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ORIGINAL RESEARCH

TNF-α and IL-1β Promote Renal Podocyte Injury in T2DM Rats by Decreasing Glomerular VEGF/eNOS Expression Levels and Altering Hemodynamic Parameters

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Pages 6657-6673 | Received 06 Oct 2022, Accepted 30 Nov 2022, Published online: 09 Dec 2022

References

  • Wong YH, Wong SH, Wong XT, Yi Yap Q, Yip KY, Wong LZ. Genetic associated complications of type 2 diabetes mellitus: a review. Panminerva Med. 2022;64(2):274–288. doi:10.23736/S0031-0808.21.04285-3
  • Silveira Rossi JL, Barbalho SM, Reverete de Araujo R, Bechara MD, Sloan KP, Sloan LA. Metabolic syndrome and cardiovascular diseases: going beyond traditional risk factors. Diabetes Metab Res Rev. 2022;38(3):e3502. doi:10.1002/dmrr.3502
  • Han Q, Zhu H, Chen X, Liu Z. Non-genetic mechanisms of diabetic nephropathy. Front Med. 2017;11(3):319–332. doi:10.1007/s11684-017-0569-9
  • Luo W, Chen X, Ye L, et al. Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: the role of TRAF6 in diabetic nephropathy. J Ethnopharmacol. 2021;268:113553. doi:10.1016/j.jep.2020.113553
  • Reinehr T. Inflammatory markers in children and adolescents with type 2 diabetes mellitus. Clin Chim Acta. 2019;496:100–107. doi:10.1016/j.cca.2019.07.006
  • Cheng D, Fei Y, Saulnier PJ, Wang N. Circulating TNF receptors and risk of renal disease progression, cardiovascular disease events and mortality in patients with diabetes: a systematic review and meta-analysis. Endocrine. 2020;68(1):32–43. doi:10.1007/s12020-019-02153-y
  • Inserra F, Forcada P, Castellaro A, Castellaro C. Chronic kidney disease and arterial stiffness: a two-way path. Front Med. 2021;8:765924. doi:10.3389/fmed.2021.765924
  • Barsom SH, Glasstetter LM, Siddiqi S, Rajagopalan KS, Eirin A, Lerman LO. Emergent players in renovascular disease. Clin Sci. 2022;136(3):239–256. doi:10.1042/CS20210509
  • Zhang Y, Liao H, Shen D, et al. Renal protective effects of Inonotus obliquus on high-fat diet/streptozotocin-induced diabetic kidney disease rats: biochemical, color Doppler ultrasound and histopathological evidence. Front Pharmacol. 2022;12:743931. doi:10.3389/fphar.2021.743931
  • Liu JY, Mu S, Zhang SP, et al. Roux-en-Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats. Exp Ther Med. 2017;14(3):2536–2542. doi:10.3892/etm.2017.4801
  • Xu LL, Gao W, Chen ZM, et al. Relationships between diabetic nephropathy and insulin resistance, inflammation, Trx, Txnip, CysC and serum complement levels. Eur Rev Med Pharmacol Sci. 2020;24(22):11700–11706. doi:10.26355/eurrev_202011_23815
  • Zhang KQ, Tian T, Hu LL, Wang HR, Fu Q. Effect of probucol on autophagy and apoptosis in the penile tissue of streptozotocin-induced diabetic rats. Asian J Androl. 2020;22(4):409–413. doi:10.4103/aja.aja_89_19
  • Wilson RD, Islam MS. Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Pharmacol Rep. 2012;64(1):129–139. doi:10.1016/s1734-1140(12)70739-9
  • Li Y, Guo S, Yang F, Liu L, Chen Z. Huayu tongluo recipe attenuates renal oxidative stress and inflammation through the activation of AMPK/Nrf2 signaling pathway in streptozotocin- (STZ-) induced diabetic rats. Evid Based Complement Alternat Med. 2021;2021:5873007. doi:10.1155/2021/5873007
  • Zou C, Jiao Y, Li X, et al. Differences between healthy adults and patients with type 2 diabetes mellitus in reactivity of toe microcirculation by ultrasound combined with a warm bath test. Medicine. 2017;96(22):e7035. doi:10.1097/MD.0000000000007035
  • Maksoud AAA, Sharara SM, Nanda A, Khouzam RN. The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding. Ann Transl Med. 2019;7(17):422. doi:10.21037/atm.2019.08.65
  • Markus B, Patsalis N, Chatzis G, et al. Impact of microaxillar mechanical left ventricular support on renal resistive index in patients with cardiogenic shock after myocardial infarction: a pilot trial to predict renal organ dysfunction in cardiogenic shock. Eur Heart J Acute Cardiovasc Care. 2020;9(2):158–163. doi:10.1177/2048872619860218
  • Wang C, Hou XX, Rui HL, et al. Artificially cultivated ophiocordyceps sinensis alleviates diabetic nephropathy and its podocyte injury via inhibiting P2X7R expression and NLRP3 inflammasome activation. J Diabetes Res. 2018;2018:1390418. doi:10.1155/2018/1390418
  • Zeng JY, Wang Y, Miao M, Bao XR. The effects of rhubarb for the treatment of diabetic nephropathy in animals: a systematic review and meta-analysis. Front Pharmacol. 2021;12:602816. doi:10.3389/fphar.2021.602816
  • Yang GM, Wang ZY, Chen LL, Wang P, Lu Y, Zhang LY. Establishment of some biological indexes in SPF SD rats. Lab Anim Sci. 2008;25(4):19–22.
  • Netter FH. Atlas of Human Anatomy. Seventh ed. Beijing: People’s Medical Publishing House; 2019. In Chinese and English.
  • Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T. Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care. 2005;28(1):164–176. doi:10.2337/diacare.28.1.164
  • Vatankhah Yazdi K, Kalantar SM, Houshmand M, et al. SLC30A8, CDKAL1, TCF7L2, KCNQ1 and IGF2BP2 are associated with type 2 diabetes mellitus in Iranian patients. Diabetes Metab Syndr Obes. 2020;13:897–906. doi:10.2147/DMSO.S225968
  • Kim H, Kim M, Lee HY, Park HY, Jhun H, Kim S. Role of dendritic cell in diabetic nephropathy. Int J Mol Sci. 2021;22(14):7554. doi:10.3390/ijms22147554
  • Huang T, Li X, Wang F, et al. The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy. Cell Death Dis. 2021;12(4):333. doi:10.1038/s41419-021-03629-4
  • Choi JSY, de Haan JB, Sharma A. Animal models of diabetes-associated vascular diseases: an update on available models and experimental analysis. Br J Pharmacol. 2022;179(5):748–769. doi:10.1111/bph.15591
  • Cuthbertson DJ, Koskinen J, Brown E, et al. Fatty liver index predicts incident risk of prediabetes, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Ann Med. 2021;53(1):1256–1264. doi:10.1080/07853890.2021.1956685
  • Kwanbunjan K, Panprathip P, Phosat C, et al. Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural Thais with high type 2 diabetes risk. BMC Endocr Disord. 2018;18(1):26. doi:10.1186/s12902-018-0254-2
  • Suriano F, Manca C, Flamand N, et al. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: links with inflammation and gut microbiota. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867(1):159056. doi:10.1016/j.bbalip.2021.159056
  • Tian B, Zhao J, Xie X, et al. Anthocyanins from the fruits of Lycium ruthenicum Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice. Food Funct. 2021;12(9):3855–3871. doi:10.1039/d0fo02936j
  • Scheen AJ, Esser N, Paquot N. Antidiabetic agents: potential anti-inflammatory activity beyond glucose control. Diabetes Metab. 2015;41(3):183–194. doi:10.1016/j.diabet.2015.02.003
  • Brosius FC, Alpers CE, Bottinger EP, et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2009;20(12):2503–2512. doi:10.1681/ASN.2009070721
  • Faisal Lutfi M, Abdel-Moneim AH, Alsharidah AS, et al. Thymoquinone lowers blood glucose and reduces oxidative stress in a rat model of diabetes. Molecules. 2021;26(8):2348. doi:10.3390/molecules26082348
  • Xu J, Wang Y, Wang Z, Guo L, Li X. Fucoidan mitigated diabetic nephropathy through the downregulation of PKC and modulation of NF-κB signaling pathway: in vitro and in vivo investigations. Phytother Res. 2021;35(4):2133–2144. doi:10.1002/ptr.6966
  • Expert Group of Chinese Society of Nephrology. Chinese guidelines for diagnosis and treatment of diabetic kidney disease. Chin J Nephrol. 2021;37(3):255–304.
  • Chen L, Wu J, Xu H, Chen J, Xie X. Effects of tanshinone combined with valsartan on hypertensive nephropathy and its influence on renal function and vascular endothelial function. Am J Transl Res. 2021;13(5):4788–4795.
  • Hu X, Zhang X, Jin G, Shi Z, Sun W, Chen F. Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways. Fundam Clin Pharmacol. 2017;31(1):54–63. doi:10.1111/fcp.12231
  • Ma F, Yadav GP, Cang YQ, et al. Contrast-enhanced ultrasonography is a valid technique for the assessment of renal microvascular perfusion dysfunction in diabetic Goto-Kakizaki rats. Nephrology. 2013;18(12):750–760. doi:10.1111/nep.12159
  • Yang J, Yang S, Xu Y, et al. Evaluation of renal oxygenation and hemodynamics in patients with chronic kidney disease by blood oxygenation level-dependent magnetic resonance imaging and intrarenal Doppler ultrasonography. Nephron. 2021;145(6):653–663. doi:10.1159/000516637
  • Abe M, Akaishi T, Miki T, et al. Influence of renal function and demographic data on intrarenal Doppler ultrasonography. PLoS One. 2019;14(8):e0221244. doi:10.1371/journal.pone.0221244
  • Veron D, Aggarwal PK, Li Q, Moeckel G, Kashgarian M, Tufro A. Podocyte VEGF-A knockdown induces diffuse glomerulosclerosis in diabetic and in eNOS knockout mice. Front Pharmacol. 2022;12:788886. doi:10.3389/fphar.2021.788886
  • Roumeliotis S, Mallamaci F, Zoccali C. Endothelial dysfunction in chronic kidney disease, from biology to clinical outcomes: a 2020 update. J Clin Med. 2020;9(8):2359. doi:10.3390/jcm9082359
  • Zhan P, Zhang Y, Shi W, et al. Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease. Kidney Int. 2022;102(3):546–559. doi:10.1016/j.kint.2022.04.027
  • Arellano-Rodríguez M, Zapata-Benavides P, Arellano-Rodríguez NC, et al. The inflammatory process modulates the expression and localization of WT1 in podocytes leading to kidney damage. In Vivo. 2021;35(6):3137–3146. doi:10.21873/invivo.12608
  • Liu XQ, Jiang L, Li YY, et al. Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease. Acta Pharmacol Sin. 2022;43(1):96–110. doi:10.1038/s41401-021-00721-5
  • Padhi UN, Mulkalwar M, Saikrishna L, Verma HK, Bhaskar L. NOS3 gene intron 4 a/b polymorphism is associated with ESRD in autosomal dominant polycystic kidney disease patients. J Bras Nefrol. 2022;44(2):224–231. doi:10.1590/2175-8239-JBN-2021-0089
  • Di Nicolò P, Granata A. Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions. J Nephrol. 2019;32(4):527–538. doi:10.1007/s40620-018-00567-x
  • Gao J, Perlman A, Kalache S, et al. Multiparametric quantitative ultrasound imaging in assessment of chronic kidney disease. J Ultrasound Med. 2017;36(11):2245–2256. doi:10.1002/jum.14209
  • Sener TE, Tanidir Y, Bin HS, et al. Effects of flexible ureteroscopy on renal blood flow: a prospective evaluation. Scand J Urol. 2018;52(3):213–218. doi:10.1080/21681805.2018.1437770
  • Zheng HP, Qin RJ. Comparative analysis of hemorheology property of blood in vitro and in vivo. Chin J Med Phys. 2017;34(10):1051–1057. doi:10.3969/j.issn.1005-202X.2017.10.017
  • Meyer S, Fuchs D, Meier M. Ultrasound and photoacoustic imaging of the kidney: basic concepts and protocols. Methods Mol Biol. 2021;2216:109–130. doi:10.1007/978-1-0716-0978-1_7
  • Wetzel MD, Gao T, Stanley K, Cooper TK, Morris SM, Awad AS. Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. Am J Physiol Renal Physiol. 2020;318(2):F509–F517. doi:10.1152/ajprenal.00518.2019
  • Katulka EK, Hirt AE, Kirkman DL, Edwards DG, Witman MAH. Altered vascular function in chronic kidney disease: evidence from passive leg movement. Physiol Rep. 2019;7(8):e14075. doi:10.14814/phy2.14075
  • Coutinho MN, Carvalho AB, Dalboni MA, et al. There is no impact of diabetes on the endothelial function of chronic kidney disease patients. J Diabetes Res. 2018;2018:7926473. doi:10.1155/2018/7926473