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ORIGINAL RESEARCH

Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model

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Pages 5999-6012 | Received 02 Jul 2022, Accepted 20 Oct 2022, Published online: 28 Oct 2022

References

  • Sewerin P, Brinks R, Schneider M, Haase I, Vordenbäumen S. Prevalence and incidence of psoriasis and psoriatic arthritis. Ann Rheum Dis. 2019;78(2):286–287. doi:10.1136/annrheumdis-2018-214065
  • Lim DS, Bewley A, Oon HH. Psychological profile of patients with psoriasis. Ann Acad Med Singap. 2018;47(12):516–522.
  • López-Ferrer A, Laiz A, Puig L. Psoriatic arthritis. Med Clin. 2022;159(1):40–46. doi:10.1016/j.medcli.2022.01.024
  • Yeung H, Takeshita J, Mehta NN, et al. Psoriasis severity and the prevalence of major medical comorbidity: a population-based study. JAMA Dermatol. 2013;149(10):1173–1179. doi:10.1001/jamadermatol.2013.5015
  • Damiani G, Pacifico A, Rizzi M, et al. Patients with psoriatic arthritis have higher levels of FeNO than those with only psoriasis, which may reflect a higher prevalence of a subclinical respiratory involvement. Clin Rheumatol. 2020;39(10):2981–2988. doi:10.1007/s10067-020-05050-2
  • Conic RR, Damiani G, Schrom KP, et al. Psoriasis and psoriatic arthritis cardiovascular disease endotypes identified by red blood cell distribution width and mean platelet volume. J Clin Med. 2020;9(1):186. doi:10.3390/jcm9010186
  • Grän F, Kerstan A, Serfling E, Goebeler M, Muhammad K. Current developments in the immunology of psoriasis. Yale J Biol Med. 2020;93(1):97–110.
  • Georgescu SR, Tampa M, Caruntu C, et al. Advances in understanding the immunological pathways in psoriasis. Int J Mol Sci. 2019;20(3):739–755. doi:10.3390/ijms20030739
  • Nestle FO, Conrad C, Tun-Kyi A, et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med. 2005;202(1):135–143. doi:10.1084/jem.20050500
  • Kamata M, Tada Y. Dendritic cells and macrophages in the pathogenesis of psoriasis. Front Immunol. 2022;13:941071. doi:10.3389/fimmu.2022.941071
  • Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis and the development of novel targeted immune therapies. J Allergy Clin Immunol. 2017;140(3):645–653. doi:10.1016/j.jaci.2017.07.004
  • Chiang CC, Cheng WJ, Korinek M, Lin CY, Hwang TL. Neutrophils in psoriasis. Front Immunol. 2019;10:2376. doi:10.3389/fimmu.2019.02376
  • van der Fits L, Mourits S, Voerman JS, et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009;182(9):5836–5845. doi:10.4049/jimmunol.0802999
  • Flutter B, Nestle FO. TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol. 2013;43(12):3138–3146. doi:10.1002/eji.201343801
  • Kim J, Lee J, Kim HJ, et al. Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic vs. regulatory immune cell subsets. J Allergy Clin Immunol. 2021;148(5):1281–1292. doi:10.1016/j.jaci.2021.04.021
  • Gao Y, Yao X, Zhai Y, et al. Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells. Cell Death Dis. 2021;12(5):450. doi:10.1038/s41419-021-03724-6
  • Liu YL, Wang H, Taylor M, et al. Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Sci Immunol. 2022;7(70):eabl9165. doi:10.1126/sciimmunol.abl9165
  • Paik DT, Cho S, Tian L, Chang HY, Wu JC. Single-cell RNA sequencing in cardiovascular development, disease and medicine. Nat Rev Cardiol. 2020;17(8):457–473. doi:10.1038/s41569-020-0359-y
  • Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis. Annu Rev Immunol. 2014;32:227–255. doi:10.1146/annurev-immunol-032713-120225
  • Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature. 2007;445(7130):866–873. doi:10.1038/nature05663
  • Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ. Skin immune sentinels in health and disease. Nat Rev Immunol. 2009;9(10):679–691. doi:10.1038/nri2622
  • Qie C, Jiang J, Liu W, et al. Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir -/- murine psoriasis. Theranostics. 2020;10(23):10483–10497. doi:10.7150/thno.45614
  • Gudjonsson JE, Kabashima K, Eyerich K. Mechanisms of skin autoimmunity: cellular and soluble immune components of the skin. J Allergy Clin Immunol. 2020;146(1):8–16. doi:10.1016/j.jaci.2020.05.009
  • Liu J, Chang HW, Huang ZM, et al. Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8 + T cells in autoimmunity and cancer. J Allergy Clin Immunol. 2021;147(6):2370–2380. doi:10.1016/j.jaci.2020.11.028
  • Cai Y, Shen X, Ding C, et al. Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity. 2011;35(4):596–610. doi:10.1016/j.immuni.2011.08.001
  • Jee MH, Mraz V, Geisler C, Bonefeld CM. γδ T cells and inflammatory skin diseases. Immunol Rev. 2020;298(1):61–73. doi:10.1111/imr.12913
  • Bugaut H, Aractingi S. Major role of the IL17/23 axis in psoriasis supports the development of new targeted therapies. Front Immunol. 2021;12:621956. doi:10.3389/fimmu.2021.621956
  • DePaula-Silva AB, Gorbea C, Doty DJ, et al. Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation. J Neuroinflammation. 2019;16(1):152–171. doi:10.1186/s12974-019-1545-x
  • Eckert RL, Broome AM, Ruse M, Robinson N, Ryan D, Lee K. S100 proteins in the epidermis. J Invest Dermatol. 2004;123(1):23–33. doi:10.1111/j.0022-202X.2004.22719.x
  • Rebane A, Zimmermann M, Aab A, et al. Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. J Allergy Clin Immunol. 2012;129(5):1297–1306. doi:10.1016/j.jaci.2012.02.020
  • Hisamatsu T, Watanabe M, Ogata H, et al. Interferon-inducible gene family 1–8U expression in colitis-associated colon cancer and severely inflamed mucosa in ulcerative colitis. Cancer Res. 1999;59(23):5927–5931.
  • Wu F, Dassopoulos T, Cope L, et al. Genome-wide gene expression differences in Crohn’s disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. Inflamm Bowel Dis. 2007;13(7):807–821. doi:10.1002/ibd.20110
  • Blauvelt A, Chiricozzi A. The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis. Clin Rev Allergy Immunol. 2018;55(3):379–390. doi:10.1007/s12016-018-8702-3
  • Zaba LC, Suárez-Fariñas M, Fuentes-Duculan J, et al. Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes. J Allergy Clin Immunol. 2009;124(5):1022–10.e1–395. doi:10.1016/j.jaci.2009.08.046
  • Zhu H, Lou F, Yin Q, et al. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease. EMBO Mol Med. 2017;9(5):589–604. doi:10.15252/emmm.201607027
  • Palamara F, Meindl S, Holcmann M, Lührs P, Stingl G, Sibilia M. Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod. J Immunol. 2004;173(5):3051–3061. doi:10.4049/jimmunol.173.5.3051
  • Yang L, Fu JR, Han X, et al. Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N 6-methyladenosine-dependent manner in atopic dermatitis and psoriasis. J Allergy Clin Immunol. 2022;149(6):2021–2033. doi:10.1016/j.jaci.2021.11.024
  • Nakamizo S, Dutertre CA, Khalilnezhad A, et al. Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis. J Exp Med. 2021;218(9):e20202345. doi:10.1084/jem.20202345
  • den Hartigh LJ, Wang S, Goodspeed L, et al. Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice. PLoS One. 2014;9(9):e108564. doi:10.1371/journal.pone.0108564
  • Lee JY, Hall JA, Kroehling L, et al. Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease. Cell. 2020;183(7):2036–2039. doi:10.1016/j.cell.2020.12.008
  • Di Ceglie I, Ascone G, Cremers NAJ, et al. Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis. Arthritis Res Ther. 2018;20(1):80. doi:10.1186/s13075-018-1584-1
  • An J, Briggs TA, Dumax-Vorzet A, et al. Tartrate-resistant acid phosphatase deficiency in the predisposition to systemic lupus erythematosus. Arthritis Rheumatol. 2017;69(1):131–142. doi:10.1002/art.39810
  • Vičić M, Kaštelan M, Brajac I, Sotošek V, Massari LP. Massari, current concepts of psoriasis immunopathogenesis. Int J Mol Sci. 2021;22(21):11574. doi:10.3390/ijms222111574
  • Clarke J. IL-17 sustains plasma cells in SLE. Nat Rev Rheumatol. 2020;16(12):666. doi:10.1038/s41584-020-00519-5
  • Faust HJ, Zhang H, Han J, et al. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J Clin Invest. 2020;130(10):5493–5507. doi:10.1172/JCI134091
  • Regen T, Isaac S, Amorim A, et al. IL-17 controls central nervous system autoimmunity through the intestinal microbiome. Sci Immunol. 2021;6(56):eaaz6563. doi:10.1126/sciimmunol.aaz6563
  • Ghoreschi K, Balato A, Enerbäck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet. 2021;397(10275):754–766. doi:10.1016/S0140-6736(21)00184-7
  • Lou F, Sun Y, Xu Z, et al. Excessive polyamine generation in keratinocytes promotes self-rna sensing by dendritic cells in psoriasis. Immunity. 2020;53(1):204–216.e10. doi:10.1016/j.immuni.2020.06.004
  • Nakajima K. Critical role of the interleukin-23/T-helper 17 cell axis in the pathogenesis of psoriasis. J Dermatol. 2012;39(3):219–224. doi:10.1111/j.1346-8138.2011.01458.x
  • Okude H, Ori D, Kawai T. Signaling through nucleic acid sensors and their roles in inflammatory diseases. Front Immunol. 2021;11:625833. doi:10.3389/fimmu.2020.625833
  • Piranavan P, Bhamra M, Perl A. Metabolic targets for treatment of autoimmune diseases. Immunometabolism. 2020;2(2):e200012. doi:10.20900/immunometab20200012
  • Franchi L, Monteleone I, Hao LY, et al. Inhibiting oxidative phosphorylation in vivo restrains Th17 effector responses and ameliorates murine colitis. J Immunol. 2017;198(7):2735–2746. doi:10.4049/jimmunol.1600810
  • Liszewska A, Robak E, Bernacka M, Bogaczewicz J, Woźniacka A. Methotrexate use and NAD+/NADH metabolism in psoriatic keratinocytes. Postepy Dermatol Alergol. 2020;37(1):19–22. doi:10.5114/ada.2020.93379
  • Ortonne JP. Aetiology and pathogenesis of psoriasis. Br J Dermatol. 1996;135(Suppl 49):1–5. doi:10.1111/j.1365-2133.1996.tb15660.x