Vanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-β1 Signaling Pathway in Obese Diabetic Patients

References

• Hall JE, Do Carmo JM, Da Silva AA, Wang Z, Hall ME. Obesity, kidney dysfunction and hypertension: mechanistic links. Nat Rev Nephrol. 2019;15:367–385. doi:10.1038/s41581-019-0145-4
   PubMed Web of Science ®Google Scholar
• Hall JE, Mouton AJ, da Silva AA, et al. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovasc Res. 2021;117:1859–1876. doi:10.1093/cvr/cvaa336
   PubMed Web of Science ®Google Scholar
• Starzak M, Stanek A, Jakubiak GK, Cholewka A, Cieślar G. Arterial stiffness assessment by pulse wave velocity in patients with metabolic syndrome and its components: is it a useful tool in clinical practice? Int J Environ Res Public Health. 2022;19:10368. doi:10.3390/ijerph191610368
   PubMed Web of Science ®Google Scholar
• Smith DM, Taylor W, Whitworth MK, Roberts S, Sibley C, Lavender T. The feasibility phase of a community antenatal lifestyle program [The Lifestyle Course (TLC)] for women with a body mass index (BMI) <30 kg / m (2.). Midwifery. 2015;31(2):280–287. doi:10.1016/j.midw.2014.10.002
   PubMed Web of Science ®Google Scholar
• Hou L, Jiang F, Huang B, et al. Dihydromyricetin ameliorates inflammation-induced insulin resistance via phospholipase C-CaMKK-AMPK signal pathway. Oxid Med Cell Longev. 2021;2021:8542809. doi:10.1155/2021/8542809
   PubMed Web of Science ®Google Scholar
• Hayashi T, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY. Visceral adiposity, not the abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans. Diabetes. 2008;57(5):1269–1275. doi:10.2337/db07-1378
   PubMed Web of Science ®Google Scholar
• Tulloch-Reid MK, Hanson RL, Sebring NG, Reynolds JC, Premkumar A, Genovese J. Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in African Americans. Obes Res Res. 2004;12(8):1352–1359. doi:10.1038/oby.2004.170
   PubMedGoogle Scholar
• Grundy SM. Metabolic syndrome update. Trends Cardiovasc Med. 2016;26(4):364–373. doi:10.1016/j.tcm.2015.10.004
   PubMed Web of Science ®Google Scholar
• Alwahsh SM, Dwyer BJ, Forbes S, Thiel DH, Lewis PJ, Ramadori G. Insulin production and resistance in different models of diet-induced obesity and metabolic syndrome. Int J Mol Sci. 2017;18(2):285. doi:10.3390/ijms18020285
   PubMed Web of Science ®Google Scholar
• Rodríguez-Correa E, González-Pérez I, Clavel-Pérez PI, Contreras-Vargas Y, Carvajal K. Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice? Nutr Diabetes. 2020;10(1):24. doi:10.1038/s41387-020-0127-4
   PubMed Web of Science ®Google Scholar
• Kwon Y, Kim JH, Ha EK, et al. Serum YKL-40 levels are associated with the atherogenic index of plasma in children. Mediators Inflamm. 2020;2020:8713908. doi:10.1155/2020/8713908
   PubMed Web of Science ®Google Scholar
• Viktorinova A, Malickova D, Svitekova K, Choudhury S, Krizko M. Low-density lipoprotein cholesterol-to-apolipoprotein B ratio as a potential indicator of LDL particle size and plasma atherogenicity in type 2 diabetes. Diabetes Res Clin Pract. 2021;176:108858. doi:10.1016/j.diabres.2021.108858
   PubMed Web of Science ®Google Scholar
• Kaneva AM, Potolitsyna NN, Bojko ER. Usefulness of the LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile. Arch Physiol Biochem. 2017;123(1):16–22. doi:10.1080/13813455.2016.1195411
   PubMed Web of Science ®Google Scholar
• Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851. doi:10.5114/aoms.2016.58928
   PubMed Web of Science ®Google Scholar
• Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol. 2004;29(8):439–443.
   PubMed Web of Science ®Google Scholar
• Stępień M, Stępień A, Wlazeł RN, Paradowski M, Banach M, Rysz J. Obesity indices and inflammatory markers in obese non-diabetic normo-and hypertensive patients: a comparative pilot study. Lipids Health Dis. 2014;13(1):29–35. doi:10.1186/1476-511X-13-29
   PubMed Web of Science ®Google Scholar
• Agusti A, Morla M, Sauleda J, Saus C, Busquets X. NF-kappaB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax. 2004;59:483–487. doi:10.1136/thx.2003.017640
   PubMed Web of Science ®Google Scholar
• Rother KI. Diabetes treatment-bridging the divide. N Engl J Med. 2007;356(15):1499–1501. doi:10.1056/NEJMp078030
   PubMed Web of Science ®Google Scholar
• Elgizawy HA, Ali AA, Hussein MA. Resveratrol: isolation, and its nanostructured lipid carriers, inhibits cell proliferation, induces cell apoptosis in certain human cell lines carcinoma and exerts protective effect against paraquat-induced hepatotoxicity. J Med Food. 2021;24(1):89–100. doi:10.1089/jmf.2019.0286
   PubMed Web of Science ®Google Scholar
• Hussein MA. Synthesis of some novel triazoloquinazolines and triazinoquinazolines and their evaluation for anti-inflammatory activity. Med Chem Res. 2012;21(8):1876–1886. doi:10.1007/s00044-011-9707-0
   Web of Science ®Google Scholar
• Abdel Maksoud HA, Elharrif MG, Mahfouz MK, Omnia MA, Abdullah MH, Eltabey ME. Biochemical study on occupational inhalation of benzene vapours in petrol station. Resp Med Case Rep. 2019;27:1–4. doi:10.1016/j.rmcr.2019.100836
   Web of Science ®Google Scholar
• El Gizawy HA, Abo-Salem HM, Ali AA, Hussein MA. Phenolic profiling and therapeutic potential of certain isolated compounds from parkia roxburghii against AChE activity as well as GABAAα5, GSK-3β, and p38α MAP-kinase genes. ACS Omega. 2021;6(31):20492–20511. doi:10.1021/acsomega.1c02340
   PubMed Web of Science ®Google Scholar
• Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem. 2005;280:7511–7518. doi:10.1074/jbc.M411871200
   PubMed Web of Science ®Google Scholar
• Yamashita N, Yashiro M, Ogawa H, et al. Metabolic pathway catalyzed by vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells. Biochem Biophys Res Commun. 2017;489(4):466–471. doi:10.1016/j.bbrc.2017.05.172
   PubMed Web of Science ®Google Scholar
• Chen S, Zhang W, Sun C, et al. Systemic nanoparticle-mediated delivery of pantetheinase vanin-1 regulates lipolysis and adiposity in abdominal white adipose tissue. Adv Sci. 2021;8(12):e2101789. doi:10.1002/advs.202101789
   Web of Science ®Google Scholar
• Ferreira DW, Naquet P, Manautou JE. Influence of vanin-1 and catalytic products in liver during normal and oxidative stress conditions. Curr Med Chem. 2015;22(20):2407–2416. doi:10.2174/092986732220150722124307
   PubMed Web of Science ®Google Scholar
• Metwaly AM, Elmoghazy HM, Hussein MA, Abdel-Aziz A, Elmasry SA. CAPE improves vanin-1/AKT/miRNA-203 signaling pathways in DSS-induced ulcerative colitis. Biomed Res Ther. 2022;9(9):5313–5325. doi:10.15419/bmrat.v9i9.769
   Web of Science ®Google Scholar
• Baikpour M, Baikpour M, Hosseini M, Sarveazad A. Variations in levels of interleukins and adiponectin in normal and obese adults; a case-control study. JMP. 2017;2(2):56–62.
   Google Scholar
• Puavilai G, Chanprasertyotin S, Sriphrapradaeng A. Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the expert committee on the diagnosis and classification of diabetes mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. World Health Organization. Diabetes Res Clin Pract. 1999;44(1):21–26. doi:10.1016/s0168-8227(99)00008-x
   PubMed Web of Science ®Google Scholar
• Fossati P, Prencipe L. Serum triacylglycerols determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982;1:2077–2080. doi:10.1093/clinchem/28.10.2077
   Google Scholar
• Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;1974(4):470–475. doi:10.1093/clinchem/20.4.470
   Google Scholar
• Burnstein M, Selvenick HR, Morfin R. Rapid method for isolation of lipoprotein from human serum with polyanions. J Lipid Res. 1970;11(11):583. doi:10.1016/S0022-2275(20)42943-8
   PubMedGoogle Scholar
• Barber RD, Harmer DW, Coleman RA, Clark BJ. GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol Genomics. 2005;21(3):389–395. doi:10.1152/physiolgenomics.00025.2005
   PubMed Web of Science ®Google Scholar
• Bae JC, Cho NH, Suh S, et al. Cardiovascular disease incidence, mortality and case fatality related to diabetes and metabolic syndrome: a community-based prospective study (Ansung-Ansan cohort 2001–12). J Diabetes. 2015;7(6):791–799. doi:10.1111/1753-0407.12248
   PubMed Web of Science ®Google Scholar
• Sung KC, Ryu S, Cheong ES, et al. All cause and cardiovascular mortality among Koreans: effects of obesity and metabolic health. Am J Prev Med. 2015;49:62–71. doi:10.1016/j.amepre.2015.02.010
   PubMed Web of Science ®Google Scholar
• Oh CM, Park JH, Chung HS, et al. Effect of body shape on the development of cardiovascular disease in individuals with metabolically healthy obesity. Medicine. 2020;99(38):e22036. doi:10.1097/MD.0000000000022036
   PubMed Web of Science ®Google Scholar
• Tsatsoulis A, Paschou SA. Metabolically healthy obesity: criteria, epidemiology, controversies, and consequences. Curr Obes Rep. 2020;9(2):109–120. doi:10.1007/s13679-020-00375-0
   PubMed Web of Science ®Google Scholar
• Tobias DK, Pan A, Jackson CL, et al. Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med. 2014;370(3):233–244. doi:10.1056/NEJMoa1304501
   PubMed Web of Science ®Google Scholar
• Santhanam P, Masannat Y. Body mass index, mortality, and the obesity paradox in type 2 diabetes mellitus: the effect of hypertension. South Med J. 2014;107(6):361. doi:10.14423/01.SMJ.0000450710.46174.e2
   PubMed Web of Science ®Google Scholar
• Moffit JS, Koza-Taylor PH, Holland RD, et al. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate. Toxicol Appl Pharmacol. 2007;222(2):169–179. doi:10.1016/j.taap.2007.04.008
   PubMed Web of Science ®Google Scholar
• González MC, Corton JC, Cattley RC, Herrera E, Bocos C. Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonists down-regulate alpha2-macroglobulin expression by a PPAR alpha-dependent mechanism. Biochimie. 2009;91(8):1029–1035. doi:10.1016/j.biochi.2009.05.007
   PubMed Web of Science ®Google Scholar
• Chen X, Li M, Sun WP, et al. Agonist-induced down-regulation of hepatic glucocorticoid receptor via peroxisome proliferator-activated receptor in SD rats. Zhonghua Yi Xue Za Zhi. 2009;89(46):3276–3279.
   PubMedGoogle Scholar
• Chen X, Li M, Sun W, et al. Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats. Biochem Biophys Res Commun. 2008;368(4):865–870. doi:10.1016/j.bbrc.2008.01.152
   PubMed Web of Science ®Google Scholar
• Shimosaka T, Makarova KS, Koonin EV, Atomi H. Identification of dephospho-coenzyme A (dephospho-CoA) kinase in thermococcus kodakarensis and elucidation of the entire CoA biosynthesis pathway in archaea. mBio. 2019;10(4):e01146–19. doi:10.1128/mBio.01146-19
   PubMed Web of Science ®Google Scholar
• Roisin-Bouffay C, Castellano R, Valéro R, Chasson L, Galland F, Naquet P. Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes. Diabetologia. 2008;51(7):1192–1201. doi:10.1007/s00125-008-1017-9
   PubMed Web of Science ®Google Scholar
• Nitto T, Inoue T, Node K. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. Gene. 2008;426(1–2):57–64. doi:10.1016/j.gene.2008.08.019
   PubMed Web of Science ®Google Scholar
• Dammanahalli KJ, Stevens S, Terkeltaub R. Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia. PLoS One. 2012;7(6):e39106. doi:10.1371/journal.pone.0039106
   PubMed Web of Science ®Google Scholar
• Nitto T, Onodera K. Linkage between coenzyme a metabolism and inflammation: roles of pantetheinase. J Pharmacol Sci. 2013;123(1):1–8. doi:10.1254/jphs.13r01cp
   PubMed Web of Science ®Google Scholar
• Rommelaere S, Millet V, Gensollen T, et al. PPAR alpha regulates the production of serum vanin-1 by liver. FEBS Lett. 2013;587(22):3742–3748. doi:10.1016/j.febslet.2013.09.046
   PubMed Web of Science ®Google Scholar
• Van Diepen JA, Jansen PA, Ballak DB, et al. PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism. J Hepatol. 2014;61(2):366–372. doi:10.1016/j.jhep.2014.04.013
   PubMed Web of Science ®Google Scholar
• Martin PG, Guillou H, Lasserre F, et al. Novel aspects of PPAR-alpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study. Hepatology. 2007;45(3):767–777. doi:10.1002/hep.21510
   PubMed Web of Science ®Google Scholar
• Francis GA, Fayard E, Picard F, Auwerx J. Nuclear receptors and the control of metabolism. Annu Rev Physiol. 2003;65:261–311. doi:10.1146/annurev.physiol.65.092101.142528
   PubMed Web of Science ®Google Scholar
• Yu S, Viswakarma N, Batra SK, Samabasiva RM, Reddy JK. Identification of promethin and PGLP as two novel up-regulated genes in PPAR-gamma1-induced adipogenic mouse liver. Biochimie. 2004;86:743–761. doi:10.1016/j.biochi.2004.09.015
   PubMed Web of Science ®Google Scholar
• Abdel-Gawad SM, Ghorab MM, El-Sharief AMSh, El-Telbany FA, Abdel-Alla M. Design, synthesis, and antimicrobial activity of some new pyrazolo[3,4-d]pyrimidines. Heteroatom Chem. 2003;14:530–534. doi:10.1002/hc.10187
   Web of Science ®Google Scholar
• Lewis JR, Mohanty SR. Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci. 2010;55:560–578. doi:10.1007/s10620-009-1081-0
   PubMed Web of Science ®Google Scholar
• Motomura W, Yoshizaki T, Takahashi N, et al. Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids. J Clin Biochem Nutr. 2012;51(3):163–169. doi:10.3164/jcbn.12-06
   PubMed Web of Science ®Google Scholar
• Hussein MA, Ismail NEM, Mohamed AH, Borik RM, Ali AA, Mosaad YO. Plasma phospholipids: a promising simple biochemical parameter to evaluate COVID-19 infection severity. Bioinform Biol Insights. 2021;15:1–14. doi:10.1177/11779322211055891
   Web of Science ®Google Scholar
• Boshra SA, Hussein MA. Cranberry extract as a supplemented food in treatment of oxidative stress and breast cancer induced by N-Methyl-N-Nitrosourea in female virgin rats. Int J Phytomedicine. 2016;8(2):217–227.
   Google Scholar
• El-Gizawy HA, Hussein MA. Fatty acids profile, nutritional values, anti-diabetic and antioxidant activity of the fixed oil of malvaparviflora growing in Egypt. Int J Phytomedicine. 2015;7:219–230.
   Google Scholar
• Gobba NAEK, Hussein A, El Sharawy DE, Hussein MA. The potential hazardous effect of exposure to iron dust in Egyptian smoking and nonsmoking welders. Arch Environ Occup Health. 2018;73(3):189–202. doi:10.1080/19338244.2017.1314930
   PubMed Web of Science ®Google Scholar
• Hu Y, Liu W, Chen Y, et al. Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose tolerance. Acta Diabetol. 2010;47(3):231–236. doi:10.1007/s00592-009-0143-2
   PubMed Web of Science ®Google Scholar
• Ley SH, Harris SB, Connelly PW. Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population. Clin Chem. 2010;56(4):666–670. doi:10.1373/clinchem.2009.136994
   PubMed Web of Science ®Google Scholar
• Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPAR-alpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5(6):426–437. doi:10.1016/j.cmet.2007.05.002
   PubMed Web of Science ®Google Scholar
• Li Y, Wong K, Giles A, et al. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014;146(2):539–49.e7. doi:10.1053/j.gastro.2013.10.059
   PubMed Web of Science ®Google Scholar
• Kaskow BJ, Proffitt JM, Blangero J, Moses EK, Abraham LJ. Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases. Biochem Biophys Res Commun. 2012;417(2):653–658. doi:10.1016/j.bbrc.2011.11.099
   PubMed Web of Science ®Google Scholar
• Jansen PA, Kamsteeg M, Rodijk-Olthuis D, et al. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. J Invest Dermatol. 2009;129(9):2167–2174. doi:10.1038/jid.2009.67
   PubMed Web of Science ®Google Scholar
• Lu H, Zhang A, Wen D, et al. Plasma vanin-1 as a novel biomarker of sepsis for trauma patients: a prospective multicenter cohort study. Infect Dis Ther. 2021;10(2):739–751. doi:10.1007/s40121-021-00414-w
   PubMed Web of Science ®Google Scholar
• Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol. 2000;59(1):95–104. doi:10.1016/s0006-2952(99)00301-9
   PubMed Web of Science ®Google Scholar
• Naquet P, Pitari G, Duprè S, Galland F. Role of the Vnn1 pantetheinase in tissue tolerance to stress. Biochem Soc Trans. 2014;42(4):1094–1100. doi:10.1042/BST20140092
   PubMed Web of Science ®Google Scholar
• Salam OM. Modulation of inflammatory paw oedema by cysteamine in the rat. Pharmacol Res. 2002;45(4):275–284. doi:10.1006/phrs.2002.0955
   PubMed Web of Science ®Google Scholar
• Berruyer C, Martin FM, Castellano R, Macone A, Malergue F, Garrido-Urbani S. Vanin-1−/− mice exhibit a glutathione-mediated tissue resistance to oxidative stress. Mol Cell Biol. 2004;24:7214–7224. doi:10.1128/MCB.24.16.7214-7224.2004
   PubMed Web of Science ®Google Scholar
• Awad MA, Aldosari SR, Abid MR. Genetic alterations in oxidant and anti-oxidant enzymes in the vascular system. Front Cardiovasc Med. 2018;5:107. doi:10.3389/fcvm.2018.00107
   PubMed Web of Science ®Google Scholar
• Li H, Horke S, Förstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis. 2014;237(1):208–219. doi:10.1016/j.atherosclerosis.2014.09.001
   PubMed Web of Science ®Google Scholar
• Williams SM, Eleftheriadou A, Alam U, Cuthbertson DJ, Wilding JPH. Correction to cardiac autonomic neuropathy in obesity, metabolic syndrome and prediabetes: a narrative review. Diabetes Ther. 2019;10(6):2023. doi:10.1007/s13300-019-00705-z
   PubMed Web of Science ®Google Scholar
• Zhang B, Lo C, Shen L, et al. The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP. Blood. 2011;117(17):4569–4579. doi:10.1182/blood-2010-09-304931
   PubMed Web of Science ®Google Scholar
• Elsalakawy WA, Ali MA, Hegazy MG, Farweez BA. Value of vanin-1 assessment in adult patients with primary immune thrombocytopenia. Platelets. 2014;25(2):86–92. doi:10.3109/09537104.2013.782484
   PubMed Web of Science ®Google Scholar
• Tinahones FJ, Murri-Pierri M, Garrido-Sánchez L, et al. Oxidative stress in severely obese persons is greater in those with insulin resistance. Obesity. 2009;17(2):240–246. doi:10.1038/oby.2008.536
   PubMed Web of Science ®Google Scholar
• Bausenwein J, Serke H, Eberle K, et al. Elevated levels of oxidized low-density lipoprotein and of catalase activity in follicular fluid of obese women. Mol Hum Reprod. 2010;16(2):117–124. doi:10.1093/molehr/gap078
   PubMed Web of Science ®Google Scholar
• Zhang R, Liu R, Zong W. Bisphenol S interacts with catalase and induces oxidative stress in mouse liver and renal cells. J Agric Food Chem. 2016;64(34):6630–6640. doi:10.1021/acs.jafc.6b02656
   PubMed Web of Science ®Google Scholar
• Ighodaro OM, Akinloy OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med. 2018;54:287–293. doi:10.1016/j.ajme.2017.09.001
   Web of Science ®Google Scholar
• Rindler PM, Plafker SM, Szweda LI, Kinter M. High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem. 2013;288(3):1979–1990. doi:10.1074/jbc.M112.412890
   PubMed Web of Science ®Google Scholar
• Mehebik N, Jaubert AM, Sabourault D, Giudicelli Y, Ribière C. Leptin-induced nitric oxide production in white adipocytes is mediated through PKA and MAP kinase activation. Am J Physiol Cell Physiol. 2005;289(2):C379–87. doi:10.1152/ajpcell.00320.2004
   PubMed Web of Science ®Google Scholar
• Ribière C, Jaubert AM, Sabourault D, Lacasa D, Giudicelli Y. Insulin stimulates nitric oxide production in rat adipocytes. Biochem Biophys Res Commun. 2002;291(2):394–399. doi:10.1006/bbrc.2002.6444
   PubMed Web of Science ®Google Scholar
• Martin F, Penet MF, Malergue F, et al. Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores. J Clin Invest. 2004;113(4):591–597. doi:10.1172/JCI19557
   PubMed Web of Science ®Google Scholar
• Montes de Oca M, Torres SH, De Sanctis J, Mata A, Hernandez N, Talamo C. Skeletal muscle inflammation and nitric oxide in patients with COPD. Eur Respir J. 2005;26:390–397.
   PubMed Web of Science ®Google Scholar
• McConell GK, Bradley SJ, Stephens TJ, Canny BJ, Kingwell BA, Lee-Young RS. Skeletal muscle nNOS mu protein content is increased by exercise training in humans. Am J Physiol Regul Integr Comp Physiol. 2007;293:R821–R828.
   PubMed Web of Science ®Google Scholar
• Lu M, Li P, Pferdekamper J, et al. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010;24:1413–1422.
   PubMedGoogle Scholar
• Torres SH, De Sanctis JB, Hernandez N, Finol HJ. Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients. J Endocrinol. 2004;181:419–427.
   PubMed Web of Science ®Google Scholar
• Lien CC, Au LC, Tsai YL, Ho LT, Juan CC. Short-term regulation of tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway. Endocrinology. 2009;150(11):4892–4900. doi:10.1210/en.2009-0403
   PubMed Web of Science ®Google Scholar
• Juan CC, Lien CC, Chang CL, Huang YH, Ho LT. Involvement of iNOS and NO in TNF-alpha-downregulated resistin gene expression in 3T3-L1 adipocytes. Obesity. 2008;16(6):1219–1225. doi:10.1038/oby.2008.200
   PubMed Web of Science ®Google Scholar
• Batra J, Chatterjee R, Ghosh B. Inducible nitric oxide synthase (iNOS): role in asthma pathogenesis. Indian J Biochem Biophys. 2007;44(5):303–309.
   PubMed Web of Science ®Google Scholar