Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia

References

• Thébaud B, Goss KN, Laughon M, et al. Bronchopulmonary dysplasia. Nat Rev Dis Primers. 2019;5(1):78. doi:10.1038/s41572-019-0127-7
   PubMed Web of Science ®Google Scholar
• Liu ZQ, Li XX, Qiu SQ, et al.Vitamin D contributes to mast cell stabilization. Allergy. 2017;72(8):1184–1192.
   PubMed Web of Science ®Google Scholar
• Corachán A, Ferrero H, Aguilar A, et al. Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/β-catenin pathway. Fertil Steril. 2019;111(2):397–407. doi:10.1016/j.fertnstert.2018.10.008
   PubMed Web of Science ®Google Scholar
• Schardey J, Globig A-M, Janssen C, et al. Vitamin D inhibits pro-inflammatory T cell function in patients with inflammatory bowel disease. J Crohns Colitis. 2019;13(12):1546–1557. doi:10.1093/ecco-jcc/jjz090
   PubMed Web of Science ®Google Scholar
• Tzilas V, Bouros E, Barbayianni I, et al. Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis. Pulm Pharmacol Ther. 2019;55:17–24. doi:10.1016/j.pupt.2019.01.003
   PubMed Web of Science ®Google Scholar
• Mao X, Qiu J, Zhao L, et al. Vitamin D and IL-10 deficiency in preterm neonates with bronchopulmonary dysplasia. Front Pediatr. 2018;6:246. doi:10.3389/fped.2018.00246
   PubMed Web of Science ®Google Scholar
• Chen C, Weng H, Zhang X, et al. Low-dose vitamin D protects hyperoxia-induced bronchopulmonary dysplasia by inhibiting neutrophil extracellular traps. Front Pediatr. 2020;8:335. doi:10.3389/fped.2020.00335
   PubMed Web of Science ®Google Scholar
• Zhen H, Hu H, Rong G, Huang X, Tan C, Yu X. VitA or VitD ameliorates bronchopulmonary dysplasia by regulating the balance between M1 and M2 macrophages. Biomed Pharmacother. 2021;141:111836. doi:10.1016/j.biopha.2021.111836
   PubMed Web of Science ®Google Scholar
• Kose M, Bastug O, Sonmez MF, et al. Protective effect of vitamin D against hyperoxia-induced lung injury in newborn rats. Pediatr Pulmonol. 2017;52(1):69–76. doi:10.1002/ppul.23500
   PubMed Web of Science ®Google Scholar
• Yao L, Shi Y, Zhao X, et al. Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4. Int J Mol Med. 2017;39(6):1403–1408. doi:10.3892/ijmm.2017.2961
   PubMed Web of Science ®Google Scholar
• Song J, Liu W, Wang J, et al. GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78. Cell Death Dis. 2020;11(5):352. doi:10.1038/s41419-020-2537-6
   PubMed Web of Science ®Google Scholar
• Stivala S, Codilupi T, Brkic S, et al. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019;129(4):1596–1611. doi:10.1172/JCI98785
   PubMed Web of Science ®Google Scholar
• Yamakawa K, Yokohira M, Nakano Y, Kishi S, Kanie S, Imaida K. Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice. Cancer Med. 2016;5(5):903–913. doi:10.1002/cam4.652
   PubMed Web of Science ®Google Scholar
• Long ME, Gong K-Q, Eddy WE, et al. MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury. JCI Insight. 2019;4(23). doi:10.1172/jci.insight.132377
   Web of Science ®Google Scholar
• Villamor-Martinez E, Álvarez-Fuente M, Ghazi AMT, et al. Association of chorioamnionitis with bronchopulmonary dysplasia among preterm infants: a systematic review, meta-analysis, and metaregression. JAMA Netw Open. 2019;2(11):e1914611. doi:10.1001/jamanetworkopen.2019.14611
   PubMed Web of Science ®Google Scholar
• Poets CF, Lorenz L. Prevention of bronchopulmonary dysplasia in extremely low gestational age neonates: current evidence. Arch Dis Child Fetal Neonatal Ed. 2018;103(3):F285–F291. doi:10.1136/archdischild-2017-314264
   PubMed Web of Science ®Google Scholar
• Shrestha AK, Gopal VYN, Menon RT, Hagan JL, Huang S, Shivanna B. Lung omics signatures in a bronchopulmonary dysplasia and pulmonary hypertension-like murine model. Am J Physiol Lung Cell Mol Physiol. 2018;315(5):L734–L741. doi:10.1152/ajplung.00183.2018
   PubMed Web of Science ®Google Scholar
• Lopez J, Tait SWG. Mitochondrial apoptosis: killing cancer using the enemy within. Br J Cancer. 2015;112(6):957–962. doi:10.1038/bjc.2015.85
   PubMed Web of Science ®Google Scholar
• Sucre JMS, Vickers KC, Benjamin JT, et al. Hyperoxia injury in the developing lung is mediated by mesenchymal expression of Wnt5A. Am J Respir Crit Care Med. 2020;201(10):1249–1262. doi:10.1164/rccm.201908-1513OC
   PubMed Web of Science ®Google Scholar
• de Oliveira LRC, Mimura LAN, Fraga-Silva TF, et al. Calcitriol prevents neuroinflammation and reduces blood-brain barrier disruption and local macrophage/microglia activation. Front Pharmacol. 2020;11:161. doi:10.3389/fphar.2020.00161
   PubMed Web of Science ®Google Scholar
• Das P, Acharya S, Prahaladan VM, et al. Chitin-derived AVR-48 prevents experimental bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension in newborn mice. Int J Mol Sci. 2021;22(16):8547. doi:10.3390/ijms22168547
   PubMed Web of Science ®Google Scholar
• Gouveia L, Kraut S, Hadzic S, et al. Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung. Am J Physiol Lung Cell Mol Physiol. 2020;318(4):L831–L843. doi:10.1152/ajplung.00295.2019
   PubMed Web of Science ®Google Scholar
• Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101–1108. doi:10.1038/nprot.2008.73
   PubMed Web of Science ®Google Scholar
• Bi C-S, Li X, Qu H-L, et al. Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17). Cell Prolif. 2020;53(6):e12827. doi:10.1111/cpr.12827
   PubMed Web of Science ®Google Scholar
• Radujkovic A, Schnitzler P, Ho AD, Dreger P, Luft T. Low serum vitamin D levels are associated with shorter survival after first-line azacitidine treatment in patients with myelodysplastic syndrome and secondary oligoblastic acute myeloid leukemia. Clin Nutr. 2017;36(2):542–551. doi:10.1016/j.clnu.2016.01.021
   PubMed Web of Science ®Google Scholar
• Chen X-Q, Wu S-H, Luo -Y-Y, et al. Lipoxin A attenuates bronchopulmonary dysplasia via upregulation of Let-7c and downregulation of TGF-β signaling pathway. Inflammation. 2017;40(6):2094–2108. doi:10.1007/s10753-017-0649-7
   PubMed Web of Science ®Google Scholar
• Zhang L, Bai X, Yan W. LncRNA-MALAT1, as a biomarker of neonatal BPD, exacerbates the pathogenesis of BPD by targeting miR-206. Am J Transl Res. 2021;13(2):462–479.
   PubMed Web of Science ®Google Scholar
• Kalikkot Thekkeveedu R, Guaman MC, Shivanna B. Bronchopulmonary dysplasia: a review of pathogenesis and pathophysiology. Respir Med. 2017;132:170–177. doi:10.1016/j.rmed.2017.10.014
   PubMed Web of Science ®Google Scholar
• Chaubey S, Thueson S, Ponnalagu D, et al. Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6. Stem Cell Res Ther. 2018;9(1):173. doi:10.1186/s13287-018-0903-4
   PubMed Web of Science ®Google Scholar
• Moreira A, Winter C, Joy J, et al. Intranasal delivery of human umbilical cord Wharton’s jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia. Stem Cells Transl Med. 2020;9(2):221–234. doi:10.1002/sctm.18-0273
   PubMed Web of Science ®Google Scholar
• Willis GR, Fernandez-Gonzalez A, Anastas J, et al. Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation. Am J Respir Crit Care Med. 2018;197(1):104–116. doi:10.1164/rccm.201705-0925OC
   PubMed Web of Science ®Google Scholar
• Ashley SL, Sjoding MW, Popova AP, et al. Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice. Sci Transl Med. 2020;12(556). doi:10.1126/scitranslmed.aau9959
   PubMed Web of Science ®Google Scholar
• Hirsch K, Taglauer E, Seedorf G, et al. Perinatal hypoxia-inducible factor stabilization preserves lung alveolar and vascular growth in experimental bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2020;202(8):1146–1158. doi:10.1164/rccm.202003-0601OC
   PubMed Web of Science ®Google Scholar
• Zhao W, Ma L, Cai C, Gong X. Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-κB and A2aR signaling in LPS-induced THP-1 macrophages. Int J Biol Sci. 2019;15(8):1571–1581. doi:10.7150/ijbs.34211
   PubMed Web of Science ®Google Scholar
• Savani RC. Modulators of inflammation in bronchopulmonary dysplasia. Semin Perinatol. 2018;42(7):459–470. doi:10.1053/j.semperi.2018.09.009
   PubMed Web of Science ®Google Scholar
• Witkowski SM, de Castro EM, Nagashima S, et al. Analysis of interleukins 6, 8, 10 and 17 in the lungs of premature neonates with bronchopulmonary dysplasia. Cytokine. 2020;131:155118. doi:10.1016/j.cyto.2020.155118
   PubMed Web of Science ®Google Scholar
• Cui TX, Fulton CT, Brady AE, Zhang Y-J, Goldsmith AM, Popova AP. Lung CD103dendritic cells and Clec9a signaling are required for neonatal hyperoxia-induced inflammatory responses to rhinovirus infection. Am J Physiol Lung Cell Mol Physiol. 2021;320(2):L193–L204. doi:10.1152/ajplung.00334.2019
   PubMed Web of Science ®Google Scholar
• Huang D, Fang F, Xu F. Hyperoxia induces inflammation and regulates cytokine production in alveolar epithelium through TLR2/4-NF-κB-dependent mechanism. Eur Rev Med Pharmacol Sci. 2016;20(7):1399–1410.
   PubMed Web of Science ®Google Scholar
• Ferder M, Inserra F, Manucha W, Ferder L. The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system. Am J Physiol Cell Physiol. 2013;304(11):C1027–C1039. doi:10.1152/ajpcell.00403.2011
   PubMed Web of Science ®Google Scholar
• Huang F, Ju Y-H, Wang H-B, Li Y-N. Maternal vitamin D deficiency impairs Treg and Breg responses in offspring mice and deteriorates allergic airway inflammation. Allergy Asthma Clin Immunol. 2020;16:89. doi:10.1186/s13223-020-00487-1
   PubMed Web of Science ®Google Scholar
• Han H, Chung SI, Park HJ, et al. Obesity-induced vitamin D deficiency contributes to lung fibrosis and airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2021;64(3):357–367. doi:10.1165/rcmb.2020-0086OC
   PubMed Web of Science ®Google Scholar
• Sari E, Oztay F, Tasci AE. Vitamin D modulates E-cadherin turnover by regulating TGF-β and Wnt signalings during EMT-mediated myofibroblast differentiation in A459 cells. J Steroid Biochem Mol Biol. 2020;202:105723. doi:10.1016/j.jsbmb.2020.105723
   PubMed Web of Science ®Google Scholar
• Fitch N, Becker AB, HayGlass KT. Vitamin D [1,25(OH)2D3] differentially regulates human innate cytokine responses to bacterial versus viral pattern recognition receptor stimuli. J Immunol. 2016;196(7):2965–2972. doi:10.4049/jimmunol.1500460
   PubMed Web of Science ®Google Scholar
• Anderson J, Do LAH, Toh ZQ, et al. Vitamin D induces differential effects on inflammatory responses during bacterial and/or viral stimulation of human peripheral blood mononuclear cells. Front Immunol. 2020;11:602. doi:10.3389/fimmu.2020.00602
   PubMed Web of Science ®Google Scholar
• Liu C, Chen Z, Li W, Huang L, Zhang Y. Vitamin D enhances alveolar development in antenatal lipopolysaccharide-treated rats through the suppression of interferon-γ production. Front Immunol. 2017;8:1923. doi:10.3389/fimmu.2017.01923
   PubMed Web of Science ®Google Scholar
• Mandell E, Seedorf G, Gien J, Abman SH. Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014;306(5):L420–L428. doi:10.1152/ajplung.00344.2013
   PubMed Web of Science ®Google Scholar
• Hauseman ZJ, Harvey EP, Newman CE, et al. Homogeneous oligomers of pro-apoptotic BAX reveal structural determinants of mitochondrial membrane permeabilization. Mol Cell. 2020;79(1):68–83.e7. doi:10.1016/j.molcel.2020.05.029
   PubMed Web of Science ®Google Scholar
• Tan Z, Xiao L, Tang M, et al. Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy. Theranostics. 2018;8(9):2329–2347. doi:10.7150/thno.21451
   PubMed Web of Science ®Google Scholar
• Ngoi NYL, Choong C, Lee J, et al. Targeting mitochondrial apoptosis to overcome treatment resistance in cancer. Cancers. 2020;12(3):574. doi:10.3390/cancers12030574
   PubMed Web of Science ®Google Scholar
• Sorrentino G, Comel A, Mantovani F, Del Sal G. Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration. Mitochondrion. 2014;19(Pt A):88–96. doi:10.1016/j.mito.2014.08.003
   PubMed Web of Science ®Google Scholar
• Yang Y, Wang G, Wu W, et al. Camalexin induces apoptosis via the ROS-ER stress-mitochondrial apoptosis pathway in AML cells. Oxid Med Cell Longev. 2018;2018:7426950. doi:10.1155/2018/7426950
   PubMed Web of Science ®Google Scholar
• Pan X, Yan D, Wang D, et al. Mitochondrion-mediated apoptosis induced by acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 cells. Mol Neurobiol. 2017;54(6):4781–4794. doi:10.1007/s12035-016-0021-1
   PubMed Web of Science ®Google Scholar
• Linke R, Pries R, Könnecke M, et al. The MEK1/2-ERK1/2 pathway is activated in chronic rhinosinusitis with nasal polyps. Arch Immunol Ther Exp. 2014;62(3):217–229. doi:10.1007/s00005-014-0281-2
   PubMed Web of Science ®Google Scholar
• Jiménez-Sousa MÁ, Martínez I, Medrano LM, Fernández-Rodríguez A, Resino S. Vitamin D in human immunodeficiency virus infection: influence on immunity and disease. Front Immunol. 2018;9:458. doi:10.3389/fimmu.2018.00458
   PubMed Web of Science ®Google Scholar