The Construction of ITP Diagnostic Modeling Based on the Expressions of Hub Genes Associated with M1 Polarization of Macrophages

References

• Tsuda H, Tsuji T, Tsuji M, et al. Life-threatening bleeding episodes in primary immune thrombocytopenia: a single-center retrospective study of 169 inpatients. Ann Hematol. 2017;96(11):1915–1920. doi:10.1007/s00277-017-3095-6
   PubMed Web of Science ®Google Scholar
• Moulis G, Palmaro A, Montastruc JL, et al. Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France. Blood. 2014;124(22):3308–3315. doi:10.1182/blood-2014-05-578336
   PubMed Web of Science ®Google Scholar
• Zufferey A, Kapur R, Semple JW. Pathogenesis and therapeutic mechanisms in Immune Thrombocytopenia (ITP). J Clin Med. 2017;6(2):16. doi:10.3390/jcm6020016
   PubMed Web of Science ®Google Scholar
• Cines DB, Bussel JB, Liebman HA, et al. The ITP syndrome: pathogenic and clinical diversity. Blood. 2009;113(26):6511–6521. doi:10.1182/blood-2009-01-129155
   PubMed Web of Science ®Google Scholar
• Khodadi E, Asnafi AA, Shahrabi S, et al. Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis. Ann Hematol. 2016;95(11):1765–1776. doi:10.1007/s00277-016-2703-1
   PubMed Web of Science ®Google Scholar
• Wang Q, Li J, Yu TS, et al. Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia. Int J Biol Sci. 2019;15(13):2798–2814. doi:10.7150/ijbs.33779
   PubMed Web of Science ®Google Scholar
• Xu P, Jiang Y, Zuo H, et al. Vincristine-loaded platelets coated with anti-CD41 mAbs: a new macrophage targeting proposal for the treatment of immune thrombocytopenia. Biomater Sci. 2019;7(11):4568–4577. doi:10.1039/C9BM01026B
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang X. Pivotal regulators of tissue homeostasis and cancer: macrophages. Exp Hematol Oncol. 2017;6:23. doi:10.1186/s40164-017-0083-4
   PubMed Web of Science ®Google Scholar
• Laskin DL, Sunil VR, Gardner CR, et al. Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol. 2011;51(1):267–288. doi:10.1146/annurev.pharmtox.010909.105812
   PubMed Web of Science ®Google Scholar
• Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23(4):344–346. doi:10.1016/j.immuni.2005.10.001
   PubMed Web of Science ®Google Scholar
• Liu YC, Zou XB, Chai YF, et al. Macrophage polarization in inflammatory diseases. Int J Biol Sci. 2014;10(5):520–529. doi:10.7150/ijbs.8879
   PubMed Web of Science ®Google Scholar
• Chang Y, Chen X, Tian Y, et al. Downregulation of microRNA-155-5p prevents immune thrombocytopenia by promoting macrophage M2 polarization via the SOCS1-dependent PD1/ PDL1 pathway. Life Sci. 2020;257:118057. doi:10.1016/j.lfs.2020.118057
   PubMed Web of Science ®Google Scholar
• Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11(11):723–737. doi:10.1038/nri3073
   PubMed Web of Science ®Google Scholar
• Zhao Y, Xu P, Guo L, et al. Tumor necrosis factor-α blockade corrects monocyte/macrophage imbalance in primary immune thrombocytopenia. Thromb Haemost. 2021;121(6):767–781. doi:10.1055/s-0040-1722186
   PubMed Web of Science ®Google Scholar
• Shao X, Wu B, Cheng L, et al. Distinct alterations of CD68+CD163+ M2-like macrophages and myeloid-derived suppressor cells in newly diagnosed primary immune thrombocytopenia with or without CR after high-dose dexamethasone treatment. J Transl Med. 2018;16(1):48. doi:10.1186/s12967-018-1424-8
   PubMed Web of Science ®Google Scholar
• Di Paola A, Palumbo G, Merli P, et al. Effects of eltrombopag on in vitro macrophage polarization in pediatric immune thrombocytopenia. Int J Mol Sci. 2020;22(1):97. doi:10.3390/ijms22010097
   PubMed Web of Science ®Google Scholar
• Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113(11):2386–2393. doi:10.1182/blood-2008-07-162503
   PubMed Web of Science ®Google Scholar
• Zhao X, Zhang L, Wang J, et al. Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis. J Transl Med. 2021;19(1):35. doi:10.1186/s12967-020-02698-x
   PubMed Web of Science ®Google Scholar
• Yan H, Zheng G, Qu J, et al. Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis. J Cell Physiol. 2019;234(12):23785–23797. doi:10.1002/jcp.28947
   PubMed Web of Science ®Google Scholar
• Feng WY, Zhong YG. Role of Th 1- and Th 2- chemokine receptor in the diagnosis and prognosis of primary immune thrombocytopenia. Clin Lab. 2019;65(6). doi:10.7754/Clin.Lab.2018.180915
   Web of Science ®Google Scholar
• Yu TS, Wang HY, Zhao YJ, et al. Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia. Blood Adv. 2021;5(20):4087–4101. doi:10.1182/bloodadvances.2020003860
   PubMed Web of Science ®Google Scholar
• Long D, Chen Y, Wu H, et al. Clinical significance and immunobiology of IL-21 in autoimmunity. J Autoimmun. 2019;99:1–14. doi:10.1016/j.jaut.2019.01.013
   PubMed Web of Science ®Google Scholar
• Fan Z, Wang X, Li P, et al. Systematic Identification of lncRNA-Associated ceRNA Networks in Immune Thrombocytopenia. Comput Math Methods Med. 2020;2020:6193593. doi:10.1155/2020/6193593
   PubMed Web of Science ®Google Scholar
• Wu TT, Chen YF, Hastie T, et al. Genome-wide association analysis by lasso penalized logistic regression. Bioinformatics. 2009;25(6):714–721. doi:10.1093/bioinformatics/btp041
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhao Z, Shi S, et al. Calcium sensing receptor initiating cystathionine-gamma-lyase/hydrogen sulfide pathway to inhibit platelet activation in hyperhomocysteinemia rat. Exp Cell Res. 2017;358(2):171–181. doi:10.1016/j.yexcr.2017.06.013
   PubMed Web of Science ®Google Scholar
• Martelli A, Testai L, Breschi MC, et al. Hydrogen sulphide: novel opportunity for drug discovery. Med Res Rev. 2012;32(6):1093–1130. doi:10.1002/med.20234
   PubMed Web of Science ®Google Scholar
• Yao Y, Zhang X, Chen HP, et al. MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine γ-lyase in THP-1 macrophages. Atherosclerosis. 2016;250:122–132. doi:10.1016/j.atherosclerosis.2016.04.030
   PubMed Web of Science ®Google Scholar
• Zhu XY, Liu SJ, Liu YJ, et al. Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages. Cell Mol Life Sci. 2010;67(7):1119–1132. doi:10.1007/s00018-009-0250-9
   PubMed Web of Science ®Google Scholar
• Trowitzsch S, Viola C, Scheer E, et al. Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules. Nat Commun. 2015;6:6011. doi:10.1038/ncomms7011
   PubMed Web of Science ®Google Scholar
• Demény MA, Soutoglou E, Nagy Z, et al. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. PLoS One. 2007;2(3):e316. doi:10.1371/journal.pone.0000316
   PubMed Web of Science ®Google Scholar
• Zhao QB, Liao RR, Sun H, et al. Identifying genetic differences between dongxiang blue-shelled and white leghorn chickens using sequencing data. G3. 2018;8(2):469–476. doi:10.1534/g3.117.300382
   Web of Science ®Google Scholar
• Shigemura T, Matsuda K, Kurata T, et al. Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia. Br J Haematol. 2019;187(2):163–173. doi:10.1111/bjh.16060
   PubMed Web of Science ®Google Scholar
• Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445–455. doi:10.1038/nature12034
   PubMed Web of Science ®Google Scholar
• Zhao HY, Zhang YY, Xing T, et al. M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity. Signal Transduct Target Ther. 2021;6(1):234. doi:10.1038/s41392-021-00627-y
   PubMed Web of Science ®Google Scholar
• Feng Q, Xu M, Yu YY, et al. High-dose dexamethasone or all-trans-retinoic acid restores the balance of macrophages towards M2 in immune thrombocytopenia. J Thromb Haemost. 2017;15(9):1845–1858. doi:10.1111/jth.13767
   PubMed Web of Science ®Google Scholar
• Mills CD, Kincaid K, Alt JM, et al. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol. 2000;164(12):6166–6173. doi:10.4049/jimmunol.164.12.6166
   PubMed Web of Science ®Google Scholar
• Hu JG, Shi LL, Chen YJ, et al. Differential effects of myelin basic protein-activated Th1 and Th2 cells on the local immune microenvironment of injured spinal cord. Exp Neurol. 2016;277:190–201. doi:10.1016/j.expneurol.2016.01.002
   PubMed Web of Science ®Google Scholar
• Anderson CF, Mosser DM. Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors. J Immunol. 2002;168(8):3697–3701. doi:10.4049/jimmunol.168.8.3697
   PubMed Web of Science ®Google Scholar
• Panitsas FP, Theodoropoulou M, Kouraklis A, et al. Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood. 2004;103(7):2645–2647. doi:10.1182/blood-2003-07-2268
   PubMed Web of Science ®Google Scholar
• Krausgruber T, Blazek K, Smallie T, et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol. 2011;12(3):231–238. doi:10.1038/ni.1990
   PubMed Web of Science ®Google Scholar
• Gobert AP, Latour YL, Asim M, et al. Bacterial pathogens hijack the innate immune response by activation of the reverse transsulfuration pathway. mBio. 2019;10(5):e02174–e02219. doi:10.1128/mBio.02174-19
   PubMed Web of Science ®Google Scholar
• Tjitro R, Campbell LA, Basova L, et al. Modeling the function of TATA box binding protein in transcriptional changes induced by HIV-1 tat in innate immune cells and the effect of methamphetamine exposure. Front Immunol. 2019;9:3110. doi:10.3389/fimmu.2018.03110
   PubMed Web of Science ®Google Scholar
• Delgado M, Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1. J Biol Chem. 2001;276(1):369–380. doi:10.1074/jbc.M006923200
   PubMed Web of Science ®Google Scholar
• Weber-Boyvat M, Zhong W, Yan D, et al. Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism. Biochem Pharmacol. 2013;86(1):89–95. doi:10.1016/j.bcp.2013.02.016
   PubMed Web of Science ®Google Scholar
• Kriegeskorte N, Golan T. Neural network models and deep learning. Curr Biol. 2019;29(7):R231–R236. doi:10.1016/j.cub.2019.02.034
   PubMed Web of Science ®Google Scholar
• Barrett DG, Morcos AS, Macke JH. Analyzing biological and artificial neural networks: challenges with opportunities for synergy? Curr Opin Neurobiol. 2019;55:55–64. doi:10.1016/j.conb.2019.01.007
   PubMed Web of Science ®Google Scholar
• Kaul P, Lall B. Riemannian curvature of deep neural networks. IEEE Trans Neural Netw Learn Syst. 2020;31(4):1410–1416. doi:10.1109/TNNLS.2019.2919705
   PubMed Web of Science ®Google Scholar