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ORIGINAL RESEARCH

Potential Pathogenetic Role of Antimicrobial Peptides Carried by Extracellular Vesicles in an in vitro Psoriatic Model

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Pages 5387-5399 | Received 11 May 2022, Accepted 01 Aug 2022, Published online: 16 Sep 2022

References

  • Mohd Affandi A, Khan I, Ngah Saaya N. Epidemiology and clinical features of adult patients with psoriasis in Malaysia: 10-year review from the Malaysian psoriasis registry (2007–2016). Dermatol Res Pract. 2018;2018:4371471. doi:10.1155/2018/4371471
  • Di Meglio P, Villanova F, Nestle FO. Psoriasis. Cold Spring Harb Perspect Med. 2014;4(8):a015354–a015354. doi:10.1101/cshperspect.a015354
  • Chovatiya R, Silverberg JI. Pathophysiology of atopic dermatitis and psoriasis: implications for management in children. Children. 2019;6(10). doi:10.3390/children6100108
  • Volarić I, Vičić M, Prpić-Massari L. The role of CD8+ T-cells and their cytokines in the pathogenesis of psoriasis. Acta Dermatovenerol Croat. 2019;27(3):159–162.
  • Fujita H. The role of IL-22 and Th22 cells in human skin diseases. J Dermatol Sci. 2013;72(1):3–8. doi:10.1016/j.jdermsci.2013.04.028
  • Wang A, Bai Y. Dendritic cells: the driver of psoriasis. J Dermatol. 2020;47(2):104–113. doi:10.1111/1346-8138.15184
  • Morizane S, Gallo RL. Antimicrobial peptides in the pathogenesis of psoriasis. J Dermatol. 2012;39(3):225–230. doi:10.1111/j.1346-8138.2011.01483.x
  • Hemshekhar M, Faiyaz S, Choi KG, Krokhin OV, Mookherjee N. Immunomodulatory functions of the human cathelicidin LL-37 (aa 13-31)-derived peptides are associated with predicted alpha-helical propensity and hydrophobic index. Biomolecules. 2019;9(9):501. doi:10.3390/biom9090501
  • Lande R, Gregorio J, Facchinetti V, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007;449(7162):564–569. doi:10.1038/nature06116
  • Morizane S, Yamasaki K, Mühleisen B, et al. Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands. J Invest Dermatol. 2012;132(1):135–143. doi:10.1038/jid.2011.259
  • Marcinkiewicz M, Majewski S. The role of antimicrobial peptides in chronic inflammatory skin diseases. Postepy Dermatol Alergol. 2016;33(1):6–12. doi:10.5114/pdia.2015.48066
  • Niyonsaba F, Ushio H, Nakano N, et al. Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol. 2007;127(3):594–604. doi:10.1038/sj.jid.5700599
  • Kolbinger F, Loesche C, Valentin MA, et al. beta-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis. J Allergy Clin Immunol. 2017;139(3):923–932.e8. doi:10.1016/j.jaci.2016.06.038
  • Xia C, Braunstein Z, Toomey AC, Zhong J, Rao X. S100 proteins as an important regulator of macrophage inflammation. Front Immunol. 2018;8:1908. doi:10.3389/fimmu.2017.01908
  • Foell D, Wittkowski H, Kessel C, et al. Proinflammatory S100A12 can activate human monocytes via toll-like receptor 4. Am J Respir Crit Care Med. 2013;187(12):1324–1334. doi:10.1164/rccm.201209-1602OC
  • Wilsmann-Theis D, Wagenpfeil J, Holzinger D, et al. Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity. J Eur Acad Dermatol Venereol. 2016;30(7):1165–1170. doi:10.1111/jdv.13269
  • Minciacchi VR, Freeman MR, Di Vizio D. Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin Cell Dev Biol. 2015;40:41–51. doi:10.1016/j.semcdb.2015.02.010
  • Hurley JH. ESCRTs are everywhere. EMBO J. 2015;34(19):2398–2407. doi:10.15252/embj.201592484
  • Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14(3):195–208. doi:10.1038/nri3622
  • Shao S, Fang H, Li Q, Wang G. Extracellular vesicles in inflammatory skin disorders: from pathophysiology to treatment. Theranostics. 2020;10(22):9937–9955. doi:10.7150/thno.45488
  • Mangino G, Iuliano M, Carlomagno S, et al. Interleukin-17A affects extracellular vesicles release and cargo in human keratinocytes. Exp Dermatol. 2019;28(9):1066–1073. doi:10.1111/exd.14015
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
  • Iuliano M, Mangino G, Chiantore MV, et al. Human Papillomavirus E6 and E7 oncoproteins affect the cell microenvironment by classical secretion and extracellular vesicles delivery of inflammatory mediators. Cytokine. 2018;106:182–189. doi:10.1016/j.cyto.2017.11.003
  • Ponti D, Bastianelli D, Rosa P, et al. The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions. BMC Cell Biol. 2015;16:27. doi:10.1186/s12860-015-0073-5
  • Franzen CA, Simms PE, Van Huis AF, Foreman KE, Kuo PC, Gupta GN. Characterization of uptake and internalization of exosomes by bladder cancer cells. Biomed Res Int. 2014;2014:619829. doi:10.1155/2014/619829
  • Rosa P, Catacuzzeno L, Sforna L, et al. BK channels blockage inhibits hypoxia-induced migration and chemoresistance to cisplatin in human glioblastoma cells. J Cell Physiol. 2018;233(9):6866–6877. doi:10.1002/jcp.26448
  • Hu SC, Yu HS, Yen FL, Lin CL, Chen GS, Lan CC. Neutrophil extracellular trap formation is increased in psoriasis and induces human β-defensin-2 production in epidermal keratinocytes. Sci Rep. 2016;6:31119. doi:10.1038/srep31119
  • Chiang -C-C, Cheng W-J, Korinek M, Lin C-Y, Hwang T-L. Neutrophils in psoriasis. Front Immunol. 2019;10:2376. doi:10.3389/fimmu.2019.02376
  • Lande R, Chamilos G, Ganguly D, et al. Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. Eur J Immunol. 2015;45(1):203–213. doi:10.1002/eji.201344277
  • Lande R, Botti E, Jandus C, et al. The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis. Nat Commun. 2014;5:5621. doi:10.1038/ncomms6621
  • Jiang M, Fang H, Shao S, et al. Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis. FASEB J. 2019;33(12):13241–13253. doi:10.1096/fj.201900642R
  • Ogawa E, Sato Y, Minagawa A, Okuyama R. Pathogenesis of psoriasis and development of treatment. J Dermatol. 2018;45(3):264–272. doi:10.1111/1346-8138.14139
  • Kriebel PW, Majumdar R, Jenkins LM, et al. Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals. J Cell Biol. 2018;217(8):2891–2910. doi:10.1083/jcb.201710170
  • Dourado MR, Korvala J, Åström P, et al. Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma. J Extracell Vesicles. 2019;8(1):1578525. doi:10.1080/20013078.2019.1578525
  • Chowdhari S, Sardana K, Saini N. miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin/integrin α9 signaling. Biochim Biophys Acta Mol Basis Dis. 2017;1863(12):3142–3152. doi:10.1016/j.bbadis.2017.08.014
  • Chiantore MV, Mangino G, Zangrillo MS, et al. Role of the microenvironment in tumourigenesis: focus on virus-induced tumors. Curr Med Chem. 2015;22(8):958–974. doi:10.2174/0929867322666141212121751
  • Ferrari SM, Fallahi P, Elia G, et al. Thyroid autoimmune disorders and cancer. Semin Cancer Biol. 2020;64:135–146. doi:10.1016/j.semcancer.2019.05.019
  • Wu MY, Li CJ, Hou MF, Chu PY. New insights into the role of inflammation in the pathogenesis of atherosclerosis. Int J Mol Sci. 2017;18(10):2034. doi:10.3390/ijms18102034
  • Colgan SP, Curtis VF, Campbell EL. The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis. 2013;19(10):2238–2244. doi:10.1097/MIB.0b013e31828dcaaf
  • Ma JY, Shao S, Wang G. Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis. Chin Med J. 2020;133(24):2966–2975. doi:10.1097/CM9.0000000000001240
  • Krueger JG, Brunner PM. Interleukin-17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities. Exp Dermatol. 2018;27(2):115–123. doi:10.1111/exd.13467
  • Bernardini N, Skroza N, Tolino E, et al. IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art. Int J Dermatol. 2020;59(4):406–411. doi:10.1111/ijd.14695
  • Coimbra S, Figueiredo A, Castro E, Rocha-Pereira P, Santos-Silva A. The roles of cells and cytokines in the pathogenesis of psoriasis. Int J Dermatol. 2012;51(4):389–95;quiz 395–8. doi:10.1111/j.1365-4632.2011.05154.x
  • He S, Wu C, Xiao J, Li D, Sun Z, Li M. Endothelial extracellular vesicles modulate the macrophage phenotype: potential implications in atherosclerosis. Scand J Immunol. 2018;87(4):e12648. doi:10.1111/sji.12648
  • Papayannakos CJ, DeVoti JA, Israr M, Alsudani H, Bonagura V, Steinberg BM. Extracellular vesicles produced by primary human keratinocytes in response to TLR agonists induce stimulus-specific responses in antigen-presenting cells. Cell Signal. 2021;83:109994. doi:10.1016/j.cellsig.2021.109994
  • Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol. 2005;17(4):359–365. doi:10.1016/j.coi.2005.06.002
  • Batycka-Baran A, Maj J, Wolf R, Szepietowski JC. The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis. J Immunol Res. 2014;2014:628289. doi:10.1155/2014/628289
  • Wu WC, Song SJ, Zhang Y, Li X. Role of extracellular vesicles in autoimmune pathogenesis. Front Immunol. 2020;11:579043. doi:10.3389/fimmu.2020.579043
  • Cho KA, Suh JW, Lee KH, Kang JL, Woo SY. IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway. Int Immunol. 2012;24(3):147–158. doi:10.1093/intimm/dxr110
  • Ekman AK, Bivik Eding C, Rundquist I, Enerbäck C. IL-17 and IL-22 promote keratinocyte stemness in the germinative compartment in psoriasis. J Invest Dermatol. 2019;139(7):1564–1573.e8. doi:10.1016/j.jid.2019.01.014
  • Pellegrini G, Dellambra E, Golisano O, et al. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A. 2001;98(6):3156–3161. doi:10.1073/pnas.061032098
  • Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9–17. doi:10.1038/s41556-018-0250-9
  • Frasca L, Palazzo R, Chimenti MS, et al. Anti-LL37 antibodies are present in psoriatic arthritis (PsA) patients: new biomarkers in PsA. Front Immunol. 2018;9:1936. doi:10.3389/fimmu.2018.01936
  • Marzano AV, Borghi A, Wallach D, Cugno M, Comprehensive A. Review of neutrophilic diseases. Clin Rev Allergy Immunol. 2018;54(1):114–130. doi:10.1007/s12016-017-8621-8
  • Albanesi C, De Pità O, Girolomoni G. Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes. Clin Dermatol. 2007;25(6):581–588. doi:10.1016/j.clindermatol.2007.08.013
  • Jacquin-Porretaz C, Cordonnier M, Nardin C, et al. Increased levels of interleukin-17A exosomes in psoriasis. Acta Derm Venereol. 2019;99(12):1143–1147. doi:10.2340/00015555-3300
  • Chang JH, Lee KJ, Kim SK, Yoo DH, Kang TY. Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model. Indian J Med Res. 2014;139(1):117–124.
  • Pang KL, Chow YY, Leong LM, et al. Establishing SW1353 chondrocytes as a cellular model of chondrolysis. Life. 2021;11(4). doi:10.3390/life11040272
  • Varoga D, Klostermeier E, Paulsen F, et al. The antimicrobial peptide HBD-2 and the Toll-like receptors-2 and −4 are induced in synovial membranes in case of septic arthritis. Virchows Arch. 2009;454(6):685–694. doi:10.1007/s00428-009-0780-4
  • Varoga D, Paulsen FP, Kohrs S, et al. Expression and regulation of human beta-defensin-2 in osteoarthritic cartilage. J Pathol. 2006;209(2):166–173. doi:10.1002/path.1974
  • Paulsen F, Pufe T, Conradi L, et al. Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. J Pathol. 2002;198(3):369–377. doi:10.1002/path.1224
  • Wang LC, Zhang HY, Shao L, et al. S100A12 levels in synovial fluid may reflect clinical severity in patients with primary knee osteoarthritis. Biomarkers. 2013;18(3):216–220. doi:10.3109/1354750X.2013.766262
  • Wittkowski H, Frosch M, Wulffraat N, et al. S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin. Arthritis Rheum. 2008;58(12):3924–3931. doi:10.1002/art.24137