Water Extract of Senecio scandens Buch.-Ham Ameliorates Pruritus by Inhibiting MrgprB2 Receptor

References

• Wang D, Huang L, Chen S. Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry pharmacology, and toxicity. J Ethnopharmacol. 2013;149:1–23. doi:10.1016/j.jep.2013.05.048
   PubMed Web of Science ®Google Scholar
• Ma J. Wild Chinese herb Senecio scandens Buch.-Ham treats sheep eye keratitis. Chin J Trad Vet Sci. 2018;35:96.
   Google Scholar
• Zou H, Hu H, Liu D, Li H, Hu Z, Li T. Effect of Senecio scandens Buch.-Ham on inflammation of cornea and conjunctiva in rats with allergic conjunctivitis via NLRP3/Caspase-1/IL-1β Pathway. Trad Chin Drug Res Clin Pharmacol. 2019;30:1346–1351.
   Google Scholar
• Yang H, Shen J, Liu Q, Peng Y. Anti-inflammatory effect of petroleum ether from Senecio scandens Buch.-Ham on LPS-stimulated RAW264.7 cells. J Huazhong Agric Univ. 2020;39:187–191.
   Google Scholar
• Zhang W, Chen H, Zhang W, Cao H. Study of the anti-inflammatory effect of total flavonoids from Senecio scandens Buch.-Ham. Lishizhen Med Mater Med Res. 2008;34:605–607.
   Google Scholar
• Yu J, Hu M, Wang Y, et al. Extraction, partial characterization and bioactivity of polysaccharides from Senecio scandens Buch.-Ham. Int J Biol Macromol. 2018;109:535–543. doi:10.1016/j.ijbiomac.2017.12.119
   PubMed Web of Science ®Google Scholar
• Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M. The neurobiology of itch. Nat Rev Neurosci. 2006;7:535–547. doi:10.1038/nrn1950
   PubMed Web of Science ®Google Scholar
• Matterne U, Apfelbacher CJ, Vogelgsang L, Loerbroks A, Weisshaar E. Incidence and determinants of chronic pruritus: a population-based cohort study. Acta Derm Venereol. 2013;93:532–537. doi:10.2340/00015555-1572
   PubMed Web of Science ®Google Scholar
• Leader B, Carr CW, Chen SC. Pruritus epidemiology and quality of life. Handb Exp Pharmacol. 2015;226:15–38.
   PubMedGoogle Scholar
• Bathe A, Weisshaar E, Matterne U. Chronic pruritus--more than a symptom: a qualitative investigation into patients’ subjective illness perceptions. J Adv Nurs. 2013;69:316–326. doi:10.1111/j.1365-2648.2012.06009.x
   PubMed Web of Science ®Google Scholar
• Abreu D, Kim BS. Innate immune regulation of dermatitis. Immunol Allergy Clin North Am. 2021;41:347–359. doi:10.1016/j.iac.2021.04.011
   PubMed Web of Science ®Google Scholar
• Church MK. Allergy, histamine and antihistamines. Handb Exp Pharmacol. 2017;241:321–331.
   PubMedGoogle Scholar
• Komiya E, Tominaga M, Kamata Y, Suga Y, Takamori K. Molecular and cellular mechanisms of itch in psoriasis. Int J Mol Sci. 2020;21:8406.
   PubMed Web of Science ®Google Scholar
• Abraham SN, St JA. Mast cell-orchestrated immunity to pathogens. Nat Rev Immunol. 2010;10:440–452. doi:10.1038/nri2782
   PubMed Web of Science ®Google Scholar
• Xia Q, Liu T, Wang J, et al. Mast cells and thymic stromal lymphopoietin (TSLP) expression positively correlates with pruritus intensity in dermatitis herpetiformis. Eur J Dermatol. 2020;30:499–504. doi:10.1684/ejd.2020.3881
   PubMed Web of Science ®Google Scholar
• Meixiong J, Anderson M, Limjunyawong N, et al. Activation of mast-cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch. Immunity. 2019;50:1163–1171. doi:10.1016/j.immuni.2019.03.013
   PubMed Web of Science ®Google Scholar
• Jiang Y, Ye F, Du Y, Zong Y, Tang Z. P2X7R in mast cells is a potential target for salicylic acid and aspirin in treatment of inflammatory pain. J Inflamm Res. 2021;14:2913–2931. doi:10.2147/JIR.S313348
   PubMed Web of Science ®Google Scholar
• Wu X, Wang Y, Chen Y, Zhu Y, Xu Y. Simultaneous determination of three components in Senecio cannabifolius var. integrifolius by accelerated solvent extraction-HPLC. Chinese Pharm J Analysis. 2016;36:1555–1562.
   Google Scholar
• Voisin T, Perner C, Messou MA, et al. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021;118:e2022087118.
   PubMed Web of Science ®Google Scholar
• Leonard A, Guttman-Yassky E. The unique molecular signatures of contact dermatitis and implications for treatment. Clin Rev Allergy Immunol. 2019;56:1–8. doi:10.1007/s12016-018-8685-0
   PubMed Web of Science ®Google Scholar
• Brown C, Yu J. Pediatric allergic contact dermatitis. Immunol Allergy Clin North Am. 2021;41:393–408. doi:10.1016/j.iac.2021.04.004
   PubMed Web of Science ®Google Scholar
• Li F, Wang C, Hu D, et al. mMrgprA3/mMrgprC11/hMrgprX1: potential therapeutic targets for allergic contact dermatitis-induced pruritus in mice and humans. Contact Dermatitis. 2022;86:286–294. doi:10.1111/cod.14051
   PubMed Web of Science ®Google Scholar
• Gimenez-Rivera VA, Siebenhaar F, Zimmermann C, et al. Mast cells limit the exacerbation of chronic allergic contact dermatitis in response to repeated allergen exposure. J Immunol. 2016;197:4240–4246. doi:10.4049/jimmunol.1600236
   PubMed Web of Science ®Google Scholar
• Yang JH, Yoo JM, Cho WK, Ma JY. Ethanol extract of sanguisorbae radix inhibits mast cell degranulation and suppresses 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions. Mediators Inflamm. 2016;2016:2947390. doi:10.1155/2016/2947390
   PubMed Web of Science ®Google Scholar
• Kim H, Kim M, Kim H, et al. Anti-inflammatory activities of Dictamnus dasycarpus Turcz., root bark on allergic contact dermatitis induced by dinitrofluorobenzene in mice. J Ethnopharmacol. 2013;149:471–477. doi:10.1016/j.jep.2013.06.055
   PubMed Web of Science ®Google Scholar
• Jo SY, Kim MH, Lee H, Lee SH, Yang WM. Ameliorative and synergic effects of Derma-H, a new herbal formula, on allergic contact dermatitis. Front Pharmacol. 2020;11:1019. doi:10.3389/fphar.2020.01019
   PubMed Web of Science ®Google Scholar
• Santos FA, Rao VS. Possible role of mast cells in cineole-induced scratching behavior in mice. Food Chem Toxicol. 2002;40:1453–1457. doi:10.1016/S0278-6915(02)00088-1
   PubMed Web of Science ®Google Scholar
• McNeil BD, Pundir P, Meeker S, et al. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015;519:237–241. doi:10.1038/nature14022
   PubMed Web of Science ®Google Scholar
• Hao Y, Peng B, Che D, et al. Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2. Int Immunopharmacol. 2020;81:106258. doi:10.1016/j.intimp.2020.106258
   PubMed Web of Science ®Google Scholar
• Ding Y, Che D, Li C, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCgamma-IP3R related Ca(2+) fluctuations. Int Immunopharmacol. 2019;66:185–197. doi:10.1016/j.intimp.2018.11.025
   PubMed Web of Science ®Google Scholar
• Cao J, Wang Y, Hu S, et al. Kaempferol ameliorates secretagogue-induced pseudo-allergic reactions via inhibiting intracellular calcium fluctuation. J Pharm Pharmacol. 2020;72:1221–1231. doi:10.1111/jphp.13312
   PubMed Web of Science ®Google Scholar
• Hao Y, Che D, Yu Y, et al. Luteolin inhibits FcepsilonRIota- and MRGPRX2-mediated mast cell activation by regulating calcium signaling pathways. Phytother Res. 2022;36:2197–2206. doi:10.1002/ptr.7447
   PubMed Web of Science ®Google Scholar