56
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome

ORCID Icon, , , , & ORCID Icon
Pages 6595-6605 | Received 27 Jul 2022, Accepted 18 Nov 2022, Published online: 06 Dec 2022

References

  • Hedayati T, Yadav N, Khanagavi J. Non-ST-segment acute coronary syndromes. Cardiol Clin. 2018;36(1):37–52. doi:10.1016/j.ccl.2017.08.003
  • Roth GA, Johnson C, Abajobir A, et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1–25. doi:10.1016/j.jacc.2017.04.052
  • Mehta SR, Wood DA, Storey RF, et al. Complete Revascularization with Multivessel PCI for Myocardial Infarction. N Engl J Med. 2019;381(15):1411–1421. doi:10.1056/NEJMoa1907775
  • Buccheri S, Franchina G, Romano S, et al. Clinical Outcomes Following Intravascular Imaging-Guided Versus Coronary Angiography–Guided Percutaneous Coronary Intervention With Stent Implantation. JACC Cardiovasc Interv. 2017;10(24):2488–2498. doi:10.1016/j.jcin.2017.08.051
  • de Carvalho LP, Gao F, Chen Q, et al. Long-term prognosis and risk heterogeneity of heart failure complicating acute myocardial infarction. Am J Cardiol. 2015;115(7):872–878. doi:10.1016/j.amjcard.2015.01.010
  • Quan X-Q, Wang R-C, Zhang Q, Zhang C-T, Sun L. The predictive value of lymphocyte-to-monocyte ratio in the prognosis of acute coronary syndrome patients: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2020;20(1):338. doi:10.1186/s12872-020-01614-x
  • Afari ME, Bhat T. Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update. Expert Rev Cardiovasc Ther. 2016;14(5):573–577. doi:10.1586/14779072.2016.1154788
  • Wang L, Cong H-L, Zhang J-X, et al. Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome. Cardiovasc Diabetol. 2020;19(1):80. doi:10.1186/s12933-020-01054-z
  • Westman PC, Lipinski MJ, Luger D, et al. Inflammation as a Driver of Adverse Left Ventricular Remodeling After Acute Myocardial Infarction. J Am Coll Cardiol. 2016;67(17):2050–2060. doi:10.1016/j.jacc.2016.01.073
  • Ruparelia N, Godec J, Lee R, Chai JT. Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans. Eur Heart J. 2015;36(29):1923–1934. doi:10.1093/eurheartj/ehv195
  • Zhang WJ, Chen SJ, Zhou SC, Wu SZ, Wang H. Inflammasomes and Fibrosis. Front Immunol. 2021;12:643149. doi:10.3389/fimmu.2021.643149
  • Haneklaus M, O’Neill LAJ. NLRP3 at the interface of metabolism and inflammation. Immunol Rev. 2015;265(1):53–62. doi:10.1111/imr.12285
  • Toldo S, Mauro AG, Cutter Z, et al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019;73(4):215–222. doi:10.1097/FJC.0000000000000658
  • Yang F, Qin Y, Wang Y, et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci. 2019;15(5):1010–1019. doi:10.7150/ijbs.29680
  • Feng H, Mou SQ, Li WJ, et al. Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation. Oxid Med Cell Longev. 2020;2020:2647807. doi:10.1155/2020/2647807
  • Afrasyab A, Qu P, Zhao Y, et al. Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients. Heart Vessels. 2016;31(8):1218–1229. doi:10.1007/s00380-015-0723-8
  • Peng H, Wu H, Zhang G, et al. Expression and Clinical Prognostic Value of Platelet NLRP3 in Acute Coronary Syndrome. Int J Gen Med. 2020;13:791–802. doi:10.2147/IJGM.S275481
  • Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: a Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(25):e1082–e1143. doi:10.1161/CIR.0000000000000625
  • Puymirat E, Bonaca M, Fumery M, et al. Atherothrombotic risk stratification after acute myocardial infarction: the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention in the light of the French Registry of Acute ST Elevation or non-ST Elevation Myocardial Infarction registries. Clin Cardiol. 2019;42(2):227–234. doi:10.1002/clc.23131
  • Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72(18):2231–2264. doi:10.1016/j.jacc.2018.08.1038
  • Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: a Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021;144(22):e368–e454.
  • Fitchett D, Inzucchi SE, Cannon CP, et al. Empagliflozin Reduced Mortality and Hospitalization for Heart Failure Across the Spectrum of Cardiovascular Risk in the EMPA-REG OUTCOME Trial. Circulation. 2019;139(11):1384–1395. doi:10.1161/CIRCULATIONAHA.118.037778
  • Toldo S, Abbate A. The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol. 2018;15(4):203–214. doi:10.1038/nrcardio.2017.161
  • Couchie D, Vaisman B, Abderrazak A, et al. Human Plasma Thioredoxin-80 Increases With Age and in ApoE −/− Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. Circulation. 2017;136(5):464–475. doi:10.1161/CIRCULATIONAHA.117.027612
  • Lliberos C, Liew SH, Zareie P, La Gruta NL, Mansell A, Hutt K. Evaluation of inflammation and follicle depletion during ovarian ageing in mice. Sci Rep. 2021;11(1):278. doi:10.1038/s41598-020-79488-4
  • Toldo S, Mezzaroma E, McGeough MD, et al. Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart. Cardiovasc Res. 2015;105(2):203–212. doi:10.1093/cvr/cvu259
  • Shen S, Wang Z, Sun H, Ma L. Role of NLRP3 Inflammasome in Myocardial Ischemia-Reperfusion Injury and Ventricular Remodeling. Med Sci Monit. 2022;28:e934255. doi:10.12659/MSM.934255
  • Sethwala AM, Goh I, Amerena JV. Combating Inflammation in Cardiovascular Disease. Heart Lung Circ. 2021;30(2):197–206. doi:10.1016/j.hlc.2020.09.003
  • Bian F, Yang X-Y, Xu G, Zheng T, Jin S. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019;10:40. doi:10.3389/fphar.2019.00040
  • Zhang X, Wang S, Liu J, et al. D-dimer and the incidence of heart failure and mortality after acute myocardial infarction. Heart. 2021;107(3):237–244. doi:10.1136/heartjnl-2020-316880
  • Chen R, Liu C, Zhou P, et al. Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study. Thromb J. 2021;19(1):30. doi:10.1186/s12959-021-00281-y
  • Koch V, Booz C, Gruenewald LD, et al. Diagnostic performance and predictive value of D-dimer testing in patients referred to the emergency department for suspected myocardial infarction. Clin Biochem. 2022;104:22–29. doi:10.1016/j.clinbiochem.2022.02.003
  • Maloberti A, Biolcati M, Ruzzenenti G, et al. The Role of Uric Acid in Acute and Chronic Coronary Syndromes. J Clin Med. 2021;10(20):20. doi:10.3390/jcm10204750
  • Rebora P, Centola M, Morici N, et al. Uric acid associated with acute heart failure presentation in Acute Coronary Syndrome patients. Eur J Intern Med. 2022;99:30–37. doi:10.1016/j.ejim.2022.01.018
  • Gao R, Shi H, Chang S, et al. The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction. Int Immunopharmacol. 2019;74:105575. doi:10.1016/j.intimp.2019.04.022
  • Zhao M, Zhang J, Xu Y, et al. Selective Inhibition of NLRP3 Inflammasome Reverses Pressure Overload-Induced Pathological Cardiac Remodeling by Attenuating Hypertrophy, Fibrosis, and Inflammation. Int Immunopharmacol. 2021;99:108046. doi:10.1016/j.intimp.2021.108046
  • Aliaga J, Bonaventura A, Mezzaroma E, et al. Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177® (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction. Molecules. 2021;26(12):12. doi:10.3390/molecules26123534
  • Nie C, Zou R, Pan S. Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats. J Cell Mol Med. 2021;25(18):8997–9010. doi:10.1111/jcmm.16863
  • Zhang X, Zhao D, Feng J, et al. LuQi Formula Regulates NLRP3 Inflammasome to Relieve Myocardial-Infarction-Induced Cardiac Remodeling in Mice. Evid Based Complement Alternat Med. 2021;2021:5518083. doi:10.1155/2021/5518083
  • Nidorf SM, Fiolet ATL, Mosterd A, et al. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020;383(19):1838–1847. doi:10.1056/NEJMoa2021372
  • Silvis MJM, Fiolet ATL, Opstal TSJ, et al. Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in chronic coronary disease: a LoDoCo2 biomarker substudy. Atherosclerosis. 2021;334:93–100. doi:10.1016/j.atherosclerosis.2021.08.005
  • Deftereos SG, Beerkens FJ, Shah B, et al. Colchicine in Cardiovascular Disease: in-Depth Review. Circulation. 2022;145(1):61–78. doi:10.1161/CIRCULATIONAHA.121.056171
  • Fiolet ATL, Opstal TSJ, Mosterd A, et al. Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials. Eur Heart J. 2021;42(28):2765–2775. doi:10.1093/eurheartj/ehab115
  • Abbate A, Van Tassell BW, Biondi-Zoccai G, et al. Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]. Am J Cardiol. 2013;111(10):1394–1400. doi:10.1016/j.amjcard.2013.01.287
  • Abbate A, Trankle CR, Buckley LF, et al. Interleukin-1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST-Segment–Elevation Myocardial Infarction. J Am Heart Assoc. 2020;9(5):e014941. doi:10.1161/JAHA.119.014941
  • Ridker PM, Libby P, MacFadyen JG, et al. Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Eur Heart J. 2018;39(38):3499–3507. doi:10.1093/eurheartj/ehy310
  • Toldo S, Mauro AG, Cutter Z, Abbate A. Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2018;315(6):H1553–H1568. doi:10.1152/ajpheart.00158.2018
  • Abbate A, Toldo S, Marchetti C, Kron J, Van Tassell BW, Dinarello CA. Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease. Circ Res. 2020;126(9):1260–1280. doi:10.1161/CIRCRESAHA.120.315937
  • Busch K, Kny M, Huang N, et al. Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy. J Cachexia Sarcopenia Muscle. 2021;12(6):1653–1668. doi:10.1002/jcsm.12763