Ferroptosis: Reviewing CRC with the Third Eye

References

• Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. doi:10.3322/caac.21708
   PubMed Web of Science ®Google Scholar
• Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343(2):78–85. doi:10.1056/nejm200007133430201
   PubMed Web of Science ®Google Scholar
• Song M, Garrett WS, Chan AT. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015;148(6):1244–60.e16. doi:10.1053/j.gastro.2014.12.035
   PubMed Web of Science ®Google Scholar
• Patel SG, Karlitz JJ, Yen T, Lieu CH, Boland CR. The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection. Lancet Gastroenterol Hepatol. 2022;7(3):262–274. doi:10.1016/S2468-1253(21)00426-X
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. CELL. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 2018;25(3):486–541. doi:10.1038/s41418-017-0012-4
   PubMed Web of Science ®Google Scholar
• Bebber CM, Müller F, Prieto Clemente L, Weber J, von Karstedt S. Ferroptosis in Cancer Cell Biology. Cancers. 2020;12(1):Jan. doi:10.3390/cancers12010164
   Web of Science ®Google Scholar
• Riegman M, Sagie L, Galed C, et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat Cell Biol. 2020;22(9):1042–1048. doi:10.1038/s41556-020-0565-1
   PubMed Web of Science ®Google Scholar
• Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin. Cell Metab. 2015;22(5):777–787. doi:10.1016/j.cmet.2015.09.006
   PubMed Web of Science ®Google Scholar
• Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105–109. doi:10.1038/nature13148
   PubMed Web of Science ®Google Scholar
• Chen X, Yu C, Kang R, Tang D. Iron Metabolism in Ferroptosis. Front Cell Dev Biol. 2020;8:590226. doi:10.3389/fcell.2020.590226
   PubMed Web of Science ®Google Scholar
• Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel? Nat Rev Cancer. 2014;14(11):709–721. doi:10.1038/nrc3803
   PubMed Web of Science ®Google Scholar
• Le NT, Richardson DR. The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta. 2002;1603(1):31–46. doi:10.1016/s0304-419x(02)
   PubMed Web of Science ®Google Scholar
• Ashmore JH, Rogers CJ, Kelleher SL, Lesko SM, Hartman TJ. Dietary iron and colorectal cancer risk: a review of human population studies. Crit Rev Food Sci Nutr. 2016;56(6):1012–1020. doi:10.1080/10408398.2012.749208
   PubMed Web of Science ®Google Scholar
• Yuan Y, Ni S, Zhuge A, Li B, Li L. Iron Regulates the Warburg Effect and Ferroptosis in Colorectal Cancer. Front Oncol. 2021;11:614778. doi:10.3389/fonc.2021.614778
   PubMed Web of Science ®Google Scholar
• Yang WS, Stockwell BR. Ferroptosis: death by Lipid Peroxidation. Trends Cell Biol. 2016;26(3):165–176. doi:10.1016/j.tcb.2015.10.014
   PubMed Web of Science ®Google Scholar
• Yin H, Xu L, Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev. 2011;111(10):5944–5972. doi:10.1021/cr200084z
   PubMed Web of Science ®Google Scholar
• Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91–98. doi:10.1038/nchembio.2239
   PubMed Web of Science ®Google Scholar
• Kuhn H, Banthiya S, van Leyen K. Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta. 2015;1851(4):308–330. doi:10.1016/j.bbalip.2014.10.002
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331. doi:10.1016/j.cell.2013.12.010
   PubMed Web of Science ®Google Scholar
• Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991;11(1):81–128. doi:10.1016/0891-5849(91)
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Patel DN, Welsch M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife. 2014;3:e02523. doi:10.7554/eLife.02523
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang X, Wei C, et al. Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis. Eur J Pharm Sci. 2020;152:105450. doi:10.1016/j.ejps.2020.105450
   PubMed Web of Science ®Google Scholar
• Sui X, Zhang R, Liu S, et al. RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer. Front Pharmacol. 2018;9:1371. doi:10.3389/fphar.2018.01371
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692. doi:10.1038/s41586-019-1705-2
   PubMed Web of Science ®Google Scholar
• Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575(7784):693–698. doi:10.1038/s41586-019-1707-0
   PubMed Web of Science ®Google Scholar
• Kraft VAN, Bezjian CT, Pfeiffer S, et al. GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling. ACS Cent Sci. 2020;6(1):41–53. doi:10.1021/acscentsci.9b01063
   PubMed Web of Science ®Google Scholar
• Hu Q, Wei W, Wu D, et al. Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis. Front Cell Dev Biol. 2022;10:810327. doi:10.3389/fcell.2022.810327
   PubMed Web of Science ®Google Scholar
• Pedrera L, Espiritu RA, Ros U, et al. Ferroptotic pores induce Ca(2+) fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ. 2021;28(5):1644–1657. doi:10.1038/s41418-020-00691-x
   PubMed Web of Science ®Google Scholar
• Wang R, Su Q, Yin H, Wu D, Lv C, Yan Z. Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression. Int J Biochem Cell Biol. 2021;134:105948. doi:10.1016/j.biocel.2021.105948
   PubMed Web of Science ®Google Scholar
• Liu XS, Yang JW, Zeng J, et al. SLC2A1 is a diagnostic biomarker involved in immune infiltration of colorectal cancer and associated with m6A Modification and ceRNA. Front Cell Dev Biol. 2022;10:853596. doi:10.3389/fcell.2022.853596
   PubMed Web of Science ®Google Scholar
• Peng B, Peng J, Kang F, Zhang W, Peng E, He Q. Ferroptosis-Related Gene MT1G as a Novel Biomarker Correlated With Prognosis and Immune Infiltration in Colorectal Cancer. Front Cell Dev Biol. 2022;10:881447. doi:10.3389/fcell.2022.881447
   PubMed Web of Science ®Google Scholar
• Zhong Y, Zhang W, Yu H, et al. Multi-platform-based characterization of ferroptosis in human colorectal cancer. iScience. 2022;25(8):104750. doi:10.1016/j.isci.2022.104750
   PubMed Web of Science ®Google Scholar
• Du S, Zeng F, Sun H, et al. Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients. Bioengineered. 2022;13(2):2498–2512. doi:10.1080/21655979.2021.2017627
   PubMed Web of Science ®Google Scholar
• Liu Y, Guo F, Guo W, Wang Y, Song W, Fu T. Ferroptosis-related genes are potential prognostic molecular markers for patients with colorectal cancer. Clin Exp Med. 2021;21(3):467–477. doi:10.1007/s10238-021-00697-w
   PubMed Web of Science ®Google Scholar
• Shao Y, Jia H, Huang L, et al. An original ferroptosis-related gene signature effectively predicts the prognosis and clinical status for colorectal cancer patients. Front Oncol. 2021;11:711776. doi:10.3389/fonc.2021.711776
   PubMed Web of Science ®Google Scholar
• Wang Y, Xia HB, Chen ZM, Meng L, Xu AM. Identification of a ferroptosis-related gene signature predictive model in colon cancer. World J Surg Oncol. 2021;19(1):135. doi:10.1186/s12957-021-02244-z
   PubMed Web of Science ®Google Scholar
• Yang C, Huang S, Cao F, Zheng Y. Role of ferroptosis-related genes in prognostic prediction and tumor immune microenvironment in colorectal carcinoma. PeerJ. 2021;9:e11745. doi:10.7717/peerj.11745
   PubMed Web of Science ®Google Scholar
• Cheok CF, Verma CS, Baselga J, Lane DP. Translating p53 into the clinic. Nat Rev Clin Oncol. 2011;8(1):25–37. doi:10.1038/nrclinonc.2010.174
   PubMed Web of Science ®Google Scholar
• Ji H, Wang W, Li X, et al. p53: a double-edged sword in tumor ferroptosis. Pharmacol Res. 2022;177:106013. doi:10.1016/j.phrs.2021.106013
   PubMed Web of Science ®Google Scholar
• Jiang L, Kon N, Li T, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520(7545):57–62. doi:10.1038/nature14344
   PubMed Web of Science ®Google Scholar
• Xie Y, Zhu S, Song X, et al. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017;20(7):1692–1704. doi:10.1016/j.celrep.2017.07.055
   PubMed Web of Science ®Google Scholar
• Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009;10(3):155–159. doi:10.1038/nrg2521
   PubMed Web of Science ®Google Scholar
• Muers M. RNA: genome-wide views of long non-coding RNAs. Nat Rev Genet. 2011;12(11):742. doi:10.1038/nrg3088
   PubMed Web of Science ®Google Scholar
• Arun G, Diermeier SD, Spector DL. Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol Med. 2018;24(3):257–277. doi:10.1016/j.molmed.2018.01.001
   PubMed Web of Science ®Google Scholar
• Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. NATURE. 2014;505(7483):344–352. doi:10.1038/nature12986
   PubMed Web of Science ®Google Scholar
• Luo Y, Huang S, Wei J, et al. Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1-Wnt/β-catenin-TFE3 feedback loop signalling. Clin Transl Med. 2022;12(4):e752. doi:10.1002/ctm2.752
   PubMed Web of Science ®Google Scholar
• Zeng JH, Liang L, He RQ, et al. Comprehensive investigation of a novel differentially expressed lncRNA expression profile signature to assess the survival of patients with colorectal adenocarcinoma. Oncotarget. 2017;8(10):16811–16828. doi:10.18632/oncotarget.15161
   PubMedGoogle Scholar
• Zhang W, Fang D, Li S, Bao X, Jiang L, Sun X. Construction and validation of a novel ferroptosis-related lncrna signature to predict prognosis in colorectal cancer patients. Front Genet. 2021;12:709329. doi:10.3389/fgene.2021.709329
   PubMed Web of Science ®Google Scholar
• Liu L, Yao H, Zhou X, et al. MiR-15a-3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer. Mol Carcinog. 2022;61(3):301–310. doi:10.1002/mc.23367
   PubMed Web of Science ®Google Scholar
• Yang Y, Lin Z, Han Z, et al. miR-539 activates the SAPK/JNK signaling pathway to promote ferroptosis in colorectal cancer by directly targeting TIPE. Cell Death Discov. 2021;7(1):272. doi:10.1038/s41420-021-00659-x
   PubMed Web of Science ®Google Scholar
• Zheng S, Hu L, Song Q, et al. miR-545 promotes colorectal cancer by inhibiting transferring in the non-normal ferroptosis signaling. Aging. 2021;13(24):26137–26147. doi:10.18632/aging.203801
   PubMedGoogle Scholar
• Angius A, Uva P, Pira G, et al. Integrated Analysis of miRNA and mRNA Endorses a Twenty miRNAs Signature for Colorectal Carcinoma. Int J Mol Sci. 2019;20(16):4067. doi:10.3390/ijms20164067
   PubMed Web of Science ®Google Scholar
• Zhong Y, Du Y, Yang X, et al. Circular RNAs function as ceRNAs to regulate and control human cancer progression. Mol Cancer. 2018;17(1):79. doi:10.1186/s12943-018-0827-8
   PubMed Web of Science ®Google Scholar
• Yang Z, Xie L, Han L, et al. Circular RNAs: regulators of Cancer-Related Signaling Pathways and Potential Diagnostic Biomarkers for Human Cancers. Theranostics. 2017;7(12):3106–3117. doi:10.7150/thno.19016
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen H, Wei X. Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells. Eur J Clin Invest. 2021;51(7):e13541. doi:10.1111/eci.13541
   PubMed Web of Science ®Google Scholar
• Xian ZY, Hu B, Wang T, et al. CircABCB10 silencing inhibits the cell ferroptosis and apoptosis by regulating the miR-326/CCL5 axis in rectal cancer. Neoplasma. 2020;67(5):1063–1073. doi:10.4149/neo_2020_191024N1084
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Kang MI, Okawa H, et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol. 2004;24(16):7130–7139. doi:10.1128/mcb.24.16.7130-7139.2004
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Kang MI, Watai Y, et al. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol. 2006;26(1):221–229. doi:10.1128/mcb.26.1.221-229.2006
   PubMed Web of Science ®Google Scholar
• Ishii T, Itoh K, Takahashi S, et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000;275(21):16023–16029. doi:10.1074/jbc.275.21.16023
   PubMed Web of Science ®Google Scholar
• Wakabayashi N, Itoh K, Wakabayashi J, et al. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003;35(3):238–245. doi:10.1038/ng1248
   PubMed Web of Science ®Google Scholar
• Fan Z, Wirth AK, Chen D, et al. Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis. 2017;6(8):e371. doi:10.1038/oncsis.2017.65
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Chen R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63(1):173–184. doi:10.1002/hep.28251
   PubMed Web of Science ®Google Scholar
• Kwon MY, Park E, Lee SJ, Chung SW. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death. Oncotarget. 2015;6(27):24393–24403. doi:10.18632/oncotarget.5162
   PubMedGoogle Scholar
• Yang J, Mo J, Dai J, et al. Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer. Cell Death Dis. 2021;12(11):1079. doi:10.1038/s41419-021-04367-3
   PubMed Web of Science ®Google Scholar
• Wei R, Zhao Y, Wang J, et al. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. Int J Biol Sci. 2021;17(11):2703–2717. doi:10.7150/ijbs.59404
   PubMed Web of Science ®Google Scholar
• Malfa GA, Tomasello B, Acquaviva R, et al. Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells. Int J Mol Sci. 2019;20(11). doi:10.3390/ijms20112723
   PubMed Web of Science ®Google Scholar
• Singhal R, Mitta SR, Das NK, et al. HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. J Clin Invest. 2021;131(12). doi:10.1172/jci143691
   Web of Science ®Google Scholar
• Song J, Liu T, Yin Y, et al. The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity. EMBO Rep. 2021;22(2):e51162. doi:10.15252/embr.202051162
   PubMed Web of Science ®Google Scholar
• Hong SH, Lee DH, Lee YS, et al. Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. Oncotarget. 2017;8(70):115164–115178. doi:10.18632/oncotarget.23046
   PubMedGoogle Scholar
• Chaudhary N, Choudhary BS, Shah SG, et al. Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. Int J Cancer. 2021;149(7):1495–1511. doi:10.1002/ijc.33711
   PubMed Web of Science ®Google Scholar
• Sharma P, Shimura T, Banwait JK, Goel A. Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer. Carcinogenesis. 2020;41(10):1385–1394. doi:10.1093/carcin/bgaa090
   PubMed Web of Science ®Google Scholar
• Yang C, Zhang Y, Lin S, Liu Y, Li W. Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin. Aging. 2021;13(10):13515–13534. doi:10.18632/aging.202774
   PubMedGoogle Scholar
• Misale S, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Bardelli A. Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution. Cancer Discov. 2014;4(11):1269–1280. doi:10.1158/2159-8290.Cd-14-0462
   PubMed Web of Science ®Google Scholar
• Chen P, Li X, Zhang R, et al. Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. Theranostics. 2020;10(11):5107–5119. doi:10.7150/thno.44705
   PubMed Web of Science ®Google Scholar
• Lorenzato A, Magrì A, Matafora V, et al. Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer. Cancers. 2020;12(3):Mar. doi:10.3390/cancers12030685
   Web of Science ®Google Scholar
• Guo J, Xu B, Han Q, et al. Ferroptosis: a Novel Anti-tumor Action for Cisplatin. Cancer Res Treat. 2018;50(2):445–460. doi:10.4143/crt.2016.572
   PubMed Web of Science ®Google Scholar
• Tian X, Li S, Ge G. Apatinib Promotes Ferroptosis in Colorectal Cancer Cells by Targeting ELOVL6/ACSL4 Signaling. Cancer Manag Res. 2021;13:1333–1342. doi:10.2147/cmar.S274631
   PubMed Web of Science ®Google Scholar
• Sun J, Cheng X, Pan S, et al. Dichloroacetate attenuates the stemness of colorectal cancer cells via triggering ferroptosis through sequestering iron in lysosomes. Environ Toxicol. 2021;36(4):520–529. doi:10.1002/tox.23057
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu W, Liu F, et al. IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer. Oxid Med Cell Longev. 2020;2020:1675613. doi:10.1155/2020/1675613
   PubMed Web of Science ®Google Scholar
• Park S, Oh J, Kim M, Jin EJ. Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis. Anim Cells Syst. 2018;22(5):334–340. doi:10.1080/19768354.2018.1512521
   PubMed Web of Science ®Google Scholar
• Vermonden P, Vancoppenolle M, Dierge E, et al. Punicic acid triggers ferroptotic cell death in carcinoma cells. Nutrients. 2021;13(8):Aug. doi:10.3390/nu13082751
   Web of Science ®Google Scholar
• Xia Y, Liu S, Li C, et al. Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo. Cell Death Dis. 2020;11(11):988. doi:10.1038/s41419-020-03194-2
   PubMed Web of Science ®Google Scholar
• Wang CX, Chen LH, Zhuang HB, et al. Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation. Biochem Biophys Res Commun. 2022;587:99–106. doi:10.1016/j.bbrc.2021.11.101
   PubMed Web of Science ®Google Scholar
• Lei X, Lei Y, Li JK, et al. Immune cells within the tumor microenvironment: biological functions and roles in cancer immunotherapy. Cancer Lett. 2020;470:126–133. doi:10.1016/j.canlet.2019.11.009
   PubMed Web of Science ®Google Scholar
• Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer. 2022;22(7):381–396. doi:10.1038/s41568-022-00459-0
   PubMed Web of Science ®Google Scholar
• Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79(18):4557–4566. doi:10.1158/0008-5472.Can-18-3962
   PubMed Web of Science ®Google Scholar
• Zhu H, Klement JD, Lu C, et al. Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021;206(6):1395–1404. doi:10.4049/jimmunol.2000500
   PubMed Web of Science ®Google Scholar
• Fan F, Liu P, Bao R, et al. A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy. Cancer Res. 2021;81(24):6233–6245. doi:10.1158/0008-5472.Can-21-1547
   PubMed Web of Science ®Google Scholar
• Han W, Duan X, Ni K, Li Y, Chan C, Lin W. Co-delivery of dihydroartemisinin and pyropheophorbide-iron elicits ferroptosis to potentiate cancer immunotherapy. BIOMATERIALS. 2022;280:121315. doi:10.1016/j.biomaterials.2021.121315
   PubMed Web of Science ®Google Scholar
• Li Q, Su R, Bao X, et al. Glycyrrhetinic acid nanoparticles combined with ferrotherapy for improved cancer immunotherapy. Acta Biomater. 2022. doi:10.1016/j.actbio.2022.03.030
   Web of Science ®Google Scholar
• Nikolova B, Semkova S, Tsoneva I, et al. Redox-related molecular mechanism of sensitizing colon cancer cells to camptothecin analog SN38. Anticancer Res. 2020;40(9):5159–5170. doi:10.21873/anticanres.14519
   PubMed Web of Science ®Google Scholar
• Wiernicki B, Maschalidi S, Pinney J, et al. Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity. Nat Commun. 2022;13(1):3676. doi:10.1038/s41467-022-31218-2
   PubMed Web of Science ®Google Scholar