The Infiltration of Neutrophil Granulocytes Due to Loss of PTEN Was Associated with Poor Response to Immunotherapy in Renal Cell Carcinoma

References

• Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33. doi:10.3322/caac.21708
   PubMed Web of Science ®Google Scholar
• Bedke J, Albiges L, Capitanio U, et al. The 2021 Updated European Association of Urology Guidelines on Renal Cell Carcinoma: immune Checkpoint Inhibitor-based Combination Therapies for Treatment-naive Metastatic Clear-cell Renal Cell Carcinoma Are Standard of Care. Eur Urol. 2021;80:393–397. doi:10.1016/j.eururo.2021.04.042
   PubMed Web of Science ®Google Scholar
• Quhal F, Mori K, Bruchbacher A, et al. First-line immunotherapy-based combinations for metastatic renal cell carcinoma: a systematic review and network meta-analysis. Eur Urol Oncol. 2021;4:755–765. doi:10.1016/j.euo.2021.03.001
   PubMed Web of Science ®Google Scholar
• Ricketts CJ, De Cubas AA, Fan H, et al. The cancer genome atlas comprehensive molecular characterization of renal cell carcinoma. Cell Rep. 2018;23(1):313–326 e315. doi:10.1016/j.celrep.2018.03.075
   PubMed Web of Science ®Google Scholar
• Dell’Atti L, Bianchi N, Aguiari G. New therapeutic interventions for kidney carcinoma: looking to the future. Cancers (Basel). 2022;14(15):3616. doi:10.3390/cancers14153616
   PubMed Web of Science ®Google Scholar
• Zhao J, Chen AX, Gartrell RD, et al. Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma. Nat Med. 2019;25:462–469. doi:10.1038/s41591-019-0349-y
   PubMed Web of Science ®Google Scholar
• Diaz-Montero CM, Rini BI, Finke JH. The immunology of renal cell carcinoma. Nat Rev Nephrol. 2020;16:721–735. doi:10.1038/s41581-020-0316-3
   PubMed Web of Science ®Google Scholar
• Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment. Blood. 2019;133:2159–2167. doi:10.1182/blood-2018-11-844548
   PubMed Web of Science ®Google Scholar
• Capucetti A, Albano F, Bonecchi R. Multiple roles for chemokines in neutrophil biology. Front Immunol. 2020;11:1259. doi:10.3389/fimmu.2020.01259
   PubMed Web of Science ®Google Scholar
• Quail DF, Amulic B, Aziz M, et al. Neutrophil phenotypes and functions in cancer: a consensus statement. J Exp Med. 2022:219. doi:10.1084/jem.20220011
   Web of Science ®Google Scholar
• Yan J, Kloecker G, Fleming C, et al. Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells. Oncoimmunology. 2014;3:e950163. doi:10.4161/15384101.2014.950163
   PubMed Web of Science ®Google Scholar
• Gershkovitz M, Caspi Y, Fainsod-Levi T, et al. TRPM2 mediates neutrophil killing of disseminated tumor cells. Cancer Res. 2018;78:2680–2690. doi:10.1158/0008-5472.CAN-17-3614
   PubMed Web of Science ®Google Scholar
• Hagerling C, Gonzalez H, Salari K, et al. Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer. Proc Natl Acad Sci U S A. 2019;116:21704–21714. doi:10.1073/pnas.1907660116
   PubMed Web of Science ®Google Scholar
• Lopez-Lago MA, Posner S, Thodima VJ, et al. Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression. Oncogene. 2013;32:1752–1760. doi:10.1038/onc.2012.201
   PubMed Web of Science ®Google Scholar
• Wu F, Dai X, Gan W, et al. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Lett. 2017;385:207–214. doi:10.1016/j.canlet.2016.10.021
   PubMed Web of Science ®Google Scholar
• Fragkoulis C, Ntoumas G, Glykas I, et al. Expression of proto-oncogene c-Myc in patients with urinary bladder transitional cell carcinoma. Curr Urol. 2021;15:231–233. doi:10.1097/CU9.0000000000000053
   PubMedGoogle Scholar
• Yu Z, Lu W, Su C, et al. Single-Cell RNA-seq identification of the cellular molecular characteristics of sporadic bilateral clear cell renal cell Carcinoma. Front Oncol. 2021;11:659251). doi:10.3389/fonc.2021.659251
   PubMed Web of Science ®Google Scholar
• Su C, Lv Y, Lu W, et al. Single-Cell RNA Sequencing in Multiple Pathologic Types of Renal Cell Carcinoma Revealed Novel Potential Tumor-Specific Markers. Front Oncol. 2021;11:719564. doi:10.3389/fonc.2021.719564
   PubMed Web of Science ®Google Scholar
• Liu Z, Zhang Z. Mapping cell types across human tissues. Science. 2022;376:695–696. doi:10.1126/science.abq2116
   PubMed Web of Science ®Google Scholar
• Braun DA, Hou Y, Bakouny Z, et al. Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma. Nat Med. 2020;26:909–918. doi:10.1038/s41591-020-0839-y
   PubMed Web of Science ®Google Scholar
• Hao Y, Hao S, Andersen-Nissen E, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184:3573–3587 e3529. doi:10.1016/j.cell.2021.04.048
   PubMed Web of Science ®Google Scholar
• McGinnis CS, Murrow LM, Gartner ZJ. DoubletFinder: doublet Detection in Single-Cell RNA sequencing data using artificial nearest neighbors. Cell Syst. 2019;8:329–337 e324. doi:10.1016/j.cels.2019.03.003
   PubMed Web of Science ®Google Scholar
• Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36:411–420. doi:10.1038/nbt.4096
   PubMed Web of Science ®Google Scholar
• Aran D, Looney AP, Liu L, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20:163–172. doi:10.1038/s41590-018-0276-y
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47–e47. doi:10.1093/nar/gkv007
   PubMed Web of Science ®Google Scholar
• Wu T, Hu E, Xu S, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021;2:100141. doi:10.1016/j.xinn.2021.100141
   Web of Science ®Google Scholar
• Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018;28:1747–1756. doi:10.1101/gr.239244.118
   PubMed Web of Science ®Google Scholar
• Dai S, Zeng H, Liu Z, et al. Intratumoral CXCL13(+)CD8(+)T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma. J Immunother Cancer. 2021:9. doi:10.1136/jitc-2020-001823
   Web of Science ®Google Scholar
• Coffelt SB, Wellenstein MD, de Visser KE. Neutrophils in cancer: neutral no more. Nat Rev Cancer. 2016;16:431–446. doi:10.1038/nrc.2016.52
   PubMed Web of Science ®Google Scholar
• SenGupta S, Hein LE, Parent CA. The recruitment of neutrophils to the tumor microenvironment is regulated by multiple mediators. Front Immunol. 2021;12:734188. doi:10.3389/fimmu.2021.734188
   PubMed Web of Science ®Google Scholar
• Khanna S, Graef S, Mussai F, et al. Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients. Clin Cancer Res. 2018;24:2859–2872. doi:10.1158/1078-0432.CCR-17-3757
   PubMed Web of Science ®Google Scholar
• Yu S, Yi M, Xu L, et al. CXCL1 as an Unfavorable Prognosis Factor Negatively Regulated by DACH1 in Non-small Cell Lung Cancer. Front Oncol. 2019;9:1515. doi:10.3389/fonc.2019.01515
   PubMed Web of Science ®Google Scholar
• Tessier-Cloutier B, Twa DD, Marzban M, et al. The presence of tumour-infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell carcinoma. J Pathol Clin Res. 2021;7:385–396. doi:10.1002/cjp2.204
   PubMedGoogle Scholar
• Cordeiro MD, Ilario EN, Abe DK, et al. Neutrophil-to-lymphocyte ratio predicts cancer outcome in locally advanced clear renal cell carcinoma. Clin Genitourin Cancer. 2022;20:102–106. doi:10.1016/j.clgc.2021.10.009
   PubMed Web of Science ®Google Scholar
• Efrimescu CI, Buggy PM, Buggy DJ. Neutrophil extracellular trapping role in cancer, metastases, and cancer-related thrombosis: a narrative review of the current evidence base. Curr Oncol Rep. 2021;23:118. doi:10.1007/s11912-021-01103-0
   PubMed Web of Science ®Google Scholar
• Yang L, Liu Q, Zhang X, et al. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature. 2020;583:133–138. doi:10.1038/s41586-020-2394-6
   PubMed Web of Science ®Google Scholar
• Xiao Y, Cong M, Li J, et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell. 2021;39(3):423–437 e427. doi:10.1016/j.ccell.2020.12.012
   PubMed Web of Science ®Google Scholar
• Mittmann LA, Haring F, Schaubächer JB, et al. Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression. J Immunother Cancer. 2021:9. doi:10.1136/jitc-2021-003495
   Web of Science ®Google Scholar
• Teijeira A, Garasa S, Ochoa MC, et al. IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy. Clin Cancer Res. 2021;27:2383–2393. doi:10.1158/1078-0432.CCR-20-1319
   PubMed Web of Science ®Google Scholar
• Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331:1565–1570. doi:10.1126/science.1203486
   PubMed Web of Science ®Google Scholar
• Eruslanov EB, Singhal S, Albelda SM. Mouse versus Human Neutrophils in Cancer: a Major Knowledge Gap. Trends Cancer. 2017;3:149–160. doi:10.1016/j.trecan.2016.12.006
   PubMed Web of Science ®Google Scholar
• Seok J, Warren HS, Cuenca AG, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013;110:3507–3512. doi:10.1073/pnas.1222878110
   PubMed Web of Science ®Google Scholar