Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates

References

• Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis. current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–272. doi:10.1164/rccm.201504-0781OC
   PubMed Web of Science ®Google Scholar
• Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med. 2014;42(3):625–631. doi:10.1097/CCM.0000000000000026
   PubMed Web of Science ®Google Scholar
• Berg D, Gerlach H. Recent advances in understanding and managing sepsis. F1000Res. 2018;7:1570. doi:10.12688/f1000research.15758.1
   Google Scholar
• Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223–230. doi:10.1016/S2213-2600(18)30063-8
   PubMed Web of Science ®Google Scholar
• Ershad M, Mostafa A, Dela Cruz M, Vearrier D. Neonatal Sepsis. Neonatal Sepsis Curr Emerg Hosp Med Rep. 2019;7(3):83–90. doi:10.1007/s40138-019-00188-z
   PubMed Web of Science ®Google Scholar
• Iroh Tam PY, Bendel CM. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatr Res. 2017;82(4):574–583. doi:10.1038/pr.2017.134
   PubMed Web of Science ®Google Scholar
• Kim F, Polin RA, Hooven TA. Neonatal sepsis. BMJ. 2020;371:m3672. doi:10.1136/bmj.m3672
   PubMed Web of Science ®Google Scholar
• Paudel R, Dogra P, Montgomery-Yates AA, Coz Yataco A. Procalcitonin: a promising tool or just another overhyped test? Int J Med Sci. 2020;17(3):332–337. doi:10.7150/ijms.39367
   PubMed Web of Science ®Google Scholar
• Lippi G, Sanchis-Gomar F. Procalcitonin in inflammatory bowel disease: drawbacks and opportunities. World J Gastroenterol. 2017;23(47):8283–8290. doi:10.3748/wjg.v23.i47.8283
   PubMed Web of Science ®Google Scholar
• Mohsen AH, Kamel BA. Predictive values for procalcitonin in the diagnosis of neonatal sepsis. Electron Physician. 2015;7(4):1190–1195. doi:10.14661/2015.1190-1195
   PubMedGoogle Scholar
• Vouloumanou EK, Plessa E, Karageorgopoulos DE, Mantadakis E, Falagas ME. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med. 2011;37(5):747–762. doi:10.1007/s00134-011-2174-8
   PubMed Web of Science ®Google Scholar
• Vijayan AL, Ravindran S, Ravindran S, et al. Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care. 2017;5:51. doi:10.1186/s40560-017-0246-8
   PubMed Web of Science ®Google Scholar
• Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13(5):426–435. doi:10.1016/S1473-3099(12)70323-7
   PubMed Web of Science ®Google Scholar
• Fanali G, Di Masi A, Trezza V, Marino M, Fasano M, Ascenzi P. Human serum albumin: from bench to bedside. Mol Aspects Med. 2012;33(3):209–290. doi:10.1016/j.mam.2011.12.002
   PubMed Web of Science ®Google Scholar
• Eckart A, Struja T, Kutz A, et al. Relationship of nutritional status, inflammation, and serum albumin levels during acute illness: a prospective study. Am J Med. 2020;133(6):713–722 e7. doi:10.1016/j.amjmed.2019.10.031
   PubMed Web of Science ®Google Scholar
• Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: pathogenesis and clinical significance. JPEN J Parenter Enteral Nutr. 2019;43(2):181–193. doi:10.1002/jpen.1451
   PubMed Web of Science ®Google Scholar
• Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial. 2004;17(6):432–437. doi:10.1111/j.0894-0959.2004.17603.x
   PubMed Web of Science ®Google Scholar
• Arnau-Barres I, Guerri-Fernandez R, Luque S, Sorli L, Vazquez O, Miralles R. Serum albumin is a strong predictor of sepsis outcome in elderly patients. Eur J Clin Microbiol Infect Dis. 2019;38(4):743–746. doi:10.1007/s10096-019-03478-2
   PubMed Web of Science ®Google Scholar
• Qian SY, Liu J. [Relationship between serum albumin level and prognosis in children with sepsis, severe sepsis or septic shock]. Zhonghua Er Ke Za Zhi. 2012;50(3):184–187. Chinese.
   PubMedGoogle Scholar
• Luo X, Yang X, Li J, et al. The procalcitonin/albumin ratio as an early diagnostic predictor in discriminating urosepsis from patients with febrile urinary tract infection. Medicine. 2018;97(28):e11078. doi:10.1097/MD.0000000000011078
   PubMed Web of Science ®Google Scholar
• Chen L, Wu X, Qin H, Zhu H. The PCT to albumin ratio predicts mortality in patients with acute kidney injury caused by abdominal infection-evoked sepsis. Front Nutr. 2021;8:584461. doi:10.3389/fnut.2021.584461
   PubMed Web of Science ®Google Scholar
• Goldstein B, Giroir B, Randolph A. International consensus conference on Pediatric S. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2–8. doi:10.1097/01.PCC.0000149131.72248.E6
   PubMedGoogle Scholar
• Wynn JL, Polin RA. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res. 2020;88(1):85–90. doi:10.1038/s41390-019-0517-2
   PubMed Web of Science ®Google Scholar
• Li T, Dong G, Zhang M, et al. Association of neutrophil-lymphocyte ratio and the presence of neonatal sepsis. J Immunol Res. 2020;2020:7650713. doi:10.1155/2020/7650713
   PubMed Web of Science ®Google Scholar
• Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770–1780. doi:10.1016/s0140-6736(17)31002-4
   PubMed Web of Science ®Google Scholar
• Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013;60(2):367–389. doi:10.1016/j.pcl.2012.12.003
   PubMed Web of Science ®Google Scholar
• Yan ST, Sun LC, Jia HB, Gao W, Yang JP, Zhang GQ. Procalcitonin levels in bloodstream infections caused by different sources and species of bacteria. Am J Emerg Med. 2017;35(4):579–583. doi:10.1016/j.ajem.2016.12.017
   PubMed Web of Science ®Google Scholar
• Leli C, Ferranti M, Moretti A, Al Dhahab ZS, Cenci E, Mencacci A. Procalcitonin levels in gram-positive, gram-negative, and fungal bloodstream infections. Dis Markers. 2015;2015:701480. doi:10.1155/2015/701480
   PubMed Web of Science ®Google Scholar
• Oussalah A, Ferrand J, Filhine-Tresarrieu P, et al. Diagnostic accuracy of procalcitonin for predicting blood culture results in patients with suspected bloodstream infection: an observational study of 35,343 consecutive patients (A STROBE-compliant article). Medicine. 2015;94(44):e1774. doi:10.1097/MD.0000000000001774
   PubMed Web of Science ®Google Scholar
• Pugh R, Grant C, Cooke RP, Dempsey G. Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults. Cochrane Database Syst Rev. 2015;(8):CD007577. doi:10.1002/14651858.CD007577.pub3
   PubMed Web of Science ®Google Scholar
• Schuetz P, Birkhahn R, Sherwin R, et al. Serial procalcitonin predicts mortality in severe sepsis patients: results from the multicenter procalcitonin MOnitoring SEpsis (MOSES) study. Crit Care Med. 2017;45(5):781–789. doi:10.1097/CCM.0000000000002321
   PubMed Web of Science ®Google Scholar
• Nargis W, Ibrahim M, Ahamed BU. Procalcitonin versus C-reactive protein: usefulness as biomarker of sepsis in ICU patient. Int J Crit Illn Inj Sci. 2014;4(3):195–199. doi:10.4103/2229-5151.141356
   PubMedGoogle Scholar
• Wirz Y, Meier MA, Bouadma L, et al. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit Care. 2018;22(1):191. doi:10.1186/s13054-018-2125-7
   PubMed Web of Science ®Google Scholar
• Schuetz P, Beishuizen A, Broyles M, et al. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med. 2019;57(9):1308–1318. doi:10.1515/cclm-2018-1181
   PubMed Web of Science ®Google Scholar
• Stocker M, Fontana M, El Helou S, Wegscheider K, Berger TM. Use of procalcitonin-guided decision-making to shorten antibiotic therapy in suspected neonatal early-onset sepsis: prospective randomized intervention trial. Neonatology. 2010;97(2):165–174. doi:10.1159/000241296
   PubMed Web of Science ®Google Scholar
• Chiesa C, Panero A, Rossi N, et al. Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis. 1998;26(3):664–672. doi:10.1086/514576
   PubMed Web of Science ®Google Scholar
• Pontrelli G, De Crescenzo F, Buzzetti R, et al. Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis. BMC Infect Dis. 2017;17(1):302. doi:10.1186/s12879-017-2396-7
   PubMed Web of Science ®Google Scholar
• Arroyo V, García-Martinez R, Salvatella X. Human serum albumin, systemic inflammation, and cirrhosis. J Hepatol. 2014;61(2):396–407. doi:10.1016/j.jhep.2014.04.012
   PubMed Web of Science ®Google Scholar
• Kaysen GA. Biochemistry and biomarkers of inflamed patients: why look, what to assess. Clin J Am Soc Nephrol. 2009;4(Suppl 1):S56–63. doi:10.2215/CJN.03090509
   PubMed Web of Science ®Google Scholar
• Yan J, Li S, Li S. The role of the liver in sepsis. Int Rev Immunol. 2014;33(6):498–510. doi:10.3109/08830185.2014.889129
   PubMed Web of Science ®Google Scholar
• Godinez-Vidal AR, Correa-Montoya A, Enriquez-Santos D, Perez-Escobedo SU, Lopez-Romero SC, Gracida-Mancilla NI. Is albumin a predictor of severity and mortality in patients with abdominal sepsis? [inverted question markEs la albumina un predictor de gravedad y de mortalidad en pacientes con sepsis abdominal?]. Cir Cir. 2019;87(5):485–489. doi:10.24875/CIRU.180003903
   PubMed Web of Science ®Google Scholar
• Yang C, Liu Z, Tian M, et al. Relationship between serum albumin levels and infections in newborn late preterm infants. Med Sci Monit. 2016;22:92–98. doi:10.12659/msm.895435
   PubMed Web of Science ®Google Scholar
• Chen H, Liu Q, Wang L. An analysis of the 28-day mortality risk factors in acute respiratory distress syndrome patients and the establishment of prediction models. Am J Transl Res. 2021;13(6):6937–6944.
   PubMed Web of Science ®Google Scholar
• Deng S, Gao J, Zhao Z, Tian M, Li Y, Gong Y. Albumin/procalcitonin ratio is a sensitive early marker of nosocomial blood stream infection in patients with intra-cerebral hemorrhage. Surg Infect (Larchmt). 2019;20(8):643–649. doi:10.1089/sur.2018.260
   PubMed Web of Science ®Google Scholar