The Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus

References

• Rudd KE, Johnson SC, Agesa KM., et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200–211. doi:10.1016/S0140-6736(19)32989-7
   PubMed Web of Science ®Google Scholar
• Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016;353:i1585. doi:10.1136/bmj.i1585
   PubMed Web of Science ®Google Scholar
• Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247. doi:10.1007/s00134-021-06506-y
   PubMed Web of Science ®Google Scholar
• Kim JS, Lee JY, Yang JW, et al. Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics. 2021;11(1):316–329. doi:10.7150/thno.49713
   PubMed Web of Science ®Google Scholar
• Maldonado RF, Sá-Correia I, Valvano MA. Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. FEMS Microbiol Rev. 2016;40(4):480–493. doi:10.1093/femsre/fuw007
   PubMed Web of Science ®Google Scholar
• Pérez-Hernández EG, Delgado-Coello B, Luna-Reyes I, Mas-Oliva J. New insights into lipopolysaccharide inactivation mechanisms in sepsis. Biomed Pharmacother. 2021;141:111890. doi:10.1016/j.biopha.2021.111890
   PubMed Web of Science ®Google Scholar
• Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci. 2021;78(4):1233–1261. doi:10.1007/s00018-020-03656-y
   PubMed Web of Science ®Google Scholar
• Kawai T, Akira S. TLR signaling. Semin Immunol. 2007;19(1):24–32. doi:10.1016/j.smim.2006.12.004
   PubMed Web of Science ®Google Scholar
• Kuzmich NN, Sivak KV, Chubarev VN, Porozov YB, Savateeva-Lyubimova TN, Peri F. TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis. Vaccines. 2017;5(4):34. doi:10.3390/vaccines5040034
   PubMed Web of Science ®Google Scholar
• Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. 2011;25(4):543–559. doi:10.1016/j.beem.2011.05.010
   PubMed Web of Science ®Google Scholar
• Bakke D, Sun J. Ancient Nuclear Receptor VDR With New Functions: microbiome and Inflammation. Inflamm Bowel Dis. 2018;24(6):1149–1154. doi:10.1093/ibd/izy092
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang J, Ge X, Du J, Deb DK, Li YC. Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein. J Biol Chem. 2013;288(27):19450–19458. doi:10.1074/jbc.M113.467670
   PubMed Web of Science ®Google Scholar
• Shang S, Wu J, Li X, et al. Artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression in a mouse model via enhancing autophagy. Br J Pharmacol. 2020;177(18):4147–4165. doi:10.1111/bph.15158
   PubMed Web of Science ®Google Scholar
• Deng J, Yang Y, He J, et al. Vitamin D receptor activated by vitamin D administration alleviates Mycobacterium tuberculosis-induced bone destruction by inhibiting NFκB-mediated aberrant osteoclastogenesis. FASEB j. 2021;35(6):e21543. doi:10.1096/fj.202100135R
   PubMed Web of Science ®Google Scholar
• Wu S, Zhang YG, Lu R, et al. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut. 2015;64(7):1082–1094. doi:10.1136/gutjnl-2014-307436
   PubMed Web of Science ®Google Scholar
• Nunes CDR, Barreto Arantes M, Menezes de Faria Pereira S, et al. Plants as Sources of Anti-Inflammatory Agents. Molecules. 2020;25(16):3726. doi:10.3390/molecules25163726
   PubMed Web of Science ®Google Scholar
• Romano B, Lucariello G, Capasso R. Topical Collection ”Pharmacology of Medicinal Plants”. Biomolecules. 2021;11(1):101. doi:10.3390/biom11010101
   PubMed Web of Science ®Google Scholar
• Tasneem S, Liu B, Li B, Choudhary MI, Wang W. Molecular pharmacology of inflammation: medicinal plants as anti-inflammatory agents. Pharmacol Res. 2019;139:126–140. doi:10.1016/j.phrs.2018.11.001
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang G, Xu ZG, et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019;178(1):176–189.e115. doi:10.1016/j.cell.2019.05.003
   PubMed Web of Science ®Google Scholar
• Dey S, Bishayi B. Killing of Staphylococcus aureus in murine macrophages by chloroquine used alone and in combination with ciprofloxacin or azithromycin. J Inflamm Res. 2015;8:29–47. doi:10.2147/JIR.S76045
   PubMed Web of Science ®Google Scholar
• Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol. 2004;1(4):337–341. doi:10.1016/j.ddtec.2004.11.007
   PubMedGoogle Scholar
• Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD. Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem. 2002;45(12):2615–2623. doi:10.1021/jm020017n
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Unver N, McAllister F. IL-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev. 2018;41:10–17. doi:10.1016/j.cytogfr.2018.04.004
   PubMed Web of Science ®Google Scholar
• Jang DI, Lee AH, Shin HY, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021;22(5):2719. doi:10.3390/ijms22052719
   PubMed Web of Science ®Google Scholar
• Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2001;46(1–3):3–26. doi:10.1016/S0169-409X(00)00129-0
   PubMed Web of Science ®Google Scholar
• Guinaudeau H, Lebœuf M, Cavé A. Aporphinoid Alkaloids, V. J Nat Prod. 1994;57(8):1033–1135. doi:10.1021/np50110a001
   Web of Science ®Google Scholar
• Wang H, Cheng X, Kong S, et al. Synthesis and Structure-Activity Relationships of a Series of Aporphine Derivatives with Antiarrhythmic Activities and Acute Toxicity. Molecules. 2016;21(12):1555. doi:10.3390/molecules21121555
   PubMed Web of Science ®Google Scholar
• Chen ZH, Zhang ZX, Wang MD. 异紫堇定对离题胆囊和离体胆道口括约肌的解痉作用. [Spasmolytic effects of isocorydine on the isolated gallbladder and Oddi’s sphincter in vitro]. Zhongguo Yao Li Xue Bao. 1985;6(1):45–48. Chinese.
   PubMed Web of Science ®Google Scholar
• Lu P, Sun H, Zhang L, et al. Isocorydine targets the drug-resistant cellular side population through PDCD4-related apoptosis in hepatocellular carcinoma. Mol Med. 2012;18(1):1136–1146. doi:10.2119/molmed.2012.00055
   PubMed Web of Science ®Google Scholar
• Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2–13. doi:10.1016/j.mce.2010.04.005
   PubMed Web of Science ®Google Scholar
• Fink MP. Animal models of sepsis and its complications. Kidney Int. 2008;74(8):991–993. doi:10.1038/ki.2008.442
   PubMed Web of Science ®Google Scholar
• Zhou H, Zheng J, Wang L, et al. Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release. Int Immunopharmacol. 2004;4(2):223–234. doi:10.1016/j.intimp.2003.12.006
   PubMed Web of Science ®Google Scholar
• Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004;25(6):280–288. doi:10.1016/j.it.2004.03.008
   PubMed Web of Science ®Google Scholar
• Chen YH, Yu Z, Fu L, et al. Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit. Sci Rep. 2015;5:10871. doi:10.1038/srep10871
   PubMed Web of Science ®Google Scholar
• Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
   PubMed Web of Science ®Google Scholar
• Behrens EM, Koretzky GA. Review: cytokine Storm Syndrome: looking Toward the Precision Medicine Era. Arthritis Rheumatol. 2017;69(6):1135–1143. doi:10.1002/art.40071
   PubMed Web of Science ®Google Scholar
• Hou XQ, Jiang WK, Song PL, et al. 贵州33个中药资源普查试点县(区)药用资源多样性分析. [Analysis of medicinal resources diversity of 33 pilots (districts) in Guizhou province]. Zhongguo Zhong Yao Za Zhi. 2019;44(2):265–269. Chinese. doi:10.19540/j.cnki.cjcmm.20181106.004
   PubMedGoogle Scholar
• He S, Wu Y, He K. 贵州药用植物种类与分布的修订研究. [Studies on revision of species and distribution of medicinal plants in Guizhou province]. Zhongguo Zhong Yao Za Zhi. 2009;34(6):770–773. Chinese.
   PubMedGoogle Scholar
• Wang X, Wang T, Yuan Y, et al. Effects of isocorydine alkaloid in Dicranostigma leptopodum(Maxim.) Fedde(DLF) on secretion of inflammatory factors in RAW 264.7 cell stimulated by LPS. J Anhui Agricultural Sci. 2020;48(4):178–180,183.
   Google Scholar
• Guo C, Jiang Y, Li L, et al. Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of Dactylicapnos scandens in rats. J Pharm Biomed Anal. 2013;74:92–100. doi:10.1016/j.jpba.2012.10.011
   PubMed Web of Science ®Google Scholar
• Deng D, Li X, Liu C, et al. Systematic investigation on the turning point of over-inflammation to immunosuppression in CLP mice model and their characteristics. Int Immunopharmacol. 2017;42:49–58. doi:10.1016/j.intimp.2016.11.011
   PubMed Web of Science ®Google Scholar
• Dickson K, Lehmann C. Inflammatory Response to Different Toxins in Experimental Sepsis Models. Int J Mol Sci. 2019;20(18):4341. doi:10.3390/ijms20184341
   PubMed Web of Science ®Google Scholar
• Liu X, Zheng J, Zhou H. TLRs as pharmacological targets for plant-derived compounds in infectious and inflammatory diseases. Int Immunopharmacol. 2011;11(10):1451–1456. doi:10.1016/j.intimp.2011.04.027
   PubMed Web of Science ®Google Scholar
• Lee SM, Meyer MB, Benkusky NA, O’Brien CA, Pike JW. The impact of VDR expression and regulation in vivo. J Steroid Biochem Mol Biol. 2018;177:36–45. doi:10.1016/j.jsbmb.2017.06.002
   PubMed Web of Science ®Google Scholar
• Dong B, Zhou Y, Wang W, et al. Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice. Hepatology. 2020;71(5):1559–1574. doi:10.1002/hep.30937
   PubMed Web of Science ®Google Scholar