS patient with hemophagocytic lymphohistiocytosis. Transfusion. 2020;60:2176–2177. doi:10.1111/trf.15955
   PubMed Web of Science ®Google Scholar
• Akashi K, Hayashi S, Gondo H, et al. Involvement of interferon‐γ and macrophage colony‐stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults. Br J Haematol. 1994;87(2):243–250. doi:10.1111/j.1365-2141.1994.tb04905.x
   PubMed Web of Science ®Google Scholar
• Shimizu M, Inoue N, Mizuta M, Nakagishi Y, Yachie A. Characteristic elevation of soluble TNF receptor II: i ratio in macrophage activation syndrome with systemic juvenile idiopathic arthritis. Clin Exp Immunol. 2018;191(3):349–355. doi:10.1111/cei.13026
   PubMed Web of Science ®Google Scholar
• Billiau AD, Roskams T, Van Damme-lombaerts R, Matthys P, Wouters C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6-and TNF-α-producing macrophages. Blood. 2005;105(4):1648–1651. doi:10.1182/blood-2004-08-2997
   PubMed Web of Science ®Google Scholar
• Henzan T, Nagafuji K, Tsukamoto H, et al. Success with infliximab in treating refractory hemophagocytic lymphohistiocytosis. Am J Hematol. 2006;81(1):59–61. doi:10.1002/ajh.20462
   PubMed Web of Science ®Google Scholar
• Ideguchi H, Ohno S, Takase K, et al. Successful treatment of refractory lupus-associated haemophagocytic lymphohistiocytosis with infliximab. Rheumatology. 2007;46(10):1621–1622. doi:10.1093/rheumatology/kem205
   PubMed Web of Science ®Google Scholar
• McGonagle D, Sharif K, O’Regan A, Bridgewood C. The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun Rev. 2020;19(6):102537. doi:10.1016/j.autrev.2020.102537
   PubMed Web of Science ®Google Scholar
• Satria RD, Huang T-W, Jhan M-K, et al. Increased TNF-α initiates cytoplasmic vacuolization in whole blood coculture with dengue virus. J Immunol Res. 2021;2021. doi:10.1155/2021/6654617
   Web of Science ®Google Scholar
• Nunes PR, Romão-Veiga M, Peraçoli JC, et al. Downregulation of CD163 in monocytes and its soluble form in the plasma is associated with a pro-inflammatory profile in pregnant women with preeclampsia. Immunol Res. 2019;67(2–3):194–201. doi:10.1007/s12026-019-09078-8
   PubMed Web of Science ®Google Scholar
• Masri MFB, Mantri CK, Rathore AP, John ALS. Peripheral serotonin causes dengue virus–induced thrombocytopenia through 5HT2 receptors. Blood. 2019;133:2325–2337.
   PubMed Web of Science ®Google Scholar
• Sun DS, King CC, Huang HS, et al. Antiplatelet autoantibodies elicited by dengue virus non‐structural protein 1 cause thrombocytopenia and mortality in mice. J Thromb Haemost. 2007;5(11):2291–2299. doi:10.1111/j.1538-7836.2007.02754.x
   PubMed Web of Science ®Google Scholar
• Chao C-H, Wu W-C, Lai Y-C, et al. Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLoS Pathog. 2019;15(4):e1007625. doi:10.1371/journal.ppat.1007625
   PubMed Web of Science ®Google Scholar
• Clarice CSH, Abeysuriya V, de Mel S, et al. Atypical lymphocyte count correlates with the severity of dengue infection. PLoS One. 2019;14(5):e0215061. doi:10.1371/journal.pone.0215061
   PubMed Web of Science ®Google Scholar
• Fadilah S, Sahrir S, Raymond A, Cheong S, Aziz JA, Sivagengei K. Quantitation of T lymphocyte subsets helps to distinguish dengue hemorrhagic fever from classic dengue fever during the acute febrile stage. Southeast Asian J Trop Med Public Health. 1999;30(4):710–717.
   PubMedGoogle Scholar
• Joshi AA, Muneer F. Dynamics of differential count in dengue; 2018.
   Google Scholar
• Ho T-S, Wang S-M, Lin Y-S, Liu -C-C. Clinical and laboratory predictive markers for acute dengue infection. J Biomed Sci. 2013;20(1):1–8. doi:10.1186/1423-0127-20-75
   PubMed Web of Science ®Google Scholar
• Achalkar GV. Dengue: a clinico-pathological study of 50 cases. J Evol Med Dent Sci. 2013;2(48):9380–9386. doi:10.14260/jemds/1626
   Google Scholar
• Patel K, Patel D, Das V. Hematological parameters and its utility in dengue fever: a prospective study. Int J Sci Res. 2016;5:1077–1079.
   Google Scholar
• Azeredo ELD, Monteiro RQ, De-oliveira Pinto LM. Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators. Mediators Inflamm. 2015;2015:1–16. doi:10.1155/2015/313842
   Web of Science ®Google Scholar
• Giang HTN, Banno K, Minh LHN, et al. Dengue hemophagocytic syndrome: a systematic review and meta‐analysis on epidemiology, clinical signs, outcomes, and risk factors. Rev Med Virol. 2018;28(6):e2005. doi:10.1002/rmv.2005
   PubMed Web of Science ®Google Scholar
• Srichaikul T, Punyagupta S, Kanchanapoom T, Chanokovat C, Likittanasombat K, Leelasiri A. Hemophagocytic syndrome in Dengue hemorrhagic fever with severe multiorgan complications. J Med Assoc Thai. 2008;91(1):104–109.
   PubMedGoogle Scholar
• Lu P-L, Hsiao -H-H, Tsai -J-J, et al. Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. Kaohsiung J Med Sci. 2005;21(1):34–39. doi:10.1016/S1607-551X(09)70274-8
   PubMedGoogle Scholar
• Ansuini V, Rigante D, Esposito S. Debate around infection-dependent hemophagocytic syndrome in paediatrics. BMC Infect Dis. 2013;13(1):1–8. doi:10.1186/1471-2334-13-15
   PubMed Web of Science ®Google Scholar
• Mroczek E, Weisenburger D, Grierson HL, Markin R, Purtilo D. Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. Arch Pathol Lab Med. 1987;111:530–535.
   PubMed Web of Science ®Google Scholar
• Janka G, Imashuku S, Elinder G, Schneider M, Henter J-I. Infection-and malignancy-associated hemophagocytic syndromes: secondary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am. 1998;12(2):435–444. doi:10.1016/S0889-8588(05)70521-9
   PubMed Web of Science ®Google Scholar
• Crayne CB, Albeituni S, Nichols KE, Cron RQ. The Immunology of macrophage activation syndrome. Front Immunol. 2019;10:119. doi:10.3389/fimmu.2019.00119
   PubMed Web of Science ®Google Scholar
• Castillo L, Carcillo J. Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. Pediatr Crit Care Med. 2009;10(3):387–392. doi:10.1097/PCC.0b013e3181a1ae08
   PubMed Web of Science ®Google Scholar
• Deane S, Selmi C, Teuber SS, Gershwin ME. Macrophage activation syndrome in autoimmune disease. Int Arch Allergy Immunol. 2010;153(2):109–120. doi:10.1159/000312628
   PubMed Web of Science ®Google Scholar
• Srikiatkhachorn A, Mathew A, Rothman AL. Immune-mediated cytokine storm and its role in severe dengue. Semin Immunopathol. 2017;39(5):563–574. doi:10.1007/s00281-017-0625-1
   PubMed Web of Science ®Google Scholar
• Mangione JN, Huy NT, Lan NTP, et al. The association of cytokines with severe dengue in children. Trop Med Health. 2014;42(4):137–144. doi:10.2149/tmh.2014-09
   PubMedGoogle Scholar
• Sun Y, Jin C, Zhan F, et al. Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis. 2012;206(7):1085–1094. doi:10.1093/infdis/jis452
   PubMed Web of Science ®Google Scholar
• Patro A, Mohanty S, Prusty BK, et al. Cytokine signature associated with disease severity in dengue. Viruses. 2019;11(1):34. doi:10.3390/v11010034
   PubMed Web of Science ®Google Scholar
• Fernandez‐Mestre M, Gendzekhadze K, Rivas‐Vetencourt P, Layrisse Z. TNF‐α‐308A allele, a possible severity risk factor of hemorrhagic manifestation in dengue fever patients. Tissue Antigens. 2004;64(4):469–472. doi:10.1111/j.1399-0039.2004.00304.x
   PubMed Web of Science ®Google Scholar
• Vejbaesya S, Luangtrakool P, Luangtrakool K, et al. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. J Infect Dis. 2009;199:1442–1448. doi:10.1086/597422
   PubMed Web of Science ®Google Scholar
• Alagarasu K, Mulay A, Singh R, Gavade V, Shah P, Cecilia D. Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever. Hum Immunol. 2013;74(5):610–617. doi:10.1016/j.humimm.2013.01.027
   PubMed Web of Science ®Google Scholar
• Wang L, Chen R, Liu J, Kuo H, Kuo H, Yang KD. Implications of dynamic changes among tumor necrosis factor-alpha (TNF-alpha), membrane TNF receptor, and soluble TNF receptor levels in regard to the severity of dengue infection. Am J Trop Med Hyg. 2007;77(2):297. doi:10.4269/ajtmh.2007.77.297
   PubMed Web of Science ®Google Scholar
• Cardier JE, Mariño E, Romano E, et al. Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-α in endothelial cell damage in dengue. Cytokine. 2005;30(6):359–365. doi:10.1016/j.cyto.2005.01.021
   PubMed Web of Science ®Google Scholar
• Meena AA, Murugesan A, Sopnajothi S, et al. Increase of plasma TNF-α is associated with decreased levels of blood platelets in clinical dengue infection. Viral Immunol. 2020;33:54–60. doi:10.1089/vim.2019.0100
   PubMed Web of Science ®Google Scholar
• Arthur J, Shen Y, Gardiner E, et al. TNF receptor‐associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011;9(1):163–172. doi:10.1111/j.1538-7836.2010.04091.x
   PubMed Web of Science ®Google Scholar
• Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res. 2003;92(9):1041–1048. doi:10.1161/01.RES.0000070111.98158.6C
   PubMed Web of Science ®Google Scholar
• Piguet PF, Vesin C, Da Kan C. Activation of platelet caspases by TNF and its consequences for kinetics. Cytokine. 2002;18(4):222–230. doi:10.1006/cyto.2002.0889
   PubMed Web of Science ®Google Scholar
• Hart PH, Hunt EK, Bonder CS, Watson CJ, Finlay-Jones JJ. Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10. J Immunol. 1996;157(8):3672–3680.
   PubMed Web of Science ®Google Scholar
• Langstein J, Michel J, Fritsche J, Kreutz M, Andreesen R, Schwarz H. CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. J Immunol. 1998;160(5):2488–2494.
   PubMed Web of Science ®Google Scholar
• Leeuwenberg J, Dentener MA, Buurman WA. Lipopolysaccharide LPS-mediated soluble TNF receptor release and TNF receptor expression by monocytes. Role of CD14, LPS binding protein, and bactericidal/permeability-increasing protein. The. J Immunol. 1994;152:5070–5076.
   PubMed Web of Science ®Google Scholar