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ORIGINAL RESEARCH

Adiponectin and Leptin as Biomarkers of Disease Activity and Metabolic Disorders in Rheumatoid Arthritis Patients

ORCID Icon & ORCID Icon
Pages 5845-5855 | Received 30 Jun 2022, Accepted 29 Sep 2022, Published online: 13 Oct 2022

References

  • Smolen JS, Landewé RBM, Bijlsma JWJ, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79(6):685–699. doi:10.1136/annrheumdis-2019-216655
  • Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A. Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev. 2021;20(4):102776. doi:10.1016/j.autrev.2021.102776
  • Albrecht K, Zink A. Poor prognostic factors guiding treatment decisions in rheumatoid arthritis patients: a review of data from randomized clinical trials and cohort studies. Arthritis Res Ther. 2017;19(1):68. doi:10.1186/s13075-017-1266-4
  • Feng X, Xu X, Shi Y, et al. Body mass index and the risk of rheumatoid arthritis: an updated dose-response meta-analysis. Biomed Res Int. 2019;2019:3579081. doi:10.1155/2019/3579081
  • Zhang Y, Johansson L, Andersson-Assarsson J, et al. Adiponectin associates with rheumatoid arthritis risk in overweight and obesity independently of other adipokines. J Clin Med. 2021;10(13):2791. doi:10.3390/jcm10132791
  • Targońska-Stepniak B, Dryglewska M, Majdan M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int. 2010;30(6):731–737. doi:10.1007/s00296-009-1053-x
  • Del Prete A, Salvi V, Sozzani S. Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm. 2014;2014:425068. doi:10.1155/2014/425068
  • Fatel ECS, Rosa FT, Anc S, Dichi I. Adipokines in rheumatoid arthritis. Adv Rheumatol. 2018;58:25. doi:10.1186/s42358-018-0026-8
  • Khoramipour K, Chamari K, Hekmatikar AA, et al. Adiponectin: structure, physiological functions, role in diseases, and effects of nutrition. Nutrients. 2021;13(4):1180. doi:10.3390/nu13041180
  • Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American college of rheumatology/European league against rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–2581. doi:10.1002/art.27584
  • Prevoo ML, Van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38(1):44–48. doi:10.1002/art.1780380107
  • Pincus T, Sokka T, Kautiainen H. Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases. J Rheumatol. 2005;32(8):1432–1439.
  • Chihara K, Hattori N, Ichikawa N, Matsuda T, Saito T. Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis. Sci Rep. 2020;10(1):15932. doi:10.1038/s41598-020-73068-2
  • Kamareddine L, Ghantous CM, Allouch S, et al. Between inflammation and autophagy: the role of leptin-adiponectin axis in cardiac remodeling. J Inflamm Res. 2021;14:5349–5365. doi:10.2147/JIR.S322231
  • Cici D, Corrado A, Rotondo C, et al. Adipokines and chronic rheumatic diseases: from inflammation to bone involvement. Clin Rev Bone Miner Metab. 2020;18:58–71. doi:10.1007/s12018-021-09275-w
  • Cao H, Lin J, Chen W, Xu G, Sun C. Baseline adiponectin and leptin levels in predicting an increased risk of disease activity in rheumatoid arthritis: a meta-analysis and systematic review. Autoimmunity. 2016;49(8):547–553. doi:10.1080/08916934.2016.1230847
  • Lee YH, Bae SC. Circulating adiponectin and visfatin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis. Int J Rheum Dis. 2018;21(3):664–672. doi:10.1111/1756-185X
  • Yoshino T, Kusunoki N, Tanaka N, et al. Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis. Intern Med. 2011;50(4):269–275. doi:10.2169/internalmedicine.50.4306
  • Carrión M, Frommer KW, Pérez-García S, Müller-Ladner U, Gomariz RP, Neumann E. The adipokine network in rheumatic joint diseases. Int J Mol Sci. 2019;20(17):4091. doi:10.3390/ijms20174091
  • Tian G, Liang JN, Wang ZY, Zhou D. Emerging role of leptin in rheumatoid arthritis. Clin Exp Immunol. 2014;177(3):557–570. doi:10.1111/cei.12372
  • Lee YH, Bae SC. Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis. Z Rheumatol. 2016;75(10):1021–1027. doi:10.1007/s00393-016-0050-1
  • Popa C, Netea MG, Radstake TR, van Riel PL, Barrera P, van der Meer JW. Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis. Ann Rheum Dis. 2005;64(8):1195–1198. doi:10.1136/ard.2004.032243
  • Oner SY, Volkan O, Oner C, Mengi A, Direskeneli H, Tasan DA. Serum leptin levels do not correlate with disease activity in rheumatoid arthritis. Acta Reumatol Port. 2015;40(1):50–54.
  • Batún-Garrido JAJ, Salas-Magaña M, Juárez-Rojop IE. Association between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. Clin Rheumatol. 2018;37(3):631–637. doi:10.1007/s10067-017-3897-x
  • Shankar A, Syamala S, Xiao J, Muntner P. Relationship between plasma leptin level and chronic kidney disease. Int J Nephrol. 2012;2012:269532. doi:10.1155/2012/269532
  • Lim CC, Teo BW, Tai ES, et al. Elevated serum leptin, adiponectin and leptin to adiponectin ratio is associated with chronic kidney disease in Asian adults. PLoS One. 2015;10(3):e0122009. doi:10.1371/journal.pone.0122009
  • Mao S, Fang L, Liu F, Jiang S, Wu L, Zhang J. Leptin and chronic kidney diseases. J Recept Signal Transduct Res. 2018;38(2):89–94. doi:10.1080/10799893.2018.1431278
  • É T, Mourot L, Dehecq B, Wendling D, É G, Dumoulin G. TNFα blockade for inflammatory rheumatic diseases is associated with a significant gain in android fat mass and has varying effects on adipokines: a 2-year prospective study. Eur J Nutr. 2014;53(3):951–961. doi:10.1007/s00394-013-0599-2
  • Marouen S, Barnetche T, Combe B, Morel J, Daïen CI. TNF inhibitors increase fat mass in inflammatory rheumatic disease: a systematic review with meta-analysis. Clin Exp Rheumatol. 2017;35(2):337–343.
  • Toussirot E, Marotte H, Mulleman D, et al. Increased high molecular weight adiponectin and lean mass during tocilizumab treatment in patients with rheumatoid arthritis: a 12-month multicentre study. Arthritis Res Ther. 2020;22(1):224. doi:10.1186/s13075-020-02297-7