Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke

References

• Virani SS, Alonso A, Aparicio HJ, et al. Heart disease and stroke statistics-2021 update: a report from the American Heart Association. Circulation. 2021;143:e254–e743. doi:10.1161/CIR.0000000000000950
   PubMed Web of Science ®Google Scholar
• Ramadan AR, Denny MC, Vahidy F, et al. Agreement among stroke faculty and fellows in treating ischemic stroke patients with tissue-type plasminogen activator and thrombectomy. Stroke. 2017;48:222–224. doi:10.1161/STROKEAHA.116.015214
   PubMed Web of Science ®Google Scholar
• Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87:779–789. doi:10.1189/jlb.1109766
   PubMed Web of Science ®Google Scholar
• Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10:471–480. doi:10.1016/S1474-4422(11)70066-7
   PubMed Web of Science ®Google Scholar
• Yilmaz G, Granger DN. Cell adhesion molecules and ischemic stroke. Neurol Res. 2008;30:783–793. doi:10.1179/174313208X341085
   PubMed Web of Science ®Google Scholar
• Tang C, Wang C, Zhang Y, et al. Recognition, Intervention, and monitoring of neutrophils in acute ischemic stroke. Nano Lett. 2019;19:4470–4477. doi:10.1021/acs.nanolett.9b01282
   PubMed Web of Science ®Google Scholar
• Zhang CY, Dong X, Gao J, Lin W, Liu Z, Wang Z. Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke. Sci Adv. 2019;5:eaax7964. doi:10.1126/sciadv.aax7964
   PubMed Web of Science ®Google Scholar
• Pu Z, Ma S, Wang L, et al. Amyloid-beta degradation and neuroprotection of dauricine mediated by unfolded protein response in a Caenorhabditis elegans model of Alzheimer’s disease. Neuroscience. 2018;392:25–37. doi:10.1016/j.neuroscience.2018.09.022
   PubMed Web of Science ®Google Scholar
• Wang K, Wang L, Chen L, et al. Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer’s disease. Drug Deliv. 2021;28:580–593. doi:10.1080/10717544.2021.1895909
   PubMed Web of Science ®Google Scholar
• Li M, Liu G, Wang K, et al. Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage. J Nanobiotechnol. 2020;18:61. doi:10.1186/s12951-020-00616-3
   PubMed Web of Science ®Google Scholar
• Li YH, Gong PL. Neuroprotective effects of dauricine against apoptosis induced by transient focal cerebral ischaemia in rats via a mitochondrial pathway. Clin Exp Pharmacol Physiol. 2007;34:177–184. doi:10.1111/j.1440-1681.2007.04569.x
   PubMed Web of Science ®Google Scholar
• Wang L, Pu Z, Li M, Wang K, Deng L, Chen W. Antioxidative and antiapoptosis: neuroprotective effects of dauricine in Alzheimer’s disease models. Life Sci. 2020;243:117237. doi:10.1016/j.lfs.2019.117237
   PubMed Web of Science ®Google Scholar
• Yang XY, Jiang SQ, Zhang L, Liu QN, Gong PL. Inhibitory effect of dauricine on inflammatory process following focal cerebral ischemia/reperfusion in rats. Am J Chin Med. 2007;35:477–486. doi:10.1142/S0192415X07004990
   PubMed Web of Science ®Google Scholar
• Dong PL, Han H, Zhang TY, Yang B, Wang QH, Eerdun GW. P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier. Mol Med Rep. 2014;9:985–988. doi:10.3892/mmr.2013.1880
   PubMed Web of Science ®Google Scholar
• Meng H, Zhao H, Cao X, et al. Double-negative T cells remarkably promote neuroinflammation after ischemic stroke. Proc Natl Acad Sci USA. 2019;116:5558–5563. doi:10.1073/pnas.1814394116
   PubMed Web of Science ®Google Scholar
• Yang XY, Liu QN, Zhang L, Jiang SQ, Gong PL. Neuroprotective effect of dauricine after transient middle cerebral artery occlusion in rats: involvement of Bcl-2 family proteins. Am J Chin Med. 2010;38:307–318. doi:10.1142/S0192415X10007865
   PubMed Web of Science ®Google Scholar
• Egashira Y, Suzuki Y, Azuma Y, et al. The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. J Neuroinflammation. 2013;10:105. doi:10.1186/1742-2094-10-105
   PubMed Web of Science ®Google Scholar
• Zhang Z, Cao X, Bao X, Zhang Y, Xu Y, Sha D. Cocaine- and amphetamine-regulated transcript protects synaptic structures in neurons after ischemic cerebral injury. Neuropeptides. 2020;81:102023. doi:10.1016/j.npep.2020.102023
   PubMed Web of Science ®Google Scholar
• Wu N, Zhang X, Bao Y, Yu H, Jia D, Ma C. Down-regulation of GAS5 ameliorates myocardial ischaemia/reperfusion injury via the miR-335/ROCK1/AKT/GSK-3beta axis. J Cell Mol Med. 2019;23:8420–8431. doi:10.1111/jcmm.14724
   PubMed Web of Science ®Google Scholar
• Cen J, Liu L, Li MS, et al. Alteration in P-glycoprotein at the blood-brain barrier in the early period of MCAO in rats. J Pharm Pharmacol. 2013;65:665–672. doi:10.1111/jphp.12033
   PubMed Web of Science ®Google Scholar
• Meng H, Fan L, Zhang CJ, et al. Synthetic VSMCs induce BBB disruption mediated by MYPT1 in ischemic stroke. iScience. 2021;24:103047. doi:10.1016/j.isci.2021.103047
   PubMed Web of Science ®Google Scholar
• Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682–2688. doi:10.1161/hs1101.098367
   PubMed Web of Science ®Google Scholar
• Zhang MJ, Sun JJ, Qian L, et al. Human umbilical mesenchymal stem cells enhance the expression of neurotrophic factors and protect ataxic mice. Brain Res. 2011;1402:122–131. doi:10.1016/j.brainres.2011.05.055
   PubMed Web of Science ®Google Scholar
• Alamri FF, Shoyaib AA, Biggers A, Jayaraman S, Guindon J, Karamyan VT. Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke. Behav Brain Res. 2018;336:250–255. doi:10.1016/j.bbr.2017.09.008
   PubMed Web of Science ®Google Scholar
• Chen J, Jin J, Zhang X, et al. Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis. Mol Ther. 2021;29:2873–2885. doi:10.1016/j.ymthe.2021.04.025
   PubMed Web of Science ®Google Scholar
• Wang Y, Jin H, Wang W, Wang F, Zhao H. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. J Neuroinflammation. 2019;16:77. doi:10.1186/s12974-019-1465-9
   PubMed Web of Science ®Google Scholar
• Deng Y, Herbert JA, Smith CM, Smyth RL. An in vitro transepithelial migration assay to evaluate the role of neutrophils in Respiratory Syncytial Virus (RSV) induced epithelial damage. Sci Rep. 2018;8:6777. doi:10.1038/s41598-018-25167-4
   PubMed Web of Science ®Google Scholar
• Seeliger D, de Groot BL. Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des. 2010;24:417–422. doi:10.1007/s10822-010-9352-6
   PubMed Web of Science ®Google Scholar
• Perez-de-puig I, Miro-Mur F, Ferrer-Ferrer M, et al. Neutrophil recruitment to the brain in mouse and human ischemic stroke. Acta Neuropathol. 2015;129:239–257. doi:10.1007/s00401-014-1381-0
   PubMed Web of Science ®Google Scholar
• Zhou YX, Wang X, Tang D, et al. IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8(+) T cells. CNS Neurosci Ther. 2019;25:532–543. doi:10.1111/cns.13084
   PubMed Web of Science ®Google Scholar
• Chauhan A, Hudobenko J, Al Mamun A, et al. Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. J Neuroinflammation. 2018;15:148. doi:10.1186/s12974-018-1188-3
   PubMed Web of Science ®Google Scholar
• Kim SW, Davaanyam D, Seol SI, Lee HK, Lee H, Lee JK. Adenosine triphosphate accumulated following cerebral ischemia induces neutrophil extracellular trap formation. Int J Mol Sci. 2020;21:7668.
   PubMed Web of Science ®Google Scholar
• Kessenbrock K, Frohlich L, Sixt M, et al. Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest. 2008;118:2438–2447. doi:10.1172/JCI34694
   PubMed Web of Science ®Google Scholar
• Chen C, Liu P, Wang J, et al. Dauricine attenuates spatial memory impairment and Alzheimer-like pathologies by enhancing mitochondrial function in a mouse model of Alzheimer’s disease. Front Cell Dev Biol. 2020;8:624339. doi:10.3389/fcell.2020.624339
   PubMed Web of Science ®Google Scholar
• Peng C, Fu X, Wang K, et al. Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol. 2021;914:174461. doi:10.1016/j.ejphar.2021.174461
   PubMed Web of Science ®Google Scholar
• Wang X, Liu Y, Sun Y, Liu W, Jin X. Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO. J Neurol Sci. 2016;363:63–68. doi:10.1016/j.jns.2016.02.035
   PubMed Web of Science ®Google Scholar
• Dziennis S, Akiyoshi K, Subramanian S, Offner H, Hurn PD. Role of dihydrotestosterone in post-stroke peripheral immunosuppression after cerebral ischemia. Brain Behav Immun. 2011;25:685–695. doi:10.1016/j.bbi.2011.01.009
   PubMed Web of Science ®Google Scholar
• Wolinski P, Glabinski A. Chemokines and neurodegeneration in the early stage of experimental ischemic stroke. Mediators Inflamm. 2013;2013:727189. doi:10.1155/2013/727189
   PubMed Web of Science ®Google Scholar
• Assem S, Abdelbaki TN, Mohy-El Dine SH, Ketat AF, Abdelmonsif DA. SERPINE-1 gene methylation and protein as molecular predictors of laparoscopic sleeve gastrectomy outcome. Obes Surg. 2020;30:2620–2630. doi:10.1007/s11695-020-04533-0
   PubMed Web of Science ®Google Scholar
• Kortlever RM, Higgins PJ, Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol. 2006;8:877–884. doi:10.1038/ncb1448
   PubMed Web of Science ®Google Scholar
• Jiang C, Liu G, Luckhardt T, et al. Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. Aging Cell. 2017;16:1114–1124. doi:10.1111/acel.12643
   PubMed Web of Science ®Google Scholar
• Marchand A, Proust C, Morange PE, Lompre AM, Tregouet DA, Chadwick BP. miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells. PLoS One. 2012;7:e44532. doi:10.1371/journal.pone.0044532
   PubMed Web of Science ®Google Scholar