Gastroprotective Effect of Azilsartan Through Ameliorating Oxidative Stress, Inflammation, and Restoring Hydroxyproline, and Gastrin Levels in Ethanol-Induced Gastric Ulcer

References

• Khushtar M, Siddiqui HH, Dixit RK, Khan MS, Iqbal D, Rahman MA. Amelioration of gastric ulcers using a hydro-alcoholic extract of Triphala in indomethacin-induced Wistar rats. Eur J Integr Med. 2016;8(4):546–551. doi:10.1016/J.EUJIM.2016.01.004
   Web of Science ®Google Scholar
• Scida S, Russo M, Miraglia C, et al. Relationship between helicobacter pylori infection and GERD. Acta Biomed. 2018;89(4):40–43. doi:10.23750/abm.v89i8-S.7918
   PubMedGoogle Scholar
• Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats prevention of gastric necrosis produced by alcohol, HCl, NaOH, Hypertonic NaCl, and thermal injury. Gastroenterology. 1979;77(3):433–443. doi:10.1016/0016-5085(79)90002-7
   PubMed Web of Science ®Google Scholar
• Tarnawski AS, Ahluwalia A. The critical role of growth factors in gastric ulcer healing: the cellular and molecular mechanisms and potential clinical implications. Cells. 2021;10(8):1964. doi:10.3390/CELLS10081964
   PubMed Web of Science ®Google Scholar
• Karampour NS, Arzi A, Rezaie A, Pashmforoosh M, Kordi F. Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats. Medicina. 2019;55(3):1–9. doi:10.3390/medicina55030064
   Web of Science ®Google Scholar
• Dimaline R, Varro A. Attack and defence in the gastric epithelium - A delicate balance. Exp Physiol. 2007;92(4):591–601. doi:10.1113/expphysiol.2006.036483
   PubMed Web of Science ®Google Scholar
• Bujanda L. The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol. 2000;95(12):3374–3382. doi:10.1016/S0002-9270(00)02140-7
   PubMed Web of Science ®Google Scholar
• Alimi H, Hfaiedh N, Bouoni Z, Sakly M, Ben Rhouma K. Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. Environ Toxicol Pharmacol. 2011;32(3):406–416. doi:10.1016/J.ETAP.2011.08.007
   PubMed Web of Science ®Google Scholar
• Cadirci E, Suleyman H, Aksoy H, et al. Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. Chem Biol Interact. 2007;170(1):40–48. doi:10.1016/J.CBI.2007.06.040
   PubMed Web of Science ®Google Scholar
• Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G. Alcoholic disease: liver and beyond. World J Gastroenterol. 2014;20(40):14652–14659. doi:10.3748/wjg.v20.i40.14652
   PubMed Web of Science ®Google Scholar
• Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology. 1985;88(1 Pt 2):228–236. doi:10.1016/S0016-5085(85)80176-1
   PubMed Web of Science ®Google Scholar
• Pan J-S, He S-Z, Xu H-Z, et al. Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury. World J Gastroenterol. 2008;14(38):5857–5867. doi:10.3748/wjg.14.5857
   PubMed Web of Science ®Google Scholar
• Arda-Pirincci P, Bolkent S, Yanardag R. The role of zinc sulfate and metallothionein in protection against ethanol-induced gastric damage in rats. Dig Dis Sci. 2006;51(12):2353–2360. doi:10.1007/S10620-006-9301-3
   PubMed Web of Science ®Google Scholar
• Siragy HM. The angiotensin II type 2 receptor and the kidney. J Renin-Angiotensin-Aldosterone Syst. 2010;11(1):33–36. doi:10.1177/1470320309347786
   PubMed Web of Science ®Google Scholar
• Paul M, Mehr AP, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev. 2006;86(3):747–803. doi:10.1152/physrev.00036.2005
   PubMed Web of Science ®Google Scholar
• Jaworska K, Koper M, Ufnal M. Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels. Am J Physiol. 2021;321(4):G355–G366. doi:10.1152/ajpgi.00099.2021
   Web of Science ®Google Scholar
• Bregonzio C, Armando I, Ando H, Jezova M, Baiardi G, Saavedra JM. Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress. Ann N Y Acad Sci. 2004;1018:351–355. doi:10.1196/ANNALS.1296.044
   PubMed Web of Science ®Google Scholar
• Yamane S, Amano H, Ito Y, et al. The role of Angiotensin II type 1A receptor signaling in gastric ulcer healing. Kitasato Med J. 2019;49:52–63.
   Google Scholar
• Bregonzio C, Armando I, Ando H, et al. Anti-inflammatory effects of angiotensin II AT 1 receptor antagonism prevent stress-induced gastric injury. Am J Physiol. 2003;285(2):G414–23. doi:10.1152/ajpgi.00058.2003
   Web of Science ®Google Scholar
• Pradhan A, Tiwari A, Sethi R. Azilsartan: current evidence and perspectives in management of hypertension. Int J Hypertens. 2019;2019:1824621. doi:10.1155/2019/1824621
   PubMed Web of Science ®Google Scholar
• Sica D, White WB, Weber MA, et al. Comparison of the novel angiotensin II receptor blocker azilsartan medoxomil vs valsartan by ambulatory blood pressure monitoring. J Clin Hypertens. 2011;13(7):467–472. doi:10.1111/J.1751-7176.2011.00482.X
   Web of Science ®Google Scholar
• Bakris GL, Sica D, Weber M, et al. The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. J Clin Hypertens. 2011;13(2):81–88. doi:10.1111/J.1751-7176.2010.00425.X
   PubMed Web of Science ®Google Scholar
• Mshelia HS, Karumi Y, Dibal NI. Therapeutic effect of Momordica balsamina leaf extract on ethanol-induced gastric ulcer in Wistar rats. Ann Res Hosp. 2017;1:1. doi:10.21037/ARH.2017.04.03
   Google Scholar
• De Araujo AA, Varela H, De Medeiros CACX, et al. Azilsartan reduced TNF-α and IL-1β levels, increased IL-10 levels and upregulated VEGF, FGF, KGF, and TGF-α in an oral mucositis model. PLoS One. 2015;10(2):1–16. doi:10.1371/journal.pone.0116799
   Web of Science ®Google Scholar
• Kim YS, Nam YS, Song J, Kim H. Gastroprotective and healing effects of Polygonum cuspidatum root on experimentally induced gastric ulcers in rats. Nutrients. 2020;12(8):1–15. doi:10.3390/nu12082241
   Web of Science ®Google Scholar
• Rao G, Sujatha D, Rupa V, Priya E, Rao K, Venkateswarlu M. Study on anti-ulcer activity of Daucus carota juice. Res J Pharm Tech. 2010;3(2):547–550.
   Google Scholar
• Ketuly KA, Abdulla MA, Hadi HA, Mariod AA, Ibrahim S, Wahab A. Anti-ulcer activity of the 9alpha-bromo analogue of Beclomethasone dipropionate against ethanol-induced gastric mucosal injury in rats. J Med Plants Res. 2011;5(4):514–520. doi:10.5897/JMPR.9000114
   Google Scholar
• Chrysant SG, Chrysant GS. The pleiotropic effects of angiotensin receptor blockers. J Clin Hypertens. 2006;8(4):261–268. doi:10.1111/J.1524-6175.2005.05264.X
   PubMedGoogle Scholar
• Brzozowski T, Ptak-Belowska A, Kwiecien S, et al. Novel concept in the mechanism of injury and protection of gastric mucosa: role of renin-angiotensin system and active metabolites of angiotensin. Curr Med Chem. 2012;19(1):55–62. doi:10.2174/092986712803413953
   PubMed Web of Science ®Google Scholar
• Wozniak-Holecka J, Josko J, Tyrpien M, Kasperczyk J, Steplewska K, Holecki T. Influence of vascular endothelial growth factor (VEGF) on gastroprotection in stress-induced gastric mucosal ulcers in rats. Methods Find Exp Clin Pharmacol. 2009;31(8):523–531. doi:10.1358/MF.2009.31.8.1419716
   PubMedGoogle Scholar
• Magierowski M, Magierowska K, Kwiecien S, Brzozowski T. Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. Molecules. 2015;20(5):9099–9123. doi:10.3390/MOLECULES20059099
   PubMed Web of Science ®Google Scholar
• Takeuchi K, Aihara E, Kimura M, Dogishi K, Hara T, Hayashi S. Gas mediators involved in modulating duodenal HCO3- secretion. Curr Med Chem. 2012;19(1):43–54. doi:10.2174/092986712803413962
   PubMed Web of Science ®Google Scholar
• Tawfik M. Protective role of telmisartan, candesartan and olmesartan on cold restraint stress -induced gastric ulcer in rats: influence of Ppar Γ Mrna. Al-Azhar J Pharm Sci. 2012;45(1):365–382. doi:10.21608/ajps.2012.7248
   Google Scholar
• Morsy M, Ashour O, Amin E, Rofaeil R. Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats. Pharmazie. 2009;64(9):590–594.
   PubMed Web of Science ®Google Scholar
• Ojima M, Igata H, Tanaka M, et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011;336(3):801–808. doi:10.1124/JPET.110.176636
   PubMed Web of Science ®Google Scholar
• Suehiro T, Tsuruya K, Yoshida H, et al. Stronger effect of azilsartan on reduction of proteinuria compared to candesartan in patients with CKD: a randomized crossover trial keywords azilsartan · candesartan · CKD · crossover trial · proteinuria. Res Artic Kidney Blood Press Res. 2021;46:173–184. doi:10.1159/000512365
   PubMed Web of Science ®Google Scholar
• Shiga Y, Miura SI, Motozato K, et al. Comparison of efficacy and safety of azilsartan and olmesartan in patients with essential hypertension. Int Heart J. 2017;58(3):416–421. doi:10.1536/IHJ.16-285
   PubMed Web of Science ®Google Scholar
• Takami T, Okada S, Saito Y, Nishijima Y, Kobori H, Nishiyama A. Effects of olmesartan and azilsartan on albuminuria and the intrarenal renin-angiotensin system. World J Res Rev. 2018;6(1):7. doi:10.31871/wjrr.6.1.18
   PubMedGoogle Scholar
• ViJardi R. Effects of azilsartan on PPAR gamma gene expression and oxidative stress in 3T3 L1 cells; 2012.
   Google Scholar
• Takeuchi K, Ohishi M, Endo K, et al. Hydroxyproline, a serum biomarker candidate for gastric ulcer in rats: a comparison study of metabolic analysis of gastric ulcer models induced by ethanol, stress, and aspirin. Biomark Insights. 2014;9:61–66. doi:10.4137/BMI.S15918
   PubMedGoogle Scholar
• Eissele R, Brunner G, Simon B, Solcia E, Arnold R. Gastric mucosa during treatment with lansoprazole: helicobacter pylori is a risk factor for argyrophil cell hyperplasia. Gastroenterology. 1997;112(3):707–717. doi:10.1053/GAST.1997.V112.PM9041231
   PubMed Web of Science ®Google Scholar
• Álvarez Á, Ibiza MS, Andrade MM, Blas-García A, Calatayud S. Gastric antisecretory drugs induce leukocyte-endothelial cell interactions through gastrin release and activation of CCK-2 receptors. J Pharmacol Exp Ther. 2007;323(1):406–413. doi:10.1124/JPET.107.122754
   PubMed Web of Science ®Google Scholar
• Álvarez Á, Ibiza S, Hernández C, et al. Gastrin induces leukocyte‐endothelial cell interactions in vivo and contributes to the inflammation caused by Helicobacter pylori. FASEB J. 2006;20(13):2396–2398. doi:10.1096/FJ.05-5696FJE
   PubMed Web of Science ®Google Scholar
• Clarke PA, Dickson JH, Harris JC, Grabowska A, Watson SA. Gastrin enhances the angiogenic potential of endothelial cells via modulation of heparin-binding epidermal-like growth factor. Cancer Res. 2006;66(7):3504–3512. doi:10.1158/0008-5472.CAN-05-0280
   PubMed Web of Science ®Google Scholar
• Antonisamy P, Duraipandiyan V, Aravinthan A, et al. Protective effects of friedelin isolated from Azima tetracantha Lam. against ethanol-induced gastric ulcer in rats and possible underlying mechanisms. Eur J Pharmacol. 2015;750:167–175. doi:10.1016/J.EJPHAR.2015.01.015
   PubMed Web of Science ®Google Scholar
• Hou N, Li L-R, Shi Y-Y, et al. Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1–Nrf2 signalling pathway. J Pharm Pharmacol. 2021;73(12):1715–1725. doi:10.1093/JPP/RGAB097
   PubMed Web of Science ®Google Scholar
• Aziz TA, Kareem AA, Othman HH, Ahmed ZA. The anti-inflammatory effect of different doses of aliskiren in rat models of inflammation. Drug Des Devel Ther. 2020;14:2841–2851. doi:10.2147/DDDT.S255607
   PubMed Web of Science ®Google Scholar
• Dong Q, Li Y, Chen J, Wang N. Azilsartan suppressed LPS-induced inflammation in U937 macrophages through suppressing oxidative stress and inhibiting the TLR2/MyD88 signal pathway. ACS omega. 2020;6(1):113–118. doi:10.1021/acsomega.0c03655
   PubMed Web of Science ®Google Scholar
• Pacurari M, Kafoury R, Tchounwou PB, Ndebele K. The renin-angiotensin-aldosterone system in vascular inflammation and remodeling. Int J Inflam. 2014;2014:689360. doi:10.1155/2014/689360
   PubMedGoogle Scholar
• Marchesi C, Paradis P, Schiffrin EL. Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci. 2008;29(7):367–374. doi:10.1016/J.TIPS.2008.05.003
   PubMed Web of Science ®Google Scholar
• Zablocki D, Sadoshima J. Angiotensin II and oxidative stress in the failing heart. Antioxidants Redox Signal. 2013;19(10):1095–1109. doi:10.1089/ars.2012.4588
   PubMed Web of Science ®Google Scholar