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ORIGINAL RESEARCH

Oral Lycopene Administration Attenuates Inflammation and Oxidative Stress by Regulating Plasma Lipids in Rats with Lipopolysaccharide-Induced Epididymitis

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Pages 6517-6531 | Received 12 Jul 2022, Accepted 23 Nov 2022, Published online: 30 Nov 2022

References

  • Michel V, Pilatz A, Hedger MP, Meinhardt A. Epididymitis: revelations at the convergence of clinical and basic sciences. Asian J Androl. 2015;17(5):756–763. doi:10.4103/1008-682X.155770
  • Haidl G, Allam JP, Schuppe HC. Chronic epididymitis: impact on semen parameters and therapeutic options. Andrologia. 2008;40(2):92–96. doi:10.1111/j.1439-0272.2007.00819.x
  • Pilatz A, Hossain H, Kaiser R, et al. Acute epididymitis revisited: impact of molecular diagnostics on etiology and contemporary guideline recommendations. Eur Urol. 2015;68(3):428–435. doi:10.1016/j.eururo.2014.12.005
  • Rodrigues A, Queiroz DB, Honda L, Silva EJ, Hall SH, Avellar MC. Activation of toll-like receptor 4 (TLR4) by in vivo and in vitro exposure of rat epididymis to lipopolysaccharide from Escherichia Coli. Biol Reprod. 2008;79(6):1135–1147. doi:10.1095/biolreprod.108.069930
  • Kwiatkowska K, Ciesielska A. Lipid-mediated regulation of pro-inflammatory responses induced by lipopolysaccharide. Postepy Biochem. 2018;64(3):175–182. doi:10.18388/pb.2018_129
  • Silva EJR, Ribeiro CM, Mirim AFM, et al. Lipopolysaccharide and lipotheicoic acid differentially modulate epididymal cytokine and chemokine profiles and sperm parameters in experimental acute epididymitis. Sci Rep. 2018;8(1):103. doi:10.1038/s41598-017-17944-4
  • Lang T, Dechant M, Sanchez V, et al. Structural and functional integrity of spermatozoa is compromised as a consequence of acute uropathogenic E. coli-associated epididymitis. Biol Reprod. 2013;89(3):59. doi:10.1095/biolreprod.113.110379
  • Michel V, Duan Y, Stoschek E, et al. Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis. J Pathol. 2016;240(1):15–24. doi:10.1002/path.4748
  • Lu Y, Bhushan S, Tchatalbachev S, et al. Necrosis is the dominant cell death pathway in uropathogenic Escherichia coli elicited epididymo-orchitis and is responsible for damage of rat testis. PLoS One. 2013;8(1):e52919. doi:10.1371/journal.pone.0052919
  • Ludwig M, Johannes S, Bergmann M, Failing K, Schiefer HG, Weidner W. Experimental Escherichia coli epididymitis in rats: a model to assess the outcome of antibiotic treatment. BJU Int. 2002;90(9):933–938. doi:10.1046/j.1464-410X.2002.03029.x
  • Klein B, Pant S, Bhushan S, et al. Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model. Hum Reprod. 2019;34(7):1195–1205. doi:10.1093/humrep/dez073
  • Imran M, Ghorat F, Ul-Haq I, et al. Lycopene as a natural antioxidant used to prevent human health disorders. Antioxidants. 2020;9:8.
  • Heymann T, Heinz P, Glomb MA. Lycopene inhibits the isomerization of beta-carotene during quenching of singlet oxygen and free radicals. J Agric Food Chem. 2015;63(12):3279–3287. doi:10.1021/acs.jafc.5b00377
  • Lee J, Lim JW, Kim H. Lycopene Inhibits IL-6 Expression by Upregulating NQO1 and HO-1 via Activation of Nrf2 in Ethanol/Lipopolysaccharide-Stimulated Pancreatic Acinar Cells. Antioxidants. 2022;11:3.
  • Goncu T, Oguz E, Sezen H, et al. Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats. Arq Bras Oftalmol. 2016;79(6):357–362. doi:10.5935/0004-2749.20160102
  • Han CH, Yang CH, Sohn DW, Kim SW, Kang SH, Cho YH. Synergistic effect between lycopene and ciprofloxacin on a chronic bacterial prostatitis rat model. Int J Antimicrob Agents. 2008;31(Suppl 1):S102–107. doi:10.1016/j.ijantimicag.2007.07.016
  • Wang J, Wang Z, Li B, et al. Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis. Int J Obes. 2019;43(9):1735–1746. doi:10.1038/s41366-018-0277-9
  • Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA. Untargeted metabolomics strategies-challenges and emerging directions. J Am Soc Mass Spectrom. 2016;27(12):1897–1905. doi:10.1007/s13361-016-1469-y
  • Wang F, Liu W, Jiang Q, et al. Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alphadagger. Biol Reprod. 2019;100(3):849–861. doi:10.1093/biolre/ioy235
  • Du L, Lei X, Wang J, et al. Lipopolysaccharides derived from gram-negative bacterial pool of human gut microbiota promote inflammation and obesity development. Int Rev Immunol. 2022;41(1):45–56. doi:10.1080/08830185.2021.1996573
  • Hwang DH, Kim JA, Lee JY. Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid. Eur J Pharmacol. 2016;785:24–35. doi:10.1016/j.ejphar.2016.04.024
  • Luvizotto Rde A, Nascimento AF, Imaizumi E, et al. Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats. Br J Nutr. 2013;110(10):1803–1809. doi:10.1017/S0007114513001256
  • Nouri M, Amani R, Nasr-Esfahani M, Tarrahi MJ. The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2019;33(12):3203–3211. doi:10.1002/ptr.6493
  • Jung YY, Nam Y, Park YS, et al. Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury. Korean J Physiol Pharmacol. 2013;17(3):209–216. doi:10.4196/kjpp.2013.17.3.209
  • Petyaev IM, Chernyshova MP, Pristensky DV, et al. Effect of lycosome-formulated phosphatidylcholine on parameters of biological oxidation after single intake of moderate amount of alcohol. Adv Prev Med. 2018;2018:5840451. doi:10.1155/2018/5840451
  • Alvi SS, Ansari IA, Ahmad MK, Iqbal J, Khan MS. Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity. Biomed Pharmacother. 2017;96:1082–1093. doi:10.1016/j.biopha.2017.11.116
  • Raja AA, Dandare A, Khan MJ, Khan MJ. Free fatty acid overload targets mitochondria: gene expression analysis of palmitic acid-treated endothelial cells. Genes. 2022;13:10. doi:10.3390/genes13101704
  • Ugbaja RN, James AS, Ugwor EI, Akamo AJ, Thomas FC, Kosoko AM. Lycopene suppresses palmitic acid-induced brain oxidative stress, hyperactivity of some neuro-signalling enzymes, and inflammation in female Wistar rat. Sci Rep. 2021;11(1):15038. doi:10.1038/s41598-021-94518-5
  • Plociennikowska A, Hromada-Judycka A, Dembinska J, Roszczenko P, Ciesielska A, Kwiatkowska K. Contribution of CD14 and TLR4 to changes of the PI(4,5)P2 level in LPS-stimulated cells. J Leukoc Biol. 2016;100(6):1363–1373. doi:10.1189/jlb.2VMA1215-577R
  • Plociennikowska A, Zdioruk MI, Traczyk G, Swiatkowska A, Kwiatkowska K. LPS-induced clustering of CD14 triggers generation of PI(4,5)P2. J Cell Sci. 2015;128(22):4096–4111. doi:10.1242/jcs.173104
  • Manabe Y, Hirata T, Sugawara T. Inhibitory effect of carotenoids on ligand-induced lipid raft translocation of immunoreceptors. J Oleo Sci. 2019;68(2):149–158. doi:10.5650/jos.ess18204
  • Engel KM, Schiller J, Galuska CE, Fuchs B. Phospholipases and reactive oxygen species derived lipid biomarkers in healthy and diseased humans and animals - A focus on lysophosphatidylcholine. Front Physiol. 2021;12:732319. doi:10.3389/fphys.2021.732319
  • Chen Z, Dai Y, Huang X, et al. Combined metabolomic analysis of plasma and tissue reveals a prognostic risk score system and metabolic dysregulation in esophageal squamous cell carcinoma. Front Oncol. 2020;10:1545. doi:10.3389/fonc.2020.01545
  • Liu J, Li J, Li S, et al. Circulating lysophosphatidylcholines in early pregnancy and risk of gestational diabetes in Chinese women. J Clin Endocrinol Metab. 2020;105:4. doi:10.1210/clinem/dgaa058
  • Liu P, Zhu W, Chen C, et al. The mechanisms of lysophosphatidylcholine in the development of diseases. Life Sci. 2020;247:117443. doi:10.1016/j.lfs.2020.117443
  • Nimptsch A, Pyttel S, Paasch U, Mohr C, Heinrich JM, Schiller J. A MALDI MS investigation of the lysophosphatidylcholine/phosphatidylcholine ratio in human spermatozoa and erythrocytes as a useful fertility marker. Lipids. 2014;49(3):287–293. doi:10.1007/s11745-013-3870-7