Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation

References

• Yin MS, Zhang YC, Xu SH, et al. Puerarin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of inflammation. J Asian Nat Prod Res. 2019;21(5):476–493.
   PubMed Web of Science ®Google Scholar
• Gilbert RE, Krum H. Heart failure in diabetes: effects of anti-hyperglycaemic drug therapy. Lancet. 2015;385(9982):2107–2117.
   PubMed Web of Science ®Google Scholar
• Li L, Luo W, Qian Y, et al. Luteolin protects against diabetic cardiomyopathy by inhibiting NF-kappaB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine. 2019;59:152774.
   PubMed Web of Science ®Google Scholar
• Colareda GA, Matera SI, Bayley M, et al. Lepidium meyenii (maca) and soy isoflavones reduce cardiac stunning of ischemia-reperfusion in rats by mitochondrial mechanisms. J Tradit Complement Med. 2021;11(6):471–480.
   PubMedGoogle Scholar
• Zhao Y, Guo R, Li L, et al. Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury. Biomed Pharmacother. 2020;132:110897.
   PubMed Web of Science ®Google Scholar
• Nian M, Lee P, Khaper N, Liu P. Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res. 2004;94(12):1543–1553.
   PubMed Web of Science ®Google Scholar
• Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. 2020;17(9):585–607.
   PubMed Web of Science ®Google Scholar
• Lin K, Yang N, Luo W, et al. Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling. Acta Pharmacol Sin. 2022;43(10):2624–2635.
   PubMed Web of Science ®Google Scholar
• Kennedy A, Martinez K, Chuang -C-C, LaPoint K, McIntosh M. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr. 2009;139(1):1–4.
   PubMed Web of Science ®Google Scholar
• Nakamura M, Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. J Physiol. 2019;598(14):2977–2993.
   PubMed Web of Science ®Google Scholar
• Frati G, Schirone L, Chimenti I, et al. An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy. Cardiovasc Res. 2017;113(4):378–388.
   PubMed Web of Science ®Google Scholar
• Haudek SB, Taffet GE, Schneider MD, Mann DL. TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. J Clin Invest. 2007;117(9):2692–2701.
   PubMed Web of Science ®Google Scholar
• Kaludercic N, Di Lisa F. Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy. Front Cardiovasc Med. 2020;7:12.
   PubMed Web of Science ®Google Scholar
• Almourani R, Chinnakotla B, Patel R, Kurukulasuriya LR, Sowers J. Diabetes and cardiovascular disease: an update. Curr Diab Rep. 2019;19(12):161.
   PubMed Web of Science ®Google Scholar
• Tsai KH, Wang WJ, Lin CW, et al. NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-kappaB in cardiomyocytes exposed to high glucose. J Cell Physiol. 2012;227(4):1347–1357.
   PubMed Web of Science ®Google Scholar
• Nizamutdinova IT, Guleria RS, Singh AB, Kendall JA, Baker KM, Pan J. Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-kappaB signaling pathway. J Cell Physiol. 2013;228(2):380–392.
   PubMed Web of Science ®Google Scholar
• Zuo G, Ren X, Qian X, et al. Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy. J Cell Physiol. 2019;234(2):1925–1936.
   PubMed Web of Science ®Google Scholar
• Xue B, Wang L, Zhang Z, et al. Puerarin may protect against Schwann cell damage induced by glucose fluctuation. J Nat Med. 2017;71(3):472–481.
   PubMed Web of Science ®Google Scholar
• Andor B, Danciu C, Alexa E, et al. Germinated and Ungerminated Seeds Extract from Two Lupinus Species. Biol Compounds Character In Vitro In Vivo Evaluat Evid Based Complement Alternat Med. 2016;2016:7638542.
   PubMed Web of Science ®Google Scholar
• Wu H, Zhao G, Jiang K, et al. Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis. Phytother Res. 2016;30(10):1658–1664.
   PubMed Web of Science ®Google Scholar
• Su W, Zhang Y, Zhang Q, et al. N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats. Cardiovasc Diabetol. 2016;15(1):146.
   PubMedGoogle Scholar
• Sun HJ, Xiong SP, Wu ZY, et al. Induction of caveolin-3/eNOS complex by nitroxyl (HNO) ameliorates diabetic cardiomyopathy. Redox Biol. 2020;32:101493.
   PubMed Web of Science ®Google Scholar
• Thangavel C, Gomes CM, Zderic SA, et al. NF-kappaB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy. Am J Pathol. 2019;189(4):847–867.
   PubMed Web of Science ®Google Scholar
• Woodman SE, Park DS, Cohen AW, et al. Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem. 2002;277(41):38988–38997.
   PubMed Web of Science ®Google Scholar
• Hiramoto S, Tsubota M, Yamaguchi K, et al. Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H(2)S/Ca(v)3.2 Signaling in Mice. Cells. 2020;9(8):65.
   Web of Science ®Google Scholar
• Talukder MA, Preda M, Ryzhova L, Prudovsky I, Pinz IM. Heterozygous caveolin-3 mice show increased susceptibility to palmitate-induced insulin resistance. Physiol Rep. 2016;4(6):3456.
   Google Scholar
• Zhu A, Wei X, Zhang Y, et al. Propofol Provides Cardiac Protection by Suppressing the Proteasome Degradation of Caveolin-3 in Ischemic/Reperfused Rat Hearts. J Cardiovasc Pharmacol. 2017;69(3):170–177.
   PubMed Web of Science ®Google Scholar
• Murfitt L, Whiteley G, Iqbal MM, Kitmitto A. Targeting caveolin-3 for the treatment of diabetic cardiomyopathy. Pharmacol Ther. 2015;151:50–71.
   PubMed Web of Science ®Google Scholar
• Varela R, Rauschert I, Romanelli G, Alberro A, Benech JC. Hyperglycemia and hyperlipidemia can induce morphophysiological changes in rat cardiac cell line. Biochem Biophys Rep. 2021;26:100983.
   PubMedGoogle Scholar
• Chang W, Zhang M, Meng Z, et al. Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5’-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells. Eur J Pharmacol. 2015;769:55–63.
   PubMed Web of Science ®Google Scholar
• Varga ZV, Giricz Z, Liaudet L, Hasko G, Ferdinandy P, Pacher P. Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochim Biophys Acta. 2015;1852(2):232–242.
   PubMed Web of Science ®Google Scholar
• Lee SH, Kim MK, Rhee EJ. Effects of cardiovascular risk factor variability on health outcomes. Endocrinol Metab. 2020;35(2):217–226.
   Google Scholar
• Zhou YX, Zhang H, Peng C. Effects of puerarin on the prevention and treatment of cardiovascular diseases. Front Pharmacol. 2021;12:771793.
   PubMed Web of Science ®Google Scholar
• Wang X, McLennan SV, Allen TJ, Tsoutsman T, Semsarian C, Twigg SM. Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. Am J Physiol Cell Physiol. 2009;297(6):C1490–500.
   PubMed Web of Science ®Google Scholar
• Kui L, Weiwei Z, Ling L, et al. Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway. Regul Pept. 2009;155(1–3):62–69.
   PubMedGoogle Scholar
• Zhang B, Li X, Liu G, et al. Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy. Biomed Pharmacother. 2021;141:111780.
   PubMed Web of Science ®Google Scholar
• Liu Y, Qiu Y, Chen Q, Han X, Cai M, Hao L. Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG(2) cells. Biomed Pharmacother. 2021;137:111325.
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu L, Wang M. Effects of puerarin on chronic inflammation: focus on the heart, brain, and arteries. Aging Med. 2021;4(4):317–324.
   PubMedGoogle Scholar
• Tang W, Xiao L, Ge G, et al. Puerarin inhibits titanium particle-induced osteolysis and RANKL-induced osteoclastogenesis via suppression of the NF-kappaB signaling pathway. J Cell Mol Med. 2020;24(20):11972–11983.
   PubMed Web of Science ®Google Scholar
• Jia G, DeMarco VG, Sowers JR. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144–153.
   PubMed Web of Science ®Google Scholar
• Ramesh P, Yeo JL, Brady EM, McCann GP. Role of inflammation in diabetic cardiomyopathy. Ther Adv Endocrinol Metab. 2022;13:20420188221083530.
   Web of Science ®Google Scholar
• Zhang S, Zhang S, Liang X, et al. Guanxinping ameliorates atherosclerosis via MAPK/NF-kappaB signaling pathway in ApoE(-/-) mice. Perfusion. 2023;38(3):557–566.
   PubMed Web of Science ®Google Scholar
• Savira F, Cao L, Wang I, et al. Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: implications for cardiorenal syndrome. PLoS One. 2017;12(11):e0187459.
   PubMed Web of Science ®Google Scholar
• Shaver A, Nichols A, Thompson E, et al. Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population. Int J Med Sci. 2016;13(3):161–168.
   PubMed Web of Science ®Google Scholar
• Wu S, Zhu J, Wu G, et al. 6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2022;2022:3027514.
   PubMed Web of Science ®Google Scholar
• Melendez GC, McLarty JL, Levick SP, Du Y, Janicki JS, Brower GL. Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension. 2010;56(2):225–231.
   PubMed Web of Science ®Google Scholar
• Ko HJ, Zhang Z, Jung DY, et al. Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart. Diabetes. 2009;58(11):2536–2546.
   PubMed Web of Science ®Google Scholar
• Li WQ, Wu JY, Xiang DX, et al. Micelles Loaded With Puerarin And Modified With Triphenylphosphonium Cation Possess Mitochondrial Targeting And Demonstrate Enhanced Protective Effect Against Isoprenaline-Induced H9c2 Cells Apoptosis. Int J Nanomedicine. 2019;14:8345–8360.
   PubMed Web of Science ®Google Scholar
• Gao S, Li L, Li L, et al. Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice. J Mol Cell Cardiol. 2019;137:59–70.
   PubMed Web of Science ®Google Scholar
• Li M, Zhang M, Huang L, et al. T-type Ca2+ channels are involved in high glucose-induced rat neonatal cardiomyocyte proliferation. Pediatr Res. 2005;57(4):550–556.
   PubMed Web of Science ®Google Scholar
• Lei S, Li H, Xu J, et al. Hyperglycemia-induced protein kinase C beta 2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling. Diabetes. 2013;62(7):2318–2328.
   PubMed Web of Science ®Google Scholar
• Stemkowski PL, Garcia-Caballero A, Gadotti VM, et al. Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway. Mol Pain. 2017;13:1744806917724698.
   Web of Science ®Google Scholar
• BenMohamed F, Ferron L, Ruchon Y, Gouadon E, Renaud J-F, Capuano V. Regulation of T-type Cav3.1 channels expression by synthetic glucocorticoid dexamethasone in neonatal cardiac myocytes. Mol Cell Biochem. 2008;320:1–2.
   PubMed Web of Science ®Google Scholar
• Ohno Y, Sugiura T, Ohira Y, Yoshioka T, Goto K. Loading-associated expression of TRIM72 and caveolin-3 in antigravitational soleus muscle in mice. Physiol Rep. 2014;2(12):24.
   Google Scholar