Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway

References

• Lambrecht B. Dendritic cells and the regulation of the allergic immune response. Allergy. 2005;60(3):271–282. doi:10.1111/j.1398-9995.2005.00708.x
   PubMed Web of Science ®Google Scholar
• Van Rijt LS, Jung S, KleinJan A, et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med. 2005;201(6):981–991. doi:10.1084/jem.20042311
   PubMed Web of Science ®Google Scholar
• Kimber I, Cumberbatch M. Dendritic cells and cutaneous immune responses to chemical allergens. Toxicol Appl Pharmacol. 1992;117(2):137–146. doi:10.1016/0041-008X(92)90230-P
   PubMed Web of Science ®Google Scholar
• Froidure A, Shen C, Pilette C. Dendritic cells revisited in human allergic rhinitis and asthma. Allergy. 2016;71(2):137–148. doi:10.1111/all.12770
   PubMed Web of Science ®Google Scholar
• Eifan AO, Durham SR. Pathogenesis of rhinitis. Clin Exp Allergy. 2016;46(9):1139–1151. doi:10.1111/cea.12780
   PubMed Web of Science ®Google Scholar
• KleinJan A, Willart M, van Rijt LS, et al. An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol Pract. 2006;118(5):1117–1125. doi:10.1016/j.jaci.2006.05.030
   Web of Science ®Google Scholar
• Takamura K, Fukuyama S, Nagatake T, et al. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007;179(9):5897–5906. doi:10.4049/jimmunol.179.9.5897
   PubMed Web of Science ®Google Scholar
• Yao Y, Wang ZC, Yu D, Liu Z. Role of allergen-specific T-follicular helper cells in immunotherapy. Curr Opin Allergy Clin Immunol. 2018;18(6):495–501. doi:10.1097/ACI.0000000000000480
   PubMed Web of Science ®Google Scholar
• Yao Y, Chen Z, Zhang H, et al. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021;22(9):1127–1139. doi:10.1038/s41590-021-00996-0
   PubMed Web of Science ®Google Scholar
• Tangye SG, Ma CS, Brink R, Deenick EK. The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol. 2013;13(6):412–426.
   PubMed Web of Science ®Google Scholar
• Kemeny DM. The role of the T follicular helper cells in allergic disease. Cell Mol Immunol. 2012;9(5):386–389. doi:10.1038/cmi.2012.31
   PubMed Web of Science ®Google Scholar
• Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2012;13(1):58–66. doi:10.1038/ni.2182
   Web of Science ®Google Scholar
• Meli AP, Fontés G, Soo CL, King IL. T follicular helper cell–derived IL-4 is required for IgE production during intestinal helminth infection. J Immunol. 2017;199(1):244–252. doi:10.4049/jimmunol.1700141
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Iijima K, Dent AL, Kita H. Follicular helper T cells mediate IgE antibody response to airborne allergens. J Allergy Clin Immunol. 2017;139(1):300. doi:10.1016/j.jaci.2016.04.021
   PubMed Web of Science ®Google Scholar
• Noble A, Zhao J. Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice. Clin Exp Allergy. 2016;46(8):1075–1082. doi:10.1111/cea.12750
   PubMed Web of Science ®Google Scholar
• Marschall P, Wei R, Segaud J, et al. Dual function of Langerhans cells in skin TSLP-promoted TFH differentiation in mouse atopic dermatitis. J Allergy Clin Immunol Pract. 2021;147(5):1778–1794. doi:10.1016/j.jaci.2020.10.006
   Web of Science ®Google Scholar
• Zhang J, Li S, Li L, et al. Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics. 2015;13(1):17–24. doi:10.1016/j.gpb.2015.02.001
   PubMed Web of Science ®Google Scholar
• van Balkom BW, de Jong OG, Smits M, et al. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. Blood. 2013;121(19):3997–4006. doi:10.1182/blood-2013-02-478925
   PubMed Web of Science ®Google Scholar
• Adler HS, Steinbrink K. Tolerogenic dendritic cells in health and disease: friend and foe! Eur J Dermatol. 2007;17(6):476–491. doi:10.1684/ejd.2007.0262
   PubMed Web of Science ®Google Scholar
• Ni Z, Kuang L, Chen H, et al. The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1beta production of macrophages and aggravated synovitis in osteoarthritis. Cell Death Dis. 2019;10(7):522. doi:10.1038/s41419-019-1739-2
   PubMed Web of Science ®Google Scholar
• Whiteside TL. Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. Semin Immunol. 2018;35:69–79. doi:10.1016/j.smim.2017.12.003
   PubMed Web of Science ®Google Scholar
• Zheng X, Sun C, Yu R, et al. CD13-specific ligand facilitates Xanthatin nanomedicine targeting dendritic cells for therapy of refractory allergic rhinitis. Int J Pharm. 2020;577:119034. doi:10.1016/j.ijpharm.2020.119034
   PubMed Web of Science ®Google Scholar
• Maskey D, Marlin MC, Kim S, et al. Cell cycle‐dependent ubiquitylation and destruction of NDE 1 by CDK 5‐FBW 7 regulates ciliary length. EMBO J. 2015;34(19):2424–2440. doi:10.15252/embj.201490831
   PubMed Web of Science ®Google Scholar
• Smith N, Vidalain P-O, Nisole S, Herbeuval J-P. An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept. Sci Rep. 2016;6(1):1–12. doi:10.1038/srep29891
   PubMed Web of Science ®Google Scholar
• Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9–17. doi:10.1038/s41556-018-0250-9
   PubMed Web of Science ®Google Scholar
• Raposo G, Nijman HW, Stoorvogel W. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996;183(3):1161–1172. doi:10.1084/jem.183.3.1161
   PubMed Web of Science ®Google Scholar
• Thomou T, Mori MA, Dreyfuss JM, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017;542(7642):450–455. doi:10.1038/nature21365
   PubMed Web of Science ®Google Scholar
• Conde-Vancells J, Rodriguez-Suarez E, Embade N, et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res. 2008;7(12):5157–5166. doi:10.1021/pr8004887
   PubMed Web of Science ®Google Scholar
• Bobrie A, Colombo M, Raposo G, Théry C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011;12(12):1659–1668. doi:10.1111/j.1600-0854.2011.01225.x
   PubMed Web of Science ®Google Scholar
• Torralba D, Baixauli F, Villarroya-Beltri C, et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018;9(1):1–17. doi:10.1038/s41467-018-05077-9
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang X, Chen K, et al. CCR7 Chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1α-Mediated Glycolysis. Immunity. 2019;50(3):600. doi:10.1016/j.immuni.2019.01.021
   PubMed Web of Science ®Google Scholar
• Sui R, Shi W, Han S, et al. MiR-142-5p directly targets cyclin-dependent kinase 5-mediated upregulation of the inflammatory process in acquired middle ear cholesteatoma. Mol Immunol. 2022;141:236–245. doi:10.1016/j.molimm.2021.11.017
   PubMed Web of Science ®Google Scholar
• Lukasik P, Zaluski M, Gutowska I. Cyclin-Dependent Kinases (CDK) and their role in diseases development-review. Int J Mol Sci. 2021;22(6):2935. doi:10.3390/ijms22062935
   PubMed Web of Science ®Google Scholar
• Hwang J, Namgung U. Cdk5 phosphorylation of STAT3 in dorsal root ganglion neurons is involved in promoting axonal regeneration after peripheral nerve injury. Int Neurourol J. 2020;24(Suppl 1):S19–27. doi:10.5213/inj.2040158.080
   PubMed Web of Science ®Google Scholar
• Hillmer EJ, Zhang H, Li HS, Watowich SS. STAT3 signaling in immunity. Cytokine Growth Factor Rev. 2016;31:1–15. doi:10.1016/j.cytogfr.2016.05.001
   PubMed Web of Science ®Google Scholar
• Eberl M, Roberts GW, Meuter S, et al. Crosstalk of human γδ T cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog. 2009;5(2):e1000308. doi:10.1371/journal.ppat.1000308
   PubMed Web of Science ®Google Scholar
• Maddur MS, Sharma M, Hegde P, et al. Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun. 2014;5(1):4092. doi:10.1038/ncomms5092
   PubMed Web of Science ®Google Scholar
• Shi B, Qi J, Yao G, et al. Mesenchymal stem cell transplantation ameliorates Sjögren’s syndrome via suppressing IL-12 production by dendritic cells. Stem Cell Res Ther. 2018;9(1):308. doi:10.1186/s13287-018-1023-x
   PubMed Web of Science ®Google Scholar
• Goers L, Freemont P, Polizzi KM. Co-culture systems and technologies: taking synthetic biology to the next level. J R Soc Interface. 2014;11(96):20140065. doi:10.1098/rsif.2014.0065
   PubMed Web of Science ®Google Scholar
• Lan Y, Papoian GA. The interplay between discrete noise and nonlinear chemical kinetics in a signal amplification cascade. J Chem Phys. 2006;125(15):154901. doi:10.1063/1.2358342
   PubMed Web of Science ®Google Scholar
• Talebi F, Ghorbani S, Chan WF, et al. MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis. J Neuroinflammation. 2017;14(1):1–14. doi:10.1186/s12974-017-0832-7
   PubMed Web of Science ®Google Scholar
• Zhu X, Wang X, Wang Y, Zhao Y. Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis. Mol Immunol. 2020;118:30–39. doi:10.1016/j.molimm.2019.11.009
   PubMed Web of Science ®Google Scholar
• Fang SB, Zhang HY, Wang C, et al. Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innate lymphoid cell-dominant allergic airway inflammation through delivery of miR-146a-5p. Journal of Extracellular Vesicles. 2020;9:1723260. doi:10.1080/20013078.2020.1723260
   PubMed Web of Science ®Google Scholar
• Shukla V, Skuntz S, Pant HC. Deregulated Cdk5 activity is involved in inducing Alzheimer’s disease. Arch Med Res. 2012;43(8):655–662. doi:10.1016/j.arcmed.2012.10.015
   PubMed Web of Science ®Google Scholar
• Courapied S, Sellier H, De C, et al. The cdk5 Kinase regulates the STAT3 transcription factor to prevent DNA damage upon Topoisomerase I inhibition *. J Biol Chem. 2010;285(35):26765–26778. doi:10.1074/jbc.M109.092304
   PubMed Web of Science ®Google Scholar
• Liu CC, Zhang HL, Zhi LL, et al. CDK5 Regulates PD-L1 expression and cell maturation in dendritic cells of CRSwNP. Inflammation. 2019;42(1):135–144. doi:10.1007/s10753-018-0879-3
   PubMed Web of Science ®Google Scholar