222
Views
3
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Identification of Immune-Related Genes in Patients with Acute Myocardial Infarction Using Machine Learning Methods

ORCID Icon, ORCID Icon, , , , , , , , & show all
Pages 3305-3321 | Published online: 03 Jun 2022

References

  • Harjola VP, Lassus J, Sionis A, et al. Clinical picture and risk prediction of short-term mortality in cardiogenic shock. Eur J Heart Fail. 2015;17(5):501–509. doi:10.1002/ejhf.260
  • McManus DD, Piacentine SM, Lessard D, et al. Thirty-year (1975 to 2005) trends in the incidence rates, clinical features, treatment practices, and short-term outcomes of patients <55 years of age hospitalized with an initial acute myocardial infarction. Am J Cardiol. 2011;108(4):477–482. doi:10.1016/j.amjcard.2011.03.074
  • Gulati R, Behfar A, Narula J, et al. Acute myocardial infarction in young individuals. Mayo Clin Proc. 2020;95(1):136–156. doi:10.1016/j.mayocp.2019.05.001
  • Roth GA, Huffman MD, Moran AE, et al. Global and regional patterns in cardiovascular mortality from 1990 to 2013. Circulation. 2015;132(17):1667–1678. doi:10.1161/CIRCULATIONAHA.114.008720
  • Abed MA, Khalil AA, Moser DK. The contribution of symptom incongruence to prehospital delay for acute myocardial infarction symptoms among Jordanian patients. Res Nurs Health. 2015;38(3):213–221. doi:10.1002/nur.21658
  • Xie Y, Wang Y, Zhao L, Wang F, Fang J. Identification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy. Bioengineered. 2021;12(1):2890–2905. doi:10.1080/21655979.2021.1937906
  • Kologrivova I, Shtatolkina M, Suslova T, Ryabov V. Cells of the immune system in cardiac remodeling: main players in resolution of inflammation and repair after myocardial infarction. Front Immunol. 2021;12:664457. doi:10.3389/fimmu.2021.664457
  • Zhao E, Xie H, Zhang Y. Predicting diagnostic gene biomarkers associated with immune infiltration in patients with acute myocardial infarction. Front Cardiovasc Med. 2020;7:586871. doi:10.3389/fcvm.2020.586871
  • Ong SB, Hernández-Reséndiz S, Crespo-Avilan GE, et al. Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities. Pharmacol Ther. 2018;186:73–87. doi:10.1016/j.pharmthera.2018.01.001
  • Ministrini S, Carbone F, Montecucco F. Updating concepts on atherosclerotic inflammation: from pathophysiology to treatment. Eur J Clin Invest. 2021;51(5):e13467. doi:10.1111/eci.13467
  • Orn S, Manhenke C, Squire IB, Ng L, Anand I, Dickstein K. Plasma MMP-2, MMP-9 and N-BNP in long-term survivors following complicated myocardial infarction: relation to cardiac magnetic resonance imaging measures of left ventricular structure and function. J Card Fail. 2007;13(10):843–849. doi:10.1016/j.cardfail.2007.07.006
  • Oba T, Yasukawa H, Hoshijima M, et al. Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2012;59(9):838–852. doi:10.1016/j.jacc.2011.10.887
  • Xu JY, Xiong YY, Lu XT, Yang YJ. Regulation of type 2 immunity in myocardial infarction. Front Immunol. 2019;10:62. doi:10.3389/fimmu.2019.00062
  • Liu W, Shen J, Li Y, et al. Pyroptosis inhibition improves the symptom of acute myocardial infarction. Cell Death Dis. 2021;12(10):852. doi:10.1038/s41419-021-04143-3
  • Xiong YY, Gong ZT, Tang RJ, Yang YJ. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics. 2021;11(3):1046–1058. doi:10.7150/thno.53326
  • Jukes E. Encyclopedia of machine learning and data mining (2nd edition). Reference Rev. 2018;32(7/8):3–4. doi:10.1108/RR-05-2018-0084
  • Chen C, Grennan K, Badner J, et al. Removing batch effects in analysis of expression microarray data: an evaluation of six batch adjustment methods. PLoS One. 2011;6(2):e17238. doi:10.1371/journal.pone.0017238
  • Li W. Volcano plots in analyzing differential expressions with mRNA microarrays. J Bioinform Comput Biol. 2012;10(6):1231003. doi:10.1142/S0219720012310038
  • Walter W, Sánchez-Cabo F, Ricote M. GOplot: an R package for visually combining expression data with functional analysis. Bioinformatics. 2015;31(17):2912–2914. doi:10.1093/bioinformatics/btv300
  • Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 2008;9:559. doi:10.1186/1471-2105-9-559
  • Kuhn M. Caret: classification and regression training. 2013.
  • Breiman, L. Random Forests. Machine Learning 45, 5–32 (2001). 10.1023/A:1010933404324
  • Dimitriadou E, Hornik K, Leisch F, Meyer D, Weingessel A. e1071: misc functions of the department of statistics (e1071). 2011.
  • Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33(1):1–22. doi:10.18637/jss.v033.i01
  • Sorokin AA, Dmitriev VN, Toan TQ, Reznikov PS. neuralnet: training of neural networks. RJ. 2014;2:30.
  • Palla TG, Tayeb S. Intelligent Mirai malware detection for IoT nodes %. J Electron. 2021;10(11):1241. doi:10.3390/electronics10111241
  • Percie du Sert N, Hurst V, Ahluwalia A, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18(7):e3000410. doi:10.1371/journal.pbio.3000410
  • Nichols M, Townsend N, Scarborough P, Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J. 2014;35(42):2950–2959. doi:10.1093/eurheartj/ehu299
  • Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, Go AS. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med. 2010;362(23):2155–2165. doi:10.1056/NEJMoa0908610
  • Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet. 2017;389(10065):197–210. doi:10.1016/S0140-6736(16)30677-8
  • Visan I. Myocardial infarct inflammation. Nat Immunol. 2018;19(2):99.
  • Nahrendorf M. Myeloid cell contributions to cardiovascular health and disease. Nat Med. 2018;24(6):711–720. doi:10.1038/s41591-018-0064-0
  • Swirski FK, Nahrendorf M. Cardioimmunology: the immune system in cardiac homeostasis and disease. Nat Rev Immunol. 2018;18(12):733–744. doi:10.1038/s41577-018-0065-8
  • Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357(11):1121–1135. doi:10.1056/NEJMra071667
  • Morton AC, Rothman AM, Greenwood JP, et al. The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study. Eur Heart J. 2015;36(6):377–384. doi:10.1093/eurheartj/ehu272
  • Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119–1131. doi:10.1056/NEJMoa1707914
  • Marinković G, Grauen Larsen H, Yndigegn T, et al. Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction. Eur Heart J. 2019;40(32):2713–2723. doi:10.1093/eurheartj/ehz461
  • Scarabelli TM, Stephanou A, Pasini E, et al. Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Circ Res. 2002;90(6):745–748. doi:10.1161/01.RES.0000015224.07870.9A
  • Baker BJ, Akhtar LN, Benveniste EN. SOCS1 and SOCS3 in the control of CNS immunity. Trends Immunol. 2009;30(8):392–400. doi:10.1016/j.it.2009.07.001
  • Negoro S, Kunisada K, Fujio Y, et al. Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. Circulation. 2001;104(9):979–981. doi:10.1161/hc3401.095947
  • Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol. 2007;7(6):454–465. doi:10.1038/nri2093
  • Chen Z, Laurence A, Kanno Y, et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A. 2006;103(21):8137–8142. doi:10.1073/pnas.0600666103
  • Barin JG, Baldeviano GC, Talor MV, et al. Macrophages participate in IL-17-mediated inflammation. Eur J Immunol. 2012;42(3):726–736. doi:10.1002/eji.201141737
  • Jiang T, Zhao Q, Sun H, et al. Scolopendra subspinipes mutilans L. Koch ameliorates rheumatic heart disease by affecting relative percentages of CD4(+)CD25(+)FoxP3 Treg and CD4(+)IL17 T Cells. eCAM. 2019;2019:4674190. doi:10.1155/2019/4674190
  • López E, Blázquez R, Marinaro F, et al. The intrapericardial delivery of extracellular vesicles from cardiosphere-derived cells stimulates M2 polarization during the acute phase of porcine myocardial infarction. Stem Cell Rev Rep. 2020;16(3):612–625. doi:10.1007/s12015-019-09926-y
  • Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol. 2014;11(5):255–265. doi:10.1038/nrcardio.2014.28
  • Yan W, Song Y, Zhou L, et al. Immune cell repertoire and their mediators in patients with acute myocardial infarction or stable angina pectoris. Int J Med Sci. 2017;14(2):181–190. doi:10.7150/ijms.17119
  • Varda-Bloom N, Leor J, Ohad DG. Cytotoxic T lymphocytes are activated following myocardial infarction and can recognize and kill healthy myocytes in vitro %. J Mol Cell Cardiol. 2000;32(12):2141–2149. doi:10.1006/jmcc.2000.1261
  • Prabhu SD, Frangogiannis NG. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circulation Research. 2016;119(1):91–112. doi:10.1161/CIRCRESAHA.116.303577
  • Carbone F, Nencioni A, Mach F, Vuilleumier N, Montecucco F. Pathophysiological role of neutrophils in acute myocardial infarction. Thromb Haemost. 2013;110(3):501–514. doi:10.1160/TH13-03-0211
  • Ma Y, Yabluchanskiy A, Iyer RP, et al. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016;110(1):51–61. doi:10.1093/cvr/cvw024
  • Braunersreuther V, Montecucco F, Pelli G, et al. Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice. Thromb Haemost. 2013;110(4):807–825. doi:10.1160/TH13-04-0297
  • Carbone F, Crowe LA, Roth A, et al. Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury. J Mol Cell Cardiol. 2016;94:82–94. doi:10.1016/j.yjmcc.2016.03.013
  • Shishido T, Nozaki N, Takahashi H, et al. Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. Biochem Biophys Res Commun. 2006;345(4):1446–1453. doi:10.1016/j.bbrc.2006.05.056
  • Gavins FN. Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia-reperfusion injury? Trends Pharmacol Sci. 2010;31(6):266–276. doi:10.1016/j.tips.2010.04.001
  • Qin C, Buxton KD, Pepe S, et al. Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1(2-26). Br J Pharmacol. 2013;168(1):238–252. doi:10.1111/j.1476-5381.2012.02176.x
  • Ren N, Wang M. microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signaling pathway. Exp Cell Res. 2018;370(2):531–541. doi:10.1016/j.yexcr.2018.07.018
  • Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994;8(15):1314–1325. doi:10.1096/fasebj.8.15.8001745
  • Peters VA, Joesting JJ, Freund GG. IL-1 receptor 2 (IL-1R2) and its role in immune regulation. Brain Behav Immun. 2013;32:1–8. doi:10.1016/j.bbi.2012.11.006