Dual Effect of the Extract from the Fungus Coriolus versicolor on Lipopolysaccharide-Induced Cytokine Production in RAW 264.7 Macrophages Depending on the Lipopolysaccharide Concentration

References

• Sekhon BK, Sze DM, Chan WK, et al. PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment. Food Chem. 2013;138(4):2201–2209. doi:10.1016/j.foodchem.2012.11.009
   PubMed Web of Science ®Google Scholar
• Saleh MH, Rashedi I, Keating A. Immunomodulatory properties of Coriolus versicolor: the role of polysaccharopeptide. Front Immunol. 2017;(8):1087. doi:10.3389/fimmu.2017.01087
   PubMed Web of Science ®Google Scholar
• Habtemariam S. Trametes versicolor (Synn. Coriolus versicolor) polysaccharides in cancer therapy: targets and efficacy. Biomedicines. 2020;8(5):135. doi:10.3390/biomedicines8050135
   PubMed Web of Science ®Google Scholar
• Chang Y, Zhang M, Jiang Y, et al. Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Discov Med. 2017;23(127):207–219.
   PubMed Web of Science ®Google Scholar
• Maehara Y, Tsujitani S, Saeki H, et al. Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives. Surg Today. 2012;42(1):8–28. doi:10.1007/s00595-011-0075-7
   PubMed Web of Science ®Google Scholar
• Jędrzejewski T, Pawlikowska M, Piotrowski J, Kozak W. Protein-bound polysaccharides from Coriolus versicolor attenuate LPS-induced synthesis of pro-inflammatory cytokines and stimulate PBMCs proliferation. Immunol Lett. 2016;178:140–147. doi:10.1016/j.imlet.2016.08.013
   PubMed Web of Science ®Google Scholar
• Kowalczewska M, Piotrowski J, Jędrzejewski T, Kozak W. Polysaccharide peptides from Coriolus versicolor exert differential immunomodulatory effects on blood lymphocytes and breast cancer cell line MCF-7 in vitro. Immunol Lett. 2016;174:37–44. doi:10.1016/j.imlet.2016.04.010
   PubMed Web of Science ®Google Scholar
• Jędrzejewski T, Pawlikowska M, Sobocińska J, Wrotek S. Protein-bound polysaccharides from coriolus versicolor fungus disrupt the crosstalk between breast cancer cells and macrophages through inhibition of angiogenic cytokines production and shifting tumour-associated macrophages from the M2 to M1 subtype. Cell Physiol Biochem. 2020;54(4):615–628. doi:10.33594/000000244
   PubMedGoogle Scholar
• Jędrzejewski T, Sobocińska J, Pawlikowska M, Dzialuk A, Wrotek S. Extract from the coriolus versicolor fungus as an anti-inflammatory agent with cytotoxic properties against endothelial cells and breast cancer cells. Int J Mol Sci. 2020;21(23):9063. doi:10.3390/ijms21239063
   PubMed Web of Science ®Google Scholar
• Jedrzejewski T, Piotrowski J, Kowalczewska M, Wrotek S, Kozak W. Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats. Int J Hyperthermia. 2015;31(6):626–634. doi:10.3109/02656736.2015.1046953
   PubMed Web of Science ®Google Scholar
• Kozak W, Wrotek S, Walentynowicz K, Waszak P. Fever and symptoms of sickness are present in mice lacking functional B and T lymphocytes. Acta Biol Crac Ser Zool. 2006;48:9–20.
   Google Scholar
• Borzęcka K, Płóciennikowska A, Björkelund H, Sobota A, Kwiatkowska K. CD14 mediates binding of high doses of LPS but is dispensable for TNF-α production. Mediators Inflamm. 2013;2013(2013):824919. doi:10.1155/2013/824919
   PubMed Web of Science ®Google Scholar
• Chan SL, Yeung JH. Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse. Life Sci. 2006;78(21):2463–2470. doi:10.1016/j.lfs.2005.10.011
   PubMed Web of Science ®Google Scholar
• Liu WK, Ng TB, Sze SF, Tsui KW. Activation of peritoneal macrophages by polysaccharopeptide from the mushroom, Coriolus versicolor. Immunopharmacology. 1993;26(2):139–146. doi:10.1016/0162-3109(93)90006-c
   PubMed Web of Science ®Google Scholar
• Vergadi E, Ieronymaki E, Lyroni K, Vaporidi K, Tsatsanis C. Akt signaling pathway in macrophage activation and M1/M2 polarization. J Immunol. 2017;198(3):1006–1014. doi:10.4049/jimmunol.1601515
   PubMed Web of Science ®Google Scholar
• Fujiwara N, Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 2005;4(3):281–286. doi:10.2174/1568010054022024
   PubMedGoogle Scholar
• Watanabe S, Alexander M, Misharin AV, Budinger GRS. The role of macrophages in the resolution of inflammation. J Clin Investig. 2019;129(7):2619–2628. doi:10.1172/JCI124615
   PubMed Web of Science ®Google Scholar
• Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140:771–776. doi:10.1016/j.cell.2010.03.006
   PubMed Web of Science ®Google Scholar
• Brightbill HD, Modlin RL. Toll-like receptors: molecular mechanisms of the mammalian immune response. Immunology. 2000;101(1):1–10. doi:10.1046/j.1365-2567.2000.00093.x
   PubMed Web of Science ®Google Scholar
• Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci. 2021;78(4):1233–1261. doi:10.1007/s00018-020-03656-y
   PubMed Web of Science ®Google Scholar
• Muniandy K, Gothai S, Badran KMH, Suresh Kumar S, Esa NM, Arulselvan P. Suppression of proinflammatory cytokines and mediators in LPS-induced RAW 264.7 macrophages by stem extract of Alternanthera sessilis via the inhibition of the NF-κB pathway. J Immunol Res. 2018;2018:3430684. doi:10.1155/2018/3430684
   PubMed Web of Science ®Google Scholar
• Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296(5573):1655–1657. doi:10.1126/science.296.5573.1655
   PubMed Web of Science ®Google Scholar
• Koyasu S. The role of PI3K in immune cells. Nat Immunol. 2003;4(4):313–319. doi:10.1038/ni0403-313
   PubMed Web of Science ®Google Scholar
• Dorrington MG, Fraser IDC. NF-κB signaling in macrophages: dynamics, crosstalk, and signal integration. Front Immunol. 2019;10(10):705. doi:10.3389/fimmu.2019.00705
   PubMed Web of Science ®Google Scholar
• Hawkins PT, Stephens LR. PI3K signalling in inflammation. Biochim Biophys Acta. 2015;1851(6):882–897. doi:10.1016/j.bbalip.2014.12.006
   PubMed Web of Science ®Google Scholar
• Ryu JK, Kim SJ, Rah SH, et al. Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14, and TLR4-MD2 for efficient LPS recognition and transfer. Immunity. 2017;46(1):38–50. doi:10.1016/j.immuni.2016.11.007
   PubMed Web of Science ®Google Scholar
• Zong A, Cao H, Wang F. Anticancer polysaccharides from natural resources: a review of recent research. Carbohydr Polym. 2012;90(4):1395–1410. doi:10.1016/j.carbpol.2012.07.026
   PubMed Web of Science ®Google Scholar
• Ho CY, Lau CB, Kim CF, et al. Differential effect of Coriolus versicolor (Yunzhi) extract on cytokine production by murine lymphocytes in vitro. Int Immunopharmacol. 2004;4(12):1549–1557. doi:10.1016/j.intimp.2004.07.021
   PubMed Web of Science ®Google Scholar
• Engel AL, Sun GC, Gad E, et al. Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant. Immunobiology. 2013;218(12):1468–1476. doi:10.1016/j.imbio.2013.05.001
   PubMed Web of Science ®Google Scholar
• Wang Z, Dong B, Feng Z, Yu S, Bao Y. A study on immunomodulatory mechanism of Polysaccharopeptide mediated by TLR4 signaling pathway. BMC Immunol. 2015;16:34. doi:10.1186/s12865-015-0100-5
   PubMed Web of Science ®Google Scholar
• Avni D, Glucksam Y, Zor T. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol. 2012;83(1):106–114. doi:10.1016/j.bcp.2011.09.025
   PubMed Web of Science ®Google Scholar
• Matsunaga N, Tsuchimori N, Matsumoto T, Li M. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol Pharmacol. 2011;79(1):34–41. doi:10.1124/mol.110.068064
   PubMed Web of Science ®Google Scholar
• Shin HM, Kim MH, Kim BH, et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett. 2004;571(1–3):50–54. doi:10.1016/j.febslet.2004.06.056
   PubMed Web of Science ®Google Scholar
• Smith WM, Purvis IJ, Bomstad CN, et al. Therapeutic targeting of immune checkpoints with small molecule inhibitors. Am J Transl Res. 2019;11(2):529–541.
   PubMed Web of Science ®Google Scholar
• Yang SF, Zhuang TF, Si YM, Qi KY, Zhao J. Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways. Mol Immunol. 2015;64:144–151. doi:10.1016/j.molimm.2014.11.007
   PubMed Web of Science ®Google Scholar
• Price LA, Wenner CA, Sloper DT, Slaton JW, Novack JP. Role for toll-like receptor 4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin, a Trametes versicolor mushroom extract. Fitoterapia. 2010;81(7):914–919. doi:10.1016/j.fitote.2010.06.002
   PubMed Web of Science ®Google Scholar
• Asai Y, Takaori K, Yamamoto T, Ogawa T. Protein-bound polysaccharide isolated from basidiomycetes inhibits endotoxin-induced activation by blocking lipopolysaccharide-binding protein and CD14 functions. FEMS Immunol Med Microbiol. 2005;43(1):91–98. doi:10.1016/j.femsim.2004.07.008
   PubMedGoogle Scholar
• Kuan YC, Wu YJ, Hung CL, Sheu F. Trametes versicolor protein YZP activates regulatory B lymphocytes - gene identification through de novo assembly and function analysis in a murine acute colitis model. PLoS One. 2013;8(9):e72422. doi:10.1371/journal.pone.0072422
   PubMed Web of Science ®Google Scholar
• Troutman TD, Bazan JF, Pasare C. Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K. Cell Cycle. 2012;11(19):3559–3567. doi:10.4161/cc.21572
   PubMed Web of Science ®Google Scholar
• Zhao Y, Qian Y, Sun Z, et al. Role of PI3K in the progression and regression of atherosclerosis. Front Pharmacol. 2021;12(12):632378. doi:10.3389/fphar.2021.632378
   PubMed Web of Science ®Google Scholar
• Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol. 2009;1(4):a000034. doi:10.1101/cshperspect.a000034
   PubMed Web of Science ®Google Scholar
• Stark AK, Sriskantharajah S, Hessel EM, Okkenhaug K. PI3K inhibitors in inflammation, autoimmunity and cancer. Curr Opin Pharmacol. 2015;23:82–91. doi:10.1016/j.coph.2015.05.017
   PubMed Web of Science ®Google Scholar
• Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N. Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol. 2008;180(6):4218–4226. doi:10.4049/jimmunol.180.6.4218
   PubMed Web of Science ®Google Scholar
• Schabbauer G, Tencati M, Pedersen B, Pawlinski R, Mackman N. PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol. 2004;24(10):1963–1969. doi:10.1161/01.ATV.0000143096.15099.ce
   PubMed Web of Science ®Google Scholar
• Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem. 2002;277(35):32124–32132. doi:10.1074/jbc.M203298200
   PubMed Web of Science ®Google Scholar
• Fukao T, Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 2003;24(7):358–363. doi:10.1016/s1471-4906(03)00139-x
   PubMed Web of Science ®Google Scholar
• Ojaniemi M, Glumoff V, Harju K, Liljeroos M, Vuori K, Hallman M. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol. 2003;33(3):597–605. doi:10.1002/eji.200323376
   PubMed Web of Science ®Google Scholar
• Park SJ, Lee SC, Hong SH, Kim HM. Degradation of IkappaBalpha in activated RAW264.7 cells is blocked by the phosphatidylinositol 3-kinase inhibitor LY294002. Cell Biol Toxicol. 2002;18(2):121–130. doi:10.1023/a:1015384201785
   PubMed Web of Science ®Google Scholar
• Saponaro C, Cianciulli A, Calvello R, Dragone T, Iacobazzi F, Panaro MA. The PI3K/Akt pathway is required for LPS activation of microglial cells. Immunopharmacol Immunotoxicol. 2012;34(5):858–865. doi:10.3109/08923973.2012.665461
   PubMed Web of Science ®Google Scholar