Mast Cell Specific Receptor Mrgprb2 Regulating Experimental Colitis is Associated with the Microbiota-Gut-Brain Axis

References

• Kobayashi T, Siegmund B, Le Berre C, et al. Ulcerative colitis. Nat Rev Dis Primers. 2020;6(1):74. doi:10.1038/s41572-020-0205-x
   PubMed Web of Science ®Google Scholar
• Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769–2778. doi:10.1016/S0140-6736(17)32448-0
   PubMed Web of Science ®Google Scholar
• Windsor JW, Kaplan GG. Evolving Epidemiology of IBD. Curr Gastroenterol Rep. 2019;21(8):40. doi:10.1007/s11894-019-0705-6
   PubMedGoogle Scholar
• Gracie DJ, Hamlin PJ, Ford AC. The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment. Lancet Gastroenterol Hepatol. 2019;4(8):632–642. doi:10.1016/S2468-1253(19)30089-5
   PubMed Web of Science ®Google Scholar
• Cryan JF, O’Riordan KJ, Cowan CSM, et al. The microbiota-gut-brain axis. Physiol Rev. 2019;99(4):1877–2013. doi:10.1152/physrev.00018.2018
   PubMed Web of Science ®Google Scholar
• Margolis KG, Cryan JF, Mayer EA. The microbiota-gut-brain axis: from motility to mood. Gastroenterology. 2021;160(5):1486–1501. doi:10.1053/j.gastro.2020.10.066
   PubMed Web of Science ®Google Scholar
• Yuan X, Chen B, Duan Z, et al. Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics. Gut Microbes. 2021;13(1):1987779. doi:10.1080/19490976.2021.1987779
   PubMed Web of Science ®Google Scholar
• Bonaz BL, Bernstein CN. Brain-gut interactions in inflammatory bowel disease. Gastroenterology. 2013;144(1):36–49. doi:10.1053/j.gastro.2012.10.003
   PubMed Web of Science ®Google Scholar
• Brzozowski B, Mazur-Bialy A, Pajdo R, et al. Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD): role of brain-gut axis. Curr Neuropharmacol. 2016;14(8):892–900. doi:10.2174/1570159X14666160404124127
   PubMed Web of Science ®Google Scholar
• Forsythe P. Mast Cells in Neuroimmune Interactions. Trends Neurosci. 2019;42(1):43–55. doi:10.1016/j.tins.2018.09.006
   PubMed Web of Science ®Google Scholar
• Chen E, Chuang LS, Giri M, et al. Inflamed ulcerative colitis regions associated with MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target. Gastroenterology. 2021;160(5):1709–1724. doi:10.1053/j.gastro.2020.12.076
   PubMed Web of Science ®Google Scholar
• Subramanian H, Gupta K, Ali H. Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases. J Allergy Clin Immunol. 2016;138(3):700–710. doi:10.1016/j.jaci.2016.04.051
   PubMed Web of Science ®Google Scholar
• Olivera A, Beaven MA, Metcalfe DD. Mast cells signal their importance in health and disease. J Allergy Clin Immunol. 2018;142(2):381–393. doi:10.1016/j.jaci.2018.01.034
   PubMed Web of Science ®Google Scholar
• Roy S, Chompunud Na Ayudhya C, Thapaliya M, Deepak V, Ali H. Multifaceted MRGPRX2: new insight into the role of mast cells in health and disease. J Allergy Clin Immunol. 2021;148(2):293–308. doi:10.1016/j.jaci.2021.03.049
   PubMed Web of Science ®Google Scholar
• Lee M, Chang EB. Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues. Gastroenterology. 2021;160(2):524–537. doi:10.1053/j.gastro.2020.09.056
   PubMed Web of Science ®Google Scholar
• van der Post S, Jabbar KS, Birchenough G, et al. Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut. 2019;68(12):2142–2151. doi:10.1136/gutjnl-2018-317571
   PubMed Web of Science ®Google Scholar
• Bergstrom K, Xia L. The barrier and beyond: roles of intestinal mucus and mucin-type O-glycosylation in resistance and tolerance defense strategies guiding host-microbe symbiosis. Gut Microbes. 2022;14(1):2052699. doi:10.1080/19490976.2022.2052699
   PubMed Web of Science ®Google Scholar
• Johansson ME, Gustafsson JK, Holmen-Larsson J, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut. 2014;63(2):281–291. doi:10.1136/gutjnl-2012-303207
   PubMed Web of Science ®Google Scholar
• Pundir P, Liu R, Vasavda C, et al. A connective tissue mast-cell-specific receptor detects bacterial quorum-sensing molecules and mediates antibacterial immunity. Cell Host Microbe. 2019;26(1):114–122 e118. doi:10.1016/j.chom.2019.06.003
   PubMed Web of Science ®Google Scholar
• Reber SO. Stress and animal models of inflammatory bowel disease--an update on the role of the hypothalamo-pituitary-adrenal axis. Psychoneuroendocrinology. 2012;37(1):1–19. doi:10.1016/j.psyneuen.2011.05.014
   PubMed Web of Science ®Google Scholar
• Bjorkholm C, Monteggia LM. BDNF - a key transducer of antidepressant effects. Neuropharmacology. 2016;102:72–79. doi:10.1016/j.neuropharm.2015.10.034
   PubMed Web of Science ®Google Scholar
• Hirsch D, Zukowska Z. NPY and stress 30 years later: the peripheral view. Cell Mol Neurobiol. 2012;32(5):645–659. doi:10.1007/s10571-011-9793-z
   PubMed Web of Science ®Google Scholar
• Boeckxstaens G. Mast cells and inflammatory bowel disease. Curr Opin Pharmacol. 2015;25:45–49. doi:10.1016/j.coph.2015.11.005
   PubMed Web of Science ®Google Scholar
• Wouters MM, Vicario M, Santos J. The role of mast cells in functional GI disorders. Gut. 2016;65(1):155–168. doi:10.1136/gutjnl-2015-309151
   PubMed Web of Science ®Google Scholar
• Green DP, Limjunyawong N, Gour N, Pundir P, Dong X. A mast-cell-specific receptor mediates neurogenic inflammation and pain. Neuron. 2019;101(3):412–420 e413. doi:10.1016/j.neuron.2019.01.012
   PubMed Web of Science ®Google Scholar
• Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69(2):238–249.
   PubMed Web of Science ®Google Scholar
• Glassner KL, Abraham BP, Quigley EMM. The microbiome and inflammatory bowel disease. J Allergy Clin Immunol. 2020;145(1):16–27. doi:10.1016/j.jaci.2019.11.003
   PubMed Web of Science ®Google Scholar
• Halfvarson J, Brislawn CJ, Lamendella R, et al. Dynamics of the human gut microbiome in inflammatory bowel disease. Nat Microbiol. 2017;2(5):17004. doi:10.1038/nmicrobiol.2017.4
   PubMed Web of Science ®Google Scholar
• Zheng Z, Lyu W, Ren Y, et al. Allobaculum involves in the modulation of intestinal ANGPTLT4 expression in mice treated by high-fat diet. Front Nutr. 2021;8:690138. doi:10.3389/fnut.2021.690138
   PubMed Web of Science ®Google Scholar
• Balakrishnan B, Luckey D, Bodhke R, et al. Prevotella histicola protects from arthritis by expansion of allobaculum and augmenting butyrate production in humanized mice. Front Immunol. 2021;12:609644. doi:10.3389/fimmu.2021.609644
   PubMed Web of Science ®Google Scholar
• van Muijlwijk GH, van Mierlo G, Jansen P, et al. Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader. Gut Microbes. 2021;13(1):1966278. doi:10.1080/19490976.2021.1966278
   PubMed Web of Science ®Google Scholar
• Gu Y, Zhang Y, Li M, et al. Ferulic acid ameliorates atherosclerotic injury by modulating gut microbiota and lipid metabolism. Front Pharmacol. 2021;12:621339. doi:10.3389/fphar.2021.621339
   PubMed Web of Science ®Google Scholar
• Hu S, Wang J, Xu Y, et al. Anti-inflammation effects of fucosylated chondroitin sulphate from Acaudina molpadioides by altering gut microbiota in obese mice. Food Funct. 2019;10(3):1736–1746. doi:10.1039/C8FO02364F
   PubMed Web of Science ®Google Scholar
• Zafar H, Saier MH Jr. Gut Bacteroides species in health and disease. Gut Microbes. 2021;13(1):1–20. doi:10.1080/19490976.2020.1848158
   PubMed Web of Science ®Google Scholar
• Wan F, Han H, Zhong R, et al. Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice. Food Funct. 2021;12(22):11420–11434.
   PubMed Web of Science ®Google Scholar
• Wieers G, Belkhir L, Enaud R, et al. How probiotics affect the microbiota. Front Cell Infect Microbiol. 2019;9:454. doi:10.3389/fcimb.2019.00454
   PubMed Web of Science ®Google Scholar
• van der Hee B, Wells JM. Microbial regulation of host physiology by short-chain fatty acids. Trends Microbiol. 2021;29(8):700–712. doi:10.1016/j.tim.2021.02.001
   PubMed Web of Science ®Google Scholar
• Goncalves P, Araujo JR, Di Santo JP. A cross-talk between microbiota-derived short-chain fatty acids and the host mucosal immune system regulates intestinal homeostasis and inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):558–572. doi:10.1093/ibd/izx029
   PubMed Web of Science ®Google Scholar
• Imhann F, Vich Vila A, Bonder MJ, et al. Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut. 2018;67(1):108–119. doi:10.1136/gutjnl-2016-312135
   PubMed Web of Science ®Google Scholar
• Fan S, Weight CM, Luissint AC, et al. Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation. Mol Biol Cell. 2019;30(5):566–578. doi:10.1091/mbc.E18-08-0531
   PubMed Web of Science ®Google Scholar
• Shibolet O, Alper R, Ilan Y, Weidenfeld J. Regulatory role of the pituitary-adrenal axis in experimental colitis: effect of adrenalectomy on the clinical course and the TH1/TH2 immune profile. Inflamm Bowel Dis. 2005;11(12):1053–1059. doi:10.1097/01.MIB.0000191610.97842.51
   PubMed Web of Science ®Google Scholar
• McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007;87(3):873–904. doi:10.1152/physrev.00041.2006
   PubMed Web of Science ®Google Scholar
• Aguilera G, Liu Y. The molecular physiology of CRH neurons. Front Neuroendocrinol. 2012;33(1):67–84. doi:10.1016/j.yfrne.2011.08.002
   PubMed Web of Science ®Google Scholar
• Im E, Rhee SH, Park YS, Fiocchi C, Tache Y, Pothoulakis C. Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis. Gastroenterology. 2010;138(7):2457–2467. doi:10.1053/j.gastro.2010.02.055
   PubMed Web of Science ®Google Scholar
• Timpl P, Spanagel R, Sillaber I, et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet. 1998;19(2):162–166. doi:10.1038/520
   PubMed Web of Science ®Google Scholar
• Bale TL, Contarino A, Smith GW, et al. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet. 2000;24(4):410–414. doi:10.1038/74263
   PubMed Web of Science ®Google Scholar
• Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev. 2000;21(5):457–487. doi:10.1210/edrv.21.5.0410
   PubMed Web of Science ®Google Scholar
• Asadi S, Alysandratos KD, Angelidou A, et al. Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells. J Invest Dermatol. 2012;132(2):324–329. doi:10.1038/jid.2011.334
   PubMed Web of Science ®Google Scholar
• Webster EL, Torpy DJ, Elenkov IJ, Chrousos GP. Corticotropin-releasing hormone and inflammation. Ann N Y Acad Sci. 1998;840:21–32. doi:10.1111/j.1749-6632.1998.tb09545.x
   PubMed Web of Science ®Google Scholar
• Sajdyk TJ, Johnson PL, Leitermann RJ, et al. Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia. J Neurosci. 2008;28(4):893–903. doi:10.1523/JNEUROSCI.0659-07.2008
   PubMed Web of Science ®Google Scholar
• Cowansage KK, LeDoux JE, Monfils MH. Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr Mol Pharmacol. 2010;3(1):12–29. doi:10.2174/1874467211003010012
   PubMedGoogle Scholar
• Ameroso D, Meng A, Chen S, Felsted J, Dulla CG, Rios M. Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis. Nat Metab. 2022;4(5):627–643. doi:10.1038/s42255-022-00566-0
   PubMedGoogle Scholar