Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats

References

• Teixeira G, Sales M, Foresto RD. Drug-induced nephrotoxicity. Rev Assoc Med Bras. 2020;66(1):82–90. doi:10.1590/1806-9282.66.S1.82
   Web of Science ®Google Scholar
• Wu H, Huang J. Drug-induced nephrotoxicity: pathogenic mechanisms, biomarkers and prevention strategies. Curr Drug Metab. 2018;19(7):559–567. doi:10.2174/1389200218666171108154419
   PubMed Web of Science ®Google Scholar
• Luciano RL, Perazella MA. Drug-induced acute kidney injury. In: Core Concepts in Acute Kidney Injury. New York, NY: Springer; 2018:145–163. doi:10.1007/978-1-4939-8628-6_9
   Google Scholar
• Ison G, Beaver JA, McGuinn WD, et al. FDA approval: uridine triacetate for the treatment of patients following fluorouracil or capecitabine overdose or exhibiting early-onset severe toxicities following administration of these drugs. Clin Cancer Res. 2016;22(18):4545–4549. doi:10.1158/1078-0432.CCR-16-0638
   PubMed Web of Science ®Google Scholar
• Adikwu E, Ebinyo N, Amgbare B. Protective activity of selenium against 5-fluorouracil-induced nephrotoxicity in rats. Cancer Transl Med. 2019;5(3):50. doi:10.4103/CTM.CTM_26_19
   Google Scholar
• Gelen V, Şengül E, Yıldırım S, Senturk E, Tekin S, Kükürt A. The protective effects of hesperidin and curcumin on 5-fluorouracil–induced nephrotoxicity in mice. Environ Sci Pollut Res. 2021;28(34):47046–47055. doi:10.1007/S11356-021-13969-5
   PubMed Web of Science ®Google Scholar
• Gelen V, Şengül E, Yıldırım S, Atila G. The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci. 2018;21(4):404–410. doi:10.22038/IJBMS.2018.27510.6714
   PubMed Web of Science ®Google Scholar
• Jules R, Maciel C, Busl K, et al. 5-fluorouracil neurotoxicity in patient without dihydropyrimidine dehydrogenase deficiency. Neurology. 2021;96(15Supplement):100.
   Google Scholar
• Yuan C, Parekh H, Allegra C, George TJ, Starr JS. 5-FU induced cardiotoxicity: case series and review of the literature. Cardio-Oncology. 2019;5(1):1–7. doi:10.1186/S40959-019-0048-3/TABLES/3
   PubMedGoogle Scholar
• Rashid S, Ali N, Nafees S, Hasan SK, Sultana S. Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in Wistar rats. Food Chem Toxicol. 2014;66:185–193. doi:10.1016/J.FCT.2014.01.026
   PubMed Web of Science ®Google Scholar
• Famurewa AC, Asogwa NT, Aja PM, et al. Moringa oleifera seed oil modulates redox imbalance and iNOS/NF-ĸB/caspase-3 signaling pathway to exert antioxidant, anti-inflammatory and antiapoptotic mechanisms against anticancer drug 5-fluorouracil-induced nephrotoxicity in rats. South African J Bot. 2019;127:96–103. doi:10.1016/J.SAJB.2019.08.038
   Web of Science ®Google Scholar
• Arab HH, Salama SA, Maghrabi IA. Camel milk ameliorates 5-fluorouracil-induced renal injury in rats: targeting MAPKs, NF-κB and PI3K/Akt/eNOS pathways. Cell Physiol Biochem. 2018;46(4):1628–1642. doi:10.1159/000489210
   PubMedGoogle Scholar
• Paul M, Mehr AP, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev. 2006;86(3):747–803. doi:10.1152/physrev.00036.2005
   PubMed Web of Science ®Google Scholar
• Ichihara A, Hayashi M, Kaneshiro Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin. J Clin Invest. 2004;114(8):1128–1135. doi:10.1172/JCI21398
   PubMed Web of Science ®Google Scholar
• Long DA, Price KL, Herrera-Acosta J, Johnson RJ. How does angiotensin ii cause renal injury? Hypertension. 2004;43(4):722–723. doi:10.1161/01.HYP.0000120964.22281.3e
   PubMed Web of Science ®Google Scholar
• Burgess E, Muirhead N, De Cotret PR, Chiu A, Pichette V, Tobe S. Supramaximal dose of candesartan in proteinuric renal disease. J Am Soc Nephrol. 2009;20(4):893–900. doi:10.1681/ASN.2008040416
   PubMed Web of Science ®Google Scholar
• Burnier M. Telmisartan: a different angiotensin II receptor blocker protecting a different population? J Int Med Res. 2009;37(6):1662–1679. doi:10.1177/147323000903700602
   PubMed Web of Science ®Google Scholar
• Kakuta H, Sudoh K, Sasamata M, Yamagishi S. Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers. Int J Clin Pharmacol Res. 2005;25(1):41–46.
   PubMedGoogle Scholar
• Zhu H, Chen X, Cai G, et al. Telmisartan combined with probucol effectively reduces urinary protein in patients with type 2 diabetes: a randomized double-blind placebo-controlled multicenter clinical study. J Diabetes. 2016;8(5):677–685. doi:10.1111/1753-0407.12347
   PubMed Web of Science ®Google Scholar
• Hassanin AE, Elmasry K, Saleh DM, Bondok AA. Possible synergistic effect of curcumin on captopril /losartan combined therapy in diabetic nephropathy. Zagazig Univ Med J. 2022. doi:10.21608/ZUMJ.2022.111158.2433
   Google Scholar
• Ożarowski M, Mikołajczak PL, Kujawski R, et al. Pharmacological effect of quercetin in hypertension and its potential application in pregnancy-induced hypertension: review of in vitro, in vivo, and clinical studies. Evid Based Complement Altern Med. 2018;2018:1–19. doi:10.1155/2018/7421489
   Web of Science ®Google Scholar
• Gomes IBS, Porto ML, Santos MC, et al. Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy. Lipids Health Dis. 2014;13(1):1–10. doi:10.1186/1476-511X-13-184/FIGURES/6
   Google Scholar
• Aziz TA. Cardioprotective effect of quercetin and sitagliptin in doxorubicin-induced cardiac toxicity in rats. Cancer Manag Res. 2021;13:2349–2357. doi:10.2147/CMAR.S300495
   PubMed Web of Science ®Google Scholar
• Ahmed ZA, Abtar AN, Othman HH, Aziz TA. Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats. Drug Des Devel Ther. 2019;13:3321–3329. doi:10.2147/DDDT.S222127
   PubMed Web of Science ®Google Scholar
• Challa VR, Ravindra Babu P, Challa SR, Johnson B, Maheswari C. Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro models. Drug Dev Ind Pharm. 2013;39(6):865–872. doi:10.3109/03639045.2012.693502
   PubMed Web of Science ®Google Scholar
• Mackraj I, Govender T, Ramesar S. The antihypertensive effects of quercetin in a salt-sensitive model of hypertension. J Cardiovasc Pharmacol. 2008;51(3):239–245. doi:10.1097/FJC.0B013E318162011F
   PubMed Web of Science ®Google Scholar
• Chen LI, Wu XI, Wang WE, Wang XI, Ma J. Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats. Libyan J Med. 2021;16(1). doi:10.1080/19932820.2021.1943924
   PubMed Web of Science ®Google Scholar
• Zhou X, Zezi MY, Li D, et al. Telmisartan ameliorates LPS-induced pneumonia in rats through regulation of the PPARγ/NF-κB pathway. Microbiol Immunol. 2022;66(7):371–378. doi:10.1111/1348-0421.12981
   PubMed Web of Science ®Google Scholar
• Al-Asmari AK, Khan AQ, Al-Masri N. Mitigation of 5-fluorouracil-induced liver damage in rats by Vitamin C via targeting redox-sensitive transcription factors. Hum Exp Toxicol. 2016;35(11):1203–1213. doi:10.1177/0960327115626583
   PubMed Web of Science ®Google Scholar
• Hadi Mohammed A, Obaid Hossain A, Gradus-Pizlo I, Hadi MA, Wozniak TC, Malik AS. Minar study the effects of anadrol overdose on kidney in rat model. Europace. 2013;15:11–17. doi:10.47832/2717-8234.11.28
   PubMedGoogle Scholar
• Azizah N, Halimah E, Puspitasari IM, Hasanah AN. Simultaneous use of herbal medicines and antihypertensive drugs among hypertensive patients in the community: a review. J Multidiscip Healthc. 2021;14:259. doi:10.2147/JMDH.S289156
   PubMed Web of Science ®Google Scholar
• Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial. Drug Des Devel Ther. 2018;12(4):735–742. doi:10.2147/DDDT.S157113
   PubMed Web of Science ®Google Scholar
• Ji JJ, Lin Y, Huang SS, Zhang HL, Diao YP, Li K. Quercetin: a potential natural drug for adjuvant treatment of rheumatoid arthritis. African J Tradit Complement Altern Med. 2013;10(3):418. doi:10.4314/ajtcam.v10i3.5
   PubMedGoogle Scholar
• Hedigan K. Herbal medicine reduces chemotherapy toxicity. Nat Rev Drug Discov. 2010;9(10):765. doi:10.1038/nrd3280
   PubMed Web of Science ®Google Scholar
• Sgrò P, Ceci R, Lista M, et al. Quercetin modulates IGF-I and IGF-II levels after eccentric exercise-induced muscle-damage: a placebo-controlled study. Front Endocrinol. 2021;12:1412. doi:10.3389/FENDO.2021.745959/BIBTEX
   Web of Science ®Google Scholar
• Gelen V, Şengül E, Gedikli S, Atila G, Uslu H, Makav M. The protective effect of rutin and quercetin on 5-FU-induced hepatotoxicity in rats. Asian Pac J Trop Biomed. 2017;7(7):647–653. doi:10.1016/J.APJTB.2017.06.013
   Web of Science ®Google Scholar
• Lotfi M, Kazemi S, Ebrahimpour A, et al. Protective effect of quercetin nanoemulsion on 5-fluorouracil-induced oral mucositis in mice. J Oncol. 2021;2021:1–10. doi:10.1155/2021/5598230
   Web of Science ®Google Scholar
• Zhang Q, Xiao X, Li M, et al. Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats. J Mol Endocrinol. 2012;49(1):35–46. doi:10.1530/JME-12-0020
   PubMed Web of Science ®Google Scholar
• Najim SM, Ulaiwy MAA, Intesar T. Nephroprotective effects of artichoke extract against 5- fluorouracil induced nephrotoxicity in rats: a comparative study with telmisartan. Int J Pharm Sci Rev Res. 2018;48(1):70–74.
   Google Scholar
• Tsai CW, Lin SY, Kuo CC, Huang CC. Serum uric acid and progression of kidney disease: a longitudinal analysis and mini-review. PLoS One. 2017;12(1):e0170393. doi:10.1371/JOURNAL.PONE.0170393
   PubMed Web of Science ®Google Scholar
• Verzola D, Ratto E, Villaggio B, et al. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. PLoS One. 2014;9(12):e115210. doi:10.1371/JOURNAL.PONE.0115210
   PubMed Web of Science ®Google Scholar
• Shi Y, Williamson G. Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. Br J Nutr. 2016;115(5):800–806. doi:10.1017/S0007114515005310
   PubMed Web of Science ®Google Scholar
• Zha D, Wu S, Gao P, Wu X. Telmisartan attenuates uric acid-induced epithelial-mesenchymal transition in renal tubular cells. Biomed Res Int. 2019;2019:1–12. doi:10.1155/2019/3851718
   Web of Science ®Google Scholar
• Andrade-Oliveira V, Foresto-Neto O, Watanabe IKM, Zatz R, Câmara NOS. Inflammation in renal diseases: new and old players. Front Pharmacol. 2019;10:1192. doi:10.3389/FPHAR.2019.01192/BIBTEX
   PubMed Web of Science ®Google Scholar
• Kratofil RM, Kubes P, Deniset JF. Monocyte conversion during inflammation and injury. Arterioscler Thromb Vasc Biol. 2017;37(1):35–42. doi:10.1161/ATVBAHA.116.308198
   PubMed Web of Science ®Google Scholar
• Sherwood ER, Toliver-Kinsky T. Mechanisms of the inflammatory response. Best Pract Res Clin Anaesthesiol. 2004;18(3):385–405. doi:10.1016/J.BPA.2003.12.002
   PubMedGoogle Scholar
• Jiang F, Lei J, Xiang J, et al. Monocyte-to-lymphocyte ratio: a potential novel predictor for acute kidney injury in the intensive care unit. Ren Fail. 2022;44(1):1004. doi:10.1080/0886022X.2022.2079521
   PubMed Web of Science ®Google Scholar
• Klinghammer L, Urschel K, Cicha I, et al. Impact of telmisartan on the inflammatory state in patients with coronary atherosclerosis--influence on IP-10, TNF-α and MCP-1. Cytokine. 2013;62(2):290–296. doi:10.1016/J.CYTO.2013.02.001
   PubMed Web of Science ®Google Scholar
• Saeedi-Boroujeni A, Mahmoudian-Sani MR. Anti-inflammatory potential of Quercetin in COVID-19 treatment. J Inflamm. 2021;18(1):1–9. doi:10.1186/S12950-021-00268-6/FIGURES/1
   Google Scholar
• Karmakova TA, Sergeeva NS, Kanukoev KY, Alekseev BY, Kaprin AD. Kidney injury molecule 1 (KIM-1): a multifunctional glycoprotein and biological marker (review). Mod Technol Med. 2021;13(3):64. doi:10.17691/STM2021.13.3.08
   Web of Science ®Google Scholar
• Ichimura T, Bonventre JV, Bailly V, et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem. 1998;273(7):4135–4142. doi:10.1074/JBC.273.7.4135
   PubMed Web of Science ®Google Scholar
• Ichimura T, Hung CC, Yang SA, Stevens JL, Bonventre JV. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol. 2004;286(3):F552–F563. doi:10.1152/AJPRENAL.00285.2002
   PubMed Web of Science ®Google Scholar
• Bolignano D, Lacquaniti A, Coppolino G, et al. Neutrophil Gelatinase-Associated Lipocalin (NGAL) and progression of chronic kidney disease. Clin J Am Soc Nephrol. 2009;4(2):337. doi:10.2215/CJN.03530708
   PubMed Web of Science ®Google Scholar
• Törnblom S, Nisula S, Petäjä L, et al. Urine NGAL as a biomarker for septic AKI: a critical appraisal of clinical utility—data from the observational FINNAKI study. Ann Intensive Care. 2020;10(1):1–10. doi:10.1186/S13613-020-00667-7/FIGURES/3
   PubMed Web of Science ®Google Scholar
• Larki RA, Jamali B, Meidani M, Mousavi S. Serum cystatin C for evaluation of acute kidney injury in adults treated with colistin. J Res Pharm Pract. 2018;7(4):178. doi:10.4103/JRPP.JRPP_18_53
   PubMed Web of Science ®Google Scholar
• Fouad AA, Qureshi HA, Al-Sultan AI, Yacoubi MT, Al-Melhim WN. Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury. Pharmacology. 2010;85(3):158–167. doi:10.1159/000269779
   PubMed Web of Science ®Google Scholar
• Bin DS, Wang YH, Liu FY, et al. The protective role of telmisartan against nephrotoxicity induced by x-ray contrast media in rat model. Acta radiol. 2009;50(7):754–759. doi:10.1080/02841850902995544
   PubMed Web of Science ®Google Scholar
• Shen Y, Croft KD, Hodgson JM, et al. Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK. Biochem Pharmacol. 2012;84(8):1036–1044. doi:10.1016/J.BCP.2012.07.016
   PubMed Web of Science ®Google Scholar
• Häckl LPN, Cuttle G, Sanches Dovichi S, Lima-Landman MT, Nicolau M. Inhibition of angiotensin-converting enzyme by quercetin alters the vascular response to bradykinin and angiotensin I. Pharmacology. 2002;65(4):182–186. doi:10.1159/000064341
   PubMed Web of Science ®Google Scholar
• D’Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256–271. doi:10.1016/j.fitote.2015.09.018
   PubMed Web of Science ®Google Scholar
• Zhang M, Swarts SG, Yin L, et al. Antioxidant properties of quercetin. Adv Exp Med Biol. 2011;701:283–289. doi:10.1007/978-1-4419-7756-4_38
   PubMed Web of Science ®Google Scholar
• Sugiyama H, Kobayashi M, Wang DH, et al. Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. Nephrol Dial Transplant. 2005;20(12):2670–2680. doi:10.1093/NDT/GFI045
   PubMed Web of Science ®Google Scholar
• Morimoto S, Yano Y, Maki K, Sawada K. Renal and vascular protective effects of telmisartan in patients with essential hypertension. Hypertens Res. 2006;29(8):567–572. doi:10.1291/HYPRES.29.567
   PubMed Web of Science ®Google Scholar
• Nakamura T, Inoue T, Suzuki T, et al. Comparison of renal and vascular protective effects between telmisartan and amlodipine in hypertensive patients with chronic kidney disease with mild renal insufficiency. Hypertens Res. 2008;31(5):841–850. doi:10.1291/HYPRES.31.841
   PubMed Web of Science ®Google Scholar
• Andreucci M, Faga T, Pisani A, et al. Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells. J Cell Physiol. 2018;233(5):4116–4125. doi:10.1002/JCP.26213
   PubMed Web of Science ®Google Scholar
• Almaghrabi OA. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi J Biol Sci. 2015;22(2):227–231. doi:10.1016/J.SJBS.2014.12.008
   PubMed Web of Science ®Google Scholar
• Chen YQ, Chen HY, Tang QQ, et al. Protective effect of quercetin on kidney diseases: from chemistry to herbal medicines. Front Pharmacol. 2022;13:3304. doi:10.3389/FPHAR.2022.968226/BIBTEX
   Web of Science ®Google Scholar