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ORIGINAL RESEARCH

Increased Systemic Immune-Inflammation Index Was Associated with Type 2 Diabetic Peripheral Neuropathy: A Cross-Sectional Study in the Chinese Population

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Pages 6039-6053 | Received 04 Aug 2023, Accepted 08 Nov 2023, Published online: 10 Dec 2023

References

  • Selvarajah D, Kar D, Khunti K, et al. Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention. Lancet Diabetes Endocrinol. 2019;7(12):938–948. doi:10.1016/S2213-8587(19)30081-6
  • Elafros MA, Andersen H, Bennett DL, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922–936. doi:10.1016/S1474-4422(22)00188-0
  • Pek SLT, Sum CF, Yeoh LY, et al. Association of apolipoprotein-CIII (apoC-III), endothelium-dependent vasodilation and peripheral neuropathy in a multi-ethnic population with type 2 diabetes. Metabolism. 2017;72:75–82. doi:10.1016/j.metabol.2017.03.016
  • Argoff CE, Cole BE, Fishbain DA, Irving GA. Diabetic peripheral neuropathic pain: clinical and quality-of-life issues. Mayo Clin Proc. 2006;81(4 Suppl):S3–S11. doi:10.1016/s0025-6196(11)61474-2
  • Sloan G, Selvarajah D, Tesfaye S. Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nat Rev Endocrinol. 2021;17(7):400–420. doi:10.1038/s41574-021-00496-z
  • Yang K, Wang Y, Li YW, et al. Progress in the treatment of diabetic peripheral neuropathy. Biomed Pharmacother. 2022;148:112717. doi:10.1016/j.biopha.2022.112717
  • Liu S, Zheng H, Zhu X, et al. Neutrophil-to-lymphocyte ratio is associated with diabetic peripheral neuropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2017;130:90–97. doi:10.1016/j.diabres.2017.05.008
  • Allwright M, Karrasch JF, O’Brien JA, Guennewig B, Austin PJ. Machine learning analysis of the UK Biobank reveals prognostic and diagnostic immune biomarkers for polyneuropathy and neuropathic pain in diabetes. Diabetes Res Clin Pract. 2023;201:110725. doi:10.1016/j.diabres.2023.110725
  • Chen M, Zhu Y, Wang J, Wang G, Wu Y. The predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio levels of diabetic peripheral neuropathy. J Pain Res. 2021;14:2049–2058. doi:10.2147/JPR.S304595
  • Xie R, Xiao M, Li L, et al. Association between SII and hepatic steatosis and liver fibrosis: a population-based study. Front Immunol. 2022;13:925690. doi:10.3389/fimmu.2022.925690
  • Zhu Q, Wu Y, Mai J, et al. Comprehensive metabolic profiling of inflammation indicated key roles of glycerophospholipid and arginine metabolism in coronary artery disease. Front Immunol. 2022;13:829425. doi:10.3389/fimmu.2022.829425
  • Yaşar E, Bayramoğlu A. Systemic immune-inflammation index as a predictor of microvascular dysfunction in patients with cardiac syndrome X. Angiology. 2022;73(7):615–621. doi:10.1177/00033197221087777
  • Liu B, Wang J, Li YY, Li KP, Zhang Q. The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018. Arthritis Res Ther. 2023;25(1):34. doi:10.1186/s13075-023-03018-6
  • Ren B, Chen X, Lei P, et al. The relationship between preoperative systemic immune inflammation index and prognostic nutritional index and the prognosis of patients with alveolar hydatid disease. Front Immunol. 2021;12:691364. doi:10.3389/fimmu.2021.691364
  • Cao Y, Li P, Zhang Y, et al. Association of systemic immune inflammatory index with all-cause and cause-specific mortality in hypertensive individuals: results from NHANES. Front Immunol. 2023;14:1087345. doi:10.3389/fimmu.2023.1087345
  • Wei C, Zhang W, Chen J, et al. Systematic analysis between inflammation-related index and sex hormones in American adults: cross-sectional research based NHANES 2013–2016. Front Immunol. 2023;14:1175764. doi:10.3389/fimmu.2023.1175764
  • Özata Gündoğdu K, Doğan E, Çelik E, Alagöz G. Serum inflammatory marker levels in serous macular detachment secondary to diabetic macular edema. Eur J Ophthalmol. 2022;32(6):3637–3643. doi:10.1177/11206721221083465
  • Guo W, Song Y, Sun Y, et al. Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: evidence from NHANES 2011–2018. Front Endocrinol (Lausanne). 2022;13:1071465. doi:10.3389/fendo.2022.1071465
  • Ozer Balin S, Ozcan EC, Uğur K. A new inflammatory marker of clinical and diagnostic importance in diabetic foot infection: systemic immune-inflammation index. Int J Low Extrem Wounds. 2022;15347346221130817. doi:10.1177/15347346221130817
  • Qin Z, Li H, Wang L, et al. Systemic immune-inflammation index is associated with increased urinary albumin excretion: a population-based study. Front Immunol. 2022;13:863640. doi:10.3389/fimmu.2022.863640
  • Taslamacioglu Duman T, Ozkul FN, Balci B. Could systemic inflammatory index predict diabetic kidney injury in type 2 diabetes mellitus?. Diagnostics. 2023;13(12):2063. doi:10.3390/diagnostics13122063
  • Kocak MZ, Aktas G, Erkus E, et al. Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus. Swiss Med Wkly. 2019;149:w20139. doi:10.4414/smw.2019.20139
  • Aktas G, Yilmaz S, Kantarci DB, et al. Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?. Postgrad Med. 2023;135(5):519–523. doi:10.1080/00325481.2023.2214058
  • Aktas G. Serum C-reactive protein to albumin ratio as a reliable marker of diabetic neuropathy in Type 2 diabetes mellitus. Preprints. 2023;2023060202. doi:10.20944/preprints202306.0202.v1
  • Mostafa SA, Davies MJ, Webb D, et al. The potential impact of using glycated haemoglobin as the preferred diagnostic tool for detecting Type 2 diabetes mellitus. Diabet Med. 2010;27(7):762–769. doi:10.1111/j.1464-5491.2010.03015.x
  • Yan P, Wu Y, Dan X, et al. Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: a cross-sectional study. Front Endocrinol (Lausanne). 2023;14:1064125. doi:10.3389/fendo.2023.1064125
  • Lee KO, Nam JS, Ahn CW, et al. Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients. Acta Diabetol. 2012;49(2):97–103. doi:10.1007/s00592-010-0176-6
  • Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–612. doi:10.7326/0003-4819-150-9-200905050-00006
  • Yan P, Zhang Z, Wan Q, et al. Association of serum uric acid with bone mineral density and clinical fractures in Chinese type 2 diabetes mellitus patients: a cross-sectional study. Clin Chim Acta. 2018;486:76–85. doi:10.1016/j.cca.2018.07.033
  • Ponirakis G, Elhadd T, Chinnaiyan S, et al. Prevalence and management of diabetic neuropathy in secondary care in Qatar. Diabetes Metab Res Rev. 2020;36(4):e3286. doi:10.1002/dmrr.3286
  • Liu M, Gao Y, Chen DW, et al. Quantitative vibration perception threshold in assessing diabetic polyneuropathy: should the cut-off value be adjusted for Chinese individuals with type 2 diabetes?. J Diabetes Investig. 2021;12(9):1663–1670. doi:10.1111/jdi.13515
  • Jiang TN, Li YF, Huo LL, et al. Association between serum uric acid and large-nerve fiber dysfunction in type 2 diabetes: a cross-sectional study. Chin Med J (Engl). 2019;132(9):1015–1022. doi:10.1097/CM9.0000000000000223
  • Li X, Xu J, Yao H, Guo Y, Chen M, Lu W. Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey. Front Med. 2012;6(3):322–328. doi:10.1007/s11684-012-0204-8
  • Wu Y, Wan Q, Xu Y, et al. Lower visceral fat area in patients with Type 2 diabetic peripheral neuropathy. Diabetes Metab Syndr Obes. 2022;15:3639–3654. doi:10.2147/DMSO.S388330
  • Xu E, Xie Y, Al-Aly Z. Risks and burdens of incident dyslipidaemia in long COVID: a cohort study. Lancet Diabetes Endocrinol. 2023;11(2):120–128. doi:10.1016/S2213-8587(22)00355-2
  • Kim SH, Baek CO, Lee KA, Park TS, Baek HS, Jin HY. Clinical implication of elevated CA 19-9 level and the relationship with glucose control state in patients with type 2 diabetes. Endocrine. 2014;46(2):249–255. doi:10.1007/s12020-013-0058-0
  • Reid A, Stöhr W, Walker AS, et al. Severe renal dysfunction and risk factors associated with renal impairment in HIV-infected adults in Africa initiating antiretroviral therapy. Clin Infect Dis. 2008;46(8):1271–1281. doi:10.1086/533468
  • National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1–S266.
  • Looker HC, Krakoff J, Funahashi T, et al. Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J Clin Endocrinol Metab. 2004;89(8):4010–4017. doi:10.1210/jc.2003-031916
  • Alonso A, Lopez FL, Matsushita K, et al. Chronic kidney disease is associated with the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 2011;123(25):2946–2953. doi:10.1161/CIRCULATIONAHA.111.020982
  • Xu JP, Zeng RX, Zhang YZ, et al. Systemic inflammation markers and the prevalence of hypertension: a NHANES cross-sectional study. Hypertens Res. 2023;46(4):1009–1019. doi:10.1038/s41440-023-01195-0
  • Xia Y, Xia C, Wu L, Li Z, Li H, Zhang J. Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and risk of all-cause mortality and cardiovascular mortality: a 20-year follow-up cohort study of 42,875 US adults. J Clin Med. 2023;12(3):1128. doi:10.3390/jcm12031128
  • Xu M, Chen R, Liu L, et al. Systemic immune-inflammation index and incident cardiovascular diseases among middle-aged and elderly Chinese adults: the Dongfeng-Tongji cohort study. Atherosclerosis. 2021;323:20–29. doi:10.1016/j.atherosclerosis.2021.02.012
  • Yildiz C, Yuksel Y, Rakici IT, Katkat F, Ayça B, Turhan Çağlar FN. Assessment of systemic immune-inflammation index and systemic inflammation-response index in different coronary artery plaque types. Angiology. 2023;74(6):536–544. doi:10.1177/00033197231158937
  • Lin H, Bai Z, Wu Q, et al. Inflammatory indexes for assessing the severity and disease progression of ulcerative colitis: a single-center retrospective study. Front Public Health. 2022;10:851295. doi:10.3389/fpubh.2022.851295
  • Yi HJ, Sung JH, Lee DH. Systemic inflammation response index and systemic immune-inflammation Index are associated with clinical outcomes in patients treated with mechanical thrombectomy for large artery occlusion. World Neurosurg. 2021;153:e282–e289. doi:10.1016/j.wneu.2021.06.113
  • Chen J, Huang W, Xu X, et al. Prognostic implications of systemic immune-inflammation index in patients with bone metastases from hepatocellular carcinoma treated with radiotherapy. Front Oncol. 2023;13:1076428. doi:10.3389/fonc.2023.1076428
  • Xu T, Weng Z, Pei C, et al. The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus. Medicine (Baltimore). 2017;96(45):e8289. doi:10.1097/MD.0000000000008289
  • Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development?. Pak J Med Sci. 2019;35(6):1511–1515. doi:10.12669/pjms.35.6.1150
  • D’Onofrio L, Ferdousi M, Kalteniece A, et al. Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia. J Clin Lipidol. 2022;16(4):463–471. doi:10.1016/j.jacl.2022.04.006
  • Geng T, Zhu K, Lu Q, et al. Healthy lifestyle behaviors, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: a cohort study. PLoS Med. 2023;20(1):e1004135. doi:10.1371/journal.pmed.1004135
  • Kamenov ZA, Parapunova RA, Georgieva RT. Earlier development of diabetic neuropathy in men than in women with type 2 diabetes mellitus. Gend Med. 2010;7(6):600–615. doi:10.1016/j.genm.2010.11.001
  • Pouwer F, Kupper N, Adriaanse MC. Does emotional stress cause type 2 diabetes mellitus? A review from the European Depression in Diabetes (EDID) Research Consortium. Discov Med. 2010;9(45):112–118.
  • Marinho FS, Moram CBM, Rodrigues PC, Leite NC, Salles GF, Cardoso CRL. Treatment adherence and its associated factors in patients with Type 2 diabetes: results from the Rio de Janeiro Type 2 diabetes cohort study. J Diabetes Res. 2018;2018:8970196. doi:10.1155/2018/8970196
  • Li Z, Lei X, Xu B, Wang S, Gao T, Lv H. Analysis of risk factors of diabetes peripheral neuropathy in type 2 diabetes mellitus and nursing intervention. Exp Ther Med. 2020;20(6):127. doi:10.3892/etm.2020.9257
  • Li Y, Liu M, Cui Y, et al. Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study. Front Endocrinol (Lausanne). 2022;13:974773. doi:10.3389/fendo.2022.974773
  • Al Hayek AA, Khader YS, Jafal S, Khawaja N, Robert AA, Ajlouni K. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med. 2013;20(3):179–186. doi:10.4103/2230-8229.122006
  • Tayama K, Inukai T, Shimomura Y. Preperitoneal fat deposition estimated by ultrasonography in patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1999;43(1):49–58. doi:10.1016/s0168-8227(98)00118-1
  • Andersen ST, Witte DR, Andersen H, et al. Risk-Factor trajectories preceding diabetic polyneuropathy: ADDITION-Denmark. Diabetes Care. 2018;41(9):1955–1962. doi:10.2337/dc18-0392
  • Furuncuoğlu Y, Tulgar S, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20(7):1300–1306.
  • Man RE, Sabanayagam C, Chiang PP, et al. Differential association of generalized and abdominal obesity with diabetic retinopathy in Asian patients with type 2 diabetes. JAMA Ophthalmol. 2016;134(3):251–257. doi:10.1001/jamaophthalmol.2015.5103
  • Cameron NE, Eaton SE, Cotter MA, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia. 2001;44(11):1973–1988. doi:10.1007/s001250100001