The Role of AIM2 Inflammasome in Knee Osteoarthritis

References

• Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol. 2014;10(7):437–441. doi:10.1038/nrrheum.2014.44
   PubMed Web of Science ®Google Scholar
• Felson DT. Priorities for osteoarthritis research: much to be done. Nat Rev Rheumatol. 2014;10(8):447–448. doi:10.1038/nrrheum.2014.76
   PubMed Web of Science ®Google Scholar
• Eymard F, Chevalier X. Inflammation of the infrapatellar fat pad. Joint Bone Spine. 2016;83(4):389–393. doi:10.1016/j.jbspin.2016.02.016
   PubMed Web of Science ®Google Scholar
• Motta F, Barone E, Sica A, Selmi C. Inflammaging and osteoarthritis. Clin Rev Allerg Immu. 2022;1–17. doi:10.1007/s12016-022-08941-1
   Web of Science ®Google Scholar
• Batushansky A, Zhu S, Komaravolu RK, South S, Mehta-D’souza P, Griffin TM; Fundamentals of OA. An initiative of osteoarthritis and cartilage. Chapter 9: obesity and metabolic factors in OA. Osteoarthr Cartilage. 2021;30(4):501–515. doi:10.1016/j.joca.2021.06.013
   PubMed Web of Science ®Google Scholar
• Coaccioli S, Sarzi-Puttini P, Zis P, Rinonapoli G, Varrassi G. Osteoarthritis: new insight on its pathophysiology. J Clin Med. 2022;11(20):6013. doi:10.3390/jcm11206013
   PubMed Web of Science ®Google Scholar
• de Lange-Brokaar BJE, Ioan-Facsinay A, van Osch GJVM, et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthr Cartilage. 2012;20(12):1484–1499. doi:10.1016/j.joca.2012.08.027
   PubMed Web of Science ®Google Scholar
• Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022;18(5):258–275. doi:10.1038/s41584-022-00749-9
   PubMed Web of Science ®Google Scholar
• Griffin TM, Scanzello CR. Innate inflammation and synovial macrophages in osteoarthritis pathophysiology. Clin Exp Rheumatol. 2019;37(5):57–63.
   PubMed Web of Science ®Google Scholar
• Arron JR, Choi Y. Bone versus immune system. Nature. 2000;408(6812):535–536. doi:10.1038/35046196
   PubMed Web of Science ®Google Scholar
• Takayanagi H. Osteoimmunology as an intrinsic part of immunology. Int Immunol. 2021;33(12):dxab057. doi:10.1093/intimm/dxab057
   Web of Science ®Google Scholar
• Robinson WH, Lepus CM, Wang Q, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(10):580–592. doi:10.1038/nrrheum.2016.136
   PubMed Web of Science ®Google Scholar
• Ghouri A, Conaghan PG. Prospects for Therapies in Osteoarthritis. Calcified Tissue Int. 2021;109(3):339–350. doi:10.1007/s00223-020-00672-9
   PubMed Web of Science ®Google Scholar
• Delplace V, Boutet MA, Visage CL, Maugars Y, Guicheux J, Vinatier C. Osteoarthritis: from upcoming treatments to treatments yet to come. Joint Bone Spine. 2021;88(5):105206. doi:10.1016/j.jbspin.2021.105206
   PubMed Web of Science ®Google Scholar
• Li D, Wu M. Pattern recognition receptors in health and diseases. Signal Transduct Target Ther. 2021;6(1):291. doi:10.1038/s41392-021-00687-0
   PubMed Web of Science ®Google Scholar
• Schroder K, Tschopp J. The Inflammasomes. Cell. 2010;140(6):821–832. doi:10.1016/j.cell.2010.01.040
   PubMed Web of Science ®Google Scholar
• Wang B, Yin Q. AIM2 inflammasome activation and regulation: a structural perspective. J Struct Biol. 2017;200(3):279–282. doi:10.1016/j.jsb.2017.08.001
   PubMed Web of Science ®Google Scholar
• Murakami T, Nakaminami Y, Takahata Y, Hata K, Nishimura R. Activation and function of NLRP3 inflammasome in bone and joint-related diseases. Int J Mol Sci. 2022;23(10):5365. doi:10.3390/ijms23105365
   PubMed Web of Science ®Google Scholar
• Uresti-Rivera EE, García-Hernández MH, Li H, Wang D. AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis. Autoimmunity. 2022;55(1):1–12. doi:10.1080/08916934.2022.2103802
   PubMed Web of Science ®Google Scholar
• Lozano-Ruiz B, Bachiller V, García-Martínez I, et al. Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis. J Hepatol. 2015;62(1):64–71. doi:10.1016/j.jhep.2014.08.027
   PubMed Web of Science ®Google Scholar
• Chao-yang G, Peng C, Hai-hong Z. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthr Cartilage. 2021;29(6):793–801. doi:10.1016/j.joca.2021.02.204
   PubMed Web of Science ®Google Scholar
• Roškar S, Hafner-Bratkovič I. The role of inflammasomes in osteoarthritis and secondary joint degeneration diseases. Life. 2022;12(5):731. doi:10.3390/life12050731
   PubMedGoogle Scholar
• Chen Y, Fujuan Q, Chen E, et al. Expression of AIM2 in rheumatoid arthritis and its role on fibroblast-like synoviocytes. Mediat Inflamm. 2020;2020:1693730. doi:10.1155/2020/1693730
   PubMed Web of Science ®Google Scholar
• Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18(9):2114–2127. doi:10.1038/s41423-021-00740-6
   PubMed Web of Science ®Google Scholar
• Lammert CR, Frost EL, Bellinger CE, et al. AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. Nature. 2020;580(7805):647–652. doi:10.1038/s41586-020-2174-3
   PubMed Web of Science ®Google Scholar
• Wang B, Bhattacharya M, Roy S, Tian Y, Yin Q. Immunobiology and structural biology of AIM2 inflammasome. Mol Aspects Med. 2020;76:100869. doi:10.1016/j.mam.2020.100869
   PubMed Web of Science ®Google Scholar
• Jin T, Perry A, Smith P, Jiang J, Xiao TS. Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of aim2 autoinhibition and inflammasome assembly*. J Biol Chem. 2013;288(19):13225–13235. doi:10.1074/jbc.m113.468033
   PubMed Web of Science ®Google Scholar
• Chang X, Kang Y, Yang Y, et al. Pyroptosis: a novel intervention target in the progression of osteoarthritis. J Inflamm Res. 2022;15:3859–3871. doi:10.2147/jir.s368501
   PubMed Web of Science ®Google Scholar
• Berthelot JM, Sellam J, Maugars Y, Berenbaum F. Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis. Rmd Open. 2019;5(2):e001037. doi:10.1136/rmdopen-2019-001037
   PubMed Web of Science ®Google Scholar
• Wei Z, Li F, Pi G. Association between gut microbiota and osteoarthritis: a review of evidence for potential mechanisms and therapeutics. Front Cell Infect Mi. 2022;12:812596. doi:10.3389/fcimb.2022.812596
   PubMed Web of Science ®Google Scholar
• Li XV, Leonardi I, Iliev ID. Gut mycobiota in immunity and inflammatory disease. Immunity. 2019;50(6):1365–1379. doi:10.1016/j.immuni.2019.05.023
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science. 2012;336(6086):1262–1267. doi:10.1126/science.1223813
   PubMed Web of Science ®Google Scholar
• Morgan XC, Tickle TL, Sokol H, et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 2012;13(9):R79. doi:10.1186/gb-2012-13-9-r79
   PubMed Web of Science ®Google Scholar
• Loeser RF, Arbeeva L, Kelley K, et al. Association of increased serum lipopolysaccharide, but not microbial dysbiosis, with obesity‐related osteoarthritis. Arthritis Rheumatol. 2022;74(2):227–236. doi:10.1002/art.41955
   PubMed Web of Science ®Google Scholar
• Hernandez CJ, Guss JD, Luna M, Goldring SR. Links between the microbiome and bone. J Bone Miner Res. 2016;31(9):1638–1646. doi:10.1002/jbmr.2887
   PubMed Web of Science ®Google Scholar
• Collins KH, Paul HA, Reimer RA, Seerattan RA, Hart DA, Herzog W. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model. Osteoarthr Cartilage. 2015;23(11):1989–1998. doi:10.1016/j.joca.2015.03.014
   PubMed Web of Science ®Google Scholar
• Témoin S, Chakaki A, Askari A, et al. Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol. 2012;18(3):117–121. doi:10.1097/rhu.0b013e3182500c95
   PubMed Web of Science ®Google Scholar
• Dunn CM, Velasco C, Rivas A, et al. Identification of cartilage microbial DNA signatures and associations with knee and hip osteoarthritis. Arthritis Rheumatol. 2020;72(7):1111–1122. doi:10.1002/art.41210
   PubMed Web of Science ®Google Scholar
• Jiang P, Sun S, Zhang J, et al. RNA expression profiling from the liquid fraction of synovial fluid in knee joint osteoarthritis patients. Am J Transl Res. 2021;14(9):6782–6791.
   Web of Science ®Google Scholar
• Schapira AH. Mitochondrial diseases. Lancet. 2012;379(9828):1825–1834. doi:10.1016/s0140-6736(11)61305-6
   PubMed Web of Science ®Google Scholar
• Martel-Pelletier J, Pelletier JP. Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review. Rmd Open. 2022;8(2):e002602. doi:10.1136/rmdopen-2022-002602
   PubMed Web of Science ®Google Scholar
• Crane DD, Bauler TJ, Wehrly TD, Bosio CM. Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome. Front Microbiol. 2014;5:438. doi:10.3389/fmicb.2014.00438
   PubMed Web of Science ®Google Scholar
• Blanco FJ, Rego I, Ruiz-Romero C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol. 2011;7(3):161–169. doi:10.1038/nrrheum.2010.213
   PubMed Web of Science ®Google Scholar
• Bae JH, Jo SI, Kim SJ, et al. Circulating cell-free mtDNA contributes to AIM2 inflammasome-mediated chronic inflammation in patients with type 2 diabetes. Cells. 2019;8(4):328. doi:10.3390/cells8040328
   PubMed Web of Science ®Google Scholar
• Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci. 2011;36(1):30–38. doi:10.1016/j.tibs.2010.07.007
   PubMed Web of Science ®Google Scholar
• Xu L, Zhou J, Che J, et al. Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease. Am J Physiolgastr L. 2021;320(6):G1034–G1044. doi:10.1152/ajpgi.00431.2020
   PubMed Web of Science ®Google Scholar
• Chen Z, Zhong H, Wei J, et al. Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther. 2019;21(1):300. doi:10.1186/s13075-019-2085-6
   PubMed Web of Science ®Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial Reactive Oxygen Species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–950. doi:10.1152/physrev.00026.2013
   PubMed Web of Science ®Google Scholar
• Savu O, Sunkari VG, Botusan IR, Grünler J, Nikoshkov A, Catrina S. Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes. Diabetes Metabol Res Rev. 2011;27(5):470–479. doi:10.1002/dmrr.1203
   PubMed Web of Science ®Google Scholar
• Wang X, Pan J, Liu H, et al. AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model. Life Sci. 2019;221:249–258. doi:10.1016/j.lfs.2019.02.035
   PubMed Web of Science ®Google Scholar
• Trachalaki A, Tsitoura E, Mastrodimou S, et al. Enhanced IL-1β release following NLRP3 and AIM2 inflammasome stimulation is linked to mtROS in airway macrophages in pulmonary fibrosis. Front Immunol. 2021;12:661811. doi:10.3389/fimmu.2021.661811
   PubMed Web of Science ®Google Scholar
• Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373–383. doi:10.1083/jcb.201211138
   PubMed Web of Science ®Google Scholar
• Yáñez‐Mó M, Siljander PRM, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4(1):27066. doi:10.3402/jev.v4.27066
   PubMed Web of Science ®Google Scholar
• Sanwlani R, Gangoda L. Role of extracellular vesicles in cell death and inflammation. Cells. 2021;10(10):2663. doi:10.3390/cells10102663
   PubMed Web of Science ®Google Scholar
• Zhou QF, Cai YZ, Lin XJ. The dual character of exosomes in osteoarthritis: antagonists and therapeutic agents. Acta Biomater. 2020;105:15–25. doi:10.1016/j.actbio.2020.01.040
   PubMed Web of Science ®Google Scholar
• Kato T, Miyaki S, Ishitobi H, et al. Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther. 2014;16(4):R163. doi:10.1186/ar4679
   PubMed Web of Science ®Google Scholar
• Wu X, Crawford R, Xiao Y, Mao X, Prasadam I. Osteoarthritic subchondral bone release exosomes that promote cartilage degeneration. Cells. 2021;10(2):251. doi:10.3390/cells10020251
   PubMed Web of Science ®Google Scholar
• Ni Z, Zhou S, Li S, et al. Exosomes: roles and therapeutic potential in osteoarthritis. Bone Res. 2020;8(1):25. doi:10.1038/s41413-020-0100-9
   PubMed Web of Science ®Google Scholar
• Noor NAM, Nurul AA, Zain MRAM, Aduni WKWN, Azlan M. Extracellular vesicles from mesenchymal stem cells as potential treatments for osteoarthritis. Cells. 2021;10(6):1287. doi:10.3390/cells10061287
   PubMed Web of Science ®Google Scholar
• Wu X, Bian B, Lin Z, et al. Identification of exosomal mRNA, lncRNA and circRNA signatures in an osteoarthritis synovial fluid-exosomal study. Exp Cell Res. 2022;410(1):112881. doi:10.1016/j.yexcr.2021.112881
   PubMed Web of Science ®Google Scholar
• Wu Y, Li J, Zeng Y, et al. Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies. Int J Oral Sci. 2022;14(1):40. doi:10.1038/s41368-022-00187-z
   PubMed Web of Science ®Google Scholar
• Fan WJ, Liu D, Pan LY, et al. Exosomes in osteoarthritis: updated insights on pathogenesis, diagnosis, and treatment. Front Cell Dev Biol. 2022;10:949690. doi:10.3389/fcell.2022.949690
   PubMed Web of Science ®Google Scholar
• Yu M, Wang D, Chen X, Zhong D, Luo J. BMSCs-derived mitochondria improve osteoarthritis by ameliorating mitochondrial dysfunction and promoting mitochondrial biogenesis in chondrocytes. Stem Cell Rev Rep. 2022;1–20. doi:10.1007/s12015-022-10436-7
   PubMed Web of Science ®Google Scholar
• Matsuyama H, Shindo A, Shimada T, et al. Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome. Brain Res. 2020;1736:146779. doi:10.1016/j.brainres.2020.146779
   PubMed Web of Science ®Google Scholar
• Lian Q, Xu J, Yan S, et al. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Res. 2017;27(6):784–800. doi:10.1038/cr.2017.54
   PubMed Web of Science ®Google Scholar
• Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definitions and controversies. Bmc Med. 2011;9(1):48. doi:10.1186/1741-7015-9-48
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Zawieja S, Wang W, Zawieja DC, Muthuchamy M. Lymphatic system: a vital link between metabolic syndrome and inflammation. Ann Ny Acad Sci. 2010;1207:E94–E102. doi:10.1111/j.1749-6632.2010.05752.x
   PubMed Web of Science ®Google Scholar
• Kulkarni K, Karssiens T, Kumar V, Pandit H. Obesity and osteoarthritis. Maturitas. 2016;89:22–28. doi:10.1016/j.maturitas.2016.04.006
   PubMed Web of Science ®Google Scholar
• Misra D, Fielding RA, Felson DT, et al. Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia. Arthritis Rheumatol. 2019;71(2):232–237. doi:10.1002/art.40692
   PubMed Web of Science ®Google Scholar
• Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U. The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2017;13(5):302–311. doi:10.1038/nrrheum.2017.50
   PubMed Web of Science ®Google Scholar
• Marshall M, Watt FE, Vincent TL, Dziedzic K. Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management. Nat Rev Rheumatol. 2018;14(11):641–656. doi:10.1038/s41584-018-0095-4
   PubMed Web of Science ®Google Scholar
• Cho SJ, Moon JS, Nikahira K, et al. GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation. Thorax. 2020;75(3):227. doi:10.1136/thoraxjnl-2019-213571
   PubMed Web of Science ®Google Scholar
• Xie M, Yu Y, Kang R, et al. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. Nat Commun. 2016;7(1):13280. doi:10.1038/ncomms13280
   PubMed Web of Science ®Google Scholar
• Pan J, Han L, Guo J, et al. AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice. Biochem Bioph Res Co. 2018;498(3):487–494. doi:10.1016/j.bbrc.2018.03.005
   PubMed Web of Science ®Google Scholar
• Dang EV, McDonald JG, Russell DW, Cyster JG. Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation. Cell. 2017;171(5):1057–1071.e11. doi:10.1016/j.cell.2017.09.029
   PubMed Web of Science ®Google Scholar
• Cunha LD, Silva ALN, Ribeiro JM, et al. AIM2 engages active but unprocessed caspase-1 to induce noncanonical activation of the NLRP3 inflammasome. Cell Rep. 2017;20(4):794–805. doi:10.1016/j.celrep.2017.06.086
   PubMed Web of Science ®Google Scholar
• Witzenrath M, Pache F, Lorenz D, et al. The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol. 2011;187(1):434–440. doi:10.4049/jimmunol.1003143
   PubMed Web of Science ®Google Scholar
• Heinisch O, Zeyen T, Goldmann T, et al. Erythropoietin abrogates post-ischemic activation of the NLRP3, NLRC4, and AIM2 inflammasomes in microglia/macrophages in a TAK1-dependent manner. Transl Stroke Res. 2022;13(3):462–482. doi:10.1007/s12975-021-00948-8
   PubMed Web of Science ®Google Scholar
• Kim J, Ahn H, Han BC, et al. Korean red ginseng extracts inhibit NLRP3 and AIM2 inflammasome activation. Immunol Lett. 2014;158(1–2):143–150. doi:10.1016/j.imlet.2013.12.017
   PubMed Web of Science ®Google Scholar