Anticipation of Relapse and Acute Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation: The Fundamental Role of Antigen-Presenting (Dendritic) Cells

References

• Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol. 2013;31:563–604. doi:10.1146/annurev-immunol-020711-074950
   PubMed Web of Science ®Google Scholar
• Hart DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood. 1997;90:3245–3287.
   PubMed Web of Science ®Google Scholar
• Thomas R, Lipsky PE. Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells. J Immunol. 1994;153:4016–4028.
   PubMed Web of Science ®Google Scholar
• Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood. 2000;95:2484–2490. doi:10.1182/blood.V95.8.2484
   PubMed Web of Science ®Google Scholar
• Ryncarz RE, Anasetti C. Expression of CD86 on human marrow CD34+ cells identifies immunocompetent committed precursors of macrophages and dendritic cells. Blood. 1998;91:3892–3900. doi:10.1182/blood.V91.10.3892
   PubMed Web of Science ®Google Scholar
• Wang Q, Su X, He Y, et al. CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation. Immunology. 2021;164:148–160. doi:10.1111/imm.13350
   PubMed Web of Science ®Google Scholar
• Porta MD, Rigolin GM, Alessandrino EP, et al. Dendritic cell recovery after allogeneic stem-cell transplantation in acute leukemia: correlations with clinical and transplant characteristics. Eur J Haematol. 2004;72:18–25. doi:10.1046/j.0902-4441.2004.00172.x
   PubMed Web of Science ®Google Scholar
• Vakkila J, Thomson AW, Hovi L, Vettenranta K, Saarinen-Pihkala UM. Circulating dendritic cell subset levels after allogeneic stem cell transplantation in children correlate with time post transplant and severity of acute graft-versus-host disease. Bone Marrow Tran. 2005;35:501–507. doi:10.1038/sj.bmt.1704827
   PubMed Web of Science ®Google Scholar
• Talarn C, Urbano-Ispizua A, Martino R, et al. Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcome. Haematologica. 2007;92:1655–1663. doi:10.3324/haematol.11076
   PubMed Web of Science ®Google Scholar
• Takebayashi M, Amakawa R, Tajima K, et al. Blood dendritic cells are decreased in acute graft-versus-host disease. Bone Marrow Tran. 2004;33:989–996. doi:10.1038/sj.bmt.1704406
   PubMed Web of Science ®Google Scholar
• Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science. 1999;283:1183–1186. doi:10.1126/science.283.5405.1183
   PubMed Web of Science ®Google Scholar
• Waller EK, Rosenthal H, Jones TW, et al. Larger numbers of CD4 (bright) dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation. Blood. 2001;97:2948–2956. doi:10.1182/blood.V97.10.2948
   PubMed Web of Science ®Google Scholar
• Mannering SI, McKenzie JL, Hart DN. Optimisation of the conditions for generating human DC initiated antigen specific T lymphocyte lines in vitro. J Immunol Methods. 1998;219:69–83. doi:10.1016/S0022-1759(98)00125-2
   PubMed Web of Science ®Google Scholar
• Przepiorka D, Weisdorf D, Martin P, et al. 1994 consensus conference on acute GVHD grading. Bone Marrow Tran. 1995;15:825–828.
   PubMed Web of Science ®Google Scholar
• Martin PJ, Rizzo JD, Wingard JR, et al. First-and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Tran. 2012;18:1150–1163. doi:10.1016/j.bbmt.2012.04.005
   PubMed Web of Science ®Google Scholar
• Kadowaki N. Dendritic cells—A conductor of T cell differentiation. Allergol Int. 2007;56:193–199. doi:10.2332/allergolint.R-07-146
   PubMedGoogle Scholar
• Willmann K, Dunne JF. A flow cytometric immune function assay for human peripheral blood dendritic cells. J Leukoc Biol. 2000;67:536–544. doi:10.1002/jlb.67.4.536
   PubMed Web of Science ®Google Scholar
• López JA, Crosbie G, Kelly C, et al. Monitoring and isolation of blood dendritic cells from apheresis products in healthy individuals: a platform for cancer immunotherapy. J Immunol Methods. 2002;267:199–212. doi:10.1016/S0022-1759(02)00185-0
   PubMed Web of Science ®Google Scholar
• Waller EK, Rosenthal H, Sagar L. DC2 effect on survival following allogeneic bone marrow transplantation. Oncology. 2002;16:19–26.
   PubMed Web of Science ®Google Scholar
• Reddy V, Iturraspe JA, Tzolas AC, Meier-Kriesche HU, Schold J, Wingard JR. Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host disease. Blood. 2004;103:4330–4335. doi:10.1182/blood-2003-09-3325
   PubMed Web of Science ®Google Scholar
• Rajasekar R, Lakshmi KM, George B, et al. Dendritic cell count in the graft predicts relapse in patients with hematologic malignancies undergoing an HLA-matched related allogeneic peripheral blood stem cell transplant. Biol Blood Marrow Tran. 2010;16:854–860. doi:10.1016/j.bbmt.2010.01.013
   PubMed Web of Science ®Google Scholar
• McQuaker I, Haynes A, Stainer C, Byrne J, Russell N. Mobilisation of peripheral blood stem cells with IVE and G-CSF improves CD34+ cell yields and engraftment in patients with non-Hodgkin’s lymphomas and Hodgkin’s disease. Bone Marrow Tran. 1999;24:715–722. doi:10.1038/sj.bmt.1701985
   PubMed Web of Science ®Google Scholar
• Gluckman J-C, Canque B, Rosenzwajg M. Dendritic cells: a complex simplicity. Transplantation. 2002;73:S3–S6. doi:10.1097/00007890-200201151-00004
   PubMed Web of Science ®Google Scholar
• Gonçalves MV, Yamamoto M, Kimura EY, et al. Low counts of plasmacytoid dendritic cells after engraftment are associated with high early mortality after allogeneic stem cell transplantation. Biol Blood Marrow Tran. 2015;21:1223–1229. doi:10.1016/j.bbmt.2015.03.010
   PubMed Web of Science ®Google Scholar
• Lee YK, Ju JM, Shon WJ, et al. Skewed dendritic cell differentiation of MyD88-deficient donor bone marrow cells, instead of massive expansion as myeloid-derived suppressor cells, aggravates GVHD. Immune Netw. 2018;18(6):e44. PMID: 30619630; PMCID: PMC6312895. doi:10.4110/in.2018.18.e44.
   PubMed Web of Science ®Google Scholar
• Hock B, Haring L, Ebbett A, Patton W, McKenzie J. Differential effects of G-CSF mobilisation on dendritic cell subsets in normal allogeneic donors and patients undergoing autologous transplantation. Bone Marrow Tran. 2002;30:733–740. doi:10.1038/sj.bmt.1703734
   PubMed Web of Science ®Google Scholar