Co-Application of C16 and Ang-1 Improves the Effects of Levodopa in Parkinson Disease Treatment

References

• Radhakrishnan DM, Goyal V. Parkinson’s disease: a review. Neurol India. 2018;66:S26–s35. doi:10.4103/0028-3886.226451
   PubMed Web of Science ®Google Scholar
• Yan A, Song L, Zhang Y, Wang X, Liu Z. Systemic inflammation increases the susceptibility to levodopa-induced dyskinesia in 6-OHDA lesioned rats by targeting the NR2B-medicated PKC/MEK/ERK pathway. Front Aging Neurosci. 2020;12:625166. doi:10.3389/fnagi.2020.625166
   PubMed Web of Science ®Google Scholar
• Lanza K, Perkins AE, Deak T, Bishop C. Late aging-associated increases in L-DOPA-induced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat. Neurobiol Aging. 2019;81:190–199. doi:10.1016/j.neurobiolaging.2019.05.019
   PubMed Web of Science ®Google Scholar
• Marino BLB, de Souza LR, Sousa KPA, et al. Parkinson’s disease: a review from pathophysiology to treatment. Mini Rev Med Chem. 2020;20:754–767. doi:10.2174/1389557519666191104110908
   PubMed Web of Science ®Google Scholar
• Del-Bel E, Bortolanza M, Dos-Santos-Pereira M, Bariotto K, Raisman-Vozari R. l-DOPA-induced dyskinesia in Parkinson’s disease: are neuroinflammation and astrocytes key elements? Synapse. 2016;70:479–500. doi:10.1002/syn.21941
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang Y, Zheng X, et al. Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice. J Neuroinflammation. 2018;15:112. doi:10.1186/s12974-018-1141-5
   PubMed Web of Science ®Google Scholar
• Fu X, Chen H, Han S. C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation. Life Sci. 2020;256:117894. doi:10.1016/j.lfs.2020.117894
   PubMed Web of Science ®Google Scholar
• Jiang H, Zhang F, Yang J, Han S. Angiopoietin-1 ameliorates inflammation-induced vascular leakage and improves functional impairment in a rat model of acute experimental autoimmune encephalomyelitis. Exp Neurol. 2014;261:245–257. doi:10.1016/j.expneurol.2014.05.013
   PubMed Web of Science ®Google Scholar
• Zhang F, Yang J, Jiang H, Han S. An ανβ3 integrin-binding peptide ameliorates symptoms of chronic progressive experimental autoimmune encephalomyelitis by alleviating neuroinflammatory responses in mice. J Neuroimmune Pharmacol. 2014;9:399–412. doi:10.1007/s11481-014-9532-6
   PubMed Web of Science ®Google Scholar
• Wang B, Tian KW, Zhang F, Jiang H, Han S. Angiopoietin-1 and C16 peptide attenuate vascular and inflammatory responses in experimental allergic encephalomyelitis. CNS Neurol Disord Drug Targets. 2016;15:496–513. doi:10.2174/1871527314666150821112546
   PubMed Web of Science ®Google Scholar
• Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson’s disease. Nat Protoc. 2007;2:141–151. doi:10.1038/nprot.2006.342
   PubMed Web of Science ®Google Scholar
• Zhang QS, Heng Y, Mou Z, Huang JY, Yuan YH, Chen NH. Reassessment of subacute MPTP-treated mice as animal model of Parkinson’s disease. Acta Pharmacol Sin. 2017;38:1317–1328. doi:10.1038/aps.2017.49
   PubMed Web of Science ®Google Scholar
• Cai HY, Fu XX, Jiang H, Han S. Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson’s disease. NPJ Parkinsons Dis. 2021;7:91. doi:10.1038/s41531-021-00233-3
   PubMed Web of Science ®Google Scholar
• Su RJ, Zhen JL, Wang W, Zhang JL, Zheng Y, Wang XM. Time-course behavioral features are correlated with Parkinson’s disease‑associated pathology in a 6-hydroxydopamine hemiparkinsonian rat model. Mol Med Rep. 2018;17:3356–3363. doi:10.3892/mmr.2017.8277
   PubMed Web of Science ®Google Scholar
• Keller AV, Rees KM, Seibt EJ, et al. Electromyographic patterns of the rat hindlimb in response to muscle stretch after spinal cord injury. Spinal Cord. 2018;56:560–568. doi:10.1038/s41393-018-0069-z
   PubMed Web of Science ®Google Scholar
• Pajares M, Manda G, Boscá L, Cuadrado A, Cuadrado A. Inflammation in Parkinson’s disease: mechanisms and therapeutic implications. Cells. 2020;9:1687. doi:10.3390/cells9071687
   PubMed Web of Science ®Google Scholar
• Dou F, Chu X, Zhang B, et al. EriB targeted inhibition of microglia activity attenuates MPP(+) induced DA neuron injury through the NF-κB signaling pathway. Mol Brain. 2018;11:75. doi:10.1186/s13041-018-0418-z
   PubMed Web of Science ®Google Scholar
• Blandini F, Armentero MT. Animal models of Parkinson’s disease. Febs J. 2012;279:1156–1166. doi:10.1111/j.1742-4658.2012.08491.x
   PubMed Web of Science ®Google Scholar
• Bishop C. Neuroinflammation: fanning the fire of l-dopa-induced dyskinesia. Mov Disord. 2019;34:1758–1760. doi:10.1002/mds.27900
   PubMed Web of Science ®Google Scholar
• Calabresi P, Standaert DG. Dystonia and levodopa-induced dyskinesias in Parkinson’s disease: is there a connection? Neurobiol Dis. 2019;132:104579. doi:10.1016/j.nbd.2019.104579
   PubMed Web of Science ®Google Scholar
• Iderberg H, Francardo V, Pioli EY. Animal models of L-DOPA-induced dyskinesia: an update on the current options. Neuroscience. 2012;211:13–27. doi:10.1016/j.neuroscience.2012.03.023
   PubMed Web of Science ®Google Scholar
• Petrozziello T, Mills AN, Vaine CA, et al. Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex. Neurobiol Dis. 2020;144:105032. doi:10.1016/j.nbd.2020.105032
   PubMed Web of Science ®Google Scholar
• Mei M, Zhou Y, Liu M, et al. Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson’s disease. Neuropharmacology. 2019;160:107758. doi:10.1016/j.neuropharm.2019.107758
   PubMed Web of Science ®Google Scholar
• Schwenkgrub J, Zaremba M, Joniec-Maciejak I, Cudna A, Mirowska-Guzel D, Kurkowska-Jastrzębska I. The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson’s disease. PLoS One. 2017;12:e0182019. doi:10.1371/journal.pone.0182019
   PubMed Web of Science ®Google Scholar
• Rui Q, Ni H, Li D, Gao R, Chen G. The role of LRRK2 in neurodegeneration of Parkinson disease. Curr Neuropharmacol. 2018;16:1348–1357. doi:10.2174/1570159x16666180222165418
   PubMed Web of Science ®Google Scholar
• Dwyer Z, Rudyk C, Thompson A, et al. Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration. Neurobiol Aging. 2020;91:45–55. doi:10.1016/j.neurobiolaging.2020.02.017
   PubMed Web of Science ®Google Scholar
• Gelders G, Baekelandt V, Van der Perren A. Linking neuroinflammation and neurodegeneration in Parkinson’s disease. J Immunol Res. 2018;2018:4784268. doi:10.1155/2018/4784268
   PubMed Web of Science ®Google Scholar
• Cai HY, Tian KW, Zhang YY, Jiang H, Han S. Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model. Aging. 2018;10:3507–3527. doi:10.18632/aging.101661
   PubMedGoogle Scholar
• Aryal S, Skinner T, Bridges B, Weber JT. The pathology of Parkinson’s disease and potential benefit of dietary polyphenols. Molecules. 2020;25:4382. doi:10.3390/molecules25194382
   PubMed Web of Science ®Google Scholar
• Abg Abd Wahab DY, Gau CH, Zakaria R, et al. Review on cross talk between neurotransmitters and neuroinflammation in striatum and cerebellum in the mediation of motor behaviour. Biomed Res Int. 2019;2019:1767203. doi:10.1155/2019/1767203
   PubMed Web of Science ®Google Scholar
• Roberts BM, Doig NM, Brimblecombe KR, et al. GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model. Nat Commun. 2020;11:4958. doi:10.1038/s41467-020-18247-5
   PubMed Web of Science ®Google Scholar
• Kish SJ, Schut L, Simmons J, Gilbert J, Chang LJ, Rebbetoy M. Brain acetylcholinesterase activity is markedly reduced in dominantly-inherited olivopontocerebellar atrophy. J Neurol Neurosurg Psychiatry. 1988;51:544–548. doi:10.1136/jnnp.51.4.544
   PubMed Web of Science ®Google Scholar