Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

References

• Rajmohan R, Reddy PH. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. J Alzheimers Dis. 2017;57(4):975–999. doi:10.3233/JAD-160612
   PubMed Web of Science ®Google Scholar
• DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener. 2019;14(1):32. doi:10.1186/s13024-019-0333-5
   PubMed Web of Science ®Google Scholar
• Tejera D, Mercan D, Sanchez-Caro JM, et al. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. EMBO J. 2019;38(17):e101064. doi:10.15252/embj.2018101064
   PubMed Web of Science ®Google Scholar
• Solleiro-Villavicencio H, Rivas-Arancibia S. Effect of chronic oxidative stress on neuroinflammatory response mediated by CD4(+) T cells in neurodegenerative diseases. Front Cell Neurosci. 2018;12:114. doi:10.3389/fncel.2018.00114
   PubMed Web of Science ®Google Scholar
• Park J, Min JS, Kim B, et al. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-kappaB pathways. Neurosci Lett. 2015;584:191–196. doi:10.1016/j.neulet.2014.10.016
   PubMed Web of Science ®Google Scholar
• Avallone R, Lucchi C, Puja G, et al. BV-2 microglial cells respond to rotenone toxic insult by modifying pregnenolone, 5alpha-dihydroprogesterone and pregnanolone levels. Cells. 2020;9(9):2091. doi:10.3390/cells9092091
   PubMed Web of Science ®Google Scholar
• Alam MB, Ju MK, Kwon YG, Lee SH. Protopine attenuates inflammation stimulated by carrageenan and LPS via the MAPK/NF-kappaB pathway. Food Chem Toxicol. 2019;131:110583. doi:10.1016/j.fct.2019.110583
   PubMed Web of Science ®Google Scholar
• Wang S, Yuan YH, Chen NH, Wang HB. The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson’s disease. Int Immunopharmacol. 2019;67:458–464. doi:10.1016/j.intimp.2018.12.019
   PubMed Web of Science ®Google Scholar
• Cai Y, Chai Y, Fu Y, et al. Salidroside ameliorates Alzheimer’s disease by targeting NLRP3 inflammasome-mediated pyroptosis. Front Aging Neurosci. 2021;13:809433. doi:10.3389/fnagi.2021.809433
   PubMed Web of Science ®Google Scholar
• Shao L, Dong C, Geng D, He Q, Shi Y. Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer’s disease. Metab Brain Dis. 2022;37(2):329–341. doi:10.1007/s11011-021-00886-2
   PubMed Web of Science ®Google Scholar
• Abu-Elfotuh K, Al-Najjar AH, Mohammed AA, Aboutaleb AS, Badawi GA. Fluoxetine ameliorates Alzheimer’s disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway. Int Immunopharmacol. 2022;104:108488. doi:10.1016/j.intimp.2021.108488
   PubMed Web of Science ®Google Scholar
• Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270–278. doi:10.4161/oxim.2.5.9498
   PubMed Web of Science ®Google Scholar
• Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev. 2016;2016:7432797. doi:10.1155/2016/7432797
   PubMed Web of Science ®Google Scholar
• Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The role of polyphenols in human health and food systems: a mini-review. Front Nutr. 2018;5:87. doi:10.3389/fnut.2018.00087
   PubMed Web of Science ®Google Scholar
• Cao K, Xu J, Pu W, et al. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. Sci Rep. 2015;5:14014. doi:10.1038/srep14014
   PubMed Web of Science ®Google Scholar
• Xu J, Cao K, Liu X, Zhao L, Feng Z, Liu J. Punicalagin regulates signaling pathways in inflammation-associated chronic diseases. Antioxidants. 2021;11(1):29. doi:10.3390/antiox11010029
   Web of Science ®Google Scholar
• Venusova E, Kolesarova A, Horky P, Slama P. Physiological and immune functions of punicalagin. Nutrients. 2021;13(7):2150. doi:10.3390/nu13072150
   PubMed Web of Science ®Google Scholar
• Huang M, Wu K, Zeng S, et al. Punicalagin inhibited inflammation and migration of fibroblast-like synoviocytes through NF-kappaB pathway in the experimental study of rheumatoid arthritis. J Inflamm Res. 2021;14:1901–1913. doi:10.2147/JIR.S302929
   PubMed Web of Science ®Google Scholar
• Hung YL, Wang SC, Suzuki K, et al. Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages. Phytomedicine. 2019;59:152785. doi:10.1016/j.phymed.2018.12.008
   PubMed Web of Science ®Google Scholar
• Lirk P, Hoffmann G, Rieder J. Inducible nitric oxide synthase–time for reappraisal. Curr Drug Targets Inflamm Allergy. 2002;1(1):89–108. doi:10.2174/1568010023344913
   PubMedGoogle Scholar
• Norregaard R, Kwon TH, Frokiaer J. Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. Kidney Res Clin Pract. 2015;34(4):194–200. doi:10.1016/j.krcp.2015.10.004
   PubMed Web of Science ®Google Scholar
• Quintanilla RA, Orellana DI, Gonzalez-Billault C, Maccioni RB. Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp Cell Res. 2004;295(1):245–257. doi:10.1016/j.yexcr.2004.01.002
   PubMed Web of Science ®Google Scholar
• Greenhill CJ, Rose-John S, Lissilaa R, et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol. 2011;186(2):1199–1208. doi:10.4049/jimmunol.1002971
   PubMed Web of Science ®Google Scholar
• Huang CH, Wang SC, Chen IC, et al. Protective effect of piplartine against LPS-induced sepsis through attenuating the MAPKs/NF-kappaB signaling pathway and NLRP3 inflammasome activation. Pharmaceuticals. 2021;14(6):588. doi:10.3390/ph14060588
   Web of Science ®Google Scholar
• Huang MY, Tu CE, Wang SC, et al. Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia. BMC Complement Altern Med. 2018;18(1):221. doi:10.1186/s12906-018-2287-5
   PubMed Web of Science ®Google Scholar
• Ravichandran KA, Heneka MT. Inflammasome activation in neurodegenerative diseases. Essays Biochem. 2021;65(7):885–904. doi:10.1042/EBC20210021
   PubMed Web of Science ®Google Scholar
• Rui W, Xiao H, Fan Y, et al. Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer’s disease. J Neuroinflammation. 2021;18(1):280. doi:10.1186/s12974-021-02329-2
   PubMed Web of Science ®Google Scholar
• Yang S, Lian G. ROS and diseases: role in metabolism and energy supply. Mol Cell Biochem. 2020;467(1–2):1–12. doi:10.1007/s11010-019-03667-9
   PubMed Web of Science ®Google Scholar
• Erkkinen MG, Kim MO, Geschwind MD. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2018;10(4):a033118. doi:10.1101/cshperspect.a033118
   PubMed Web of Science ®Google Scholar
• Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–446. doi:10.1016/S0140-6736(20)30367-6
   PubMed Web of Science ®Google Scholar
• Muzio L, Viotti A, Martino G. Microglia in neuroinflammation and neurodegeneration: from understanding to therapy. Front Neurosci. 2021;15:742065. doi:10.3389/fnins.2021.742065
   PubMed Web of Science ®Google Scholar
• Naeem K, Tariq Al Kury L, Nasar F, et al. Natural dietary supplement, carvacrol, alleviates LPS-induced oxidative stress, neurodegeneration, and depressive-like behaviors via the Nrf2/HO-1 pathway. J Inflamm Res. 2021;14:1313–1329. doi:10.2147/JIR.S294413
   PubMed Web of Science ®Google Scholar
• Alzheimer’s Association. 2021 Alzheimer’s disease facts and figures. Alzheimers Dement. 2021;17(3):327–406. doi:10.1002/alz.12328
   PubMed Web of Science ®Google Scholar
• Riaz M, Al Kury LT, Atzaz N, et al. Carvacrol alleviates hyperuricemia-induced oxidative stress and inflammation by modulating the NLRP3/NF-kappaB pathwayt. Drug Des Devel Ther. 2022;16:1159–1170. doi:10.2147/DDDT.S343978
   PubMed Web of Science ®Google Scholar
• Wu S, Tian L. Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum). Molecules. 2017;22(10):1606. doi:10.3390/molecules22101606
   PubMed Web of Science ®Google Scholar
• Xu X, Yin P, Wan C, et al. Punicalagin inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4-mediated MAPKs and NF-kappaB activation. Inflammation. 2014;37(3):956–965. doi:10.1007/s10753-014-9816-2
   PubMed Web of Science ®Google Scholar
• Cao Y, Chen J, Ren G, Zhang Y, Tan X, Yang L. Punicalagin prevents inflammation in LPS-induced RAW264.7 macrophages by inhibiting FoxO3a/autophagy signaling pathway. Nutrients. 2019;11(11):2794. doi:10.3390/nu11112794
   PubMed Web of Science ®Google Scholar
• Zeng Y, Zhao H, Zhang T, et al. Lung-protective effect of punicalagin on LPS-induced acute lung injury in mice. Biosci Rep. 2022;42(1):BSR20212196. doi:10.1042/BSR20212196
   PubMed Web of Science ®Google Scholar
• Peng J, Wei D, Fu Z, et al. Punicalagin ameliorates lipopolysaccharide-induced acute respiratory distress syndrome in mice. Inflammation. 2015;38(2):493–499. doi:10.1007/s10753-014-9955-5
   PubMed Web of Science ®Google Scholar
• Fouad AA, Qutub HO, Al-Melhim WN. Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury. Toxicol Mech Methods. 2016;26(7):538–543. doi:10.1080/15376516.2016.1211207
   PubMed Web of Science ®Google Scholar
• Atrahimovich D, Samson AO, Khattib A, Vaya J, Khatib S. Punicalagin decreases serum glucose levels and increases PON1 activity and HDL anti-inflammatory values in balb/c mice fed a high-fat diet. Oxid Med Cell Longev. 2018;2018:2673076. doi:10.1155/2018/2673076
   PubMed Web of Science ®Google Scholar
• Panthi S, Manandhar S, Gautam K. Hydrogen sulfide, nitric oxide, and neurodegenerative disorders. Transl Neurodegener. 2018;7:3. doi:10.1186/s40035-018-0108-x
   PubMed Web of Science ®Google Scholar
• Ryan JC, Cross CA, Van Dolah FM. Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid. Neurosci Lett. 2011;487(1):83–87. doi:10.1016/j.neulet.2010.10.001
   PubMed Web of Science ®Google Scholar
• Imran M, Shah FA, Nadeem H, et al. Synthesis and biological evaluation of benzimidazole derivatives as potential neuroprotective agents in an ethanol-induced rodent model. ACS Chem Neurosci. 2021;12(3):489–505. doi:10.1021/acschemneuro.0c00659
   PubMed Web of Science ®Google Scholar
• Ali A, Shah FA, Zeb A, et al. NF-kappaB inhibitors attenuate MCAO induced neurodegeneration and oxidative stress-a reprofiling approach. Front Mol Neurosci. 2020;13:33. doi:10.3389/fnmol.2020.00033
   PubMed Web of Science ®Google Scholar
• Kim YE, Hwang CJ, Lee HP, et al. Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB. Neuropharmacology. 2017;117:21–32. doi:10.1016/j.neuropharm.2017.01.025
   PubMed Web of Science ®Google Scholar
• Fann DY, Lim YA, Cheng YL, et al. Evidence that NF-kappaB and MAPK signaling promotes NLRP inflammasome activation in neurons following ischemic stroke. Mol Neurobiol. 2018;55(2):1082–1096. doi:10.1007/s12035-017-0394-9
   PubMed Web of Science ®Google Scholar
• Usman H, Tan Z, Gul M, et al. Identification of novel and potential PPARgamma stimulators as repurposed drugs for MCAO associated brain degeneration. Toxicol Appl Pharmacol. 2022;446:116055. doi:10.1016/j.taap.2022.116055
   PubMed Web of Science ®Google Scholar
• Pellegrini C, Antonioli L, Lopez-Castejon G, Blandizzi C, Fornai M. Canonical and non-canonical activation of NLRP3 inflammasome at the crossroad between immune tolerance and intestinal inflammation. Front Immunol. 2017;8:36. doi:10.3389/fimmu.2017.00036
   PubMed Web of Science ®Google Scholar
• Gordon R, Albornoz EA, Christie DC, et al. Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice. Sci Transl Med. 2018;10(465):eaah4066. doi:10.1126/scitranslmed.aah4066
   PubMed Web of Science ®Google Scholar
• Xue J, Jia P, Zhang D, Yao Z. TTP488 ameliorates NLRP3-associated inflammation, viability, apoptosis, and ROS production in an Alzheimer’s disease cell model by mediating the JAK1/STAT3/NFkappaB/IRF3 pathway. Cell Biochem Funct. 2021;39(4):555–561. doi:10.1002/cbf.3623
   PubMed Web of Science ®Google Scholar
• An X, Zhang Y, Cao Y, Chen J, Qin H, Yang L. Punicalagin protects diabetic nephropathy by inhibiting pyroptosis based on TXNIP/NLRP3 pathway. Nutrients. 2020;12(5):1516. doi:10.3390/nu12051516
   PubMed Web of Science ®Google Scholar
• Walia V, Kaushik D, Mittal V, et al. Delineation of neuroprotective effects and possible benefits of antioxidants therapy for the treatment of Alzheimer’s diseases by targeting mitochondrial-derived reactive oxygen species: bench to bedside. Mol Neurobiol. 2022;59(1):657–680. doi:10.1007/s12035-021-02617-1
   PubMed Web of Science ®Google Scholar