72
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

An inflammatory Signature of Glucose Impairment in Cystic Fibrosis

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 5677-5685 | Received 16 Mar 2022, Accepted 09 Aug 2022, Published online: 10 Oct 2022

References

  • Cystic Fibrosis Foundation. Cystic fibrosis foundation patient registry, 2019 annual data report and ECFSPR annual report; 2018.
  • Kotnala S, Dhasmana A, Kashyap VK, Chauhan SC, Yallapu MM, Jaggi M. A bird eye view on cystic fibrosis: an underestimated multifaceted chronic disorder. Life Sci. 2021;268:118959. doi:10.1016/j.lfs.2020.118959
  • Morrison CB, Markovetz MR, Ehre C. Mucus, mucins, and cystic fibrosis. Pediatr Pulmonol. 2021;54(S3). doi:10.1002/ppul.24530
  • Turcios NL. Cystic fibrosis lung disease: an overview. Respir Care. 2020;65(2):233–251. doi:10.4187/respcare.06697
  • Moran A, Pillay K, Becker D, Granados A, Hameed S, Acerini CL. ISPAD clinical practice consensus guidelines 2018: management of cystic fibrosis-related diabetes in children and adolescents. Pediatr Diabetes. 2018;19:64–74. doi:10.1111/pedi.12732
  • Davis PB. Cystic Fibrosis. Pediatr Rev. 2001;22(8):257–264. doi:10.1542/pir.22-8-257
  • Bogdani M, Blackman SM, Ridaura C, Bellocq J-P, Powers AC, Aguilar-Bryan L. Structural abnormalities in islets from very young children with cystic fibrosis may contribute to cystic fibrosis-related diabetes. Sci Rep. 2017;7(1):17231. doi:10.1038/s41598-017-17404-z
  • Hart NJ, Aramandla R, Poffenberger G, et al. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight. 2018;3(8):e98240. doi:10.1172/jci.insight.98240
  • Kelsey R, Manderson Koivula FN, McClenaghan NH, Kelly C. Cystic fibrosis–related diabetes: pathophysiology and therapeutic challenges. Clin Med Insights Endocrinol Diabetes. 2019;12:117955141985177. doi:10.1177/1179551419851770
  • Doan LV, Madison LD. Cystic Fibrosis Related Diabetes. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.
  • Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10(12):826–837. doi:10.1038/nri2873
  • Hunt WR, Hansen JM, Stecenko AA. Glucose ingestion in cystic fibrosis induces severe redox imbalance: a potential role in diabetes. J Cyst Fibros. 2020;19(3):476–482. doi:10.1016/j.jcf.2020.02.010
  • Sajadi S, Khoramdelazad H, Hassanshahi G, et al. Plasma Levels of CXCL1 (GRO-α) and CXCL10 (IP-10) are elevated in type 2 diabetic patients: evidence for the involvement of inflammation and angiogenesis/angiostasis in this disease state. Clin Lab. 2013;59. doi:10.7754/Clin.Lab.2012.120225
  • Omatsu T, Cepinskas G, Clarson C, et al. CXCL1/CXCL8 (GROα/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro. Am J Physiol. 2014;306(9):E1077–84. doi:10.1152/ajpendo.00659.2013
  • Meyer N, Nuss SJ, Siebenhüner A, Akdis CA, Menz G, Rothe T. Differential serum protein markers and the clinical severity of asthma. JAA. 2014;67. doi:10.2147/JAA.S53920
  • Wheeler KC, Jena MK, Pradhan BS, et al. VEGF may contribute to macrophage recruitment and M2 polarization in the decidua. PLoS One. 2018;13(1):e0191040. doi:10.1371/journal.pone.0191040
  • Sun X, Zhang H, Liu J, Wang G. Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus. J Int Med Res. 2019;47(11):5584–5592. doi:10.1177/0300060519872033
  • Lamoke F, Labazi M, Montemari A, Parisi G, Varano M, Bartoli M. Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina. Exp Eye Res. 2011;93(4):350–354. doi:10.1016/j.exer.2011.02.007
  • Compernolle V, Brusselmans K, Acker T, et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002;8(7):702–710. doi:10.1038/nm721
  • Al-Husseini A, Kraskauskas D, Mezzaroma E, et al. Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension. Pulm Circ. 2015;5(1):101–116. doi:10.1086/679704
  • Akturk HK, Kahramangil D, Sarwal A, Hoffecker L, Murad MH, Michels AW. Immune checkpoint inhibitor‐induced Type 1 diabetes: a systematic review and meta‐analysis. Diabet Med. 2019;36(9):1075–1081. doi:10.1111/dme.14050
  • Colli ML, Hill JLE, Marroquí L, et al. PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. EBioMedicine. 2018;36:367–375. doi:10.1016/j.ebiom.2018.09.040
  • Geng Y, Liu X, Liang J, et al. PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis. JCI Insight. 2019. doi:10.1172/jci.insight.125326
  • Yuan S, Zhang S, Zhuang Y, Zhang H, Bai J, Hou Q. Interleukin-17 stimulates STAT3-mediated endothelial cell activation for neutrophil recruitment. Cell Physiol Biochem. 2015;36(6):2340–2356. doi:10.1159/000430197
  • Song TL, Nairismägi M-L, Laurensia Y, et al. Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma. Blood. 2018;132(11):1146–1158. doi:10.1182/blood-2018-01-829424
  • Hwang S, Seong H, Ryu J, et al. Phosphorylation of STAT3 and ERBB2 mediates hypoxia‑induced VEGF release in ARPE‑19 cells. Mol Med Rep. 2020. doi:10.3892/mmr.2020.11344
  • Kohan M, Puxeddu I, Reich R, Levi-Schaffer F, Berkman N. Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts. Ann Allergy Asthma Immunol. 2010;104(1):66–72. doi:10.1016/j.anai.2009.11.003
  • Van Dyke AL, Lang Kuhs KA, Shiels MS, et al. Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States. PLoS One. 2017;12(7):e0182359. doi:10.1371/journal.pone.0182359
  • Coomans de Brachène A, Dos Santos RS, Marroqui L, et al. IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells. Diabetologia. 2018;61(3):636–640. doi:10.1007/s00125-017-4536-4
  • Shan Z, Xu C, Wang W, Li W. Enhanced PDGF signaling in gestational diabetes mellitus is involved in pancreatic β-cell dysfunction. Biochem Biophys Res Commun. 2019;516(2):402–407. doi:10.1016/j.bbrc.2019.06.048
  • Lam GY, Goodwin J, Wilcox PG, Quon BS. Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes. ERJ Open Res. 2021;7(1):00475–2020. doi:10.1183/23120541.00475-2020